FR2410013A1 - Polymer articles prodn. with reduced thrombogenic tendency - by treating with soln. of synthetic fibrinolytic cpd. - Google Patents
Polymer articles prodn. with reduced thrombogenic tendency - by treating with soln. of synthetic fibrinolytic cpd.Info
- Publication number
- FR2410013A1 FR2410013A1 FR7735250A FR7735250A FR2410013A1 FR 2410013 A1 FR2410013 A1 FR 2410013A1 FR 7735250 A FR7735250 A FR 7735250A FR 7735250 A FR7735250 A FR 7735250A FR 2410013 A1 FR2410013 A1 FR 2410013A1
- Authority
- FR
- France
- Prior art keywords
- acid
- deriv
- cpd
- soln
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003527 fibrinolytic agent Substances 0.000 title abstract 2
- 230000003480 fibrinolytic effect Effects 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 title abstract 2
- 230000002885 thrombogenetic effect Effects 0.000 title 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 abstract 2
- 239000002861 polymer material Substances 0.000 abstract 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 abstract 1
- IRMCWHUVXQCWKI-UHFFFAOYSA-N 1,2-diphenylpyrazolidine Chemical compound C1CCN(C=2C=CC=CC=2)N1C1=CC=CC=C1 IRMCWHUVXQCWKI-UHFFFAOYSA-N 0.000 abstract 1
- ZZEWMYILWXCRHZ-UHFFFAOYSA-N 3-phenylbutyric acid Chemical compound OC(=O)CC(C)C1=CC=CC=C1 ZZEWMYILWXCRHZ-UHFFFAOYSA-N 0.000 abstract 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 abstract 1
- JZFPYUNJRRFVQU-UHFFFAOYSA-N Niflumic acid Chemical compound OC(=O)C1=CC=CN=C1NC1=CC=CC(C(F)(F)F)=C1 JZFPYUNJRRFVQU-UHFFFAOYSA-N 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 230000002965 anti-thrombogenic effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229930016911 cinnamic acid Natural products 0.000 abstract 1
- 235000013985 cinnamic acid Nutrition 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- -1 heterocyclic carboxylic acid Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- HYYBABOKPJLUIN-UHFFFAOYSA-N mefenamic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C(O)=O)=C1C HYYBABOKPJLUIN-UHFFFAOYSA-N 0.000 abstract 1
- 229960003464 mefenamic acid Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 abstract 1
- 229960000916 niflumic acid Drugs 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract 1
- 229960002895 phenylbutazone Drugs 0.000 abstract 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 abstract 1
- 229960004889 salicylic acid Drugs 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000003356 suture material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Materials For Medical Uses (AREA)
Abstract
Prodn. of antithrombogenic polymer materials comprises treating a polymer material (I) with a soln. of a synthetic fibrinolytic cpd. (II) so that (II) is attached to (I) by chemical bonding or adsorption. (II) can be a 1,2-diphenylpyrazolidine deriv. (e.g. phenylbutazone), an anthranilic acid deriv. (e.g. mefenamic acid), a salicylic acid), a salicyclic acid deriv. (e. g. a chlorobenzyl-salicyclic acid), a cinnamic acid deriv. (e.g. an alpha-alkyl-halocinnamic acid), a Beta-aryl-substd. aliphatic acid (e.g. Beta-phenyl-n-butyric acid) or a heterocyclic carboxylic acid deriv. (e.g. niflumic acid). The process can be used to treat polymer articles coming into direct contact with blood, e.g. prosthetic devices, catheters, artificial organs and suture materials. The coating of (II) is easy to apply (even to complicated shapes) and provides long lasting inhibition of thrombus formation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7735250A FR2410013A1 (en) | 1977-11-23 | 1977-11-23 | Polymer articles prodn. with reduced thrombogenic tendency - by treating with soln. of synthetic fibrinolytic cpd. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7735250A FR2410013A1 (en) | 1977-11-23 | 1977-11-23 | Polymer articles prodn. with reduced thrombogenic tendency - by treating with soln. of synthetic fibrinolytic cpd. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2410013A1 true FR2410013A1 (en) | 1979-06-22 |
| FR2410013B1 FR2410013B1 (en) | 1984-09-14 |
Family
ID=9197958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7735250A Granted FR2410013A1 (en) | 1977-11-23 | 1977-11-23 | Polymer articles prodn. with reduced thrombogenic tendency - by treating with soln. of synthetic fibrinolytic cpd. |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2410013A1 (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2071904A5 (en) * | 1969-12-08 | 1971-09-17 | Baxter Laboratories Inc | |
| US3625745A (en) * | 1970-03-18 | 1971-12-07 | Gen Electric | Antithrombogenic article and process |
| FR2142277A5 (en) * | 1971-06-18 | 1973-01-26 | Gen Electric | Antithrombogenic surfaces |
| FR2187849A1 (en) * | 1972-06-06 | 1974-01-18 | Atomic Energy Commission | |
| FR2399836A1 (en) * | 1977-07-27 | 1979-03-09 | Snam Progetti | PROCESS FOR PREPARING BIOCOMPATIBLE PRODUCTS AND ARTICLES THUS OBTAINED |
-
1977
- 1977-11-23 FR FR7735250A patent/FR2410013A1/en active Granted
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2071904A5 (en) * | 1969-12-08 | 1971-09-17 | Baxter Laboratories Inc | |
| US3625745A (en) * | 1970-03-18 | 1971-12-07 | Gen Electric | Antithrombogenic article and process |
| FR2142277A5 (en) * | 1971-06-18 | 1973-01-26 | Gen Electric | Antithrombogenic surfaces |
| FR2187849A1 (en) * | 1972-06-06 | 1974-01-18 | Atomic Energy Commission | |
| FR2399836A1 (en) * | 1977-07-27 | 1979-03-09 | Snam Progetti | PROCESS FOR PREPARING BIOCOMPATIBLE PRODUCTS AND ARTICLES THUS OBTAINED |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2410013B1 (en) | 1984-09-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |