FR2302734A1 - Thienyl-benzimidazolylcarbamic acid esters against neoplasias - prepd. by reacting 3-methylisothiourea salt with chloroformic acid ester, then with diaminopheny-thienylketone (BE030976) - Google Patents
Thienyl-benzimidazolylcarbamic acid esters against neoplasias - prepd. by reacting 3-methylisothiourea salt with chloroformic acid ester, then with diaminopheny-thienylketone (BE030976)Info
- Publication number
- FR2302734A1 FR2302734A1 FR7604202A FR7604202A FR2302734A1 FR 2302734 A1 FR2302734 A1 FR 2302734A1 FR 7604202 A FR7604202 A FR 7604202A FR 7604202 A FR7604202 A FR 7604202A FR 2302734 A1 FR2302734 A1 FR 2302734A1
- Authority
- FR
- France
- Prior art keywords
- diaminopheny
- thienylketone
- methylisothiourea
- prepd
- thienyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 230000009826 neoplastic cell growth Effects 0.000 title abstract 3
- KQJQICVXLJTWQD-UHFFFAOYSA-N N-Methylthiourea Chemical class CNC(N)=S KQJQICVXLJTWQD-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- -1 chloroformic acid ester Chemical class 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 230000003211 malignant effect Effects 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000711 cancerogenic effect Effects 0.000 abstract 1
- 231100000315 carcinogenic Toxicity 0.000 abstract 1
- 230000001394 metastastic effect Effects 0.000 abstract 1
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 231100000590 oncogenic Toxicity 0.000 abstract 1
- 230000002246 oncogenic effect Effects 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Medicinal preparations for the treatment of malignant neoplasias, contain 5(6)-(2-thenoyl)-2-benzimidazolyl carbamic acid ester of formula (I): where R=opt. branched (1-5C)alkyl; including the acid-addition salts of (I). (I) are active against malignant neoplasias which include all types of cancer-ogenic or oncogenic processes, metastatic malignantly deformed cells, tissues and organs, independent of their histopathological type or stage.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55566275A | 1975-03-05 | 1975-03-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2302734A1 true FR2302734A1 (en) | 1976-10-01 |
Family
ID=24218138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7604202A Withdrawn FR2302734A1 (en) | 1975-03-05 | 1976-02-16 | Thienyl-benzimidazolylcarbamic acid esters against neoplasias - prepd. by reacting 3-methylisothiourea salt with chloroformic acid ester, then with diaminopheny-thienylketone (BE030976) |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS51110037A (en) |
| AU (1) | AU1172076A (en) |
| BE (1) | BE839119A (en) |
| DE (1) | DE2608796A1 (en) |
| FR (1) | FR2302734A1 (en) |
| IL (1) | IL49152A0 (en) |
| ZA (1) | ZA761301B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0091796A1 (en) * | 1982-04-08 | 1983-10-19 | Eli Lilly And Company | Process for removing 1-sulfonyl groups from benzimidazoles |
-
1976
- 1976-02-16 FR FR7604202A patent/FR2302734A1/en not_active Withdrawn
- 1976-03-03 JP JP51022289A patent/JPS51110037A/ja active Pending
- 1976-03-03 DE DE19762608796 patent/DE2608796A1/en active Pending
- 1976-03-03 BE BE164792A patent/BE839119A/en unknown
- 1976-03-04 IL IL49152A patent/IL49152A0/en unknown
- 1976-03-04 ZA ZA761301A patent/ZA761301B/en unknown
- 1976-03-05 AU AU11720/76A patent/AU1172076A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0091796A1 (en) * | 1982-04-08 | 1983-10-19 | Eli Lilly And Company | Process for removing 1-sulfonyl groups from benzimidazoles |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2608796A1 (en) | 1976-09-16 |
| JPS51110037A (en) | 1976-09-29 |
| BE839119A (en) | 1976-09-03 |
| AU1172076A (en) | 1977-09-08 |
| ZA761301B (en) | 1977-10-26 |
| IL49152A0 (en) | 1976-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |