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FR2338043A1 - Antidepressant 4-aryl-piperidines and salts - some having local anaesthetic and antiarrhythmic activity - Google Patents

Antidepressant 4-aryl-piperidines and salts - some having local anaesthetic and antiarrhythmic activity

Info

Publication number
FR2338043A1
FR2338043A1 FR7600727A FR7600727A FR2338043A1 FR 2338043 A1 FR2338043 A1 FR 2338043A1 FR 7600727 A FR7600727 A FR 7600727A FR 7600727 A FR7600727 A FR 7600727A FR 2338043 A1 FR2338043 A1 FR 2338043A1
Authority
FR
France
Prior art keywords
opt
substd
aryl
halo
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7600727A
Other languages
French (fr)
Other versions
FR2338043B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Delmar Chemicals Inc
Original Assignee
Delmar Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delmar Chemicals Inc filed Critical Delmar Chemicals Inc
Priority to FR7600727A priority Critical patent/FR2338043A1/en
Publication of FR2338043A1 publication Critical patent/FR2338043A1/en
Application granted granted Critical
Publication of FR2338043B1 publication Critical patent/FR2338043B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

4-Aryl-amino-hydroxypiperidines of formula (I) are new together with their acid-addn. salts (where R' is H,alkyl, alkenyl, alkynyl, aralkyl, acyl, 2-6C alkylamino opt. substd. by one or two alkyls or opt. substd. by alkylene to complete a satd. N-heterocycle; a gp. where R7 and R8 are H, phenyl opt. substd. by halo, or alkyl; or R7 + R8 and the attached N-atom form a 6 or 7-membered heterocyclic ring opt. contg. an O-atom; n is 1, 2, 3 or 4; a gp. -(CH2)n. CO2H; a gp. where X is H or halo; one of R2 and R3 is CN, free NH2 or a radical derived from it; the other is a free or protected OH; or R2 is where R3 is free or protected OH; or R2 + R3 and the attached C atoms form an oxazepin ring; Ar is aryl opt. substd. by one or more alkyl, alkoxy, halo or CF3). One subgp. has antidepressant activity, another gp. has local anaesthetic and antiarrhythmic activity. Other activities in the gp. include antihistamine, anticholinergic, spasmolytic, and diuretic activity.
FR7600727A 1976-01-13 1976-01-13 Antidepressant 4-aryl-piperidines and salts - some having local anaesthetic and antiarrhythmic activity Granted FR2338043A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7600727A FR2338043A1 (en) 1976-01-13 1976-01-13 Antidepressant 4-aryl-piperidines and salts - some having local anaesthetic and antiarrhythmic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7600727A FR2338043A1 (en) 1976-01-13 1976-01-13 Antidepressant 4-aryl-piperidines and salts - some having local anaesthetic and antiarrhythmic activity

Publications (2)

Publication Number Publication Date
FR2338043A1 true FR2338043A1 (en) 1977-08-12
FR2338043B1 FR2338043B1 (en) 1978-11-03

Family

ID=9167862

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7600727A Granted FR2338043A1 (en) 1976-01-13 1976-01-13 Antidepressant 4-aryl-piperidines and salts - some having local anaesthetic and antiarrhythmic activity

Country Status (1)

Country Link
FR (1) FR2338043A1 (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0965588A1 (en) * 1998-06-18 1999-12-22 Hoechst Marion Roussel Process for the preparation of 4-phenyl-1,2,3,6-tetrahydropyridine derivatives and intermediates used in this process
US7129228B2 (en) 1999-05-25 2006-10-31 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
US7361666B2 (en) * 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US10265310B2 (en) * 2016-09-21 2019-04-23 Grünenthal GmbH 6-membered cyclic amines or lactames substituted with urea and phenyl
US10562925B2 (en) 2015-05-18 2020-02-18 Tolero Pharmaceuticals, Inc. Alvocidib prodrugs having increased bioavailability
US10568887B2 (en) 2015-08-03 2020-02-25 Tolero Pharmaceuticals, Inc. Combination therapies for treatment of cancer
US10624880B2 (en) 2015-04-20 2020-04-21 Tolero Pharmaceuticals, Inc. Predicting response to alvocidib by mitochondrial profiling
US11034710B2 (en) 2018-12-04 2021-06-15 Sumitomo Dainippon Pharma Oncology, Inc. CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
US11279694B2 (en) 2016-11-18 2022-03-22 Sumitomo Dainippon Pharma Oncology, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
US11497756B2 (en) 2017-09-12 2022-11-15 Sumitomo Pharma Oncology, Inc. Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib
US11793802B2 (en) 2019-03-20 2023-10-24 Sumitomo Pharma Oncology, Inc. Treatment of acute myeloid leukemia (AML) with venetoclax failure

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0965588A1 (en) * 1998-06-18 1999-12-22 Hoechst Marion Roussel Process for the preparation of 4-phenyl-1,2,3,6-tetrahydropyridine derivatives and intermediates used in this process
FR2780056A1 (en) * 1998-06-18 1999-12-24 Hoechst Marion Roussel Inc NEW PROCESS FOR PREPARATION OF 4-PHENYL-1-2 3,6-TETRAHYDROPYRIDINE DERIVATIVES AND THE INTERMEDIATE PRODUCTS USED
US6136981A (en) * 1998-06-18 2000-10-24 Hoechst Marion Roussel Preparation of 4-phenyl-1,2,3,6-tetrahydropyridines
US7129228B2 (en) 1999-05-25 2006-10-31 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
US7361666B2 (en) * 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US10624880B2 (en) 2015-04-20 2020-04-21 Tolero Pharmaceuticals, Inc. Predicting response to alvocidib by mitochondrial profiling
US10562925B2 (en) 2015-05-18 2020-02-18 Tolero Pharmaceuticals, Inc. Alvocidib prodrugs having increased bioavailability
US12338261B2 (en) 2015-05-18 2025-06-24 Sumitomo Pharma Oncology, Inc. Alvocidib prodrugs having increased bioavailability
US10568887B2 (en) 2015-08-03 2020-02-25 Tolero Pharmaceuticals, Inc. Combination therapies for treatment of cancer
US10682356B2 (en) 2015-08-03 2020-06-16 Tolero Pharmaceuticals, Inc. Combination therapies for treatment of cancer
US10835537B2 (en) 2015-08-03 2020-11-17 Sumitomo Dainippon Pharma Oncology, Inc. Combination therapies for treatment of cancer
US10265310B2 (en) * 2016-09-21 2019-04-23 Grünenthal GmbH 6-membered cyclic amines or lactames substituted with urea and phenyl
US11279694B2 (en) 2016-11-18 2022-03-22 Sumitomo Dainippon Pharma Oncology, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
US11497756B2 (en) 2017-09-12 2022-11-15 Sumitomo Pharma Oncology, Inc. Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib
US11034710B2 (en) 2018-12-04 2021-06-15 Sumitomo Dainippon Pharma Oncology, Inc. CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
US11530231B2 (en) 2018-12-04 2022-12-20 Sumitomo Pharma Oncology, Inc. CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
US12077554B2 (en) 2018-12-04 2024-09-03 Sumitomo Pharma Oncology, Inc. CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
US11793802B2 (en) 2019-03-20 2023-10-24 Sumitomo Pharma Oncology, Inc. Treatment of acute myeloid leukemia (AML) with venetoclax failure

Also Published As

Publication number Publication date
FR2338043B1 (en) 1978-11-03

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