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FR2164520A2 - 2-(n-heterocyclic amino)thiazolin-4-ones - with respiratory analeptic activity - Google Patents

2-(n-heterocyclic amino)thiazolin-4-ones - with respiratory analeptic activity

Info

Publication number
FR2164520A2
FR2164520A2 FR7146616A FR7146616A FR2164520A2 FR 2164520 A2 FR2164520 A2 FR 2164520A2 FR 7146616 A FR7146616 A FR 7146616A FR 7146616 A FR7146616 A FR 7146616A FR 2164520 A2 FR2164520 A2 FR 2164520A2
Authority
FR
France
Prior art keywords
alkyl
thiazolin
ones
heterocyclic amino
respiratory analeptic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7146616A
Other languages
French (fr)
Other versions
FR2164520B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ARON SAMUEL JAN
Original Assignee
ARON SAMUEL JAN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR87395A priority Critical patent/FR6278M/fr
Application filed by ARON SAMUEL JAN filed Critical ARON SAMUEL JAN
Priority to FR7146616A priority patent/FR2164520A2/en
Publication of FR2164520A2 publication Critical patent/FR2164520A2/en
Application granted granted Critical
Publication of FR2164520B2 publication Critical patent/FR2164520B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Therapeutic compsns. contg. as active component a cpd. of formula: where R1 is phenyl opt. substd. by >=1 halogen, alkyl, alkoxy; R2 is H, alkyl; A is pyrrolidino, piperidino, piperazino, homopiperazino, morpholino; R3 is alkyl, alkenyl, hydroxyalkyl; phenyl opt. substd. by >=1 halogen, alkyl, alkoxy; benzyl; also their acid-addn. salts. The cpds., originally described in the parent patent as antiinflammatory and analgesic agents, have been found to have respiratory analeptic activity.
FR7146616A 1966-12-14 1971-12-24 2-(n-heterocyclic amino)thiazolin-4-ones - with respiratory analeptic activity Granted FR2164520A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR87395A FR6278M (en) 1966-12-14 1966-12-14
FR7146616A FR2164520A2 (en) 1966-12-14 1971-12-24 2-(n-heterocyclic amino)thiazolin-4-ones - with respiratory analeptic activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR87395A FR6278M (en) 1966-12-14 1966-12-14
FR7146616A FR2164520A2 (en) 1966-12-14 1971-12-24 2-(n-heterocyclic amino)thiazolin-4-ones - with respiratory analeptic activity

Publications (2)

Publication Number Publication Date
FR2164520A2 true FR2164520A2 (en) 1973-08-03
FR2164520B2 FR2164520B2 (en) 1975-02-07

Family

ID=26174355

Family Applications (2)

Application Number Title Priority Date Filing Date
FR87395A Expired FR6278M (en) 1966-12-14 1966-12-14
FR7146616A Granted FR2164520A2 (en) 1966-12-14 1971-12-24 2-(n-heterocyclic amino)thiazolin-4-ones - with respiratory analeptic activity

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR87395A Expired FR6278M (en) 1966-12-14 1966-12-14

Country Status (1)

Country Link
FR (2) FR6278M (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008500353A (en) * 2004-05-24 2008-01-10 アムゲン インコーポレイティッド Inhibitors of type 1 11-beta-hydroxysteroid dehydrogenase
US8686011B2 (en) 2004-05-24 2014-04-01 Amgen Inc. Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008500353A (en) * 2004-05-24 2008-01-10 アムゲン インコーポレイティッド Inhibitors of type 1 11-beta-hydroxysteroid dehydrogenase
US7807700B2 (en) 2004-05-24 2010-10-05 Amgen Inc. Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
JP4789934B2 (en) * 2004-05-24 2011-10-12 アムジエン・インコーポレーテツド Inhibitors of type 1 11-beta-hydroxysteroid dehydrogenase
US8686011B2 (en) 2004-05-24 2014-04-01 Amgen Inc. Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1

Also Published As

Publication number Publication date
FR6278M (en) 1968-09-02
FR2164520B2 (en) 1975-02-07

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