[go: up one dir, main page]

FR2388794A1 - Isoindolines et leur preparation - Google Patents

Isoindolines et leur preparation

Info

Publication number
FR2388794A1
FR2388794A1 FR7812382A FR7812382A FR2388794A1 FR 2388794 A1 FR2388794 A1 FR 2388794A1 FR 7812382 A FR7812382 A FR 7812382A FR 7812382 A FR7812382 A FR 7812382A FR 2388794 A1 FR2388794 A1 FR 2388794A1
Authority
FR
France
Prior art keywords
isoindolines
preparation
indolines
novel
following formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7812382A
Other languages
English (en)
Other versions
FR2388794B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoire Glaxo Wellcome SA
Glaxo Laboratories Ltd
Original Assignee
Laboratoires Glaxo SA
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Glaxo SA, Glaxo Laboratories Ltd filed Critical Laboratoires Glaxo SA
Publication of FR2388794A1 publication Critical patent/FR2388794A1/fr
Application granted granted Critical
Publication of FR2388794B1 publication Critical patent/FR2388794B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/373—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

L'invention concerne de nouvelles isoindolines ainsi que leur préparation. Les indolines en question répondent à la formule suivante :
FR7812382A 1977-04-26 1978-04-26 Isoindolines et leur preparation Granted FR2388794A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB17305/77A GB1599907A (en) 1977-04-26 1977-04-26 Isoindolines

Publications (2)

Publication Number Publication Date
FR2388794A1 true FR2388794A1 (fr) 1978-11-24
FR2388794B1 FR2388794B1 (fr) 1982-12-31

Family

ID=10092855

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7812382A Granted FR2388794A1 (fr) 1977-04-26 1978-04-26 Isoindolines et leur preparation

Country Status (13)

Country Link
US (1) US4351842A (fr)
JP (1) JPS53149972A (fr)
AU (1) AU523819B2 (fr)
BE (1) BE866327A (fr)
DE (1) DE2817661A1 (fr)
DK (1) DK171778A (fr)
FR (1) FR2388794A1 (fr)
GB (1) GB1599907A (fr)
IE (1) IE46724B1 (fr)
NL (1) NL7804424A (fr)
NZ (1) NZ187020A (fr)
SE (1) SE7804736L (fr)
ZA (1) ZA782202B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1582884A (en) * 1977-05-19 1981-01-14 Beecham Group Ltd Clavulanic acid derivatives their preparation and use
DK330880A (da) * 1979-08-03 1981-02-04 Beecham Group Ltd Fremgangsmaade til fremstilling af clavulansyrederivater
US4423229A (en) * 1980-11-18 1983-12-27 The Upjohn Company Composition of matter and process
EP0053893B1 (fr) * 1980-12-09 1985-03-20 Beecham Group Plc Dérivés de l'acide clavulanique, leur préparation et leur application
US4562182A (en) * 1980-12-23 1985-12-31 Beecham Group P.L.C. Compounds containing beta-lactams
DE3509546A1 (de) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
WO2003040096A2 (fr) * 2001-11-08 2003-05-15 Elan Pharmaceuticals, Inc. Derives 1,3-diamino-2-hydroxypropane n-n'-substitues
NZ601629A (en) * 2010-01-27 2014-11-28 Pharma Ltd Ab Polyheterocyclic compounds highly potent as hcv inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2740795A (en) * 1956-04-03 Isoindolineicompounds
DD31901A (fr) *
DK107175A (fr) * 1974-03-26 1975-09-27 Sandoz Ag
SE7501669L (sv) * 1974-04-05 1975-10-06 Ciba Geigy Ag Pyrrol-derivat och sett att framstella desamma.
US4052508A (en) * 1974-08-19 1977-10-04 Merck & Co., Inc. Heterocyclic dihydroanthracen imines
US3897452A (en) * 1974-08-19 1975-07-29 Merck & Co Inc Substituted 1,4-dihydro(and 1,2,3,4-tetrahydro)-naphthalen-1,4-imines
US4088772A (en) * 1975-01-30 1978-05-09 E. I. Du Pont De Nemours And Company Methanodibenzocycloheptapyrroles

Also Published As

Publication number Publication date
US4351842A (en) 1982-09-28
SE7804736L (sv) 1978-10-27
IE780751L (en) 1978-10-26
NZ187020A (en) 1980-11-28
GB1599907A (en) 1981-10-07
NL7804424A (nl) 1978-10-30
AU3546778A (en) 1979-11-01
AU523819B2 (en) 1982-08-19
DE2817661A1 (de) 1978-11-02
DK171778A (da) 1978-10-27
ZA782202B (en) 1979-04-25
BE866327A (fr) 1978-10-25
JPS53149972A (en) 1978-12-27
FR2388794B1 (fr) 1982-12-31
IE46724B1 (en) 1983-09-07

Similar Documents

Publication Publication Date Title
FR2446832A1 (fr) Octahydro-pyrazolo(3,4-g)quinoleines et leur utilisation therapeutique
FR2391183A1 (fr) Hydroxyalkylphenones et leur application comme photosensibilisateurs
FR2416891A1 (fr) 6-n-propyl-8-methoxymethyl ou methylmercaptomethylergolines et composes apparentes, et leur utilisation therapeutique
FR2400517A1 (fr) Triazolo-2,4-benzodiazepines et leur utilisation therapeutique
BG31499A3 (en) Method for obtaining of 1- vinyl- triazol derivatives
FR2366297A1 (fr) Nouvelles cephalosporines, leur procede de preparation et leur application en therapeutique
FR2392007A1 (fr) 3,3,3-triarylalkyl-4-phenylalkyl-4-hydroxy-piperidines, leurs derives, leur preparation et leur utilisation comme antidiarrheiques et analgesiques
FR2391215A1 (fr) Nouvelles imidazoazines et imidazodiazines, leur preparation et leur application en tant que medicaments
BR8003841A (pt) Quadro de comutacao encoberto
FR2381762A1 (fr) Dibenzodiazepines utilisables comme antischizophreniques
FR2442836A1 (fr) 1,2,4,5-tetra-alkyl-4-arylpiperidines, leur preparation et leur utilisation therapeutique
FR2387988A1 (fr) Esters de cefuroxime, leur preparation et leur application therapeutique
OA07525A (fr) Dérivés d'acides-animés, leur préparation et utilisation ainsi que les compositions contenant ces dérivés.
FR2388794A1 (fr) Isoindolines et leur preparation
FR2390446A1 (fr) Nouvelles triazines 1,3,5-s-hexahydrotrisubstituees, leur preparation et leur application a la lutte contre le developpement microbien
FR2375234A1 (fr) 1,2-dihydro-3h-pyrrolo(1,2-a)pyrrole-1-carboxylates et leur obtention
FR2393031A1 (fr) Pigments monoazoiques et leur preparation
FR2453169A1 (fr) Composes de pyranone substitues en position 6 et leur utilisation comme produits pharmaceutiques
FR2389597A1 (fr)
FR2446833A1 (fr) Octahydro-2h-pyrrolo(3,4-g)quinoleines et leur utilisation therapeutiques
FR2389624A1 (fr)
FR2381030A1 (fr) Phenylaminomethyl-2 imidazolines et leur preparation
FR2381758A1 (fr) Nouvelles thiazoline-2-thiones
FR2442236A1 (fr)
FR2380281A1 (fr) Nouvelles imidazo(1,5-b)-pyridazines utiles comme medicaments

Legal Events

Date Code Title Description
ST Notification of lapse