FI973879A0 - Tienyl-,furyl-,pyrrolyl- och bifenylsulfonamider och derivat daerav sommodulerar endotelinativiteten - Google Patents

Tienyl-,furyl-,pyrrolyl- och bifenylsulfonamider och derivat daerav sommodulerar endotelinativiteten

Info

Publication number: FI973879A0
Authority: FI; Finland
Prior art keywords: pyrrolyl; furyl; thienyl; derivatives; endothelin
Prior art date: 1995-04-04

Application number

FI973879A

Other languages

English (en)

Inventor

Ming Fai Chan

Bore Gowda Raju

Adam Kois

Erik Joel Verner

Chengde Wu

Rosario Silvestre Castillo

Venkatachalapathi Yalamoori

Vitukudi Narayanaiyenga Balaji

Timothy Kogan

Original Assignee

Texas Biotechnology Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-04

Filing date

1997-10-03

Publication date

1997-10-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27411089&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI973879(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-06-06 Priority claimed from US08/477,223 external-priority patent/US5594021A/en

1997-10-03 Application filed by Texas Biotechnology Corp filed Critical Texas Biotechnology Corp

1997-10-03 Publication of FI973879A0 publication Critical patent/FI973879A0/fi

Links

SBXDENYROQKXBE-UHFFFAOYSA-N 2-phenylbenzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1C1=CC=CC=C1 SBXDENYROQKXBE-UHFFFAOYSA-N 0.000 title 1
125000002541 furyl group Chemical group 0.000 title 1
125000000168 pyrrolyl group Chemical group 0.000 title 1
125000001544 thienyl group Chemical group 0.000 title 1
108050009340 Endothelin Proteins 0.000 abstract 2
229940124530 sulfonamide Drugs 0.000 abstract 2
150000003456 sulfonamides Chemical class 0.000 abstract 2
102000002045 Endothelin Human genes 0.000 abstract 1
102000010180 Endothelin receptor Human genes 0.000 abstract 1
108050001739 Endothelin receptor Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A61P13/00—Drugs for disorders of the urinary system
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)

FI973879A 1995-04-04 1997-10-03 Tienyl-,furyl-,pyrrolyl- och bifenylsulfonamider och derivat daerav sommodulerar endotelinativiteten FI973879A0 (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US41619995A	1995-04-04	1995-04-04
US41707595A	1995-04-04	1995-04-04
US08/477,223 US5594021A (en)	1993-05-20	1995-06-06	Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
PCT/US1996/004759 WO1996031492A1 (en)	1995-04-04	1996-04-04	Thienyl-, furyl-, pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin

Publications (1)

Publication Number	Publication Date
FI973879A0 true FI973879A0 (fi)	1997-10-03

Family

ID=27411089

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI973879A FI973879A0 (fi)	1995-04-04	1997-10-03	Tienyl-,furyl-,pyrrolyl- och bifenylsulfonamider och derivat daerav sommodulerar endotelinativiteten

Country Status (25)

Country	Link
EP (2)	EP1048657A1 (fi)
JP (3)	JP3233642B2 (fi)
KR (2)	KR100359396B1 (fi)
CN (1)	CN1130355C (fi)
AT (1)	ATE243203T1 (fi)
AU (1)	AU711968B2 (fi)
CA (1)	CA2217169C (fi)
CZ (1)	CZ299246B6 (fi)
DE (2)	DE69628740T2 (fi)
DK (1)	DK0819125T3 (fi)
EA (2)	EA007107B1 (fi)
EE (1)	EE9700251A (fi)
ES (1)	ES2201181T3 (fi)
FI (1)	FI973879A0 (fi)
HK (1)	HK1001769A1 (fi)
HU (1)	HUP9802034A3 (fi)
NL (1)	NL300251I2 (fi)
NO (1)	NO315607B1 (fi)
NZ (2)	NZ306734A (fi)
OA (1)	OA10621A (fi)
PL (1)	PL186854B1 (fi)
PT (1)	PT819125E (fi)
TR (1)	TR199701096T1 (fi)
TW (1)	TW492966B (fi)
WO (1)	WO1996031492A1 (fi)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
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AU6187898A (en) *	1997-01-30	1998-08-25	Bristol-Myers Squibb Company	Method for preventing or treating low renin hypertension by administering an endothelin antagonist
US5783705A (en)	1997-04-28	1998-07-21	Texas Biotechnology Corporation	Process of preparing alkali metal salys of hydrophobic sulfonamides
WO1998049162A1 (en) *	1997-04-28	1998-11-05	Texas Biotechnology Corporation	Sulfonamides for treatment of endothelin-mediated disorders
GB9716657D0 (en)	1997-08-07	1997-10-15	Zeneca Ltd	Chemical compounds
GB9803228D0 (en)	1998-02-17	1998-04-08	Zeneca Ltd	Chemical compounds
GB9803226D0 (en)	1998-02-17	1998-04-08	Zeneca Ltd	Chemical compounds
ID26984A (id) *	1998-07-06	2001-02-22	Bristol Myers Squibb Co	Senyawa-senyawa sulfonamida sebagai antagonis reseptor angiotensin endotelin ganda
DK1095016T3 (da)	1998-07-08	2006-03-13	Sanofi Aventis Deutschland	Svovlsubstituerede sulfonylaminocarboxylsyre-N-arylamider, deres fremstilling, deres anvendelse og farmaceutiske præparater omfattende dem
GB9902453D0 (en)	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB9902452D0 (en)	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB9902461D0 (en)	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
GB9902455D0 (en)	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
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WO2001049289A1 (en) *	1999-12-31	2001-07-12	Texas Biotechnology Corporation	Pharmaceutical and veterinary uses of endothelin antagonists
EP1533311B1 (en) *	1999-12-31	2007-04-25	Encysive Pharmaceuticals, Inc	Sulfonamides and derivatives thereof that modulate the activity of endothelin
DK1533311T3 (da)	1999-12-31	2007-09-17	Encysive Pharmaceuticals Inc	Sulfonamider og derivater deraf, der modulerer aktiviteten af endothelin
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SE0301882D0 (sv) *	2003-06-25	2003-06-25	Biovitrum Ab	New use I
SE0301886D0 (sv) *	2003-06-25	2003-06-25	Biovitrum Ab	New use V
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1996
- 1996-04-04 EE EE9700251A patent/EE9700251A/xx unknown
- 1996-04-04 HU HU9802034A patent/HUP9802034A3/hu unknown
- 1996-04-04 AT AT96912600T patent/ATE243203T1/de active
- 1996-04-04 EA EA199700208A patent/EA007107B1/ru not_active IP Right Cessation
- 1996-04-04 ES ES96912600T patent/ES2201181T3/es not_active Expired - Lifetime
- 1996-04-04 KR KR1019970707078A patent/KR100359396B1/ko not_active IP Right Cessation
- 1996-04-04 EP EP00113076A patent/EP1048657A1/en not_active Withdrawn
- 1996-04-04 NZ NZ306734A patent/NZ306734A/en unknown
- 1996-04-04 DE DE69628740T patent/DE69628740T2/de not_active Expired - Lifetime
- 1996-04-04 EA EA199900808A patent/EA199900808A1/ru unknown
- 1996-04-04 NZ NZ500282A patent/NZ500282A/xx unknown
- 1996-04-04 CN CN96193973A patent/CN1130355C/zh not_active Expired - Fee Related
- 1996-04-04 PT PT96912600T patent/PT819125E/pt unknown
- 1996-04-04 CA CA002217169A patent/CA2217169C/en not_active Expired - Fee Related
- 1996-04-04 EP EP96912600A patent/EP0819125B1/en not_active Expired - Lifetime
- 1996-04-04 TR TR97/01096T patent/TR199701096T1/xx unknown
- 1996-04-04 CZ CZ0311697A patent/CZ299246B6/cs not_active IP Right Cessation
- 1996-04-04 WO PCT/US1996/004759 patent/WO1996031492A1/en active IP Right Grant
- 1996-04-04 DE DE1996628740 patent/DE122006000068I1/de active Pending
- 1996-04-04 JP JP53052496A patent/JP3233642B2/ja not_active Expired - Lifetime
- 1996-04-04 KR KR1019997007068A patent/KR100359397B1/ko not_active IP Right Cessation
- 1996-04-04 AU AU55367/96A patent/AU711968B2/en not_active Ceased
- 1996-04-04 DK DK96912600T patent/DK0819125T3/da active
- 1996-10-04 TW TW085112218A patent/TW492966B/zh not_active IP Right Cessation
1997
- 1997-10-01 PL PL96322707A patent/PL186854B1/pl not_active IP Right Cessation
- 1997-10-02 OA OA70095A patent/OA10621A/en unknown
- 1997-10-03 FI FI973879A patent/FI973879A0/fi not_active Application Discontinuation
- 1997-10-03 NO NO19974577A patent/NO315607B1/no not_active IP Right Cessation
1998
- 1998-02-05 HK HK98100844A patent/HK1001769A1/xx not_active IP Right Cessation
2001
- 2001-06-06 JP JP2001171692A patent/JP3527217B2/ja not_active Expired - Fee Related
2003
- 2003-09-10 JP JP2003318261A patent/JP2004043495A/ja active Pending
2006
- 2006-12-13 NL NL300251C patent/NL300251I2/nl unknown

Also Published As

Publication number	Publication date
JP2002030075A (ja)	2002-01-29
NO315607B1 (no)	2003-09-29
EA199900808A1 (ru)	2000-06-26
EE9700251A (et)	1998-04-15
HK1001769A1 (en)	1998-07-10
EP0819125A1 (en)	1998-01-21
CA2217169A1 (en)	1996-10-10
PL186854B1 (pl)	2004-03-31
ES2201181T3 (es)	2004-03-16
NZ500282A (en)	2000-01-28
EP0819125B1 (en)	2003-06-18
KR100359396B1 (ko)	2003-03-15
AU711968B2 (en)	1999-10-28
WO1996031492A1 (en)	1996-10-10
EP1048657A1 (en)	2000-11-02
DE69628740T2 (de)	2004-05-13
NZ306734A (fi)	2000-01-28
NL300251I1 (nl)	2007-02-01
ATE243203T1 (de)	2003-07-15
CZ311697A3 (cs)	1998-09-16
PL322707A1 (en)	1998-02-16
HUP9802034A2 (hu)	2000-03-28
DK0819125T3 (da)	2003-10-13
CN1184470A (zh)	1998-06-10
TW492966B (en)	2002-07-01
KR100359397B1 (ko)	2002-11-01
NL300251I2 (nl)	2007-03-01
CN1130355C (zh)	2003-12-10
JP2004043495A (ja)	2004-02-12
PT819125E (pt)	2003-11-28
JP3527217B2 (ja)	2004-05-17
OA10621A (en)	2001-03-16
EA007107B1 (ru)	2006-06-30
DE122006000068I1 (de)	2007-05-10
JPH11507015A (ja)	1999-06-22
AU5536796A (en)	1996-10-23
NO974577D0 (no)	1997-10-03
HUP9802034A3 (en)	2000-04-28
CZ299246B6 (cs)	2008-05-28
EA199700208A1 (ru)	1998-08-27
NO974577L (no)	1997-12-04
CA2217169C (en)	2005-03-29
KR19980703679A (ko)	1998-12-05
TR199701096T1 (xx)	1998-02-21
DE69628740D1 (de)	2003-07-24
JP3233642B2 (ja)	2001-11-26

Publication	Publication Date	Title
FI973879A0 (fi)	1997-10-03	Tienyl-,furyl-,pyrrolyl- och bifenylsulfonamider och derivat daerav sommodulerar endotelinativiteten
DK0891325T3 (da)	2002-05-21	Para-substituerede phenylpropansyrederivater som integrinantagonister
EP0638071A1 (en)	1995-02-15	HETEROCYCLIC CARBONIC ACID DERIVATIVES THAT CAN BIND TO RARE RECEPTORS.
FI950309A0 (fi)	1995-01-24	Proliiniamidijohdannaisia
DK0889876T3 (da)	2001-09-24	Meta-substituerede phenylensulfonamidderivater
ATE156116T1 (de)	1997-08-15	Auf aromatischen sulfonamiden basierende hydroxamsäurederivate
DE69627164D1 (de)	2003-05-08	Pyrrolydin-derivate mit einer phospholipase a2 inhibierenden wirkung
DK0699191T3 (da)	1999-08-23	Sulfonamider og derivater deraf, der modulerer aktiviteten af endotelin
ES2158537T3 (es)	2001-09-01	Derivados de acidos ciclopropilalcanoicos.
NO975666L (no)	1998-02-09	Pyrrolderivater og medisinsk sammensetning
KR950701615A (ko)	1995-04-28	혈소판 응집 저해작용을 갖는 신규한 화합물(novel compound with plate-let aggregation inhibitor activity)
KR910014395A (ko)	1991-08-31	신규 화합물
EA200000082A1 (ru)	2000-08-28	Производные циклопентенона
EP1026162A4 (en)	2001-01-17	ANTI-RHUMATISMAL AGENT
DK1180094T3 (da)	2004-11-01	Kondenserede polycykliske aminosyrer som farmaceutiske midler
AU3721389A (en)	1990-01-04	Glycerin derivative and its pharmacological use
ATE114309T1 (de)	1994-12-15	N-azabicyclo(3.3.0>octanamide von aromatischen säuren.
DE68908958D1 (de)	1993-10-14	Peptide.
ATE229963T1 (de)	2003-01-15	Phosphinsäurederivate mit metallopeptidase- inhibitorischer wirkung
MX9202845A (es)	1992-06-30	Derivado de pradimicina.
EA200000415A1 (ru)	2000-10-30	Синтез 3-карбометокси-4,5-диметилтиофена
ES2195309T3 (es)	2003-12-01	Derivados de tetrahidrofurano.
TH14587A (th)	1994-08-26	อนุพันธ์แคมพ์โทธีซินที่ละลายน้ำได้

Legal Events

Date	Code	Title	Description
1998-01-08	FA	Application withdrawn [patent]