FR24C1015I1 - BARDOXOLONE METHYL 2,2-DIFLUOROPROPIONAMIDE DERIVATIVES, THEIR POLYMORPHIC FORMS AND METHODS OF USE - Google Patents

BARDOXOLONE METHYL 2,2-DIFLUOROPROPIONAMIDE DERIVATIVES, THEIR POLYMORPHIC FORMS AND METHODS OF USE

Info

Publication number: FR24C1015I1
Authority: FR; France
Prior art keywords: methods; polymorphic forms; bardoxolone methyl; difluoropropionamide; derivatives
Prior art date: 2012-04-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

FR24C1015C

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Reata Pharmaceuticals Holdings LLC

Original Assignee

Reata Pharmaceuticals Holdings LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-04-27

Filing date

2024-04-17

Publication date

2024-06-28

2024-04-17 Application filed by Reata Pharmaceuticals Holdings LLC filed Critical Reata Pharmaceuticals Holdings LLC

2024-06-28 Publication of FR24C1015I1 publication Critical patent/FR24C1015I1/en

2025-05-02 Application granted granted Critical

2025-05-02 Publication of FR24C1015I2 publication Critical patent/FR24C1015I2/en

Status Active legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Toxicology (AREA)
Immunology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Diabetes (AREA)
Biochemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

FR24C1015C 2012-04-27 2024-04-17 2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF METHYLATED BARDOXOLONE, THEIR POLYMORPHIC FORMS AND METHODS OF USE Active FR24C1015I2 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US201261687669P	2012-04-27	2012-04-27
US201361775288P	2013-03-08	2013-03-08
US201361780444P	2013-03-13	2013-03-13
PCT/US2013/038064 WO2013163344A1 (en)	2012-04-27	2013-04-24	2.2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof

Publications (2)

Publication Number	Publication Date
FR24C1015I1 true FR24C1015I1 (en)	2024-06-28
FR24C1015I2 FR24C1015I2 (en)	2025-05-02

Family

ID=49483867

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR24C1015C Active FR24C1015I2 (en)	2012-04-27	2024-04-17	2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF METHYLATED BARDOXOLONE, THEIR POLYMORPHIC FORMS AND METHODS OF USE

Country Status (40)

Country	Link
US (5)	US8993640B2 (en)
EP (2)	EP3444261B1 (en)
JP (2)	JP6410710B2 (en)
KR (1)	KR102101774B1 (en)
CN (1)	CN104395332B (en)
AR (1)	AR092823A1 (en)
AU (1)	AU2013251602B2 (en)
BR (1)	BR112014026640B1 (en)
CA (1)	CA2869783C (en)
CL (1)	CL2014002886A1 (en)
CO (1)	CO7170182A2 (en)
CY (3)	CY1119333T1 (en)
DK (2)	DK3444261T3 (en)
DO (1)	DOP2014000236A (en)
EA (1)	EA030468B1 (en)
ES (2)	ES2634315T3 (en)
FI (1)	FIC20240012I1 (en)
FR (1)	FR24C1015I2 (en)
HK (1)	HK1207085A1 (en)
HR (1)	HRP20171275T1 (en)
HU (3)	HUE035673T2 (en)
IL (1)	IL235275B (en)
LT (2)	LT2841445T (en)
ME (1)	ME02926B (en)
MX (2)	MX357060B (en)
MY (1)	MY172750A (en)
NL (1)	NL301276I2 (en)
NZ (1)	NZ630222A (en)
PE (1)	PE20150160A1 (en)
PL (2)	PL3444261T3 (en)
PT (2)	PT2841445T (en)
RS (2)	RS56154B1 (en)
SG (1)	SG11201406868XA (en)
SI (2)	SI3444261T1 (en)
SM (2)	SMT202100166T1 (en)
TW (2)	TWI623548B (en)
UA (1)	UA116209C2 (en)
UY (1)	UY34764A (en)
WO (1)	WO2013163344A1 (en)
ZA (1)	ZA201407326B (en)

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EP3444261B1 (en)	2021-01-13
AR092823A1 (en)	2015-05-06
SG11201406868XA (en)	2014-11-27
CL2014002886A1 (en)	2015-02-06
US20250051388A1 (en)	2025-02-13
PT2841445T (en)	2017-09-01
FIC20240012I1 (en)	2024-04-18
LT2841445T (en)	2017-09-11
MY172750A (en)	2019-12-11
US20210355156A1 (en)	2021-11-18
SMT202100166T1 (en)	2021-05-07
US20150259377A1 (en)	2015-09-17
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EP2841445A1 (en)	2015-03-04
ME02926B (en)	2018-04-20
DOP2014000236A (en)	2015-04-30
ZA201407326B (en)	2016-10-26
PL3444261T3 (en)	2021-07-19
US9701709B2 (en)	2017-07-11
KR102101774B1 (en)	2020-04-20
MX2014013076A (en)	2015-05-11
JP6410710B2 (en)	2018-10-24
AU2013251602A1 (en)	2014-10-23
DK3444261T3 (en)	2021-03-08
SI2841445T1 (en)	2017-12-29
JP6637136B2 (en)	2020-01-29
TW201348245A (en)	2013-12-01
EP3444261A1 (en)	2019-02-20
CN104395332B (en)	2017-01-18
IL235275B (en)	2018-03-29
CY2024012I1 (en)	2024-12-13
HUE053113T2 (en)	2021-06-28
LT3444261T (en)	2021-05-10
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BR112014026640B1 (en)	2021-05-18
SMT201700396T1 (en)	2017-09-07
JP2019011349A (en)	2019-01-24
BR112014026640A2 (en)	2017-07-18
EA201491972A1 (en)	2015-02-27
PT3444261T (en)	2021-03-12
CY1124130T1 (en)	2022-05-27
JP2015521166A (en)	2015-07-27
WO2013163344A1 (en)	2013-10-31
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EA030468B1 (en)	2018-08-31
FR24C1015I2 (en)	2025-05-02
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UY34764A (en)	2013-11-29
HK1207086A1 (en)	2016-01-22
NZ630222A (en)	2016-06-24
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HRP20171275T1 (en)	2017-10-20
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MX387999B (en)	2025-03-19
DK2841445T3 (en)	2017-09-11
CY1119333T1 (en)	2018-02-14
HK1207085A1 (en)	2016-01-22
HUS2400010I1 (en)	2024-05-28
UA116209C2 (en)	2018-02-26

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