FI971104A0 - Menetelmä COX-inhibiittoreina käyttökelpoisten fenyyliheterosyklien valmistamiseksi - Google Patents
Menetelmä COX-inhibiittoreina käyttökelpoisten fenyyliheterosyklien valmistamiseksiInfo
- Publication number
- FI971104A0 FI971104A0 FI971104A FI971104A FI971104A0 FI 971104 A0 FI971104 A0 FI 971104A0 FI 971104 A FI971104 A FI 971104A FI 971104 A FI971104 A FI 971104A FI 971104 A0 FI971104 A0 FI 971104A0
- Authority
- FI
- Finland
- Prior art keywords
- preparation
- cox inhibitors
- phenyl heterocycles
- heterocycles useful
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30797294 | 1994-09-16 | ||
| US08/307,972 US5585504A (en) | 1994-09-16 | 1994-09-16 | Process of making cox-2 inhibitors having a lactone bridge |
| US9511539 | 1995-09-12 | ||
| PCT/US1995/011539 WO1996008482A1 (en) | 1994-09-16 | 1995-09-12 | Process for making phenyl heterocycles useful as cox-2 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI971104L FI971104L (fi) | 1997-03-14 |
| FI971104A0 true FI971104A0 (fi) | 1997-03-14 |
| FI106376B FI106376B (fi) | 2001-01-31 |
Family
ID=23191976
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI971104A FI106376B (fi) | 1994-09-16 | 1997-03-14 | Menetelmä COX-inhibiittoreina käyttökelpoisten fenyyliheterosyklien valmistamiseksi |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5585504A (fi) |
| CN (1) | CN1065533C (fi) |
| AU (1) | AU3510595A (fi) |
| BR (1) | BR9508927A (fi) |
| CZ (1) | CZ288797B6 (fi) |
| FI (1) | FI106376B (fi) |
| RO (1) | RO118585B1 (fi) |
| RU (1) | RU2160257C2 (fi) |
| SK (1) | SK282789B6 (fi) |
| TW (1) | TW325468B (fi) |
| UA (1) | UA49809C2 (fi) |
| WO (1) | WO1996008482A1 (fi) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6180651B1 (en) * | 1996-04-04 | 2001-01-30 | Bristol-Myers Squibb | Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics |
| FR2747123B1 (fr) * | 1996-04-04 | 1998-06-26 | Union Pharma Scient Appl | Nouveaux derives diarylmethylidene tetrahydrofurane, leurs procedes de preparation, et leurs utilisations en therapeutique |
| US5807873A (en) * | 1996-04-04 | 1998-09-15 | Laboratories Upsa | Diarylmethylidenefuran derivatives and their uses in therapeutics |
| US5883267A (en) * | 1996-05-31 | 1999-03-16 | Merck & Co., Inc. | Process for making phenyl heterocycles useful as cox-2 inhibitors |
| HRP970289A2 (en) * | 1996-05-31 | 1998-04-30 | Merck & Co Inc | Process for preparing phenyl heterocycles useful as cox-2 inhibitors |
| US5985930A (en) | 1996-11-21 | 1999-11-16 | Pasinetti; Giulio M. | Treatment of neurodegenerative conditions with nimesulide |
| WO1998037235A1 (en) | 1997-02-24 | 1998-08-27 | Cornell Research Foundation, Inc. | Method of screening agents as candidates for drugs or sources of drugs |
| US6071954A (en) * | 1997-03-14 | 2000-06-06 | Merk Frosst Canada, Inc. | (methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as COX-2 inhibitors |
| JP2001514668A (ja) * | 1997-03-14 | 2001-09-11 | メルク フロスト カナダ アンド カンパニー | Ｃｏｘ−２阻害薬としての酸素連結部を有する（メチルスルホニル）フェニル−２−（５ｈ）−フラノン類 |
| US6727238B2 (en) | 1998-06-11 | 2004-04-27 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
| TNSN99111A1 (fr) * | 1998-06-11 | 2005-11-10 | Pfizer | Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| US6294558B1 (en) * | 1999-05-31 | 2001-09-25 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
| AU778538B2 (en) * | 1999-03-10 | 2004-12-09 | G.D. Searle & Co. | Method and composition for administering a cyclooxygenase-2 inhibitor |
| DK1104759T3 (da) | 1999-12-03 | 2004-01-26 | Pfizer Prod Inc | Heteroarylphenylpyrazolforbindelser som antiinflammatoriske/analgetiske midler |
| DE60004001T2 (de) | 1999-12-03 | 2004-04-15 | Pfizer Products Inc., Groton | Acetylenderivate zur Verwendung als schmerzstillendes oder entzündungshemmendes Mittel |
| DE60001623T2 (de) | 1999-12-03 | 2003-12-18 | Pfizer Products Inc., Groton | Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
| DZ3246A1 (fr) | 1999-12-03 | 2001-06-07 | Pfizer Prod Inc | Dérivé heterocyclo-alkylsulfonyle pyrazole en tant qu'agents anti-inflammatoires/analgesiques |
| IL144760A0 (en) | 1999-12-08 | 2002-06-30 | Pharmacia Corp | Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect |
| DE10012825B4 (de) | 2000-03-16 | 2004-04-15 | Bayer Corp. | Verfahren zur Herstellung von spirocyclischen Tetronsäurederivaten |
| CN1102586C (zh) * | 2000-04-07 | 2003-03-05 | 中国科学院上海有机化学研究所 | β位含有芳基取代基的γ－丁烯酸内酯及其固相合成法 |
| CA2414674A1 (en) * | 2000-07-13 | 2002-01-24 | Pharmacia Corporation | Use of cox-2 inhibitors in the treatment and prevention of ocular cox-2 mediated disorders |
| AU2001285334A1 (en) * | 2000-08-29 | 2002-03-13 | Peter Van Patten | Combination for the treatment of migraine comprising a cyclooxygenase-2 inhibitor and acetylsalicylic acid |
| US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| PE20021017A1 (es) | 2001-04-03 | 2002-11-24 | Pharmacia Corp | Composicion parenteral reconstituible |
| DE60204823T2 (de) | 2001-07-05 | 2005-12-29 | Pfizer Products Inc., Groton | Heterocyclo-alkylsulfonyl Pyrazole als entzündungshemmende/analgetische Mittel |
| UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
| GT200200183A (es) | 2001-09-28 | 2003-05-23 | Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol | |
| WO2003037336A1 (en) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer |
| ES2213485B1 (es) | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
| PT2266584E (pt) * | 2003-05-07 | 2012-12-19 | Osteologix As | Composição com estrôncio e vitamina d para a profilaxia/tratamento de patologias da cartilagem e/ou do osso |
| EP1534305B9 (en) * | 2003-05-07 | 2007-03-07 | Osteologix A/S | Treating cartilage / bone conditions with water-soluble strontium salts |
| AU2003263582A1 (en) * | 2003-08-14 | 2005-03-07 | Shasun Chemicals And Drugs Limited | Process for the manufacture of rofecoxib |
| WO2005044227A1 (en) * | 2003-11-05 | 2005-05-19 | Glenmark Pharmaceuticals Limited | Topical pharmaceutical compositions |
| US20050100594A1 (en) * | 2003-11-12 | 2005-05-12 | Nilendu Sen | Pharmaceutical formulation containing muscle relaxant and COX-II inhibitor |
| CN113660934A (zh) | 2018-11-21 | 2021-11-16 | 特默罗制药股份有限公司 | 罗非昔布的纯化形式、制备方法和用途 |
| US10945992B1 (en) | 2019-11-13 | 2021-03-16 | Tremeau Pharmaceuticals, Inc. | Dosage forms of rofecoxib and related methods |
| US11161833B1 (en) | 2021-04-09 | 2021-11-02 | Tremeau Pharmaceuticals, Inc. | Deuterated etoricoxib, methods of manufacture, and use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2111288T3 (es) * | 1993-01-15 | 1998-03-01 | Searle & Co | Nuevos 3,4-diaril tiofenos y analogos de los mismos utiles como agentes antiinflamatorios. |
| US5462939A (en) * | 1993-05-07 | 1995-10-31 | Sterling Winthrop Inc. | Peptidic ketones as interleukin-1β-converting enzyme inhibitors |
| CN1143365A (zh) * | 1994-01-10 | 1997-02-19 | 麦克弗罗斯特(加拿大)有限公司 | 作为cox-2抑制剂的苯基杂环类化合物 |
-
1994
- 1994-09-16 US US08/307,972 patent/US5585504A/en not_active Expired - Fee Related
-
1995
- 1995-09-08 TW TW084109387A patent/TW325468B/zh active
- 1995-09-12 RO RO97-00484A patent/RO118585B1/ro unknown
- 1995-09-12 CN CN95195075A patent/CN1065533C/zh not_active Expired - Fee Related
- 1995-09-12 BR BR9508927A patent/BR9508927A/pt not_active Application Discontinuation
- 1995-09-12 WO PCT/US1995/011539 patent/WO1996008482A1/en active Search and Examination
- 1995-09-12 AU AU35105/95A patent/AU3510595A/en not_active Abandoned
- 1995-09-12 CZ CZ1997792A patent/CZ288797B6/cs not_active IP Right Cessation
- 1995-09-12 RU RU97106093/04A patent/RU2160257C2/ru not_active IP Right Cessation
- 1995-09-12 UA UA97041788A patent/UA49809C2/uk unknown
- 1995-09-12 SK SK316-97A patent/SK282789B6/sk unknown
-
1997
- 1997-03-14 FI FI971104A patent/FI106376B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SK282789B6 (sk) | 2002-12-03 |
| RU2160257C2 (ru) | 2000-12-10 |
| US5585504A (en) | 1996-12-17 |
| UA49809C2 (uk) | 2002-10-15 |
| TW325468B (en) | 1998-01-21 |
| CN1065533C (zh) | 2001-05-09 |
| SK31697A3 (en) | 1997-10-08 |
| WO1996008482A1 (en) | 1996-03-21 |
| CZ288797B6 (cs) | 2001-09-12 |
| AU3510595A (en) | 1996-03-29 |
| CZ79297A3 (en) | 1997-07-16 |
| FI971104L (fi) | 1997-03-14 |
| RO118585B1 (ro) | 2003-07-30 |
| BR9508927A (pt) | 1997-12-30 |
| CN1159191A (zh) | 1997-09-10 |
| FI106376B (fi) | 2001-01-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI971104A0 (fi) | Menetelmä COX-inhibiittoreina käyttökelpoisten fenyyliheterosyklien valmistamiseksi | |
| FI20012510L (fi) | Fenyyliheterosyklejä syklo-oksigenaasi-2-inhibiittoreina | |
| FI962800A0 (fi) | Fenyyliheterosyklisiä yhdisteitä COX-2 inhibiittoreina | |
| NO985874D0 (no) | Bestemte fosfinylderivater nyttige som naaladase inhibitorer | |
| FI972555L (fi) | Päällystettyjen tablettien valmistus | |
| FI20000564A0 (fi) | Menetelmä nanolaminaattien valmistamiseksi | |
| DK1007520T3 (da) | 2-aminopyridiner som indeholder sammensluttede ringsubstituenter som NOS inhibitorer | |
| FI950800L (fi) | Menetelmä heterosyklisten yhdisteiden sulfinyloimiseksi | |
| FI973440L (fi) | Trisubstituoituja fenyylijohdannaisia | |
| FI973281L (fi) | Menetelmä tiettyjen atsasykloheksapeptidien valmistamiseksi | |
| DK0606248T3 (da) | Heteroarylaminer som hidtil ukendte acetylcholinesteraseinhibitorer | |
| FI970427L (fi) | Menetelmä mikrobinvastaisten yhdisteiden valmistamiseksi | |
| FI972495A (fi) | Menetelmä orgaanisia yhdisteitä hajottavien mikroorganismien valmistamiseksi | |
| NO992309L (no) | FremgangsmÕte for anvendelse av cyklooksygenase-2 inhibitorer som anti-angiogene midler | |
| FI20000553L (fi) | Proteaasi-inhibiittoreina käyttökelpoisten 4-hydroksi-2-oksopyraanijohdannaisten valmistusmenetelmä | |
| FI972065L (fi) | Menetelmä N-fosfonometyyliglysiinin valmistamiseksi | |
| NO911459D0 (no) | Anvendelse av metallion-komplekser som belegginhibitorer. | |
| FI942102A0 (fi) | Menetelmä alumiinioksaanien valmistamiseksi | |
| FI990509A0 (fi) | Häiriönpoistomenetelmä | |
| FI970564L (fi) | Uusi menetelmä di-isopinokamfeyyliklooriboraanin valmistamiseksi | |
| FI940992A0 (fi) | Cylindergrupp med enkelt viradrag i torkningspartiet av en pappersmaskin och torkningsparti i pappersmaskin som innehaoller dessa | |
| FI982623A0 (fi) | Menetelmä alkyyliketeenidimeerien valmistamiseksi | |
| FI972440L (fi) | Menetelmä kefalosporiinien synteesissä käyttökelpoisten välituotteiden valmistamiseksi | |
| FI952134A0 (fi) | Menetelmä alkyykibentseenin valmistamiseksi | |
| DK0944601T3 (da) | Heterocykliske quanidinylaminoforbindelser som alfa-2-adrenoceptoragonister |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |