FR2481116A1 - OPAQUE DENTAL CREAM CONTAINING FLUORIN - Google Patents

Abstract

THE PRESENT INVENTION AIMS AN OPAQUE DENTAL CREAM, COMPRISING, BY WEIGHT, FROM 0.5 TO 2 OF AN OPACIFYING AGENT; A BINARY SYSTEM, SUPPLIER OF FLUORINE, PROVIDING APPROXIMATELY 750 TO 1225 PPM OF FLUORINE FROM SODIUM MONOFLUOROPHOSPHATE AND FROM 50 TO 1000 PPM OF FLUORINE FROM SODIUM FLUORIDE; AND 15 TO 20 OF A POLISHING AGENT ESSENTIALLY CONSTITUTED BY A SYNTHETIC SILICA CONTAINING UP TO 1 OF ALUMIN BOUND WITH IT.

Description

2 4 B111 6

  The present invention relates to a den-

  keep quiet to promote oral hygiene.

  In the past, dental creams that contained a single fluorine-providing agent were used, such as sodium fluoride, stannous fluoride or mono-

  sodium fluorophosphate (it being understood that some

  minor tie of commercial sodium monofluorophosphate

contains sodium fluoride).

  Recently, in British Patent 1,435,627 to

  Beecham Group and in the U.S. Patent from Colgate-

  Palmolive has been described dental creams to promote oral hygiene which contain two supplier agents

  fluorine which are added separately, namely: fluoru-

  sodium re and sodium monofluorophosphate. Any-

  We have not yet described dental creams containing two fluorine-supplying agents of this type as well as a siliceous polishing material comprising a small

amount of alumina combined.

  The present invention aims to: - provide a dental cream containing sodium fluoride and sodium monofluorophosphate which promotes dental hygiene, for example by reducing the formation of cavities and remineralizing the teeth; - to provide an abrasive dental cream based on

  silica in which fluorine is very stable.

  According to the present invention, a den-

  opaque silencer contains, by weight: 0.5 to 2% of an opacifying agent, a binary fluorine-supplying system supplying approximately 750 to 1225 ppm of fluorine coming from sodium monofluorophosphate and approximately 50 to 1000 ppm of fluorine from sodium fluoride, and about 20% of a polishing agent essentially consisting of a synthetic precipitated silica containing up to

  about 1% by weight of alumina bound with it.

  Sodium monofluorophosphate is used in a proportion that supplies approximately 750 to 1225 ppm of fluoride to dental cream. This corresponds to approximately 0.5 to 1% by weight of sodium monofluorophosphate in dental cream. The preferable proportion is 0.76% which

  provides approximately 1000 ppm of fluoride to dental cream.

  Sodium monofluorophosphate, Na2PO3F, such as ac-

  commercially transferable, may have very high purity

  variable. It can be used in any state of purity

  prayed provided that it does not contain risky impurities

  as to significantly affect the desired properties.

  In general, it is desirable that the purity

  or at least 80%. To get the best results

  their, it must be at least 85%, and preferably at least 90% by weight of sodium monofluorophosphate, the remainder being mainly constituted by impurities or by-products of manufacture such as sodium fluoride and phosphate water soluble sodium. In other words, the sodium monofluorophosphate used must have a total fluoride content greater than 12% and preferably greater than 12.7%; a content of free sodium fluoride of not more than 1.5% and preferably

  not more than 1.2%; and a content of monofluorophospha-

  te of sodium of at least 12%, preferably at least

  12.1%, the whole being calculated in fluorine.

  Sodium fluoride is added separately to provide

  wear an additional amount of fluorine of about 50 to 1000 ppm (for example 50 to 100 ppm). That corresponds

  to about 0.01 to 0.2% sodium fluoride.

  The polishing material is precipitated silica

  synthetic containing up to about 1% by weight of aluminum

mine linked with it.

  These polishing materials can also be considered as aluminosilicates, in particular

  sodium aluminosilicates. Examples can be found

  examples of these materials in the U.S. patent

  3906090 from Colgate-Palmolive and in U.S. patents

  4015996, 4105757 and 41221160 by J.M. Huber. As examples of commercially available materials of this type, we

  cite EZO 49 and ZEO 49 B (Hubera and TIXOSIL 53 (Sifrance).

  The polishing agent is used in a weighted proportion

  about 15 to 20%. o A minor proportion, for example about 0.5 to 1% of dicalcium phosphate, may be present as an additional polishing agent.

  The dental cream according to the invention is opaque.

  As the polishing agent is characterized as having a refractive index close to that of humectants such as glycerin and sorbitol which are commonly used in dental creams, approximately 0.5 to 2% is used.

  an opacifying agent such as titanium dioxide or

  equivalent equivalent. Dental cream contains, so

  presentative, by weight: about 50 to 80% of humectant, for example about 20 to 30% of glycerin and about

  30 to 60% sorbitol (70% solution).

  Other opacifying agents, such as zinc oxide, can be used in amounts acceptable for oral use that do not react adversely

  with other constituents of dental cream.

  There may also be the presence of water, in small proportions, for example around 2 to 7% by weight. If you want to color the dental cream, you can dissolve

dyes in water.

  Dental cream usually also contains a gelling agent, such as natural and synthetic gums and gummy products, for example Irish moss, gum tragacanth, sodium carboxymethylcellulose,

polyvinylpyrrolidone, and starch.

  Sodium carboxymethylcellulose is preferable. The content of gelling agent is usually about 0.1 to 5% by weight, preferably about 0.1 to 0.5%. The effect of the gelling agent can be supplemented with the help of approximately

  7 to 8% of a filler, such as a pyrogenic silica or an aerosol

  silica gel. ZEOSYL 200 (J.M.Huber) is a filler based

  desirable silica ("Zeosyl" is a trademark).

  Any suitable surfactant or detergent

  can be included in toothpaste compositions.

  A, These compatible materials are desirable to impart

  detergent, foaming and anti-bacterial properties

  nes, according to the particular type of surfactant material, and are chosen in a similar manner. These detergents are usually water-soluble compounds, and can

  have an anionic, nonionic or cationic structure.

  It is usually best to use deter-

  water-soluble synthetic non-soap or organic gents.

  Suitable detergent materials are well known. These are, for example: the water-soluble salts of monoglycerides monosulfates of detergent higher fatty acids (such as monosulfate of monoglyceride of coconut fatty acids, sodium salt), (sup.) Alkyl sulfates (such as

  sodium lauryl sulfate), alkylaryl sulfonates (com-

  me sodium dodecyl benzene sulfonate), esters

  1,2-dihydroxypropane sulfona- higher fatty acids

te, etc.

  As other surfactants, mention may be made of substantially saturated higher aliphatic acyl amides.

  of compounds of aliphatic aliphatic aminocarboxylic acids

  laughers, like those containing from 12 to 16 carbon atoms in the acyl radical. The amino moiety is generally derived from lower C2 to C6 aliphatic saturated monoaminocarboxylic acids, usually compounds of monocarboxylic acids. Examples of suitable compounds include the fatty acid amides of

  glycine, sarcosine, alanine, 3- acid

  aminopropanoic acid and valine containing from about 12 to 16 carbon atoms in the acyl group. However, to obtain optimum effects, it is preferable to use

  N-lauroyl, myristoyl and palmitoyl sarcosides.

  The amides can be used in the form of acid.

  free or, preferably, in the form of their water-soluble salts, in particular the alkali metal, ammonium, amine and alkylolamine salts. As examples

  individuals, we will mention, the N-lauroyl, myristoyl and pal-

  mitoyl sarcosides of sodium and potassium; N-lauroyl 248 1 il 6 sarcosides of ammonium and ethanolamine; the N-lauroyl

  sarcosine; and N-lauroyl glycine and alanine sodium.

  The surfactant is, in a representative manner, used in a proportion by weight of approximately 1 to 5% and a proportion of approximately 1 to 3% of lauryl sulphate.

sodium is preferable.

  Any flavoring or sweetening material can be used.

  rant in the composition of a flavor for the compositions

  according to the present invention. As examples of constit-

  ants suitable flavorings, there will be mentioned essential oils

  flavors such as fried mint essences,

  peppermint, wintergreen, sassafras', giro-

  gle, eucalyptus, sage, marjoram, cinnamon,

  lemon and orange, as well as methyl salicylate.

  Examples of suitable sweetening agents include:

  sucrose, lactose, maltose, sorbitol, cy-

  sodium clamate and sodium saccharin. Saccharin

  sodium is preferable. The flavoring agent is usual-

  Lately present in a weight proportion of about 0.5 to 15%, preferably about 1%, and the sweetener in a

proportion of about 0.1 to 0.2%.

  Visible particles of pearly glitter, such as

  mica flakes coated with titanium dioxide, may

  wind may be distributed in the dental cream, usually in a weight proportion of about 0.1 to 0.3%. Dental cream may also show "scratches". Dental cream can be introduced into tubes

  conventional, such as aluminum tubes

  dull or not lined, or in coated lead tubes

internally of wax.

  Dental creams must have a pH allowing

  their practical use. A pH of about 5 to 10 is per-

  particularly desirable. It is understood that

  this is the pH determined directly on the toothpaste

  frice. The following nonlimiting examples are given by way of illustration of the invention. Unless otherwise indicated, all quantities and proportions are expressed by weight.

EXAMPLE 1

  The following dental cream is prepared, in a conventional manner. Parts Glycerol 25.00 Sorbitol (70%) 42.31 Carboxymethylcellulose sodium 0.18 Saccharin sodium 0.17 Sodium monofluorophosphate 0.82 Sodium fluoride 0.02 Water 3.0 Titanium bioXyde 0.5 Low-grade silica (about 1%) in alumina 17.0 Zeosyl 200 7.0 Dicalcium phosphate dihydrate 1.0 Sodium lauryl sulfate 2.0 Flavor 1.0

EXAMPLE 2

  Another dental cream is prepared, also conventionally, with the composition of Example 1, but by adding 0.25 part of mica flakes coated with titanium dioxide, and thereby reducing the water content accordingly. Table I below indicates compositions of 3

  dental creams prepared in a conventional manner, that iden-

  tified as Example 3 being according to the present invention It follows from the table that the composition of Example 3 has an increased fluorine content and an increased fluoride retention during the test period, compared with conventional opaque dental creams Comparatives A and B. The fluorine content was determined by the standard operating protocol described by Cropper and Puttnam, p.533, Vol. 21 (1970), The Journal of the Society of Cosmetic

Chemists of Great Britain.

TABLE I

  Constituents Comparative examples Example 3

5. _ _A B

  lycherol 22.222 20.202 25.0 orbitol (70% solution) - - 43.05 arboxymethylcellulose sodium 0.9 1.1 0.2 accharine sodium 0.2 0.2 0.17

tetrasodium yrophosphate 0.5 - -

benzoic cide - 0.2 -

  titanium dioxide - - 1.0 sodium onofluorophosphate 0.76 0.76 0.76 sodium luoride 0.1 0.1 0.1 to 25.018 23.138 3.96

  dicalcium phosphate dihydrate 48.0 - -

lumine (Alcoa C333) - 52.0 -

  eo 49 - 17.0 yloid 244 - - 6.0 sodium auryl sulfate 1.5 1.5 | 1.76 ome 0.8 0.8 1.0 Aging tests Retention of soluble fluoride :! Initial 0.110 0.121 0.132 (% by weight) after i month 0.103 0.111 3 months 0.093 0.104 0.140 6 months 0.081 0.096 0.138

1 year 0.069 0.090 -

2 years 0.061 0.080 -

Claims (5)

  1. Opaque dental cream, comprising, by weight, from 0.5 to 2% of an opacifying agent; a binary system, supplier of fluorine, supplying from approximately 750 to 1225 ppm of fluorine coming from sodium monofluorophosphate and from 50 to 1000 ppm of fluorine coming from fluoride   sodium; and from 15 to 20% of an essential polishing agent-   Lement constituted by a synthetic silica containing   up to 1% of alumina bound with it.   2. Dental cream according to claim 1, charac-   terized in that the opacifying agent is titanium dioxide. 3. Dental cream according to claim 1 or 2, characterized in that the sodium fluoride provides 50 to 100 ppm fluorine.   4. Dental cream according to any of the   previous sales, characterized in that it   contains about 0.5 to 1% by weight of dicalcium phosphate.   5. Dental cream according to any one of the res-   previous indications, characterized in that it contains   from about 0.1 to 0.3% pearly flakes.