FR24C1054I1 - THERAPEUTIC COMPOSITIONS COMPRISING AN ANTAGONIST SPECIFIC TO ENDOTHELIN RECEPTORS AND A PDE5 INHIBITOR - Google Patents

THERAPEUTIC COMPOSITIONS COMPRISING AN ANTAGONIST SPECIFIC TO ENDOTHELIN RECEPTORS AND A PDE5 INHIBITOR

Info

Publication number: FR24C1054I1
Authority: FR; France
Prior art keywords: therapeutic compositions; pde5 inhibitor; endothelin receptors; antagonist specific; antagonist
Prior art date: 2006-08-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

FR24C1054C

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Actelion Pharmaceuticals Ltd

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-08-29

Filing date

2024-12-16

Publication date

2025-02-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38954615&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR24C1054(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2024-12-16 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2025-02-21 Publication of FR24C1054I1 publication Critical patent/FR24C1054I1/en

Status Active legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

FR24C1054C 2006-08-29 2024-12-16 THERAPEUTIC COMPOSITIONS COMPRISING AN ANTAGONIST SPECIFIC TO ENDOTHELIN RECEPTORS AND A PDE5 INHIBITOR Active FR24C1054I1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IB2006052999		2006-08-29
IB2006053857		2006-10-19
PCT/IB2007/053448 WO2008026156A2 (en)	2006-08-29	2007-08-28	Therapeutic compositions comprising a specific endothelin receptor antagonist and a pde5 inhibitor

Publications (1)

Publication Number	Publication Date
FR24C1054I1 true FR24C1054I1 (en)	2025-02-21

Family

ID=38954615

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR24C1054C Active FR24C1054I1 (en)	2006-08-29	2024-12-16	THERAPEUTIC COMPOSITIONS COMPRISING AN ANTAGONIST SPECIFIC TO ENDOTHELIN RECEPTORS AND A PDE5 INHIBITOR

Country Status (31)

Country	Link
US (8)	US8268847B2 (en)
EP (1)	EP2059246B1 (en)
JP (1)	JP5208113B2 (en)
KR (1)	KR101473022B1 (en)
CN (1)	CN101511365B (en)
AR (1)	AR062501A1 (en)
AU (1)	AU2007290099B2 (en)
BR (1)	BRPI0715698B8 (en)
CA (1)	CA2659770C (en)
CL (1)	CL2007002494A1 (en)
CY (1)	CY1114735T1 (en)
DK (1)	DK2059246T3 (en)
ES (1)	ES2438792T3 (en)
FI (1)	FIC20240045I1 (en)
FR (1)	FR24C1054I1 (en)
HK (1)	HK1133597A1 (en)
HR (1)	HRP20131233T1 (en)
HU (1)	HUS2400046I1 (en)
IL (1)	IL197235A (en)
MA (1)	MA30704B1 (en)
MX (1)	MX2009002057A (en)
MY (1)	MY154591A (en)
NL (1)	NL301308I2 (en)
NO (1)	NO342554B1 (en)
NZ (1)	NZ575702A (en)
PL (1)	PL2059246T3 (en)
PT (1)	PT2059246E (en)
RU (1)	RU2462249C2 (en)
SI (1)	SI2059246T1 (en)
TW (1)	TWI388556B (en)
WO (1)	WO2008026156A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1928409T3 (en)	2005-09-12	2012-11-05	Actelion Pharmaceuticals Ltd	STABLE PHARMACEUTICAL COMPOSITION INCLUDING PYRIMIDINE SULFAMIDE
MX2010001837A (en)	2007-08-17	2010-03-10	Actelion Pharmaceuticals Ltd	DERIVATIVES OF 4-PYRIMIDINASULFAMIDA.
JP5514123B2 (en) *	2008-02-20	2014-06-04	アクテリオンファーマシューティカルズリミテッド	Combination drug containing paclitaxel for the treatment of ovarian cancer
LT2315587T (en)	2008-08-13	2018-01-10	Actelion Pharmaceuticals Ltd.	Therapeutic compositions containing macitentan
TWI462739B (en) *	2010-11-02	2014-12-01	Univ Kaohsiung Medical	Processes for preparing piperazinium salts of sildenafil-analogues and use thereof
CN102949395A (en) *	2011-09-22	2013-03-06	荆志成	Application of vardenafil hydrochloride tables in preparation of medicine for treating pulmonary arterial hypertension
CN102839165B (en) *	2012-09-26	2014-12-10	金普诺安生物科技（苏州）有限公司	Gene mutation type recombined protease K and industrialized production method thereof
WO2014198178A1 (en) *	2013-06-14	2014-12-18	杭州普晒医药科技有限公司	Macitentan crystal, preparation method therefor, pharmaceutical composition and use thereof
KR20190030805A (en)	2017-09-14	2019-03-25	경상대학교산학협력단	Inhalants for the prevention or treatment of pulmonary hypertension, and methods of administration thereof
DK3897646T3 (en)	2018-12-21	2024-07-01	Actelion Pharmaceuticals Ltd	MACITENTAN FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION
TW202042818A (en)	2019-01-25	2020-12-01	瑞士商艾克泰聯製藥有限公司	Pharmaceutical composition for the treatment of chronic thromboembolic pulmonary hypertension

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2801584A1 (en)	1978-01-14	1979-07-19	Bayer Ag	HALOGEN-SUBSTITUTED PYRIMIDIN (2) YL-THIONO-THIOL-PHOSPHOR (PHOSPHONE) - ACID ESTERS, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS INSECTICIDES AND ACARICIDES
US5250534A (en)	1990-06-20	1993-10-05	Pfizer Inc.	Pyrazolopyrimidinone antianginal agents
RU2086544C1 (en)	1991-06-13	1997-08-10	Хоффманн-Ля Рош АГ	Benzenesulfonamide derivatives of pyrimidine or their salts, pharmaceutical composition for treatment of diseases associated with endothelin activity
TW394761B (en)	1993-06-28	2000-06-21	Hoffmann La Roche	Novel Sulfonylamino Pyrimidines
US5589006A (en) *	1993-11-30	1996-12-31	Canon Kabushiki Kaisha	Solar battery module and passive solar system using same
IL111959A (en)	1993-12-17	2000-07-16	Tanabe Seiyaku Co	N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
GB9401090D0 (en)	1994-01-21	1994-03-16	Glaxo Lab Sa	Chemical compounds
WO1996016963A1 (en)	1994-11-25	1996-06-06	F. Hoffmann-La Roche Ag	Sulfonamides and their use as medicaments
TW313568B (en)	1994-12-20	1997-08-21	Hoffmann La Roche
US5739333A (en)	1995-05-16	1998-04-14	Tanabe Seiyaku Co., Ltd.	Sulfonamide derivative and process for preparing the same
WO1997022595A1 (en)	1995-12-20	1997-06-26	Yamanouchi Pharmaceutical Co., Ltd.	Arylethenesulfonamide derivatives and drug composition containing the same
EP2295436A1 (en)	1997-11-12	2011-03-16	Bayer Schering Pharma AG	2-Phenyl-subsitituted Imidazotriazinones as Phosphodiesterase V inhibitors
US6087368A (en) *	1998-06-08	2000-07-11	Bristol-Myers Squibb Company	Quinazolinone inhibitors of cGMP phosphodiesterase
KR100353014B1 (en)	1998-11-11	2002-09-18	동아제약 주식회사	Pyrazolopyrimidinone derivatives for the treatment of impotence
TWI284642B (en)	1999-01-18	2007-08-01	Hoffmann La Roche	Novel heterocyclic sulfonamides
CN100424079C (en)	1999-09-03	2008-10-08	埃科特莱茵药品有限公司	Bis-sulfonamides
TWI224966B (en)	1999-11-02	2004-12-11	Pfizer	Pharmaceutical composition (I) useful for treating or preventing pulmonary hypertension in a patient
AU3536701A (en)	1999-12-22	2001-07-03	Actelion Pharmaceuticals Ltd	Butyne diol derivatives
AU2001263850A1 (en)	2000-04-20	2001-11-07	Actelion Pharmaceuticals Ltd	Pyrimidine-sulfonamides having endothelin-antagonist activity
WO2001081338A1 (en)	2000-04-25	2001-11-01	Actelion Pharmaceuticals Ltd	Substituted sulfonylaminopyrimidines
JP4245130B2 (en) *	2000-12-18	2009-03-25	アクテリオンファーマシューティカルズリミテッド	New sulfamides
DE10148883A1 (en) *	2001-10-04	2003-04-10	Merck Patent Gmbh	New fused bi- or tricyclic pyrimidine derivatives, are phosphodiesterase V inhibitors useful e.g. for treating impotence, cardiovascular disorders, inflammation or tumors
US20060205733A1 (en) *	2004-08-26	2006-09-14	Encysive Pharmaceuticals	Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof
US7094081B1 (en)	2005-03-24	2006-08-22	Delphi Technologies, Inc.	Electrical connector assembly
DK1928409T3 (en)	2005-09-12	2012-11-05	Actelion Pharmaceuticals Ltd	STABLE PHARMACEUTICAL COMPOSITION INCLUDING PYRIMIDINE SULFAMIDE
RU2435585C2 (en)	2006-04-13	2011-12-10	Актелион Фармасьютиклз Лтд	Antagonists of endoteline receptor intended for early stage of idiopatic pulmonary fibrosis

2007
- 2007-08-23 AR ARP070103749A patent/AR062501A1/en not_active Application Discontinuation
- 2007-08-27 CL CL200702494A patent/CL2007002494A1/en unknown
- 2007-08-28 ES ES07826167.4T patent/ES2438792T3/en active Active
- 2007-08-28 US US12/439,290 patent/US8268847B2/en active Active
- 2007-08-28 WO PCT/IB2007/053448 patent/WO2008026156A2/en active Application Filing
- 2007-08-28 CA CA2659770A patent/CA2659770C/en active Active
- 2007-08-28 EP EP07826167.4A patent/EP2059246B1/en active Active
- 2007-08-28 CN CN2007800321481A patent/CN101511365B/en active Active
- 2007-08-28 TW TW096131928A patent/TWI388556B/en active
- 2007-08-28 SI SI200731367T patent/SI2059246T1/en unknown
- 2007-08-28 PT PT78261674T patent/PT2059246E/en unknown
- 2007-08-28 AU AU2007290099A patent/AU2007290099B2/en active Active
- 2007-08-28 MX MX2009002057A patent/MX2009002057A/en active IP Right Grant
- 2007-08-28 DK DK07826167.4T patent/DK2059246T3/en active
- 2007-08-28 KR KR1020097005029A patent/KR101473022B1/en active IP Right Grant
- 2007-08-28 MY MYPI20090795A patent/MY154591A/en unknown
- 2007-08-28 PL PL07826167T patent/PL2059246T3/en unknown
- 2007-08-28 NZ NZ575702A patent/NZ575702A/en unknown
- 2007-08-28 BR BRPI0715698A patent/BRPI0715698B8/en active IP Right Grant
- 2007-08-28 JP JP2009526239A patent/JP5208113B2/en active Active
- 2007-08-28 RU RU2009111378/15A patent/RU2462249C2/en active
2009
- 2009-02-25 IL IL197235A patent/IL197235A/en active IP Right Grant
- 2009-03-06 MA MA31695A patent/MA30704B1/en unknown
- 2009-03-26 NO NO20091254A patent/NO342554B1/en unknown
2010
- 2010-02-11 HK HK10101538.5A patent/HK1133597A1/en unknown
2012
- 2012-09-05 US US13/604,148 patent/US20130210830A9/en not_active Abandoned
2013
- 2013-12-27 CY CY20131101163T patent/CY1114735T1/en unknown
- 2013-12-30 HR HRP20131233TT patent/HRP20131233T1/en unknown
2014
- 2014-01-23 US US14/162,280 patent/US20140148460A1/en not_active Abandoned
2018
- 2018-01-26 US US15/881,060 patent/US20180147205A1/en not_active Abandoned
- 2018-11-16 US US16/193,859 patent/US20190083494A1/en not_active Abandoned
2019
- 2019-10-11 US US16/599,582 patent/US20200038401A1/en not_active Abandoned
2020
- 2020-07-30 US US16/942,895 patent/US20200352944A1/en not_active Abandoned
2021
- 2021-02-25 US US17/185,238 patent/US20210177849A1/en not_active Abandoned
2024
- 2024-12-16 FI FIC20240045C patent/FIC20240045I1/en unknown
- 2024-12-16 FR FR24C1054C patent/FR24C1054I1/en active Active
- 2024-12-17 HU HUS2400046C patent/HUS2400046I1/en unknown
- 2024-12-18 NL NL301308C patent/NL301308I2/en unknown

Also Published As

Publication number	Publication date
BRPI0715698A2 (en)	2013-08-06
US20090318459A1 (en)	2009-12-24
AR062501A1 (en)	2008-11-12
CN101511365A (en)	2009-08-19
FIC20240045I1 (en)	2024-12-16
MX2009002057A (en)	2009-03-06
BRPI0715698B8 (en)	2021-05-25
HK1133597A1 (en)	2010-04-01
MA30704B1 (en)	2009-09-01
HRP20131233T1 (en)	2014-01-31
TW200823198A (en)	2008-06-01
PL2059246T3 (en)	2014-03-31
AU2007290099A1 (en)	2008-03-06
KR20090057009A (en)	2009-06-03
IL197235A (en)	2014-04-30
US20180147205A1 (en)	2018-05-31
CA2659770A1 (en)	2008-03-06
IL197235A0 (en)	2009-12-24
NO342554B1 (en)	2018-06-11
US20140148460A1 (en)	2014-05-29
NL301308I2 (en)	2024-12-30
JP5208113B2 (en)	2013-06-12
US20190083494A1 (en)	2019-03-21
DK2059246T3 (en)	2013-12-02
JP2010502588A (en)	2010-01-28
RU2009111378A (en)	2010-10-10
US20130210830A9 (en)	2013-08-15
CN101511365B (en)	2011-08-17
RU2462249C2 (en)	2012-09-27
US20200352944A1 (en)	2020-11-12
BRPI0715698B1 (en)	2020-01-21
NO20091254L (en)	2009-03-26
EP2059246B1 (en)	2013-10-16
CY1114735T1 (en)	2017-01-25
CL2007002494A1 (en)	2008-04-04
NZ575702A (en)	2011-11-25
US8268847B2 (en)	2012-09-18
WO2008026156A2 (en)	2008-03-06
KR101473022B1 (en)	2014-12-15
US20200038401A1 (en)	2020-02-06
HUS2400046I1 (en)	2025-01-28
SI2059246T1 (en)	2014-01-31
TWI388556B (en)	2013-03-11
WO2008026156A3 (en)	2008-10-16
EP2059246A2 (en)	2009-05-20
US20130005734A1 (en)	2013-01-03
ES2438792T3 (en)	2014-01-20
AU2007290099B2 (en)	2013-01-31
US20210177849A1 (en)	2021-06-17
MY154591A (en)	2015-06-30
PT2059246E (en)	2013-12-16
CA2659770C (en)	2014-11-18

Publication	Publication Date	Title
FR24C1054I1 (en)	2025-02-21	THERAPEUTIC COMPOSITIONS COMPRISING AN ANTAGONIST SPECIFIC TO ENDOTHELIN RECEPTORS AND A PDE5 INHIBITOR
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