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FR2306690A1 - Analgesic indole (1)-acetic acids and esters - with (6)-methoxy, (2)-methyl and (3)-benzoyl substituents - Google Patents

Analgesic indole (1)-acetic acids and esters - with (6)-methoxy, (2)-methyl and (3)-benzoyl substituents

Info

Publication number
FR2306690A1
FR2306690A1 FR7511162A FR7511162A FR2306690A1 FR 2306690 A1 FR2306690 A1 FR 2306690A1 FR 7511162 A FR7511162 A FR 7511162A FR 7511162 A FR7511162 A FR 7511162A FR 2306690 A1 FR2306690 A1 FR 2306690A1
Authority
FR
France
Prior art keywords
indole
methoxy
methyl
analgesic
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7511162A
Other languages
French (fr)
Other versions
FR2306690B1 (en
Inventor
Philippe Michel Jacque Manoury
Jean Louis Christian Binet
Bogdan Iliesco-Branceni
Monique Prouteau
Henry Najer
Don Pierre Rene Luc Giudicelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7511162A priority Critical patent/FR2306690A1/en
Publication of FR2306690A1 publication Critical patent/FR2306690A1/en
Application granted granted Critical
Publication of FR2306690B1 publication Critical patent/FR2306690B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Indole-acetic acid derivs. of formula (I) are new together with their acid addn salts. (where R1 is CF3.S-; R2 is H or the gp. (I) are almost free of antiinflammatory activity. Used for human and veterinary medicine. A typical cpd. 2- 6-methoxy-2-methyl-3-(3-trifluoromethylthiobenzoyl)-1-indole acetic acid is prepd. by treating the analogue with unsubstd. N atom with an alkyl haloacetate and hydrolysing the ester.
FR7511162A 1975-04-10 1975-04-10 Analgesic indole (1)-acetic acids and esters - with (6)-methoxy, (2)-methyl and (3)-benzoyl substituents Granted FR2306690A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7511162A FR2306690A1 (en) 1975-04-10 1975-04-10 Analgesic indole (1)-acetic acids and esters - with (6)-methoxy, (2)-methyl and (3)-benzoyl substituents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7511162A FR2306690A1 (en) 1975-04-10 1975-04-10 Analgesic indole (1)-acetic acids and esters - with (6)-methoxy, (2)-methyl and (3)-benzoyl substituents

Publications (2)

Publication Number Publication Date
FR2306690A1 true FR2306690A1 (en) 1976-11-05
FR2306690B1 FR2306690B1 (en) 1979-08-10

Family

ID=9153726

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7511162A Granted FR2306690A1 (en) 1975-04-10 1975-04-10 Analgesic indole (1)-acetic acids and esters - with (6)-methoxy, (2)-methyl and (3)-benzoyl substituents

Country Status (1)

Country Link
FR (1) FR2306690A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1515721A4 (en) * 2002-06-14 2006-07-26 Merck & Co Inc Ophthalmic compositions for treating ocular hypertension
CN101691347A (en) * 2009-09-28 2010-04-07 唐保清 Preparation process of 4-(Trifluoromethylthio)benzoyl chloride

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1515721A4 (en) * 2002-06-14 2006-07-26 Merck & Co Inc Ophthalmic compositions for treating ocular hypertension
CN101691347A (en) * 2009-09-28 2010-04-07 唐保清 Preparation process of 4-(Trifluoromethylthio)benzoyl chloride

Also Published As

Publication number Publication date
FR2306690B1 (en) 1979-08-10

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Legal Events

Date Code Title Description
ST Notification of lapse