FR2579460A1 - NEW POWDER POWDERS CONTAINING A BIOACTIVE SUBSTANCE AND PROCESS FOR THEIR PREPARATION - Google Patents

Abstract

THE INVENTION RELATES TO NEW COMPOSITIONS OF POWDERING POWDERS CONTAINING CYCLODEXTRIN OR POLYMERS BY DERIVATING AND POSSIBLY ONE OR MORE COMPLEX (S) INCLUDING CYCLODEXTRIN AS A VEHICLE, THINNER OR EXCIPIENT FROM 0.1 TO 99, 9 AND ONE OR MORE BIOLOGICALLY ACTIVE SUBSTANCE (S) AND OR PERFUME (S) AND OR COLOR (S) IN QUANTITY OF 99.9 TO 0.1. THE POWDERING POWDER COMPOSITIONS OF THE INVENTION CAN BE USED THERAPEUALLY TO DISINFECT, AS WELL AS TO CALM SKIN INFLAMMATIONS AND SURFACE PAIN.

Description

The invention relates to novel powder powders

  treament containing a bioactive substance. More particultâ-

  In addition, the novel powder coating compositions of this invention contain cyclodextrin as the carrier or diluent.

  The subject of the invention is also a method for preparing

of these dusting powders.

  Dusting powders are powders or molds

  thin, powdery cloths with a high degree of stickiness applied to the skin to protect, dry or cool. In addition, in the case of

  dusting powders containing a de-

  the object is to obtain a therapeutic action, for example a disinfecting or anti-inflammatory effect and, in certain cases, to promote the percutaneous absorption of

active ingredient.

  The dusting powders must have a good capacity of binding water and fats in order to bind

  sweat or fatty acids excreted by the skin.

  It is important that the powder particles of

  dust are not electrostatically

  they do not agglomerate under the effect of friction

  causes storage or agitation during application.

  It is for this reason that we must provide for the

  powdering properties of suitable rheological properties.

  The basic materials commonly used for dusting powders are zinc stearate,

  zinc, talc, calcium carbonate, bentonite, ar-

  aluminum hydroxide, magnesium carbonate,

  colloidal silicon hydroxide and various types of

  donations. Reference has been made to a summary of the

  Dusting powder: F. Gstirner: Grundstoffe und Verfahren der Arzneibereitung (Ferdinand Enke Verlag, Stuttgart,

1960, pp. 885-902).

  The basic materials of the dusting powders used

  so far can be divided into two groups.

  One of these groups involves various types of starches while the other is represented by

  mineral source such as talc, kaolin and the like.

  Starch, which is frequently used in dusting powders, in particular in cosmetics,

  proves to be an advantageous culture medium for

  cutaneous glands in humans and one can therefore, if one obtains

  serve the proliferation of fungal infections, almost consider the use of starch or starch in

  dusting powders as a practice mistake.

  The basic materials of the powder dusts of o-

  rigidity are frequently contaminated in proportion

  raised by bacteria such as Clostridium tetani, Clos-

  tridium perfringens, Bacillus anthracis (The Pharmaceutical

  Codex, XIth Edition, p. 315). Therefore, before the

  these substances should be heated to at least

   C for over an hour, which makes their job difficult.

  Fungal infection of the skin in the human world

  hand was formerly caused mainly by Dermatophyta.

  In the last decade, however, the proliferation of Blastomycetes has been observed, probably as a result of the widespread use of antibiotics. Blastomycetes is now responsible for most dermatomycoses. In

  Hungary, fungal infections are mainly caused by

  by Candida albicans, Trichophyton rubrum and Tricho-

phyton mentagrophytes.

  The purpose of these studies is to prepare a

  dusting powder containing a new vehicle and diluent which is devoid of the disadvantageous properties of the

  basics of dusting powders used until now.

  Surprisingly, it has been found that cyclodextrins are suitable

  for the use as basic materials of the powder coating powder.

  This is why the present invention relates to a method of

  preparation of a dusting powder composition comprising

  the mixture of cyclodextrin or polymers thereof and optionally one or more cyclodextrin inclusion complex (s) as carrier, diluent or excipient, in an amount of 0.1 to 99.9% and one or several biologically active substance (s) and / or perfume (s) and / or

  dye (s) in an amount of 99.9% to 0.1%.

  The present invention also relates to the composition

obtained by this method.

  It is known that cyclodextrins are macrocycles constructed from 6, 7 or 8 glucopyranose units which are designated according to the increasing number of

  glucose, by alpha-, beta- or gamma-cyclodextrin. The cy-

  clodextrins are prepared from the starch so that the starch as a substrate is broken down and then

  directly cyclized by the enzyme cyclodextrin-transglycol

sylase (CTG).

  The polymers are prepared from the cyclodex-

  trines according to known methods, for example in the form of a pearl (Hungarian patent r 177419), or block (patent

  US 4 547 572) or foam (Hungarian Patent 185866).

  Mainly, cyclodextrins can be

  considered to be molecular-size capsules

  lar. The spatial structure of the molecule is arranged in such a way that all the hydroxyl groups are in the outer part of the molecule, whereas there exists along the central axis of the molecule a weak apolar hole of significant size compared to the molecule as a whole. This forms the basis of the formation capacity of an inclusion complex, namely the capacity

  molecular encapsulation, cyclodextrins.

  Many articles in the literature concern

  the preparation, analysis and toxicology of cyclo-

  dextrins as well as the extraordinarily high number of industrial application possibilities based on their ability to form inclusion complexes [J. Szejtli:

  Cyclodextrins and their Inclusion Complexes (Cyclodextrins and their

  trines and their inclusion complexes), Akadémiai Kiad6, Budapest, 1982; and J. Sze3tli (eds): Proceedings of the International Symposium on Cyclodextrins (Proceedings of the 1st International Symposium on Cyclodextrins),

Akademia Kiad6, Budapest, 19821.

  The use of cyclodextrins as a vehicle and

  luent in dusting powders is by no means

  dent to the skilled person, it seems even contraindicated on the basis of previous knowledge. Namely, it is obvious to those skilled in the art that crystallizable, i.e., non-polymeric, carbohydrates should not be used in dusting powders as they represent culture media for cutaneous fungi in humans; in addition, they are hygroscopic, sticky, so the idea

  even their use in dusting powders must be rejected.

  On the other hand, it has been discovered that cyclodextrins do not represent a suitable culture medium for fungi infecting the skin and are therefore suitable

  for use as a vehicle and thinner in dusting powders.

  The following series of experiments were carried out

  to study the use of the various sources of

  carbon in the different species of mushrooms.

  Microorganisms studied: I.) Blastomycetes a) Candida albicans CBS 562 b) Candida tropicalis CBS 433 c) Candida guilliermondii 191 d) Candida krusei K 47 e) Candida pseudotropicalis 372 f) Saccharomyces cerevisiae OKI 1282 II.) Hyphomycetes a) Trichophyton rubrum CBS 30338 b) Trichophyton mentagrophytes CBS 50148 c) Trichophyton (Keratomyces) ajelloi OKI d) Epidermophyton floccosum OKI IV e) Microsporum persicolor OKI f) Microsporum gypseum var. virosum CBS 10064 Carbon sources investigated: Soluble starch (Amylum solubile) Corn starch (Amylum maydis) Glucose Maltose beta-Cyclodextrin polymeric beta-cyclodextrin in pearl form

  The base medium used was a culture medium.

  sabouraud tea having the following composition: Peptone 10 g Glucose 10 g

Z579460

  Maltose 20 g Disodium phosphate 10. g Potassium dihydrogen phosphate 1 g Distilled water q.s. 1000 ml In the following culture media, replace

  the amount of 10 g of glucose and 20 g of malt

  used as sources of carbon by sources of

  carbon listed above, we obtain 18 outputs

  Variants of culture media as follows: 1. Sabouraud (control) 2. Sabouraud without carbon source 3. Sabouraud with 30 g of glucose as carbon source 4. Sabouraud with 30 g of maltose as carbon source 5. Sabouraud with 30 g of soluble starch as carbon source 6. Sabouraud with 30 g of maize starch as carbon source 7. SaDouraud with 10 g of beta-cyclodextrin and 20 g of maltose as carbon source 8. Sabouraud with 20 g of beta-cyclodextrin and 10 g of glucose as carbon source 9. Sabouraud with 30 g of betacyclodextrin as a carbon source 10. Distilled water with 30 g of glucose 11. Distilled water with 30 g of maltose 12. Distilled water with 30 g of soluble starch 13. Distilled water with 30 g of corn starch

  14. Distilled water with 30 g of beta-cyclodextrin.

  15. Sabouraud with 10 g of beta-pearl polymer

  cyclodextrin and 20 g of maltose

  16. Sabouraud with 20 g of beta pearl polymer

  cyclodextrin as well as 10 g of glucose

  17. Sabouraud with 30 g of beta pearl polymer

cyclodextrin

  18. Distilled water with 30 g of beta-pearl polymer

  cyclodextrin. The experiments were carried out in such a way that 5 ml of the culture media were inoculated with x105 cells / ml of the organism studied and incubated at 27 ° C. The incubation lasted 24 and 48 hours, respectively (1 or 2 days, respectively) for 3Blastomycetes and 72, 144 or 288 hours, respectively (ie, 3, 6 or 12 days, respectively) for Hyphomycetes. The results

  are grouped in Tables I and II.

  In the tables, the following abbreviations are used:

  vantes: O: no growth +: very weak growth +: weak growth ++: average growth +++: intense growth

Table I

  Exploitation of nutrients by Blastamycetes Culture media studied Microorganisms studied and observation period (days) * b c d * f

1 2 1 2 1 2 1 2 1 2 1 2

  1. Sabouraud (control) +++ +++ +++ +++ +++ +++ +++ +++ +++ +++ +++ +++ 2. Sabouraud without source of + + + + + ++ +++ +++ 0 ooo carbon 3. Sobouroud with 30 g glucose carbon source ++ +++ +++ ++ +++ + +++ + +++ ++ ++ + 4. Sabouraud with 30 g of rmaltose ccirom + carbon source +++ +++ +++ +++ +++ ++++++ +4+ ++ + ++ + ++++ commie carbon source 5. Sabouraud with 30 g soluble starch cacme carbon source ++ ++ +++ ++ +++ +++ ++ +++ +++ +++ + 6. Sabouraud with 30 g maize starch as carbon source ++ ++ +++ .. + ++ +++ +++ +++ +. + 7. Sabouraud with 10 g of bâta-cyclodextrin + 20 g of maltose cam source ......... +++ +++ ++ +++ ++ ++ +++ +++ +++ of carbon 8. Sabouraud with 20 g of beta-cyclodextrin +. 10 g glucose as carbon source +++ +++ +++ +++ +++ +++ +++ +++ +++ +++ +++ +++ 9. Sabouraud with 30 g of bWtacyclodextrin as carbon source oo + + + + ++ + + oooo 10. Distilled water with 30 g of glucose oo ++ ++ + ++ +++ ooo oo o 11. Distilled water with 30 g of maltose ++ + +++ ++ ++ ++ ++ ++ ++ + + + + 12. Distilled water with 30 g of soluble starch + +++ +++ ++ +++. +++ +++ +++. . +++, 13. Distilled water with 30 g starch o months + ++ +++ +++ +++. +++ +++ ++ +++++++ +++ ++ + 14. Distilled water with 30 g of bata-cyclodextrin o

CONTINUATION OF TABLE 1

  Culture media studied Microorganisms studied and observation period (days) a b c d e f

1 2 1 2 1 2 1 2 1 2 1 2

15. Sabouraud with 10 g of

  pearl polymer of beta-cyclodex-

  trine and 20 g of maltose. i +++ f +++ ++ +++. +++ +++. ++ +++ +++ +++ 16. Sabouraud with 20 g beta pearl cyclodextrin polymer and g glucose +++ + i +++ +++ ++ +++. ++ +++ +++ .... +++ 17. Sabouraud with 30 g beta pearl cyclodextrin polymer + + ++ +++ + ++ + ++++ + + + + ++ 18. Distilled water with 30 g of betacyclodextrin pearl polymer 0 0 0 0 0 0 0 0 0 0 0 0 0-O

Table II

  Nutrient Exploitation by Hyphomycetes Culture media studied Microorganisms studied and period of observation (days) a b c d e

  3 6 12 3 6 12 3 6 12 3 6 12 3 6 12 3 6 12

  1. Sobouraud (control) + ++ + + + ++ + ++ +++ ++ +++ +++ ..

  2. Sabouroud carbon source sounds + ++++ + + + + + +++ + ++ +++++ ++ +++ +++ + + + + +++ +++ 3. Sobouroud with 30 g glucose cane carbon source + +++ ++++ + + +++ + _ + * +++ + +++ +++ + + ++ +++ ccmme source of carbon 4. Sobouraud with 30 g of carbon source maltose + ++ + ++ +++ + +++ ++ ooo + +++ +++ 5. Sabouraud with 30 g of soluble starch carbon source + + + + + + ++ +++ ++ ++ ++ + ++ + +++ +++ 6. Sabouraud with 30 g corn starch as a carbon source + +++ +++ o + + +++ o +++ + +++ +++ o - ++ +++ 7. Sabouraud with 10 g beta-cyclodextrin

  + 20 9 of maltose coane source + ++ +++ 0 + + + + ++ + ++. 0 0 0 4.

  carbon 8. Sabouraud with 20 g of beta-cyclodextrin + 10 g of glucose Ca e carbon source + ++ ++ +++ ++ ++ ++ +++ +++ oo 0 + +++ +++ 9. Sabouraud with 30 g of beta-cyclodextrin omne carbon source + ++ ++ + ++ ++ + + + ++ ooo + +++ +++ 10. Distilled water with 30 g glucose ooooo + + + + o + + oooooo 11. Distilled water with 30 g of rmaltose + + ++ + + + + + + + + + o + + + + 12. Distilled water with 30 g soluble starch oooo + + o + + o + + o + o + + 13, Distilled water with 30 g of starch of ms 0 + + o + + o + + o + + o + + o 14. Distilled water with 30 g of bWto-cycelodextrin ooooooooooooooo ooo ba cyclodxrna oaooooooaooaoooo oo o o- '

TABLE II (CONTINUED)

  Culture media studied Microorganisms studied and observation period (days) a b c d e f

  3 6 12 3 6 12 3 6 12 3 6 12 3 6 12 3 6 12

15. Sabouraud with 10 g of

Pearl polymer of beta

  cyclodextrin as well as maltose + ++ +++ + ++ +++ + + +++ o o + + +++ +++ + ++ +++ 16. Sabouraud with 20 g of

Pearl polymer of beta

  o Cyclodextrin as well as glucose + ++ ++. + ++ +++ + ++ +++ 0 O: 4 + ++ +++ + ++ +++ 17. Sabouraud with 30 g of

Pearl polymer of beta

  cyclodextrin + ++ +++ 0 0 0 + + ++ 0 0 0 + +++ +++ + ++ +++ 18. Distilled water with 30 g of

Pearl polymer of beta

  It is clear from the results of the tables that the various fungi studied show different growth depending on the culture medium. Among

  the 18 variants of culture media with 5 sources of car-

  Only two of them have been found in which none of the chan-

  The studied studies used did not spread: it is

  places of culture n 1! containing distilled water as well

  than beta-cyclodextrin and beta-cyclodextrin polymer.

  Cyclodextrin and their polymers have not been used as

  killing culture medium usable for any of the

  mushrooms studied and it therefore seems that among the subspecies

  studied, it is the only one to be a vehicle or

  useful diluent whose presence on the skin does not

  a culture medium for various cutaneous fungi.

  Cyclodextrins and their inclusion complexes are not hygroscopic and do not become sticky even in the presence of a high relative humidity content and do not liquefy. They are not carriers of

  electrostatic charges and are therefore micronizable.

  Inclusion complexes of cyclodextrins can be prepared with a microcrystalline structure. Based on these characteristics, cyclodextrins and their inclusion complexes are suitable for use as

  vehicles in the dusting powders.

  In addition to the role of vehicles and diluents,

  Clodextrins may have another role in dusting powders, related to their ability to form complexes

  inclusion. Namely, it is known that the complexes of inclusion

  cyclodextrins can effectively protect entrapped molecules, called "host molecules", from external influences such as decomposition, oxidation by

  air, polymerization, volatilization and the like.

  The complexes are always stable in the absence of water but are however decomposed by a minimal amount of water,

  thus releasing the substances locked in the complexes.

