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FR2564845B1 - Mercaptocycloalkylcarbonyl et mercaptoarylcarbonyl dipeptides a action therapeutique - Google Patents

Mercaptocycloalkylcarbonyl et mercaptoarylcarbonyl dipeptides a action therapeutique

Info

Publication number
FR2564845B1
FR2564845B1 FR858507862A FR8507862A FR2564845B1 FR 2564845 B1 FR2564845 B1 FR 2564845B1 FR 858507862 A FR858507862 A FR 858507862A FR 8507862 A FR8507862 A FR 8507862A FR 2564845 B1 FR2564845 B1 FR 2564845B1
Authority
FR
France
Prior art keywords
mercaptocycloalkylcarbonyl
mercaptoarylcarbonyl
dipeptides
therapeutic action
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR858507862A
Other languages
English (en)
Other versions
FR2564845A1 (fr
Inventor
Harold N Weller Iii
Eric M Gordon
Norma G Delaney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2564845A1 publication Critical patent/FR2564845A1/fr
Application granted granted Critical
Publication of FR2564845B1 publication Critical patent/FR2564845B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR858507862A 1984-05-25 1985-05-24 Mercaptocycloalkylcarbonyl et mercaptoarylcarbonyl dipeptides a action therapeutique Expired - Fee Related FR2564845B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/614,090 US4560506A (en) 1984-05-25 1984-05-25 Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides

Publications (2)

Publication Number Publication Date
FR2564845A1 FR2564845A1 (fr) 1985-11-29
FR2564845B1 true FR2564845B1 (fr) 1990-04-27

Family

ID=24459829

Family Applications (1)

Application Number Title Priority Date Filing Date
FR858507862A Expired - Fee Related FR2564845B1 (fr) 1984-05-25 1985-05-24 Mercaptocycloalkylcarbonyl et mercaptoarylcarbonyl dipeptides a action therapeutique

Country Status (7)

Country Link
US (1) US4560506A (fr)
JP (1) JPH0762029B2 (fr)
CA (1) CA1269496C (fr)
DE (1) DE3518817A1 (fr)
FR (1) FR2564845B1 (fr)
GB (1) GB2159160B (fr)
IT (1) IT1183677B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749688A (en) * 1986-06-20 1988-06-07 Schering Corporation Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
US5686422A (en) * 1987-03-17 1997-11-11 Research Corporation Technologies, Inc. Synthetic inhibitors of mammalian collagenase
EP0358660B1 (fr) * 1987-03-17 1994-05-25 Research Corporation Technologies, Inc. Inhibiteurs synthetiques de collagenase mammifere
CA1337400C (fr) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibiteurs de l'endopeptidase neutre
US4849525A (en) * 1987-09-21 1989-07-18 E. R. Squibb & Sons, Inc. Phosphinylcycloalkylcarbonyl and phosphinylcycloalkenylcarbonyl dipeptides
US5117335A (en) * 1989-12-28 1992-05-26 Koito Manufacturing Co., Ltd. Headlight for vehicle
ATE183645T1 (de) * 1993-10-13 1999-09-15 Karla Lehmann Verwendung von lithiumverbindungen in kombination mit ace-hemmern und/oder angiotensin ii-rezeptor- antagonisten zur behandlung von erhöhtem blutdruck
FR2729668A1 (fr) * 1995-01-23 1996-07-26 Adir Nouveaux derives de mercaptoalcanoyldipeptides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7022677B1 (en) * 1999-02-18 2006-04-04 Kaken Pharmaceutical Co., Ltd. Amide derivatives as growth hormone secretagogues
EP1425262B1 (fr) * 2001-08-03 2014-01-08 The Gov. of USA, as represented by the Secretary, Dept. of Health and Human services, National Institutes of Health Acylthiols et leurs compositions utilisés en tant qu'agents anti-HIV et en tant qu'agents anti-retroviraux
ES2443242T3 (es) 2005-12-23 2014-02-18 Zealand Pharma A/S Compuestos modificados miméticos de lisina
PL2468724T3 (pl) 2006-12-21 2016-05-31 Zealand Pharma As Synteza związków pirolidynowych
WO2018202865A1 (fr) 2017-05-05 2018-11-08 Zealand Pharma A/S Modulateurs de la communication intercellulaire par les jonctions lacunaires et leur utilisation pour le traitement d'une maladie oculaire diabétique

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS559058A (en) * 1978-07-06 1980-01-22 Dainippon Pharmaceut Co Ltd 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative
AU537592B2 (en) * 1979-04-02 1984-07-05 E.R. Squibb & Sons, Inc. Mercaptoacyldipeptides
GR75019B (fr) * 1980-09-17 1984-07-12 Univ Miami
US4440941A (en) * 1980-12-22 1984-04-03 Usv Pharmaceutical Corporation Aroyl-aminoacids, amides and esters thereof
IT1195287B (it) * 1981-11-05 1988-10-12 Ausonia Farma Srl Derivato tiazolico,procedimento per la sua preparazione e relative composizioni farmaceutiche
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4456595A (en) * 1982-12-06 1984-06-26 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy aroly peptides
ZA843899B (en) * 1983-05-23 1984-12-24 Usv Pharma Corp Compounds for treating hypertension

Also Published As

Publication number Publication date
JPS617295A (ja) 1986-01-13
FR2564845A1 (fr) 1985-11-29
CA1269496A (fr) 1990-05-22
US4560506A (en) 1985-12-24
IT1183677B (it) 1987-10-22
GB2159160A (en) 1985-11-27
CA1269496C (fr) 1990-05-22
GB2159160B (en) 1987-10-28
DE3518817A1 (de) 1985-11-28
IT8520872A0 (it) 1985-05-24
GB8513178D0 (en) 1985-06-26
JPH0762029B2 (ja) 1995-07-05

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Legal Events

Date Code Title Description
ST Notification of lapse
ST Notification of lapse