FR2022200A1 - Retikinonase enzyme with anti-inflammatory - activity - Google Patents
Retikinonase enzyme with anti-inflammatory - activityInfo
- Publication number
- FR2022200A1 FR2022200A1 FR6932489A FR6932489A FR2022200A1 FR 2022200 A1 FR2022200 A1 FR 2022200A1 FR 6932489 A FR6932489 A FR 6932489A FR 6932489 A FR6932489 A FR 6932489A FR 2022200 A1 FR2022200 A1 FR 2022200A1
- Authority
- FR
- France
- Prior art keywords
- enzyme
- retikinonase
- activity
- inflammatory
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 3
- 108090000790 Enzymes Proteins 0.000 title abstract 3
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 101800004538 Bradykinin Proteins 0.000 abstract 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
- 102100035792 Kininogen-1 Human genes 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 229940079919 digestives enzyme preparation Drugs 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 230000000415 inactivating effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002797 proteolythic effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Retikinonase 1, a new protein enzyme with proteolytic activity, capable of inactivating bradykinin, is prepared by culturing a Streptomyces strain using methods similar to those used for antibiotic or enzyme preparations, and extracting the enzyme from the cultured medium followed by purification.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6946768 | 1968-09-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2022200A1 true FR2022200A1 (en) | 1970-07-31 |
Family
ID=13403478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR6932489A Withdrawn FR2022200A1 (en) | 1968-09-27 | 1969-09-24 | Retikinonase enzyme with anti-inflammatory - activity |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE1948710A1 (en) |
| FR (1) | FR2022200A1 (en) |
-
1969
- 1969-09-24 FR FR6932489A patent/FR2022200A1/en not_active Withdrawn
- 1969-09-26 DE DE19691948710 patent/DE1948710A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE1948710A1 (en) | 1970-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |