[go: up one dir, main page]

FR2228779A1 - (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use - Google Patents

(4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use

Info

Publication number
FR2228779A1
FR2228779A1 FR7316634A FR7316634A FR2228779A1 FR 2228779 A1 FR2228779 A1 FR 2228779A1 FR 7316634 A FR7316634 A FR 7316634A FR 7316634 A FR7316634 A FR 7316634A FR 2228779 A1 FR2228779 A1 FR 2228779A1
Authority
FR
France
Prior art keywords
phenylpiperazino
human
halogen
alkyl esters
analgesic activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7316634A
Other languages
French (fr)
Other versions
FR2228779B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7316634A priority Critical patent/FR2228779A1/en
Priority to BE143707A priority patent/BE814287A/en
Priority to DE19742421537 priority patent/DE2421537C3/en
Priority to GB1987374A priority patent/GB1437868A/en
Priority to US05/467,595 priority patent/US3953449A/en
Priority to NL7406258A priority patent/NL7406258A/xx
Priority to ES426135A priority patent/ES426135A1/en
Application granted granted Critical
Publication of FR2228779B1 publication Critical patent/FR2228779B1/fr
Publication of FR2228779A1 publication Critical patent/FR2228779A1/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Cpds. of formula: and their acid-addition salts where n is 1,2,3 or 4; R1 is 1-10C alkyl; phenyl opt. subst. by 1-3 halogen, OH, acetoxy, 1-5C alkoxy, NH2, or: where R3 is H, halogen, CF3, -OCF3, -SCF3; the group where R is 1-5C alkyl; where Ar is phenyl, cyclohexyl, piperidiono, and R4 is H, OH; where m is 2 to 6; where R5 is H, halogen or -NH- where R6 is one or two opt. 1-3C alkyl, halogen, CF3, -OCF3, -SCF3; R7NH - where R7 is 1-6C alkyl, phenyl or naphthyl; or where R8 is H or Cl; R2 is H, halogen, 1-3C alkoxy, CF3, -OCF3, -SCF3; does of 50-2000 mg orally and up to 1000 mg parenterally are used.
FR7316634A 1973-05-09 1973-05-09 (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use Granted FR2228779A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR7316634A FR2228779A1 (en) 1973-05-09 1973-05-09 (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use
BE143707A BE814287A (en) 1973-05-09 1974-04-26 ARYL-PIPERAZINO ALCANOLS ESTERS
DE19742421537 DE2421537C3 (en) 1973-05-09 1974-05-03 2- (4-Phenyl-plperazJno) -ethyl-ester, a process for their preparation and pharmaceutical preparations
GB1987374A GB1437868A (en) 1973-05-09 1974-05-06 Arylpiperazinoalkyl esters
US05/467,595 US3953449A (en) 1973-05-09 1974-05-06 2-(4-M-CF3 or -SCF3 phenylpiperazino)-ethyl benzoates
NL7406258A NL7406258A (en) 1973-05-09 1974-05-09
ES426135A ES426135A1 (en) 1973-05-09 1974-05-09 2-(4-M-CF{HD 3 {B or -SCF{HD 3 {B phenylpiperazino)-ethyl benzoates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7316634A FR2228779A1 (en) 1973-05-09 1973-05-09 (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use

Publications (2)

Publication Number Publication Date
FR2228779B1 FR2228779B1 (en) 1975-08-22
FR2228779A1 true FR2228779A1 (en) 1975-08-22

Family

ID=9119011

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7316634A Granted FR2228779A1 (en) 1973-05-09 1973-05-09 (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use

Country Status (2)

Country Link
BE (1) BE814287A (en)
FR (1) FR2228779A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives

Also Published As

Publication number Publication date
FR2228779B1 (en) 1975-08-22
BE814287A (en) 1974-10-28

Similar Documents

Publication Publication Date Title
SE7508789L (en) PROCEDURE FOR THE PREPARATION OF NEW 5,9-BETA-DISUBSTITUTED 2-TETRAHYDROFURFURYL-6,7-BENZOMORPHANES, THEIR ACID ADDITIONAL SALTS AND USE AS MEDICINES
FR2258840A1 (en) (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use
FR2228779A1 (en) (4-Phenylpiperazino) alkyl esters - with analgesic activity for human and veterinary use
FR2024548A1 (en) Ortho-substd phenethylamines and medicaments
FR2047882A1 (en) Analgesic antiinflammatory 4-(2-alkoxy - phenylamino-quinolines and intermediates
IE38361L (en) Fish feed
ES405479A1 (en) Benzodiazepin-2-ones
FR2244514A1 (en) 1,2-Dihydroquinoline derivs - useful as anti-inflammatories
FR2194436A1 (en) 3-formyloxindoles prepn - useful as medicaments for treating fatty degener-ation
ES8400384A1 (en) Carbacyclines, process for their preparation and their use as medicines.
ES405946A1 (en) PROCEDURE FOR THE PREPARATION OF NEW AMIDES OF ACIDO4- (4-BIPHENYLIL) -BUTYRICO.
ES424346A1 (en) 5-Oxo-2,3-dihydro-imidazo(1,2-a)-s-triazines
FR2193822A1 (en) Trifluoromethoxy quinoline derivs - useful as inters in org. syntheses
FR2226163A2 (en) 2-Amino-5-methyl-4-phenyl-1-pyrrolines - with antidepressant and antiarrhythmic activity
ES413056A1 (en) PROCEDURE FOR THE PREPARATION OF NEW AMIDES OF ACID4- (4-BIPHENYLIL) -4-HYDROXY-BUTYRICO.
FR2232305A1 (en) 3-(4-Biphenylyl)-propionic acids - prepd. by hydrogenation of corresp. unsatd. cpd
FR2240009A1 (en) 3-(5-Nitro-2-imidazolyl)pyrazoles - antibacterials antifungals and antiprotozoals useful in veterinary medicine
FR2196813A1 (en) Substd hydroxy guanidines - as anti depressants
FR2265369A1 (en) Opt substd benzo isoindolines - as antiaggressive and analgesic agents of low toxicity
FR2128168A2 (en) Pyrazine carboxamido ethyl benzene sulphonyl ureas - - hypoglycemiants
FR2226173A1 (en) 1-Amino-3-(cyclopropa (b) napthoxy)-2-propanols - as anti-arrhythmics, prepd. by aminating corresp. epoxides
FR2135978A5 (en) Pyrazoloquinoxalines - useful as fluorescent dyes
GB1081634A (en) Novel benzdiaz[1,4]epine derivatives and a process for the manufacture and conversion thereof
FR2251267A1 (en) Herbicidal compsns. - contg. 3-cyclo hexyl-5,6-trimethylene -uracil and 3-carbamoyloxy-acylanilines
FR2134121A1 (en) Piperazino ethyl phloroglucates prepn - useful as vasodilators

Legal Events

Date Code Title Description
ST Notification of lapse