  For the use of cosmetics to be more agreeable

  A number of natural and synthetic fragrances are used in the cosmetics industry. In dusting and washing powders, these perfumes have a large surface of contact with the air and their resistance to oxidation is thus particularly important. The preparation of dusting and washing powders with

  aromas of lemon and orange therefore require

complicated and costly.

  Part of the active ingredients used in the powdered powder for therapeutic purposes are volatile, unstable or sensitive to environmental influences and can be dispossessed of much of their therapeutic activity during storage or use. Thus, another role of cyclodextrins in

  dusting powders may consist of protecting the prin-

  active ingredients of therapeutic dusting powders and perfumes, dyes and other agents of dusting powders

  harmful environmental influences of the environ-

  in the form of inclusion complexes.

  Inclusion complexes of cyclodextrins, which are stable in the dry state, are decomposed by the effect of moisture. The natural moisture of the skin is sufficient

  to allow the slow release of perfumes or

  active therapeutic disinfectant and anti-inflammatory

  inclusion complexes to obtain the desired action.

read.

  A large number of studies have been conducted to

  the powdering powders of the invention with the

  dusts of the trade. The perfume content and the

  flavorability of the trade in baby powders have

  studied after extraction by chromatography, or di-

  in powder powder by thermofractogra-

  graphy. It has been observed that these dusting powders contained

  different perfumes, for the most part, in very small quantities

  (depending on the interval between production and

  mercialisation). Top quality chamomile and lanolin baby powder has been lost

  its odor during a six-week storage period in a fla-

  con open at room temperature. Inclusion complexes of beta-cyclodextrin have been prepared with lavender, sage, pine and rose oil and mixed with dusting powders in a proportion that provides a pleasant odor when

  their application on the skin. The compositions thus obtained

  Naked cells were stored at room temperature in open Petri dishes for six weeks. According to

  instrumental analytical examinations, the decrease in

  neur in perfume in the powders was within the limits

  uncertainty of the assays; it was only possible to detect

  decrease in the most volatile minor constituents,

  in some cases, by gas chromatography.

  Some stages of the preparation technology

  cyclodextrins (heating at high temperatures and

  use of disinfectants to precipitate ions)

  result that cyclodextrins are not practiced

  not contaminated by microorganisms, the decompo-

  germs being less than 100 per gram of cyclo-

crystalline dextrins ready.

  The use of cyclodextrins is mainly

  related to the formation of inclusion complexes: either an inclusion complex of a cyclodextrin formed with an active ingredient is used or a so-called hollow cyclodextrin is used whose capacity to form a

  complex becomes effective during employment.

  In the dusting powder compositions according to the invention, the two complexing effects of the cyclodextrins mentioned above are claimed. On the one hand, the cyclodextrin complexes of therapeutically active ingredients and / or perfumes are used; on the other hand,

  cyclodextrin digs as a vehicle has the

  ability to form inclusion complexes with fatty acids passing from the pores to the surface of the skin, thus having deodorant, anti-inflammatory and infection prevention properties. An overwhelming majority of enzymes breaking down

  starches do not have the capacity to break down cyclodex-

  or break down the cyclodextrins in a very small

  measure. Alpha-cyclodextrin, which has the smallest molecular size, is the least vulnerable, while

  gamma-cyclodextrin, which has the largest

  Molecular weight is relatively easy to break down.

  Alpha-cyclodextrin is suitable for forming inclusion complexes with smaller molecules, whereas gamma-cyclodextrin has the ability to form complexes with larger molecules such as steroids. The solubilities in the water of the various cyclodextrins are extraordinarily different: 100 ml of murinewind 14 g of alphacyclodextrin, 1.8 g of beta-cyclodextrin and 22

  g of gamma-cyclodextrin at room temperature.

  On the basis of these facts, it has been found during the course of studying the powder coating compositions of the invention that gamma-cyclodextrin appears to be the least

  well suited for use in powder powders

  because of its high solubility in water and its lower resistance to starch decomposing enzymes, whereas alpha- and beta-cyclodextrin seemed very suitable for this purpose. These cyclodextrins can be basic materials or vehicles of dusting powders

  ideal for the active ingredients of the dusting powders.

  The subject of the invention is a new dusting powder containing a bioactive substance, which comprises

  cyclodextrin in an amount of 0.1 to 99.9%. As constitution

  cyclodextrin, the alpha- or the beta-cyclo-

  dextrin, or polymers prepared therefrom

  The subject of the invention is also a method for preparing

  new dusts containing a

  bioactive substance, which includes the use of cyclodex-

  trine, preferably alpha- or beta-cyclodextrin, or the polymers prepared therefrom, in an amount of 0.1 to 99.9%, as a carrier or diluent for the dusts /

  According to the preferred embodiment of the invention,

  the active ingredient and / or the substances

  the advantageous properties of the powder of powders

  ge, preferably perfumes, are mixed in the form of

  inclusion complexes of cyclodextrin, with the materials

dusting powder.

  Depending on the therapeutic goals sought, the

  The medicinal dusts of the invention may contain

  disinfectants such as boric acid, sulfanilamide derivatives, antibiotics, salicylic acid and the like; or astringents (styptic agents), for example the basic gallate of bismuth, the substances of

  tannins, zinc oxide; or keratolytic drugs

c.

  According to the desired cosmetic purpose, the compositions

  powdering powders of the invention may contain di-

  substances which provide advantageous properties

  the dusting powder, preferably species of

  such as lavender oil, pine oil,

  camphor, menthol, chamomile oil and the like.

  The invention is illustrated in detail by the examples

non-limiting ples that follow.

Example 1

  Preparation of a dusting powder containing chlorbutol A mixture is prepared from the following constituents: Chlorbutol 5 g Inclusive complex of beta-cyclodextrin with camphor (content of active ingredient 12%) 50 g Complex for inclusion of beta-cyclodextrin with menthol (9.5% active ingredient content) 5 g beta-Finely pulverized cyclodextrin 39.5 g Aerosil 0.5 g

  Chlorbutol is an anti-bacterial and anti-

  fungal that can be used in the treatment of pruritus

* and other irritations of the skin.

Example 2

  Preparation of a baby powder A mixture is prepared from the following constituents: Basic bismuth gallate 1 g Magnesium carbonate 9 g Inclusion complex of beta-cyclodextrin with blue chamomile oil (content of active ingredient 9 %) 20 g beta-Cyclodextrin 68 g Magnesium stearate 2 g The powder coating thus prepared is suitable for

  treat the eczematous and inflamed skin of babies.

Example 3

  Preparation of a Zinc-Containing Powder A mixture is prepared from the following constituents: Zinc Undecanoate 10 g Inclusion complex of beta-cyclodextrin with undecanoic acid (active substance content 8.5%) Inclusion complex of betacyclodextrin with pine oil (% active ingredient content) 5 g Kaolin 15 g beta-Cyclodextrin 50 g

Example 4

  Preparation of a dusting powder containing the para-

formaldehyde-

  A mixture is prepared from the following constituents: Paraformaldehyde 5 g Inclusion complex of beta-cyclodextrin with lavender oil (10% active ingredient content) 2 g Talc 43 g beta-Finely pulverized cyclodextrin 50 g

Example 5

  Preparation of a Deodorant Dusting Powder A mixture is prepared from the following constituents: Hydroxyquinoline 0.1 g Beta-cyclodextrin inclusion complex with lavender oil (10% active ingredient content) 2 g alpha- Cyclodextrin qsp 100 g

Example 6

  Preparation of a dusting powder containing anti-

  biotic A mixture is prepared from the following constituents: Bacitracin 500 mg Neomycin sulphate 250 mg Sodium hydrogencarbonate 750 mg Aerosil 500 mg beta-Cyclodextrin 98 g

Example 7

  Preparation of a dusting powder A mixture is prepared from the following constituents: Inclusion complex of beta-cyclodextrin with lidocaine base (10% active ingredient content) 25 g Aerosil 0.5 g Sodium hydrogencarbonate 0 , 5 g beta-Cyclodextrin 74 g The powdering powder thus prepared has a

  external analgesic effect (superficial).

Example 8

  Preparation of a dusting powder containing salicylic acid A mixture is prepared from the following constituents: Inclusion complex of beta-cyclodextrin with salicylic acid (content of active ingredient 7%) 40 g Aerosil 0.5 g Zinc oxide 5 g betaCyclodextrin qsp 100 g

Example 9

  Preparation of a dusting powder for the feet A mixture is prepared from the following constituents: Inclusion complex of betacyclodextrin with pentachlorophenol (9.5% active substance content) 5 g Inclusion complex of the beta-chlorophenol cyclodextrin with salicylic acid (active substance content 7%) 5 g Alum 5 g Zinc oxide 5 g Vanillin carbonate 5 g beta-Cyclodextrin qs 100 g

Example 10

  Preparation of a baby powder - A mixture is prepared from the following constituents: Inclusion complex of beta-cyclodextrin with lavender oil (10% active ingredient content) 3 g Boric acid 5 g beta-Cyclodextrin 42 g Talc 48 g Aerosil 2 g

Example 11

  Preparation of a dusting powder A mixture is prepared from the following constituents: Beta-cyclodextrin inclusion complex with vitamin A (content of active ingredient 9%) 1 g Inclusion complex of beta-cyclodextrin with lavender oil (content of active ingredient 10%) 2 g Aerosil 1 g beta-Cyclodextrin 60 g Talc qsp 100 g

Example 12

  Preparation of Foot Dusting Powder A mixture was prepared from the following constituents: Pearlacyclodextrin Pearl Polymer 89.5 g Aerosil 0.5 g Talc 10.0 g

  Bead pearl polymer is used as a

  cyclodextrin, a secondary product fraction, with particles of size from 5 to 50 μm, formed in the production of cyclodextrin polymer. The powder obtained can be used as a dusting powder for the feet and for the

treatment of rubber gloves.

Example 13

  Preparation of baby powder The components of the mixture are the same as in Example 2 except that a beta-cyclodextrin polymer base block is used instead of beta-cyclodextrin.

Example 14

  Preparation of a deodorant dusting powder The components of the mixture are the same as in Example 5, except that a base foam of

  polymer-alpha-cyclodextrin instead of alpha-cyclodextrin.

  All the dusting powders listed above must pass through a sieve with openings

250 micrometers in diameter.

Claims (12)

R E V E N D I C A T IO N S   1. A process for preparing a dusting powder composition, characterized in that it comprises the mixture of cyclodextrin or polymers derived therefrom and optionally one or more complex (s) for inclusion of the cyclodextrin coime vehicle , diluent or excipient, in an amount of 0.1 to 99.9%, and one or more biologically active substance (s) and / or perfume (s) and / or dye (s) in an amount of 99.9% at 0.1%.   2. A process according to claim 1, characterized in that it comprises the use of beta-cyclodextrin as vehicle, diluent or excipient.   3. A process according to claim 1, characterized in that it comprises the use of alpha-cyclodextrin as vehicle, diluent or excipient.   4. A process according to any one of claims 1   at 3, characterized in that it comprises the use of   biologically active principle (s) of the powdered powders   ge as an inclusion complex (s) of the cyclodex- Triune.   5. A process according to any one of claims 1   at 4, characterized in that it comprises the use of the perfume (s) and / or dye (s) of the dusting powder   in the form of inclusion complex (s) of cyclodextrin.   6 .-: oposition of dusting powder, characterized in that it contains cyclodextrin or polymer polymers deriving from it and optionally one or more cyclodextrin inclusion complex (s) as a vehicle, diluent or excipient in an amount of 0.1 to 99.9% and one or more biologically   active ingredient (s) and / or fragrance (s) and / or color (s) and / or   rant (s) in an amount of 99.9% to 0.1%.   7. Composition according to claim 6, characterized   in that it contains beta-cyclodextrin as a carrier cule, diluent or excipient.   8. Composition according to claim 6, characterized   in that it contains alpha-cyclodextrin as a carrier cule, diluent or excipient.   9.- Composition according to any one of the claims   6 to 8, characterized in that it contains the perfume (s) and / or dye (s) of the dusting powder under   the form of complex (s) of inclusion of the cyclodextrin.   10. Composition according to claim 9, characterized   in that it contains an inclusion complex of beta-   cyclodextrin with camphor oil, menthol oil, pine and / or lavender.   11. Composition according to any one of the claims   6 to 8, characterized in that it contains the   biologically active principle (s) of the powdered powders   ge in the form of complex (s) of inclusion of the cyclodextri   born. 12. Composition according to claim 11, characterized   in that it contains an inclusion complex of beta-   cyclodextrin with lidocaine base, salicylic acid,   pentachlorophenol, vitamin A and / or camomile oil blue mile.