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FR2416885A1 - NEW LONG-CHAIN FATTY ACID DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS - Google Patents

NEW LONG-CHAIN FATTY ACID DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Info

Publication number
FR2416885A1
FR2416885A1 FR7900438A FR7900438A FR2416885A1 FR 2416885 A1 FR2416885 A1 FR 2416885A1 FR 7900438 A FR7900438 A FR 7900438A FR 7900438 A FR7900438 A FR 7900438A FR 2416885 A1 FR2416885 A1 FR 2416885A1
Authority
FR
France
Prior art keywords
preparation
acid derivatives
application
fatty acid
chain fatty
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7900438A
Other languages
French (fr)
Other versions
FR2416885B1 (en
Inventor
Faizulla Gulamhusein Kathawala
John G Heider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/881,780 external-priority patent/US4229463A/en
Priority claimed from US05/891,298 external-priority patent/US4194002A/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2416885A1 publication Critical patent/FR2416885A1/en
Application granted granted Critical
Publication of FR2416885B1 publication Critical patent/FR2416885B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B22/00—Use of inorganic materials as active ingredients for mortars, concrete or artificial stone, e.g. accelerators, shrinkage compensating agents
    • C04B22/0013—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Ceramic Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Structural Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne de nouveaux dérivés d'acides à longue chaîne et leur préparation. Les composés de l'invention répondent à la formule :The invention relates to novel long-chain acid derivatives and their preparation. The compounds of the invention correspond to the formula:

FR7900438A 1978-01-09 1979-01-09 NEW LONG-CHAIN FATTY ACID DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS Granted FR2416885A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US86782478A 1978-01-09 1978-01-09
US86781378A 1978-01-09 1978-01-09
US87283678A 1978-01-27 1978-01-27
US88178178A 1978-02-27 1978-02-27
US05/881,780 US4229463A (en) 1978-02-27 1978-02-27 Unsaturated fatty acid hydrazides
US05/891,298 US4194002A (en) 1978-03-29 1978-03-29 Cholesterol ester-reducing amides of hexahydroindolinols

Publications (2)

Publication Number Publication Date
FR2416885A1 true FR2416885A1 (en) 1979-09-07
FR2416885B1 FR2416885B1 (en) 1983-04-22

Family

ID=27560330

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7900438A Granted FR2416885A1 (en) 1978-01-09 1979-01-09 NEW LONG-CHAIN FATTY ACID DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Country Status (20)

Country Link
JP (1) JPS54109930A (en)
AU (1) AU529328B2 (en)
CA (1) CA1101871A (en)
CH (1) CH644842A5 (en)
CY (1) CY1294A (en)
DE (1) DE2856856A1 (en)
DK (1) DK3079A (en)
FI (1) FI790025A (en)
FR (1) FR2416885A1 (en)
GB (1) GB2012261B (en)
HK (1) HK80985A (en)
IE (1) IE48077B1 (en)
IL (1) IL56393A (en)
IT (1) IT1110603B (en)
KE (1) KE3546A (en)
MY (1) MY8500133A (en)
NZ (1) NZ189331A (en)
PT (1) PT69052A (en)
SE (1) SE446093B (en)
SG (1) SG42985G (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2436133A1 (en) * 1978-09-18 1980-04-11 Sandoz Sa NOVEL SECONDARY 2-ALCYNOIC ACID AMIDES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4297349A (en) 1980-04-15 1981-10-27 Sandoz, Inc. Silicon-bearing carboxylic acids and amides
US4722927A (en) * 1986-04-28 1988-02-02 Warner-Lambert Company Pyrimidine amides of oleic or linoleic acid, composition containing them and their use as inhibitors of acyl-CoA cholesterol acyltransferase
FR2633617B1 (en) * 1988-07-04 1991-02-08 Adir NOVEL BENZOCYCLOHEPTENE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5290814A (en) * 1988-11-21 1994-03-01 Burroughs Wellcome Co. Anti-atherosclerotic diaryl compounds
JP5607025B2 (en) * 2008-04-21 2014-10-15 シグナム バイオサイエンシーズ， インコーポレイテッド Compounds, compositions and methods of making them

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2000945A1 (en) * 1968-01-30 1969-09-19 Sumitomo Chemical Co
FR8182M (en) * 1967-12-21 1970-09-07

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835505B2 (en) * 1976-01-09 1983-08-03 エーザイ株式会社 N-(α-methyl-benzyl)-fatty acid amide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR8182M (en) * 1967-12-21 1970-09-07
FR2000945A1 (en) * 1968-01-30 1969-09-19 Sumitomo Chemical Co

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2436133A1 (en) * 1978-09-18 1980-04-11 Sandoz Sa NOVEL SECONDARY 2-ALCYNOIC ACID AMIDES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS

Also Published As

Publication number Publication date
AU4323379A (en) 1979-07-19
IE790031L (en) 1979-07-09
JPS6323987B2 (en) 1988-05-18
GB2012261B (en) 1982-12-22
FR2416885B1 (en) 1983-04-22
IT1110603B (en) 1985-12-23
HK80985A (en) 1985-10-25
SE7900142L (en) 1979-07-10
IL56393A (en) 1982-08-31
CY1294A (en) 1985-10-18
JPS54109930A (en) 1979-08-29
IT7919059A0 (en) 1979-01-04
FI790025A (en) 1979-07-10
IE48077B1 (en) 1984-09-19
SE446093B (en) 1986-08-11
IL56393A0 (en) 1979-03-12
DK3079A (en) 1979-07-10
AU529328B2 (en) 1983-06-02
CH644842A5 (en) 1984-08-31
PT69052A (en) 1979-02-01
MY8500133A (en) 1985-12-31
KE3546A (en) 1985-07-19
DE2856856A1 (en) 1979-07-12
NZ189331A (en) 1981-07-13
CA1101871A (en) 1981-05-26
GB2012261A (en) 1979-07-25
SG42985G (en) 1985-12-13

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