FR2408591A1 - 4-aroyl-4-hydroxypiperidines substituees en position 1, leurs sels d'addition avec des acides, utilisables comme medicaments antipsychotiques - Google Patents
4-aroyl-4-hydroxypiperidines substituees en position 1, leurs sels d'addition avec des acides, utilisables comme medicaments antipsychotiquesInfo
- Publication number
- FR2408591A1 FR2408591A1 FR7831594A FR7831594A FR2408591A1 FR 2408591 A1 FR2408591 A1 FR 2408591A1 FR 7831594 A FR7831594 A FR 7831594A FR 7831594 A FR7831594 A FR 7831594A FR 2408591 A1 FR2408591 A1 FR 2408591A1
- Authority
- FR
- France
- Prior art keywords
- aroyl
- substituted
- additional salts
- acids
- hydroxypiperidines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 230000000561 anti-psychotic effect Effects 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010001488 Aggression Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000016571 aggressive behavior Effects 0.000 abstract 1
- 208000012761 aggressive behavior Diseases 0.000 abstract 1
- 150000005215 alkyl ethers Chemical class 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 150000008378 aryl ethers Chemical class 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 238000007086 side reaction Methods 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
- C07D211/50—Aroyl radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
ETHERS D'ARYLE DE N-ALCOYLPIPERIDINES, LEURS SELS D'ADDITION AVEC DES ACIDES PHARMACEUTIQUEMENT ACCEPTABLES, MODES OPERATOIRES PERMETTANT DE LES PREPARER, ET COMPOSITIONS PHARMACEUTIQUES CONTENANT AU MOINS UN TEL COMPOSE COMME INGREDIENT ACTIF. ON PREPARE UN COMPOSE DU GENRE EN QUESTION EN FAISANT REAGIR UNE 4-AROYL-4-HYDROXYPIPERIDINE, QUI PEUT ETRE CONVENABLEMENT SUBSTITUEE, AVEC UN ETHER D'ALCOYLE ET D'ARYLE APPROPRIE. LES COMPOSES EN QUESTION, REMARQUABLEMENT PEU TOXIQUES ET DONT L'ADMINISTRATION NE PROVOQUE QUE PEU OU PAS DE REACTIONS SECONDAIRES INDESIRABLES OU GENANTES, SONT REMARQUABLEMENT EFFICACES COMME ANALGESIQUES, COMME SEDATIFS DU SYSTEME NERVEUX CENTRAL, COMME NEUROLEPTIQUES OU ANTIPSYCHOTIQUES SUR DES ETRES HUMAINS SOUFFRANT DE TROUBLES NERVEUX; ILS PERMETTENT DE SUPPRIMER OU D'ATTENUER LE COMPORTEMENT AGRESSIF D'ANIMAUX, PRINCIPALEMENT DE MAMMIFERES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4668077 | 1977-11-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2408591A1 true FR2408591A1 (fr) | 1979-06-08 |
| FR2408591B1 FR2408591B1 (fr) | 1982-06-18 |
Family
ID=10442183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7831594A Granted FR2408591A1 (fr) | 1977-11-09 | 1978-11-08 | 4-aroyl-4-hydroxypiperidines substituees en position 1, leurs sels d'addition avec des acides, utilisables comme medicaments antipsychotiques |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4366162A (fr) |
| JP (1) | JPS5498774A (fr) |
| DE (1) | DE2847624A1 (fr) |
| DK (1) | DK491678A (fr) |
| FR (1) | FR2408591A1 (fr) |
| IT (1) | IT1100469B (fr) |
| SE (1) | SE7811551L (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5776963A (en) | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
| US5240927A (en) * | 1992-05-19 | 1993-08-31 | Hoechst-Roussel Pharmaceuticals Incorporated | Benzo[β]thiophen-3-yl piperazines as antipsychotic agents |
| CN101824030B (zh) * | 2009-03-04 | 2014-06-18 | 北京德众万全药物技术开发有限公司 | 一种伊潘立酮的制备方法 |
| WO2011061750A2 (fr) * | 2009-11-19 | 2011-05-26 | Symed Labs Limited | Procédé pour la préparation d'ilopéridone à l'aide d'un nouvel intermédiaire |
| WO2011154860A1 (fr) | 2010-06-08 | 2011-12-15 | Alembic Pharmaceuticals Limited | Procédé amélioré pour la préparation de l'ilopéridone |
| ITMI20120511A1 (it) * | 2012-03-29 | 2013-09-30 | Procos Spa | Processo one-pot per la sintesi di iloperidone |
| WO2016100940A1 (fr) | 2014-12-19 | 2016-06-23 | The Broad Institute, Inc. | Ligands des récepteurs dopaminergiques d2 |
| US10752588B2 (en) | 2014-12-19 | 2020-08-25 | The Broad Institute, Inc. | Dopamine D2 receptor ligands |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1535791A (en) * | 1975-05-07 | 1978-12-13 | Ferrosan Ab | Derivatives of 4-piperidinol |
-
1978
- 1978-10-25 US US05/954,340 patent/US4366162A/en not_active Expired - Lifetime
- 1978-10-31 JP JP13441378A patent/JPS5498774A/ja active Granted
- 1978-11-02 DE DE19782847624 patent/DE2847624A1/de not_active Withdrawn
- 1978-11-03 DK DK491678A patent/DK491678A/da not_active Application Discontinuation
- 1978-11-07 IT IT29507/78A patent/IT1100469B/it active
- 1978-11-08 SE SE7811551A patent/SE7811551L/xx unknown
- 1978-11-08 FR FR7831594A patent/FR2408591A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5498774A (en) | 1979-08-03 |
| SE7811551L (sv) | 1979-05-10 |
| IT7829507A0 (it) | 1978-11-07 |
| US4366162A (en) | 1982-12-28 |
| DK491678A (da) | 1979-05-10 |
| IT1100469B (it) | 1985-09-28 |
| DE2847624A1 (de) | 1979-05-10 |
| FR2408591B1 (fr) | 1982-06-18 |
| JPS5710110B2 (fr) | 1982-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |