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FR2261779A1 - Anti-rabies vaccine - obtd. from rabies virus grown on foetal calf kidney cells in a synthetic serum-free medium - Google Patents

Anti-rabies vaccine - obtd. from rabies virus grown on foetal calf kidney cells in a synthetic serum-free medium

Info

Publication number
FR2261779A1
FR2261779A1 FR7406445A FR7406445A FR2261779A1 FR 2261779 A1 FR2261779 A1 FR 2261779A1 FR 7406445 A FR7406445 A FR 7406445A FR 7406445 A FR7406445 A FR 7406445A FR 2261779 A1 FR2261779 A1 FR 2261779A1
Authority
FR
France
Prior art keywords
rabies
obtd
virus
cells
foetal calf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7406445A
Other languages
French (fr)
Other versions
FR2261779B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur
Original Assignee
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur filed Critical Institut Pasteur
Priority to FR7406445A priority Critical patent/FR2261779A1/en
Priority to OA55421A priority patent/OA04947A/en
Publication of FR2261779A1 publication Critical patent/FR2261779A1/en
Application granted granted Critical
Publication of FR2261779B1 publication Critical patent/FR2261779B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/205—Rhabdoviridae, e.g. rabies virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20111—Lyssavirus, e.g. rabies virus
    • C12N2760/20134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20111—Lyssavirus, e.g. rabies virus
    • C12N2760/20161—Methods of inactivation or attenuation
    • C12N2760/20164—Methods of inactivation or attenuation by serial passage

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Anti-rabies vaccine comprising inactivated rabies virus obtd. from a fixed, rabid strain of virus which is adapted to the primary transplantation cells of foetal calf kidney by serial passage in these cells, the adapted rabies virus being inoculated into the cells after suitable tissue culture and removal of medium, the incubation and virus culture being continued to give a viral suspension which is separated, inactivated and converted into the active vaccine, which is for use in man and animals, gives rise to no adverse side-effects e.g. encephalitis or local reactions. IT is a more economic process cf. earlier techniques using tissues, eg. brain. High antibody titses are produced giving a complete resistance to rabies. no serum proteins are present.
FR7406445A 1974-02-26 1974-02-26 Anti-rabies vaccine - obtd. from rabies virus grown on foetal calf kidney cells in a synthetic serum-free medium Granted FR2261779A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR7406445A FR2261779A1 (en) 1974-02-26 1974-02-26 Anti-rabies vaccine - obtd. from rabies virus grown on foetal calf kidney cells in a synthetic serum-free medium
OA55421A OA04947A (en) 1974-02-26 1975-02-20 Process for obtaining a new anti-rabies vaccine.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7406445A FR2261779A1 (en) 1974-02-26 1974-02-26 Anti-rabies vaccine - obtd. from rabies virus grown on foetal calf kidney cells in a synthetic serum-free medium

Publications (2)

Publication Number Publication Date
FR2261779A1 true FR2261779A1 (en) 1975-09-19
FR2261779B1 FR2261779B1 (en) 1977-11-04

Family

ID=9135447

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7406445A Granted FR2261779A1 (en) 1974-02-26 1974-02-26 Anti-rabies vaccine - obtd. from rabies virus grown on foetal calf kidney cells in a synthetic serum-free medium

Country Status (1)

Country Link
FR (1) FR2261779A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0210552A2 (en) * 1985-07-26 1987-02-04 BEHRINGWERKE Aktiengesellschaft Live rabies vaccine

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4429045A (en) 1980-07-30 1984-01-31 Norden Laboratories, Inc. Rabies virus adapted for growth in swine testicle cell culture
US4347239A (en) 1980-07-30 1982-08-31 Norden Laboratories, Inc. Inactivated rabies vaccine for veterinary use

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0210552A2 (en) * 1985-07-26 1987-02-04 BEHRINGWERKE Aktiengesellschaft Live rabies vaccine
EP0210552A3 (en) * 1985-07-26 1989-03-22 Behringwerke Aktiengesellschaft Live rabies vaccine

Also Published As

Publication number Publication date
FR2261779B1 (en) 1977-11-04

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Legal Events

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