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FR2386521A1 - Interphenylene 8-aza-9-dioxathia-11,12-secoprostaglandines utiles comme medicaments - Google Patents

Interphenylene 8-aza-9-dioxathia-11,12-secoprostaglandines utiles comme medicaments

Info

Publication number
FR2386521A1
FR2386521A1 FR7809266A FR7809266A FR2386521A1 FR 2386521 A1 FR2386521 A1 FR 2386521A1 FR 7809266 A FR7809266 A FR 7809266A FR 7809266 A FR7809266 A FR 7809266A FR 2386521 A1 FR2386521 A1 FR 2386521A1
Authority
FR
France
Prior art keywords
secoprostaglandins
interphenylene
aza
dioxathia
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7809266A
Other languages
English (en)
Other versions
FR2386521B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2386521A1 publication Critical patent/FR2386521A1/fr
Application granted granted Critical
Publication of FR2386521B1 publication Critical patent/FR2386521B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des interphénylène 8-aza-9-dioxothia-11,12-secoprostaglandines. On prépare des interphénylène 8-aza-9-dioxothia-11,12-secoprostaglandines par l'alcoylation en deux étapes de l'anion d'un (alcoyl inférieur)sulfonamide, R** 1SO2 NH2 , en utilisant d'abord un composé de la formule :
FR7809266A 1977-04-04 1978-03-30 Interphenylene 8-aza-9-dioxathia-11,12-secoprostaglandines utiles comme medicaments Granted FR2386521A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/783,998 US4112236A (en) 1977-04-04 1977-04-04 Interphenylene 8-aza-9-dioxothia-11,12-secoprostaglandins

Publications (2)

Publication Number Publication Date
FR2386521A1 true FR2386521A1 (fr) 1978-11-03
FR2386521B1 FR2386521B1 (fr) 1982-11-19

Family

ID=25131052

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7809266A Granted FR2386521A1 (fr) 1977-04-04 1978-03-30 Interphenylene 8-aza-9-dioxathia-11,12-secoprostaglandines utiles comme medicaments

Country Status (16)

Country Link
US (1) US4112236A (fr)
AR (1) AR225727A1 (fr)
AU (1) AU516540B2 (fr)
BE (1) BE865624A (fr)
DE (1) DE2814321A1 (fr)
DK (1) DK146578A (fr)
ES (1) ES468510A1 (fr)
FR (1) FR2386521A1 (fr)
GB (1) GB1576688A (fr)
IE (1) IE46699B1 (fr)
IT (1) IT1103475B (fr)
LU (1) LU79356A1 (fr)
NL (1) NL7802824A (fr)
PT (1) PT67847B (fr)
SE (1) SE7803606L (fr)
ZA (1) ZA781885B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2809377A1 (de) * 1978-03-04 1979-09-13 Boehringer Mannheim Gmbh Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3000377A1 (de) * 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3641099A1 (de) * 1986-12-02 1988-06-09 Hoechst Ag Verfahren zur herstellung von 4-(2'-chlorethyl)benzoesaeure
UA59384C2 (uk) 1996-12-20 2003-09-15 Пфайзер, Інк. Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі
HUP0001836A3 (en) 1996-12-20 2001-05-28 Pfizer Prevention and treatment of skeletal disorder with ep2 receptor subtype selective prostaglandin e2 agonists
UA67754C2 (uk) * 1997-10-10 2004-07-15 Пфайзер, Інк. Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти)
US6124314A (en) * 1997-10-10 2000-09-26 Pfizer Inc. Osteoporosis compounds
ES2263557T3 (es) 2000-01-31 2006-12-16 Pfizer Products Inc. Uso de agonistas selectivos del receptor 4(ep4) de prostablandinas (pge2) para el tratamiento de insuficiencia renal aguda y cronica.
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
US9029382B2 (en) 2012-12-17 2015-05-12 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
MX379300B (es) 2012-12-17 2025-03-11 Parion Sciences Inc Derivados de cloro-pirazin carboxamida con actividad bloqueadora sobre los canales de sodio epiteliales.
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2284320A1 (fr) * 1974-09-13 1976-04-09 Merck & Co Inc Secoprostaglandines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2284320A1 (fr) * 1974-09-13 1976-04-09 Merck & Co Inc Secoprostaglandines

Also Published As

Publication number Publication date
IE46699B1 (en) 1983-08-24
IT1103475B (it) 1985-10-14
IT7848626A0 (it) 1978-03-28
GB1576688A (en) 1980-10-15
AU3436678A (en) 1979-09-27
NL7802824A (nl) 1978-10-06
DE2814321A1 (de) 1978-10-05
AU516540B2 (en) 1981-06-11
AR225727A1 (es) 1982-04-30
ZA781885B (en) 1979-06-27
DK146578A (da) 1978-10-05
BE865624A (fr) 1978-10-03
FR2386521B1 (fr) 1982-11-19
ES468510A1 (es) 1979-09-16
PT67847A (en) 1978-04-01
LU79356A1 (fr) 1978-11-27
IE780632L (en) 1978-10-04
SE7803606L (sv) 1978-10-05
US4112236A (en) 1978-09-05
PT67847B (en) 1980-04-04

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Legal Events

Date Code Title Description
ST Notification of lapse