FR2431491A1 - Nouveaux derives aminoalkoxy-5 benzofurannes et indoles, leur procede de preparation et leur application en therapeutique - Google Patents
Nouveaux derives aminoalkoxy-5 benzofurannes et indoles, leur procede de preparation et leur application en therapeutiqueInfo
- Publication number
- FR2431491A1 FR2431491A1 FR7821290A FR7821290A FR2431491A1 FR 2431491 A1 FR2431491 A1 FR 2431491A1 FR 7821290 A FR7821290 A FR 7821290A FR 7821290 A FR7821290 A FR 7821290A FR 2431491 A1 FR2431491 A1 FR 2431491A1
- Authority
- FR
- France
- Prior art keywords
- acetyl
- para
- methyl
- styrylcarbonyl
- nr2r3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000003288 anthiarrhythmic effect Effects 0.000 title abstract 2
- 239000003416 antiarrhythmic agent Substances 0.000 title abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 2
- 230000001882 diuretic effect Effects 0.000 title 1
- 230000002526 effect on cardiovascular system Effects 0.000 title 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 6
- -1 diethylamino, pyrrolidino, piperidino, morpholino, hexamethyleneimino Chemical group 0.000 abstract 5
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 241000699670 Mus sp. Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 150000001907 coumarones Chemical class 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
- 231100000820 toxicity test Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
a. Nouveaux dérivés aminoalkoxy-5 benzofurannes et indoles. b. Ils répondent à la formule générale :
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7821290A FR2431491A1 (fr) | 1978-07-18 | 1978-07-18 | Nouveaux derives aminoalkoxy-5 benzofurannes et indoles, leur procede de preparation et leur application en therapeutique |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7821290A FR2431491A1 (fr) | 1978-07-18 | 1978-07-18 | Nouveaux derives aminoalkoxy-5 benzofurannes et indoles, leur procede de preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2431491A1 true FR2431491A1 (fr) | 1980-02-15 |
Family
ID=9210853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7821290A Withdrawn FR2431491A1 (fr) | 1978-07-18 | 1978-07-18 | Nouveaux derives aminoalkoxy-5 benzofurannes et indoles, leur procede de preparation et leur application en therapeutique |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2431491A1 (fr) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0058977A1 (fr) * | 1981-02-25 | 1982-09-01 | Hoechst-Roussel Pharmaceuticals Incorporated | 1,2-Benzisoxazoloxyéthylamines, produits intermédiaires, procédés pour leur préparation, composition pharmaceutique les contenant et leur utilisation comme agents diurétiques |
| US5192799A (en) * | 1987-12-11 | 1993-03-09 | Mitsui Petrochemical Industries, Ltd. | Coumaran group containing amine compounds and their acid addition salts and quaternary ammonium salts and the use thereof as anti arrhythmic agents and as psychotropic agents |
| EP1942896A2 (fr) * | 2005-11-04 | 2008-07-16 | Amira Pharmaceuticals, Inc. | Inhibiteurs de la proteine d'activation de la 5-lipoxygenase (flap) |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| US8697730B2 (en) | 2007-10-26 | 2014-04-15 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase activating protein (FLAP) inhibitor |
| US8772495B2 (en) | 2008-05-23 | 2014-07-08 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein inhibitor |
| WO2023227696A1 (fr) * | 2022-05-25 | 2023-11-30 | Katholieke Universiteit Leuven | Nouveaux dérivés pour le traitement de troubles médiés par trpm3 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1415355A (fr) * | 1963-12-02 | 1965-10-22 | Haessle Ab | Dérivés du benzofurane et procédé d'obtention |
| FR5157M (fr) * | 1965-12-23 | 1967-07-17 |
-
1978
- 1978-07-18 FR FR7821290A patent/FR2431491A1/fr not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1415355A (fr) * | 1963-12-02 | 1965-10-22 | Haessle Ab | Dérivés du benzofurane et procédé d'obtention |
| FR5157M (fr) * | 1965-12-23 | 1967-07-17 |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0058977A1 (fr) * | 1981-02-25 | 1982-09-01 | Hoechst-Roussel Pharmaceuticals Incorporated | 1,2-Benzisoxazoloxyéthylamines, produits intermédiaires, procédés pour leur préparation, composition pharmaceutique les contenant et leur utilisation comme agents diurétiques |
| US5192799A (en) * | 1987-12-11 | 1993-03-09 | Mitsui Petrochemical Industries, Ltd. | Coumaran group containing amine compounds and their acid addition salts and quaternary ammonium salts and the use thereof as anti arrhythmic agents and as psychotropic agents |
| EP1942896A2 (fr) * | 2005-11-04 | 2008-07-16 | Amira Pharmaceuticals, Inc. | Inhibiteurs de la proteine d'activation de la 5-lipoxygenase (flap) |
| EP1942896A4 (fr) * | 2005-11-04 | 2010-06-02 | Amira Pharmaceuticals Inc | Inhibiteurs de la proteine d'activation de la 5-lipoxygenase (flap) |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| US8710081B2 (en) | 2005-11-04 | 2014-04-29 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| US8841295B2 (en) | 2005-11-04 | 2014-09-23 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| US8697730B2 (en) | 2007-10-26 | 2014-04-15 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase activating protein (FLAP) inhibitor |
| US8772495B2 (en) | 2008-05-23 | 2014-07-08 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein inhibitor |
| US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| WO2023227696A1 (fr) * | 2022-05-25 | 2023-11-30 | Katholieke Universiteit Leuven | Nouveaux dérivés pour le traitement de troubles médiés par trpm3 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |