FR2217010A1 - Phosphate fixing agents - comprising an ion-exchange hydrogel based on aluminium co-gelled with a hydrating agent, for treatment of hyperphosphataemia - Google Patents
Phosphate fixing agents - comprising an ion-exchange hydrogel based on aluminium co-gelled with a hydrating agent, for treatment of hyperphosphataemiaInfo
- Publication number
- FR2217010A1 FR2217010A1 FR7404157A FR7404157A FR2217010A1 FR 2217010 A1 FR2217010 A1 FR 2217010A1 FR 7404157 A FR7404157 A FR 7404157A FR 7404157 A FR7404157 A FR 7404157A FR 2217010 A1 FR2217010 A1 FR 2217010A1
- Authority
- FR
- France
- Prior art keywords
- hydrating agent
- gelled
- hyperphosphataemia
- aluminium
- ion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003795 chemical substances by application Substances 0.000 title abstract 6
- 230000000887 hydrating effect Effects 0.000 title abstract 5
- 239000000017 hydrogel Substances 0.000 title abstract 2
- 229910019142 PO4 Inorganic materials 0.000 title 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 title 1
- 229910052782 aluminium Inorganic materials 0.000 title 1
- 239000004411 aluminium Substances 0.000 title 1
- 201000005991 hyperphosphatemia Diseases 0.000 title 1
- 238000005342 ion exchange Methods 0.000 title 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title 1
- 239000010452 phosphate Substances 0.000 title 1
- JLDSOYXADOWAKB-UHFFFAOYSA-N aluminium nitrate Chemical compound [Al+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O JLDSOYXADOWAKB-UHFFFAOYSA-N 0.000 abstract 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 abstract 2
- 239000000499 gel Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 229920000084 Gum arabic Polymers 0.000 abstract 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 1
- 241000978776 Senegalia senegal Species 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 235000010489 acacia gum Nutrition 0.000 abstract 1
- 239000000205 acacia gum Substances 0.000 abstract 1
- 229910000329 aluminium sulfate Inorganic materials 0.000 abstract 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 abstract 1
- 235000011128 aluminium sulphate Nutrition 0.000 abstract 1
- -1 cmc Polymers 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 229910001388 sodium aluminate Inorganic materials 0.000 abstract 1
- 239000008279 sol Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
- C01F7/00—Compounds of aluminium
- C01F7/02—Aluminium oxide; Aluminium hydroxide; Aluminates
- C01F7/34—Preparation of aluminium hydroxide by precipitation from solutions containing aluminium salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/06—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04
- B01J20/08—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04 comprising aluminium oxide or hydroxide; comprising bauxite
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Inorganic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Geology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Colloid Chemistry (AREA)
Abstract
The hydrating agent is pref. a hydrophilic polymer, esp a high mol. wt polymer e.g. cmc, gum arabic, gelatin, sol. starch or an ethylene-maleic anhydride copolymer. The co-gel pref. contains 1-80 wt.% of the hydrating agent. The Al salt may be (in)org. e.g. AlCl3, NaAlO2, Al2(SO4)3, Al(NO3)3, Al lactate or Al tartrate. The co-gels are prepd by neutralising the Al salt, pref. at pH 3.5-8.0 (esp. 4.0-7.0) to give a hydrogel which is co-gelled with the hydrating agent. Alternatively the hydrating agent may be added before neutralisation.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33115173A | 1973-02-09 | 1973-02-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2217010A1 true FR2217010A1 (en) | 1974-09-06 |
| FR2217010B1 FR2217010B1 (en) | 1976-12-03 |
Family
ID=23292823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7404157A Granted FR2217010A1 (en) | 1973-02-09 | 1974-02-07 | Phosphate fixing agents - comprising an ion-exchange hydrogel based on aluminium co-gelled with a hydrating agent, for treatment of hyperphosphataemia |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS5821606B2 (en) |
| BE (1) | BE810731A (en) |
| CA (1) | CA1034043A (en) |
| CH (1) | CH604722A5 (en) |
| DD (1) | DD112636A5 (en) |
| DE (1) | DE2406120A1 (en) |
| DK (1) | DK136015B (en) |
| ES (1) | ES422997A1 (en) |
| FR (1) | FR2217010A1 (en) |
| IT (1) | IT1043870B (en) |
| NL (1) | NL7401543A (en) |
| SE (1) | SE414577B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1133989A3 (en) * | 1993-08-11 | 2004-05-12 | Genzyme Corporation | Polymer compositions for use in therapy |
| US7014846B2 (en) | 1993-08-11 | 2006-03-21 | Genzyme Corporation | Phosphate-binding polymers for oral administration |
| US8187631B2 (en) | 1999-10-19 | 2012-05-29 | Genzyme Corporation | Direct compression polymer tablet core |
| US9095509B2 (en) | 2005-09-15 | 2015-08-04 | Genzyme Corporation | Sachet formulation for amine polymers |
| US9895315B2 (en) | 2004-11-01 | 2018-02-20 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| US11267924B2 (en) | 2014-12-18 | 2022-03-08 | Genzyme Corporation | Crosslinked polydiallymine copolymers for the treatment of type 2 diabetes |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2510663C3 (en) * | 1975-03-12 | 1981-08-06 | Dr. Madaus & Co, 5000 Köln | Aluminum polyhydroxisulphate, process for its production and medicament containing it |
| JPS5528961A (en) * | 1978-08-22 | 1980-02-29 | Rorer Inc William H | Method of decreasing drug viscosity |
| WO1996021454A1 (en) * | 1995-01-12 | 1996-07-18 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
| EP1951266A2 (en) | 2005-09-02 | 2008-08-06 | Genzyme Corporation | Method for removing phosphate and polymer used therefore |
-
1974
- 1974-01-31 DK DK52074AA patent/DK136015B/en not_active IP Right Cessation
- 1974-01-31 CH CH132774A patent/CH604722A5/xx not_active IP Right Cessation
- 1974-02-01 SE SE7401364A patent/SE414577B/en unknown
- 1974-02-05 NL NL7401543A patent/NL7401543A/xx not_active Application Discontinuation
- 1974-02-07 DD DD176452A patent/DD112636A5/xx unknown
- 1974-02-07 ES ES422997A patent/ES422997A1/en not_active Expired
- 1974-02-07 FR FR7404157A patent/FR2217010A1/en active Granted
- 1974-02-07 BE BE140655A patent/BE810731A/en not_active IP Right Cessation
- 1974-02-08 IT IT20322/74A patent/IT1043870B/en active
- 1974-02-08 DE DE19742406120 patent/DE2406120A1/en not_active Ceased
- 1974-02-08 CA CA192,101A patent/CA1034043A/en not_active Expired
- 1974-02-08 JP JP49015526A patent/JPS5821606B2/en not_active Expired
Non-Patent Citations (1)
| Title |
|---|
| NEANT * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1133989A3 (en) * | 1993-08-11 | 2004-05-12 | Genzyme Corporation | Polymer compositions for use in therapy |
| US7014846B2 (en) | 1993-08-11 | 2006-03-21 | Genzyme Corporation | Phosphate-binding polymers for oral administration |
| US7459151B2 (en) | 1993-08-11 | 2008-12-02 | Genzyme Corporation | Phosphate-binding polymers for oral administration |
| US8187631B2 (en) | 1999-10-19 | 2012-05-29 | Genzyme Corporation | Direct compression polymer tablet core |
| US9931358B2 (en) | 1999-10-19 | 2018-04-03 | Genzyme Corporation | Direct compression polymer tablet core |
| US9895315B2 (en) | 2004-11-01 | 2018-02-20 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
| US9095509B2 (en) | 2005-09-15 | 2015-08-04 | Genzyme Corporation | Sachet formulation for amine polymers |
| US11267924B2 (en) | 2014-12-18 | 2022-03-08 | Genzyme Corporation | Crosslinked polydiallymine copolymers for the treatment of type 2 diabetes |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7401543A (en) | 1974-08-13 |
| IT1043870B (en) | 1980-02-29 |
| CA1034043A (en) | 1978-07-04 |
| ES422997A1 (en) | 1976-11-16 |
| DK136015B (en) | 1977-08-01 |
| DK136015C (en) | 1978-02-06 |
| SE414577B (en) | 1980-08-11 |
| CH604722A5 (en) | 1978-09-15 |
| JPS49109515A (en) | 1974-10-18 |
| DD112636A5 (en) | 1975-04-20 |
| BE810731A (en) | 1974-05-29 |
| JPS5821606B2 (en) | 1983-05-02 |
| FR2217010B1 (en) | 1976-12-03 |
| DE2406120A1 (en) | 1974-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |