FR2290431A1 - 2,4-bis-sulphanilamido-5-benzyl-pyrimidines - with antibacterial and anti-infective activity - Google Patents
2,4-bis-sulphanilamido-5-benzyl-pyrimidines - with antibacterial and anti-infective activityInfo
- Publication number
- FR2290431A1 FR2290431A1 FR7436773A FR7436773A FR2290431A1 FR 2290431 A1 FR2290431 A1 FR 2290431A1 FR 7436773 A FR7436773 A FR 7436773A FR 7436773 A FR7436773 A FR 7436773A FR 2290431 A1 FR2290431 A1 FR 2290431A1
- Authority
- FR
- France
- Prior art keywords
- antibacterial
- bis
- sulphanilamido
- pyrimidines
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- BGJJPRCDPABKIE-UHFFFAOYSA-N 4-amino-N-[2-[(4-aminophenyl)sulfonylamino]-5-benzylpyrimidin-4-yl]benzenesulfonamide Chemical class S(=O)(C1=CC=C(C=C1)N)(=O)NC1=NC=C(C(=N1)NS(=O)(C1=CC=C(C=C1)N)=O)CC1=CC=CC=C1 BGJJPRCDPABKIE-UHFFFAOYSA-N 0.000 title 1
- 230000002924 anti-infective effect Effects 0.000 title 1
- ZPZHLRXPDKLOKU-UHFFFAOYSA-N N-[2-[acetyl-(4-aminophenyl)sulfonylamino]-5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidin-4-yl]-N-(4-aminophenyl)sulfonylacetamide Chemical compound C(C)(=O)N(S(=O)(C1=CC=C(C=C1)N)=O)C1=NC=C(C(=N1)N(S(=O)(C1=CC=C(C=C1)N)=O)C(C)=O)CC1=CC(=C(C(=C1)OC)OC)OC ZPZHLRXPDKLOKU-UHFFFAOYSA-N 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229960005475 antiinfective agent Drugs 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- LDBTVAXGKYIFHO-UHFFFAOYSA-N diaveridine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=CN=C(N)N=C1N LDBTVAXGKYIFHO-UHFFFAOYSA-N 0.000 abstract 1
- 229950000246 diaveridine Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 abstract 1
- 229960001082 trimethoprim Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
are of formula (I): (where R is H or one to four alkyl, alkoxy, NO2 or halo; Y is H or acetyl). (I) have antibacterial and anti-infective agents with greater activity than the free 2,4-diamines, e.g. trimethoprim and diaveridine, and are specif. 2,4-bis-(N-acetylsulphanilamido)-5-(3,4,5-trimethoxybenzyl) pyrimidine.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7436773A FR2290431A1 (en) | 1974-11-06 | 1974-11-06 | 2,4-bis-sulphanilamido-5-benzyl-pyrimidines - with antibacterial and anti-infective activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7436773A FR2290431A1 (en) | 1974-11-06 | 1974-11-06 | 2,4-bis-sulphanilamido-5-benzyl-pyrimidines - with antibacterial and anti-infective activity |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2290431A1 true FR2290431A1 (en) | 1976-06-04 |
FR2290431B3 FR2290431B3 (en) | 1977-08-05 |
Family
ID=9144696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7436773A Granted FR2290431A1 (en) | 1974-11-06 | 1974-11-06 | 2,4-bis-sulphanilamido-5-benzyl-pyrimidines - with antibacterial and anti-infective activity |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2290431A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7393873B2 (en) * | 2003-07-02 | 2008-07-01 | Merck & Co., Inc. | Arylsulfonamide derivatives |
-
1974
- 1974-11-06 FR FR7436773A patent/FR2290431A1/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7393873B2 (en) * | 2003-07-02 | 2008-07-01 | Merck & Co., Inc. | Arylsulfonamide derivatives |
Also Published As
Publication number | Publication date |
---|---|
FR2290431B3 (en) | 1977-08-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |