FR2365347A2 - Thymus factor polypeptide hormone which is recovered from blood - useful for treating auto-immune diseases and selective T-cell stimulation - Google Patents
Thymus factor polypeptide hormone which is recovered from blood - useful for treating auto-immune diseases and selective T-cell stimulationInfo
- Publication number
- FR2365347A2 FR2365347A2 FR7707624A FR7707624A FR2365347A2 FR 2365347 A2 FR2365347 A2 FR 2365347A2 FR 7707624 A FR7707624 A FR 7707624A FR 7707624 A FR7707624 A FR 7707624A FR 2365347 A2 FR2365347 A2 FR 2365347A2
- Authority
- FR
- France
- Prior art keywords
- factor polypeptide
- blood
- polypeptide hormone
- selective
- recovered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C07K7/062—Serum thymic factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Thymus factor polypeptide hormone (I) is a new cpd. (I) is a solid with (i) isoelectric point at pH 7.5 plus-or-minus 0.1; (ii) no affinity for active charcoal; (iii) mol. wt. 700-3000 as determined by molecular sieve and membrane filtrations; (iv) is bound to carboxymethylcellulose (CMC) at pH below 7; (v) is bound to diethylaminoethyl-cellulose at pH above 9; (vi) has rf value on cellulose plates of 0.32 (20:20:9 methanol/CHCl3/NH4OH); 0.8 (0.01N acetic acid and 1.0 (distilled water); (vii) contains no aromatic amino acids and (vii) on 'Sephadex' (RTM) G-25 elutes after 2.1 dead-space volumes with pH 7.3 0.2M phosphate buffer. (I) has the formula Pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn. and is prepd. from defibrinated blood by first dialysing through a polyacrylonitrile membrane, then dialysis and successive chromatography. (I) is used in treatment of autoimmune disorders, esp. lupus erythematosus, and also in geriatric medicine for selective stimulation of T-cell activity. It is administered by intravenous or intramuscular injection pref. at 10-4 to 10-2 mg./kg./day.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7707624A FR2365347A2 (en) | 1976-09-22 | 1977-03-15 | Thymus factor polypeptide hormone which is recovered from blood - useful for treating auto-immune diseases and selective T-cell stimulation |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/725,594 US4133804A (en) | 1974-03-25 | 1976-09-22 | Polypeptide possessing thymic activity |
| FR7707624A FR2365347A2 (en) | 1976-09-22 | 1977-03-15 | Thymus factor polypeptide hormone which is recovered from blood - useful for treating auto-immune diseases and selective T-cell stimulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2365347A2 true FR2365347A2 (en) | 1978-04-21 |
| FR2365347B2 FR2365347B2 (en) | 1982-01-15 |
Family
ID=26219910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7707624A Granted FR2365347A2 (en) | 1976-09-22 | 1977-03-15 | Thymus factor polypeptide hormone which is recovered from blood - useful for treating auto-immune diseases and selective T-cell stimulation |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2365347A2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2513125A1 (en) * | 1981-09-22 | 1983-03-25 | Mitsui Pharmaceuticals | CURING DRUG FOR IMMUNE DEFICIT |
-
1977
- 1977-03-15 FR FR7707624A patent/FR2365347A2/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2513125A1 (en) * | 1981-09-22 | 1983-03-25 | Mitsui Pharmaceuticals | CURING DRUG FOR IMMUNE DEFICIT |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2365347B2 (en) | 1982-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property |