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FI974640A - 1,6-Disubstituted isochromanes for the treatment of migraine - Google Patents

1,6-Disubstituted isochromanes for the treatment of migraine Download PDF

Info

Publication number
FI974640A
FI974640A FI974640A FI974640A FI974640A FI 974640 A FI974640 A FI 974640A FI 974640 A FI974640 A FI 974640A FI 974640 A FI974640 A FI 974640A FI 974640 A FI974640 A FI 974640A
Authority
FI
Finland
Prior art keywords
isochromanes
migraine
disubstituted
treatment
disubstituted isochromanes
Prior art date
Application number
FI974640A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI974640A0 (en
Inventor
Michael D Ennis
Ruth E Tenbrink
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FI974640A publication Critical patent/FI974640A/en
Publication of FI974640A0 publication Critical patent/FI974640A0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76Benzo[c]pyrans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI974640A 1995-06-30 1997-12-30 1,6-Disubstituted isochromanes for the treatment of migraine FI974640A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74195P 1995-06-30 1995-06-30
US1123496P 1996-02-06 1996-02-06
PCT/US1996/008681 WO1997002259A1 (en) 1995-06-30 1996-06-07 1,6-disubstituted isochromans for treatment of migraine headaches

Publications (2)

Publication Number Publication Date
FI974640A true FI974640A (en) 1997-12-30
FI974640A0 FI974640A0 (en) 1997-12-30

Family

ID=26668092

Family Applications (1)

Application Number Title Priority Date Filing Date
FI974640A FI974640A0 (en) 1995-06-30 1997-12-30 1,6-Disubstituted isochromanes for the treatment of migraine

Country Status (12)

Country Link
EP (1) EP0836599A1 (en)
JP (1) JPH11509532A (en)
AU (1) AU6252296A (en)
BR (1) BR9609631A (en)
CA (1) CA2225282A1 (en)
CZ (1) CZ418597A3 (en)
FI (1) FI974640A0 (en)
MX (1) MX9710260A (en)
NO (1) NO976112L (en)
PL (1) PL324319A1 (en)
SK (1) SK164297A3 (en)
WO (1) WO1997002259A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2370270A (en) * 2000-12-20 2002-06-26 Lilly Co Eli Pharmaceutical compounds
GB0130339D0 (en) * 2001-12-19 2002-02-06 Lilly Co Eli Isochroman compounds
US7335660B2 (en) 2001-12-19 2008-02-26 Eli Lilly And Company Isochroman compounds for treatment of CNS disorders
US7110576B2 (en) 2002-12-30 2006-09-19 Pitney Bowes Inc. System and method for authenticating a mailpiece sender
RU2372344C2 (en) 2004-05-05 2009-11-10 Ф. Хоффманн-Ля Рош Аг Arylsulphonyl benzodioxanes used for modulating 5-ht6 receptor, 5-ht2a receptor or both
ATE396183T1 (en) 2004-12-21 2008-06-15 Hoffmann La Roche CHROMEAND DERIVATIVES AND THEIR USE AS LIGANDS OF THE 5-HT RECEPTOR
ATE409179T1 (en) 2004-12-21 2008-10-15 Hoffmann La Roche TETRALIN AND INDANDE DERIVATIVES AND THEIR APPLICATIONS AS 5-HT ANTAGONISTS
MX2007007485A (en) 2004-12-21 2007-07-20 Hoffmann La Roche Chroman derivatives and uses thereof in the treatment of cns disorders.
JP2008524274A (en) 2004-12-21 2008-07-10 エフ.ホフマン−ラ ロシュ アーゲー Tetralin and indane derivatives and their use
MX2007007558A (en) 2004-12-21 2007-07-24 Hoffmann La Roche Tetralin and indane derivatives and uses thereof.
RU2008115032A (en) 2005-11-03 2009-12-10 Ф. Хоффманн-Ля Рош Аг (Ch) ARILSULFONILCHROMANES AS 5-NT6 INHIBITORS
JP2009541248A (en) 2006-06-20 2009-11-26 エフ.ホフマン−ラ ロシュ アーゲー Arylsulfonamidyltetralin derivatives and their use
WO2007147763A1 (en) 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Arylsulfonyl naphthalene derivatives and uses thereof
EP2035370A2 (en) 2006-06-20 2009-03-18 F. Hoffmann-Roche AG Tetralin and indane derivatives and uses thereof
KR20110125258A (en) * 2009-03-05 2011-11-18 스미또모 가가꾸 가부시끼가이샤 Process for producing halogen substituted benzenedimethanol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552004A (en) * 1976-05-26 1979-09-05 Takeda Chemical Industries Ltd Isochroman derivatives
US5877317A (en) * 1993-12-28 1999-03-02 Pharmacia & Upjohn Company Heterocyclic compounds for the treatment of CNS and cardiovascular disorders

Also Published As

Publication number Publication date
PL324319A1 (en) 1998-05-25
CZ418597A3 (en) 1998-06-17
EP0836599A1 (en) 1998-04-22
SK164297A3 (en) 1998-09-09
BR9609631A (en) 1999-03-02
CA2225282A1 (en) 1997-01-23
WO1997002259A1 (en) 1997-01-23
MX9710260A (en) 1998-03-29
NO976112D0 (en) 1997-12-29
JPH11509532A (en) 1999-08-24
NO976112L (en) 1998-03-02
AU6252296A (en) 1997-02-05
FI974640A0 (en) 1997-12-30

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