FR2422619A2 - Procede de preparation d'acide 2-(3-benzoylphenyl)-propionique - Google Patents
Procede de preparation d'acide 2-(3-benzoylphenyl)-propioniqueInfo
- Publication number
- FR2422619A2 FR2422619A2 FR7908999A FR7908999A FR2422619A2 FR 2422619 A2 FR2422619 A2 FR 2422619A2 FR 7908999 A FR7908999 A FR 7908999A FR 7908999 A FR7908999 A FR 7908999A FR 2422619 A2 FR2422619 A2 FR 2422619A2
- Authority
- FR
- France
- Prior art keywords
- benzoylphenyl
- propionic acid
- preparation process
- acid preparation
- methylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- MHKMCTCMEDUINO-UHFFFAOYSA-N 2-(3-benzoylphenyl)acetonitrile Chemical compound C=1C=CC(CC#N)=CC=1C(=O)C1=CC=CC=C1 MHKMCTCMEDUINO-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000004703 alkoxides Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000012022 methylating agents Substances 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B61—RAILWAYS
- B61D—BODY DETAILS OR KINDS OF RAILWAY VEHICLES
- B61D3/00—Wagons or vans
- B61D3/04—Wagons or vans with movable floors, e.g. rotatable or floors which can be raised or lowered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Transportation (AREA)
- Mechanical Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procédé de préparation d'acide 2-(3-benzoyl-phényl)-propionique selon le brevet principal, dans lequel on fait réagir sur un agent de méthylation le 3-benzoylphényl-acétonitrile ou un alcoxyde correspondant dont le fragment alcoxyle contient 1 à 4 atomes de carbone, en un système à deux phases, après quoi on hydrolyse le mélange et facultativement, on convertit l'acide obtenu en sel métallique ou en sel d'addition d'une base azotée. On conduit la méthylation en présence de coordinats non cycliques neutres à chaîne ouverte, à une tempémture de - 10 à + 50 degrés C. Applicable à la fabrication du produit recherché avec des substances facilement accessibles.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU853/78A YU39415B (en) | 1978-04-10 | 1978-04-10 | Process for preparing 2-(3-benzoyl-phenyl)-propionic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2422619A2 true FR2422619A2 (fr) | 1979-11-09 |
Family
ID=25551715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7908999A Pending FR2422619A2 (fr) | 1978-04-10 | 1979-04-10 | Procede de preparation d'acide 2-(3-benzoylphenyl)-propionique |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4230884A (fr) |
| AT (1) | AT365163B (fr) |
| DE (1) | DE2914006A1 (fr) |
| FR (1) | FR2422619A2 (fr) |
| GB (1) | GB2021562A (fr) |
| PL (1) | PL214797A1 (fr) |
| YU (1) | YU39415B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07100678B2 (ja) * | 1987-03-12 | 1995-11-01 | 日本石油化学株式会社 | α−（３−ベンゾイルフエニル）プロピオン酸の製造方法 |
| JP2782080B2 (ja) * | 1989-03-06 | 1998-07-30 | 日本石油化学株式会社 | α―（３―ベンゾイルフェニル）プロピオン酸誘導体の製造方法 |
| CN1115320C (zh) * | 1999-08-20 | 2003-07-23 | 复旦大学 | 酮基布洛芬的合成方法 |
| CN101591236B (zh) * | 2009-06-11 | 2013-04-24 | 浙江工业大学 | 一种管道化合成酮洛芬的方法 |
| PL242620B1 (pl) | 2021-07-21 | 2023-03-27 | Nader Miroslaw | Kolejowy wagon transportowy |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1546478A (fr) * | 1967-01-27 | 1968-11-22 | Rhone Poulenc Sa | Nouveaux dérivés de l'acide benzoyl-3 phénylacétique et leur préparation |
-
1978
- 1978-04-10 YU YU853/78A patent/YU39415B/xx unknown
-
1979
- 1979-04-06 DE DE19792914006 patent/DE2914006A1/de not_active Withdrawn
- 1979-04-09 AT AT0261879A patent/AT365163B/de not_active IP Right Cessation
- 1979-04-10 GB GB7912571A patent/GB2021562A/en not_active Withdrawn
- 1979-04-10 PL PL21479779A patent/PL214797A1/xx unknown
- 1979-04-10 US US06/028,779 patent/US4230884A/en not_active Expired - Lifetime
- 1979-04-10 FR FR7908999A patent/FR2422619A2/fr active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| YU85378A (en) | 1982-10-31 |
| US4230884A (en) | 1980-10-28 |
| AT365163B (de) | 1981-12-28 |
| ATA261879A (de) | 1981-05-15 |
| PL214797A1 (pl) | 1979-12-17 |
| YU39415B (en) | 1984-12-31 |
| DE2914006A1 (de) | 1979-10-18 |
| GB2021562A (en) | 1979-12-05 |
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