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FR2134218A1 - Phloroglucinol aminoketones - vasodilators and antispasmodics - Google Patents

Phloroglucinol aminoketones - vasodilators and antispasmodics

Info

Publication number
FR2134218A1
FR2134218A1 FR7115024A FR7115024A FR2134218A1 FR 2134218 A1 FR2134218 A1 FR 2134218A1 FR 7115024 A FR7115024 A FR 7115024A FR 7115024 A FR7115024 A FR 7115024A FR 2134218 A1 FR2134218 A1 FR 2134218A1
Authority
FR
France
Prior art keywords
phloroglucinol
alkyl
aminoketones
antispasmodics
vasodilators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7115024A
Other languages
French (fr)
Other versions
FR2134218B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PENCIOLELLI MADELEINE FR
Original Assignee
PENCIOLELLI MADELEINE FR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PENCIOLELLI MADELEINE FR filed Critical PENCIOLELLI MADELEINE FR
Priority to FR7115024A priority Critical patent/FR2134218A1/en
Publication of FR2134218A1 publication Critical patent/FR2134218A1/en
Application granted granted Critical
Publication of FR2134218B1 publication Critical patent/FR2134218B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cpds. are of formula (I): where R1, R2, R3 = H or alkyl, pref. 1-5C; R4, R5 = H, alkyl (pref. 1-5C) or, together with the N atom, form a 5-7 membered heterocycle which may contain further heteroatoms (O, N or S) and may be substd. by alkyl, aryl, amino, aminoalkyl, OH, hydroxyalkyl, anilide or N-substd. amidoalkyl; n = 1-4). The cpds. may be prepd. by a Houben-Hoesch reaction of the appropriate phloroglucinol deriv. with an aminoalkyl nitrile followed by hydrolysis of the ketimine formed.
FR7115024A 1971-04-27 1971-04-27 Phloroglucinol aminoketones - vasodilators and antispasmodics Granted FR2134218A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7115024A FR2134218A1 (en) 1971-04-27 1971-04-27 Phloroglucinol aminoketones - vasodilators and antispasmodics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7115024A FR2134218A1 (en) 1971-04-27 1971-04-27 Phloroglucinol aminoketones - vasodilators and antispasmodics

Publications (2)

Publication Number Publication Date
FR2134218A1 true FR2134218A1 (en) 1972-12-08
FR2134218B1 FR2134218B1 (en) 1974-08-30

Family

ID=9076017

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7115024A Granted FR2134218A1 (en) 1971-04-27 1971-04-27 Phloroglucinol aminoketones - vasodilators and antispasmodics

Country Status (1)

Country Link
FR (1) FR2134218A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2404003A1 (en) * 1977-09-26 1979-04-20 Lafon Labor NEW DERIVATIVES OF PHLOROGLUCINOL, THEIR PROCESS FOR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
EP0063075A1 (en) * 1981-04-15 1982-10-20 LABORATOIRE L. LAFON Société anonyme dite: (2,6-Dimethoxy-4-hydroxyphenyl)-(3-piperidinopropyl) ketone and its salts, its use in therapeutic preparations and process for its production
FR2534916A1 (en) * 1982-10-26 1984-04-27 Lafon Labor NOVEL PHENYL- (3-AMINOPROPYL) -CETONE DERIVATIVES, THERAPEUTIC USE AND PREPARATION METHOD
EP0183002A1 (en) * 1984-10-26 1986-06-04 Laboratorio Italiano Biochimico Farmaceutico Lisapharma S.P.A. Pharmaceutically active salt derivative of 3-hydroxy -5-(hydroxymethyl)-2-methylisonicotinaldehyde phosphate
EP0490769A1 (en) * 1990-12-12 1992-06-17 Laboratoire L. Lafon Aminoalkylketone derivatives, process for their preparation and their therapeutical use
US5280020A (en) * 1988-11-16 1994-01-18 Sergio Bertini Curri Drug and method for increasing the microcirculatory flow-rate and volume in the capillaries to the skin
WO2006137335A1 (en) * 2005-06-20 2006-12-28 Otsuka Pharmaceutical Co., Ltd. Process for producing piperazine derivative

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2404003A1 (en) * 1977-09-26 1979-04-20 Lafon Labor NEW DERIVATIVES OF PHLOROGLUCINOL, THEIR PROCESS FOR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
JPS5495562A (en) * 1977-09-26 1979-07-28 Lafon Labor Novel phloroglucine derivative*its manufacture and use as medicine
EP0063075A1 (en) * 1981-04-15 1982-10-20 LABORATOIRE L. LAFON Société anonyme dite: (2,6-Dimethoxy-4-hydroxyphenyl)-(3-piperidinopropyl) ketone and its salts, its use in therapeutic preparations and process for its production
FR2504136A1 (en) * 1981-04-15 1982-10-22 Lafon Labor (2,6-DIMETHOXY-4-HYDROXYPHENYL) - (3-PIPERIDINOPROPYL) -CETONE AND ITS ADDITION SALTS, THERAPEUTIC USE AND PREPARATION METHOD
FR2534916A1 (en) * 1982-10-26 1984-04-27 Lafon Labor NOVEL PHENYL- (3-AMINOPROPYL) -CETONE DERIVATIVES, THERAPEUTIC USE AND PREPARATION METHOD
EP0110748A1 (en) * 1982-10-26 1984-06-13 LABORATOIRE L. LAFON Société anonyme dite: Derivatives of phenyl-(3-aminopropyl) ketone, their therapeutical use and process for their preparation
EP0183002A1 (en) * 1984-10-26 1986-06-04 Laboratorio Italiano Biochimico Farmaceutico Lisapharma S.P.A. Pharmaceutically active salt derivative of 3-hydroxy -5-(hydroxymethyl)-2-methylisonicotinaldehyde phosphate
US5280020A (en) * 1988-11-16 1994-01-18 Sergio Bertini Curri Drug and method for increasing the microcirculatory flow-rate and volume in the capillaries to the skin
EP0490769A1 (en) * 1990-12-12 1992-06-17 Laboratoire L. Lafon Aminoalkylketone derivatives, process for their preparation and their therapeutical use
FR2670492A1 (en) * 1990-12-12 1992-06-19 Lafon Labor NOVEL AMINOALKYLCETONE DERIVATIVES, PROCESS FOR PREPARING THEM AND THERAPEUTIC USES THEREOF.
US5446060A (en) * 1990-12-12 1995-08-29 Laboratoire L. Lafon Aminoalkyl thienyl ketone derivatives and their use as peripheral vasodilators
WO2006137335A1 (en) * 2005-06-20 2006-12-28 Otsuka Pharmaceutical Co., Ltd. Process for producing piperazine derivative

Also Published As

Publication number Publication date
FR2134218B1 (en) 1974-08-30

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Legal Events

Date Code Title Description
TP Transmission of property
TP Transmission of property
CC Supplementary certificate of protection laid open to the public (law of 25 june 1990)

Free format text: 92C0025, 920219

CB Supplementary certificate of protection granted (law of 25 june 1990)

Free format text: 92C0025, 710427

CP Supplementary certificate of protection filed