FR2439788A1 - NEW DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM - Google Patents
NEW DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEMInfo
- Publication number
- FR2439788A1 FR2439788A1 FR7830627A FR7830627A FR2439788A1 FR 2439788 A1 FR2439788 A1 FR 2439788A1 FR 7830627 A FR7830627 A FR 7830627A FR 7830627 A FR7830627 A FR 7830627A FR 2439788 A1 FR2439788 A1 FR 2439788A1
- Authority
- FR
- France
- Prior art keywords
- preparation
- new
- products containing
- medicinal products
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical class O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NOUVEAUX DERIVES DE LA DAUNORUBICINE, DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE LES SYMBOLES R IDENTIQUES OU DIFFERENTS SONT HYDROGENE OU ALCOYLE (1 OU 2ATOMES DE CARBONE) ET R EST HYDROGENE, ALCOYLE DROIT OU RAMIFIE (1 A 4ATOMES DE CARBONE), PHENYLE OU BENZYLE, LEURS FORMES DIASTEREOISOMERES ET LEURS MELANGES A L'ETAT DE BASES OU DE SELS D'ADDITION AVEC LES ACIDES. CES NOUVEAUX DERIVES SONT PARTICULIEREMENT UTILES COMME AGENTS ANTITUMORAUX.NEW DAUNORUBICIN DERIVATIVES, OF GENERAL FORMULA: (CF DRAWING IN BOPI) IN WHICH THE IDENTICAL OR DIFFERENT R SYMBOLS ARE HYDROGEN OR ALKYL (1 OR 2 ATOMS OF CARBON) AND R IS HYDROGEN, RIGHT ALCOHOL WITH 4 CARBON OR RAMATOMI ), PHENYL OR BENZYL, THEIR DIASTEROISOMERIC FORMS AND THEIR MIXTURES IN THE STATE OF BASES OR ADDITIONAL SALTS WITH ACIDS. THESE NEW DERIVATIVES ARE PARTICULARLY USEFUL AS ANTITUMOR AGENTS.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7830627A FR2439788A1 (en) | 1978-10-27 | 1978-10-27 | NEW DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM |
| DE19792943438 DE2943438A1 (en) | 1978-10-27 | 1979-10-26 | NEW DERIVATIVES OF DAUNORUBICIN, THEIR PRODUCTION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| GB7937184A GB2033393A (en) | 1978-10-27 | 1979-10-26 | New Daunorubicin Derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7830627A FR2439788A1 (en) | 1978-10-27 | 1978-10-27 | NEW DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2439788A1 true FR2439788A1 (en) | 1980-05-23 |
Family
ID=9214248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7830627A Pending FR2439788A1 (en) | 1978-10-27 | 1978-10-27 | NEW DAUNORUBICIN DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE2943438A1 (en) |
| FR (1) | FR2439788A1 (en) |
| GB (1) | GB2033393A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4916217A (en) * | 1987-01-08 | 1990-04-10 | Bristol-Myers Company | Phosphorus containing derivatives of epipodophyllotoxin |
| GB8708927D0 (en) * | 1987-04-14 | 1987-05-20 | Erba Farmitalia | Chiral synthesis of anthracyclines |
| DK0648503T3 (en) * | 1993-09-22 | 2000-10-02 | Hoechst Ag | Pro-prodrugs, their manufacture and use |
-
1978
- 1978-10-27 FR FR7830627A patent/FR2439788A1/en active Pending
-
1979
- 1979-10-26 DE DE19792943438 patent/DE2943438A1/en not_active Withdrawn
- 1979-10-26 GB GB7937184A patent/GB2033393A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE2943438A1 (en) | 1980-05-08 |
| GB2033393A (en) | 1980-05-21 |
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