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FR2506616A1 - Preparation de gamma-globuline pour injectio n intraveineuse et procede de fabrication, et agent therapeutique ainsi produit - Google Patents

Preparation de gamma-globuline pour injectio n intraveineuse et procede de fabrication, et agent therapeutique ainsi produit

Info

Publication number
FR2506616A1
FR2506616A1 FR8209497A FR8209497A FR2506616A1 FR 2506616 A1 FR2506616 A1 FR 2506616A1 FR 8209497 A FR8209497 A FR 8209497A FR 8209497 A FR8209497 A FR 8209497A FR 2506616 A1 FR2506616 A1 FR 2506616A1
Authority
FR
France
Prior art keywords
globulin
gamma
preparation
therapeutic agent
intravenous injection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8209497A
Other languages
English (en)
Other versions
FR2506616B1 (fr
Inventor
Haruo Ohnishi
Ohnishi Hiroshi Kosuzume Yasuo Suzuki Et Ei Mochida Haruo
Hiroshi Kosuzume
Yasuo Suzuki
Ei Mochida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mochida Pharmaceutical Co Ltd
Original Assignee
Mochida Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharmaceutical Co Ltd filed Critical Mochida Pharmaceutical Co Ltd
Publication of FR2506616A1 publication Critical patent/FR2506616A1/fr
Application granted granted Critical
Publication of FR2506616B1 publication Critical patent/FR2506616B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'INVENTION A POUR OBJET UN PROCEDE DE PREPARATION DE GAMMA-GLOBULINE ADMINISTRABLE PAR VOIE INTRAVEINEUSE SANS REACTIONS NUISIBLES NI PERTE D'ACTIVITE OPSONIQUE, CONSISTANT A TRAITER DE LA GAMMA-GLOBULINE AVEC DE LA PEPSINE OU DE L'UROPEPSINE DANS DES LIMITES DE PH NEUTRE DE 6,0 A 7,5. LES AGREGATS PRESENTS DANS LA GAMMA-GLOBULINE SONT SELECTIVEMENT DECOMPOSES PAR LE PROCEDE SUIVANT L'INVENTION TANDIS QUE TOUTE DECOMPOSITION DES MOLECULES DE GAMMA-GLOBULINE MONOMERES EST PRATIQUEMENT EMPECHEE, AINSI QU'UN AGENT THERAPEUTIQUE POUR L'INJECTION INTRAVEINEUSE DONT L'ACTIVITE ANTICOMPLEMENTAIRE EST REDUITE ET QUI EST STABILISE PAR ADDITION D'UROPEPSINE QUI JOUE SIMULTANEMENT LE ROLE D'ENZYME PROTEOLYTIQUE ET DE STABILISANT POUR LA GAMMA-GLOBULINE HUMAINE. L'UROPEPSINOGENE PEUT EGALEMENT ETRE UTILISE COMME STABILISANT.
FR8209497A 1981-05-29 1982-06-01 Preparation de gamma-globuline pour injectio n intraveineuse et procede de fabrication, et agent therapeutique ainsi produit Granted FR2506616A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP56082903A JPS57206608A (en) 1981-05-29 1981-05-29 Production of gamma-globulin for intravenous injection
CH4039/82A CH657376A5 (en) 1981-05-29 1982-07-02 Process for the preparation of gamma-globulin for intravenous injection
AU85637/82A AU551759B2 (en) 1981-05-29 1982-07-06 Alpha-globulin preparation

Publications (2)

Publication Number Publication Date
FR2506616A1 true FR2506616A1 (fr) 1982-12-03
FR2506616B1 FR2506616B1 (fr) 1984-08-10

Family

ID=36764503

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8209497A Granted FR2506616A1 (fr) 1981-05-29 1982-06-01 Preparation de gamma-globuline pour injectio n intraveineuse et procede de fabrication, et agent therapeutique ainsi produit

Country Status (9)

Country Link
US (1) US4436724A (fr)
JP (1) JPS57206608A (fr)
AU (1) AU551759B2 (fr)
BE (1) BE893798A (fr)
CA (1) CA1181008A (fr)
CH (1) CH657376A5 (fr)
DE (1) DE3220309A1 (fr)
FR (1) FR2506616A1 (fr)
GB (1) GB2104080B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0247998A2 (fr) * 1986-05-30 1987-12-02 IMMUNO Aktiengesellschaft Procédé d'inactivation de microbes pathogènes propageables filtrables

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT383737B (de) * 1983-03-16 1987-08-10 Immuno Ag Verfahren zur verwendung einer immunoglobulin-g enthaltenden fraktion
AT383739B (de) * 1983-03-16 1987-08-10 Immuno Ag Verfahren zur inaktivierung von unvertraeglichkeitsreaktionen verursachenden substanzen in immunglobulinhaeltigen blutfraktionen
AT383738B (de) * 1983-03-16 1987-08-10 Immuno Ag Verfahren zur verwendung einer immunglobulin-g enthaltenden fraktion
GB8406560D0 (en) * 1984-03-13 1984-04-18 Central Lab Of The Blood Donor Organic compounds
DE3411735A1 (de) * 1984-03-30 1985-10-03 Karl Pfisterer Elektrotechnische Spezialartikel Gmbh & Co Kg, 7000 Stuttgart Ueberspannungsableiter
JPH07121875B2 (ja) * 1985-10-08 1995-12-25 武田薬品工業株式会社 免疫グロブリンフラクシヨンの製造法
US5328834A (en) * 1989-09-08 1994-07-12 Unisyn Technologies, Inc. Method for preparing immunoglobulin fragments
US5340737A (en) * 1993-06-10 1994-08-23 Marcel Siegler Process of preparing pepsin for bating hides
US6348346B1 (en) 1994-05-27 2002-02-19 University Of Kentucky Research Foundation Method of inhibiting binding activity of immunoglobulins
FI952196A0 (fi) * 1995-05-08 1995-05-08 Suomen Punainen Risti Veripalv Framstaellning av immunoglobulin
US20020077276A1 (en) * 1999-04-27 2002-06-20 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US6962700B1 (en) 2000-09-13 2005-11-08 Atopix Pharmaceuticals Corporation Method of manufacturing immune globulin

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2382M (fr) * 1961-10-11 1964-03-09 Behringwerke Ag Médicament a base de gamma globuline désagrégée.
CH392780A (de) * 1961-12-07 1965-05-31 Schweiz Rotes Kreuz Verfahren zur Herstellung von intravenös anwendbaren Antikörperpräparaten humanen Ursprungs
JPS5615215A (en) * 1979-07-14 1981-02-14 Nippon Sekijiyuujishiya Preparation of human immunoglobulin for intravenous injection with immobilized pepsin gel

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3553317A (en) 1969-06-02 1971-01-05 Joseph B Michaelson Ig-a antibody from lacteal fluids
CA1064396A (fr) 1975-02-18 1979-10-16 Myer L. Coval Precipitation fractionnee de la gamma globuline a l'aide de polyethylene glycol
DE2835843A1 (de) * 1978-08-16 1980-02-28 Blutspendedienst Dt Rote Kreuz Verfahren zur herstellung einer fuer die intravenoese anwendung geeigneten gammaglobulinloesung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2382M (fr) * 1961-10-11 1964-03-09 Behringwerke Ag Médicament a base de gamma globuline désagrégée.
CH392780A (de) * 1961-12-07 1965-05-31 Schweiz Rotes Kreuz Verfahren zur Herstellung von intravenös anwendbaren Antikörperpräparaten humanen Ursprungs
JPS5615215A (en) * 1979-07-14 1981-02-14 Nippon Sekijiyuujishiya Preparation of human immunoglobulin for intravenous injection with immobilized pepsin gel

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 94, no. 20, 18 mai 1981, page 389, no. 162780x, Columbus Ohio (USA); & JP - A - 81 15 215 (JAPANESE RED CROSS SOCIETY) (14-02-1981) *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0247998A2 (fr) * 1986-05-30 1987-12-02 IMMUNO Aktiengesellschaft Procédé d'inactivation de microbes pathogènes propageables filtrables
EP0247998A3 (en) * 1986-05-30 1989-12-27 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Process for the inactivation of propagating filtrable pathogenic microbes

Also Published As

Publication number Publication date
DE3220309A1 (de) 1982-12-16
JPS6136811B2 (fr) 1986-08-20
GB2104080A (en) 1983-03-02
CA1181008A (fr) 1985-01-15
AU8563782A (en) 1984-01-12
JPS57206608A (en) 1982-12-18
GB2104080B (en) 1984-08-01
FR2506616B1 (fr) 1984-08-10
CH657376A5 (en) 1986-08-29
BE893798A (fr) 1982-11-03
AU551759B2 (en) 1986-05-08
US4436724A (en) 1984-03-13

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