FR2290219A1 - ACTIVE PRINCIPLE OF ANTIPYOCYANIC VACCINE - Google Patents
ACTIVE PRINCIPLE OF ANTIPYOCYANIC VACCINEInfo
- Publication number
- FR2290219A1 FR2290219A1 FR7436747A FR7436747A FR2290219A1 FR 2290219 A1 FR2290219 A1 FR 2290219A1 FR 7436747 A FR7436747 A FR 7436747A FR 7436747 A FR7436747 A FR 7436747A FR 2290219 A1 FR2290219 A1 FR 2290219A1
- Authority
- FR
- France
- Prior art keywords
- vaccine
- liq
- vaccines
- bacterium
- collecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960005486 vaccine Drugs 0.000 title abstract 4
- 241000894006 Bacteria Species 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 230000029142 excretion Effects 0.000 abstract 2
- 239000001963 growth medium Substances 0.000 abstract 2
- 239000012535 impurity Substances 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241000589516 Pseudomonas Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 231100001231 less toxic Toxicity 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000877 morphologic effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/104—Pseudomonadales, e.g. Pseudomonas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Process for recovering the active principle (A) of the vaccine or serum against Pseudomonas aeniginosa comprises (i) culturing, pref. in the absence of impurities in the culture medium, a vinilent strain of the bacterium of morphological type 1a; (ii) collecting the cells, removing any culture medium impurities if necessary; (iii) washing with a liq. of low ionic strength, such as distilled water, to remove the labile bacterial excretion products; (iv) suspending the washed cells in a liq. and heating the suspension to 37-80 degrees C at which temp. the medium has sufficient ionic strength to extract the components (peribaccilary substances) from the capsule surrounding the bacterium, then (v) removing solids and collecting the soln. of (A). Vaccines contg. (A) and antisera obtained from animals inoculated with (A) are also new. (A) are at least as active as previously prepared antigen extracts but since the bacterial excretion products, esp. extracellular enzymes, have been removed they are much less toxic. The vaccines/antisera can be used for prophylaxis/treatment of humans and animals.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7436747A FR2290219A1 (en) | 1974-11-05 | 1974-11-05 | ACTIVE PRINCIPLE OF ANTIPYOCYANIC VACCINE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7436747A FR2290219A1 (en) | 1974-11-05 | 1974-11-05 | ACTIVE PRINCIPLE OF ANTIPYOCYANIC VACCINE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2290219A1 true FR2290219A1 (en) | 1976-06-04 |
| FR2290219B1 FR2290219B1 (en) | 1978-12-29 |
Family
ID=9144684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7436747A Granted FR2290219A1 (en) | 1974-11-05 | 1974-11-05 | ACTIVE PRINCIPLE OF ANTIPYOCYANIC VACCINE |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2290219A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0120532A3 (en) * | 1983-03-23 | 1985-12-18 | Brigham And Women's Hospital | Mucoid exopolysaccharide vaccine against pseudomonas aeruginosa |
| US4702910A (en) * | 1984-05-25 | 1987-10-27 | Mitsui Toatsu Chemicals, Inc. | Common antigen (PSC-A) to Pseudomonas aeruginosa which acts as an agent for pretecting Pseudomonas aeruginosa infection |
| US5114712A (en) * | 1985-11-14 | 1992-05-19 | Mitsui Toatsu Chemicals, Inc. | Common antigen (PSC-A) to Pseudomonas aeruginosa which acts as an agent for protecting Pseudomonas aeruginosa infection |
-
1974
- 1974-11-05 FR FR7436747A patent/FR2290219A1/en active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0120532A3 (en) * | 1983-03-23 | 1985-12-18 | Brigham And Women's Hospital | Mucoid exopolysaccharide vaccine against pseudomonas aeruginosa |
| AU571495B2 (en) * | 1983-03-23 | 1988-04-21 | Brigham And Women's Hospital | Mucoid exopolysaccharide vaccine against pseudomonas aeruginosa |
| US4702910A (en) * | 1984-05-25 | 1987-10-27 | Mitsui Toatsu Chemicals, Inc. | Common antigen (PSC-A) to Pseudomonas aeruginosa which acts as an agent for pretecting Pseudomonas aeruginosa infection |
| US5114712A (en) * | 1985-11-14 | 1992-05-19 | Mitsui Toatsu Chemicals, Inc. | Common antigen (PSC-A) to Pseudomonas aeruginosa which acts as an agent for protecting Pseudomonas aeruginosa infection |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2290219B1 (en) | 1978-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |