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FR2426473A1 - Treatment of leukaemia by UV irradiation of blood - in presence of a phenothiazine amine as radiation sensitiser - Google Patents

Treatment of leukaemia by UV irradiation of blood - in presence of a phenothiazine amine as radiation sensitiser

Info

Publication number
FR2426473A1
FR2426473A1 FR7815726A FR7815726A FR2426473A1 FR 2426473 A1 FR2426473 A1 FR 2426473A1 FR 7815726 A FR7815726 A FR 7815726A FR 7815726 A FR7815726 A FR 7815726A FR 2426473 A1 FR2426473 A1 FR 2426473A1
Authority
FR
France
Prior art keywords
blood
leukaemia
radiation
phenothiazine
irradiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7815726A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR7815726A priority Critical patent/FR2426473A1/en
Publication of FR2426473A1 publication Critical patent/FR2426473A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Leukaemia is treated by establishing extra-corporeal circulation of the blood contg. leukaemia tumour cells and irradiating this blood with UV rays in the presence of a phenothiazine amine (I) as radiation sensitiser. The appts. for obtaining a thin layer of the blood for irradiation is also claimed. Suitable phenothiazines (I) include methopromazine, thioproperazine, prochlorpemazine, acepromazine, levomepromazine, promethazine, alimemazine and esp. chlorpromazine. (I) is perfused into the blood at the radiation zone at a dose of about 2 mg./kg. body wt. It is usually infused slowly at 0.5 ml./min. as an aq. soln. contg. 10 mg. (I)/ml. The UV radiation is usually at 2200-5800 angstroms.
FR7815726A 1978-05-26 1978-05-26 Treatment of leukaemia by UV irradiation of blood - in presence of a phenothiazine amine as radiation sensitiser Withdrawn FR2426473A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7815726A FR2426473A1 (en) 1978-05-26 1978-05-26 Treatment of leukaemia by UV irradiation of blood - in presence of a phenothiazine amine as radiation sensitiser

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7815726A FR2426473A1 (en) 1978-05-26 1978-05-26 Treatment of leukaemia by UV irradiation of blood - in presence of a phenothiazine amine as radiation sensitiser

Publications (1)

Publication Number Publication Date
FR2426473A1 true FR2426473A1 (en) 1979-12-21

Family

ID=9208735

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7815726A Withdrawn FR2426473A1 (en) 1978-05-26 1978-05-26 Treatment of leukaemia by UV irradiation of blood - in presence of a phenothiazine amine as radiation sensitiser

Country Status (1)

Country Link
FR (1) FR2426473A1 (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030358A3 (en) * 1979-12-11 1982-03-24 Leukocyte Research, Inc. Method and system for externally treating human blood
FR2507482A1 (en) * 1981-06-12 1982-12-17 Edelson Richard METHOD AND DEVICE FOR THE EXTRACORPOREAL TREATMENT OF BLOOD
US4428744A (en) 1979-12-11 1984-01-31 Frederic A. Bourke, Jr. Method and system for externally treating the blood
EP0138489A1 (en) * 1983-09-29 1985-04-24 McNeilab, Inc. Apparatus and methods for treating cells with radiation
US4612007A (en) * 1981-06-16 1986-09-16 Edelson Richard Leslie Method and system for externally treating the blood
US4613322A (en) * 1982-12-08 1986-09-23 Edelson Richard Leslie Method and system for externally treating the blood
US4684521A (en) * 1982-12-08 1987-08-04 Frederic A. Bourke, Jr. Method and system for externally treating the blood
US4683889A (en) * 1983-03-29 1987-08-04 Frederic A. Bourke, Jr. Method and system for externally treating the blood
EP0240152A1 (en) * 1986-02-27 1987-10-07 McNeilab, Inc. Irradiation chamber for photoactivation patient treatment system
FR2607705A1 (en) * 1986-12-08 1988-06-10 Carraz Gilbert Device for extracorporeal irradiation of blood
WO2002096400A1 (en) * 2001-06-01 2002-12-05 Molecular Engines Laboratories Medicament which can be used for the treatment of cancer
WO2004080445A1 (en) * 2003-03-12 2004-09-23 Molecular Engines Laboratories Sa Methods and compositions for the treatment of cancer
WO2006128047A3 (en) * 2005-05-27 2007-01-11 Energex Systems Inc Blood irradiation system device

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1233327A (en) * 1959-03-26 1960-10-12 Device for blood processing
US3325641A (en) * 1964-02-17 1967-06-13 George W Jones Apparatus for treating a thin film of liquid by exposure to radiant energy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1233327A (en) * 1959-03-26 1960-10-12 Device for blood processing
US3325641A (en) * 1964-02-17 1967-06-13 George W Jones Apparatus for treating a thin film of liquid by exposure to radiant energy

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4428744A (en) 1979-12-11 1984-01-31 Frederic A. Bourke, Jr. Method and system for externally treating the blood
EP0030358A3 (en) * 1979-12-11 1982-03-24 Leukocyte Research, Inc. Method and system for externally treating human blood
FR2507482A1 (en) * 1981-06-12 1982-12-17 Edelson Richard METHOD AND DEVICE FOR THE EXTRACORPOREAL TREATMENT OF BLOOD
DE3222244A1 (en) * 1981-06-12 1983-02-24 Richard Leslie Roseland N.J. Edelson METHOD AND DEVICE FOR TREATING HUMAN BLOOD
US4612007A (en) * 1981-06-16 1986-09-16 Edelson Richard Leslie Method and system for externally treating the blood
US4613322A (en) * 1982-12-08 1986-09-23 Edelson Richard Leslie Method and system for externally treating the blood
US4684521A (en) * 1982-12-08 1987-08-04 Frederic A. Bourke, Jr. Method and system for externally treating the blood
US4683889A (en) * 1983-03-29 1987-08-04 Frederic A. Bourke, Jr. Method and system for externally treating the blood
EP0138489A1 (en) * 1983-09-29 1985-04-24 McNeilab, Inc. Apparatus and methods for treating cells with radiation
EP0240152A1 (en) * 1986-02-27 1987-10-07 McNeilab, Inc. Irradiation chamber for photoactivation patient treatment system
FR2607705A1 (en) * 1986-12-08 1988-06-10 Carraz Gilbert Device for extracorporeal irradiation of blood
WO2002096400A1 (en) * 2001-06-01 2002-12-05 Molecular Engines Laboratories Medicament which can be used for the treatment of cancer
FR2825279A1 (en) * 2001-06-01 2002-12-06 Molecular Engines Lab MEDICINE USEFUL IN THE TREATMENT OF CANCER
WO2004080445A1 (en) * 2003-03-12 2004-09-23 Molecular Engines Laboratories Sa Methods and compositions for the treatment of cancer
WO2006128047A3 (en) * 2005-05-27 2007-01-11 Energex Systems Inc Blood irradiation system device

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