FI960184L - Förfarande för tillverkning av HIV-proteasinhibitorer - Google Patents

Förfarande för tillverkning av HIV-proteasinhibitorer Download PDF

Info

Publication number: FI960184L
Authority: FI; Finland
Prior art keywords: protease inhibitors; hiv protease; preparing hiv; preparing; inhibitors
Prior art date: 1993-07-16

Application number

FI960184A

Other languages

English (en)

Finnish (fi)

Other versions

FI960184A0 (sv

FI119473B (sv

Inventor

David Askin

Ralph P Volante

Kan K Eng

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-16

Filing date

1996-01-15

Publication date

1996-03-14

1994-01-26 Priority claimed from US08/187,664 external-priority patent/US5463067A/en

1996-01-15 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1996-01-15 Publication of FI960184A0 publication Critical patent/FI960184A0/sv

1996-03-14 Publication of FI960184L publication Critical patent/FI960184L/sv

2008-11-28 Application granted granted Critical

2008-11-28 Publication of FI119473B publication Critical patent/FI119473B/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Epoxy Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FI960184A 1993-07-16 1996-01-15 Förfarande för tillverkning av HIV-proteasinhibitorer FI119473B (sv)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US9322593A	1993-07-16	1993-07-16
US9322593		1993-07-16
US08/187,664 US5463067A (en)	1993-07-16	1994-01-26	Process for making HIV protease inhibitors
US18766494		1994-01-26
US9407706		1994-07-11
PCT/US1994/007706 WO1995002584A2 (en)	1993-07-16	1994-07-11	Process for making hiv protease inhibitors

Publications (3)

Publication Number	Publication Date
FI960184A0 FI960184A0 (sv)	1996-01-15
FI960184L true FI960184L (sv)	1996-03-14
FI119473B FI119473B (sv)	2008-11-28

Family

ID=26787287

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI960184A FI119473B (sv)	1993-07-16	1996-01-15	Förfarande för tillverkning av HIV-proteasinhibitorer

Country Status (22)

Country	Link
US (2)	US5491238A (sv)
EP (1)	EP0708762B1 (sv)
JP (1)	JP3547136B2 (sv)
CN (2)	CN1066723C (sv)
AT (1)	ATE200079T1 (sv)
AU (1)	AU676079B2 (sv)
CZ (1)	CZ293953B6 (sv)
DE (1)	DE69426979T2 (sv)
DK (1)	DK0708762T3 (sv)
ES (1)	ES2155091T3 (sv)
FI (1)	FI119473B (sv)
GR (1)	GR3035645T3 (sv)
HU (1)	HUT74583A (sv)
IL (1)	IL110342A (sv)
LV (1)	LV12825B (sv)
NO (1)	NO306297B1 (sv)
NZ (1)	NZ269904A (sv)
PL (1)	PL179039B1 (sv)
PT (1)	PT708762E (sv)
RU (1)	RU2125561C1 (sv)
SK (1)	SK282616B6 (sv)
WO (1)	WO1995002584A2 (sv)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL110255A (en) *	1993-07-16	1998-12-06	Merck & Co Inc	Formation and resolution of 2-tert-butylcarboxamido-piperazine
IL111584A0 (en) *	1993-11-18	1995-01-24	Merck & Co Inc	Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them
US5792869A (en) *	1994-11-04	1998-08-11	Yamakawa Chemical Industry Co., Ltd	Process for preparing optically active piperazine derivatives and Intermediates for preparation
DE4446025A1 (de) *	1994-12-22	1996-06-27	Basf Ag	2-Caroxamido-1,4,5,6-tetrahydropyrazine
EP1125930A1 (de) *	1995-05-23	2001-08-22	Lonza Ag	Optisch aktive 2-Piperazincarbonsäurederivate und Verfahren zu ihrer Herstellung
EP0744401B1 (de) *	1995-05-23	2001-11-21	Lonza Ag	Verfahren zur Herstellung von optisch aktiven 2-Piperazincarbonsäurederivaten
CA2201218C (en) *	1996-04-23	2004-09-28	Rudolf Fuchs	Process for the preparation of optically active piperazine-2-carboxylic acid derivatives
US6645961B1 (en)	1997-03-07	2003-11-11	Merck & Co., Inc.	Dry granulation formulation for an HIV protease inhibitor
US6482952B2 (en)	2000-06-20	2002-11-19	Merck & Co., Inc.	Process for preparing acetonides
US7218837B2 (en)	2000-09-25	2007-05-15	Victor Company Of Japan, Ltd.	Program-signal recording and reproducing apparatus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2052907A1 (en) *	1990-10-11	1992-04-12	Joseph P. Vacca	Hiv protease inhibitors having symmetrical structure
US5169952A (en) *	1991-07-02	1992-12-08	Merck & Co., Inc.	Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides
CA2072237A1 (en) *	1991-07-02	1993-01-03	Merck & Co., Inc.	Stereoselective production of hydroxyamide compounds from chiral -amino epoxides

1994
- 1994-07-11 AT AT94922511T patent/ATE200079T1/de not_active IP Right Cessation
- 1994-07-11 JP JP50463295A patent/JP3547136B2/ja not_active Expired - Fee Related
- 1994-07-11 HU HU9600077A patent/HUT74583A/hu unknown
- 1994-07-11 CN CN94193304A patent/CN1066723C/zh not_active Expired - Fee Related
- 1994-07-11 EP EP94922511A patent/EP0708762B1/en not_active Expired - Lifetime
- 1994-07-11 DE DE69426979T patent/DE69426979T2/de not_active Expired - Lifetime
- 1994-07-11 PT PT94922511T patent/PT708762E/pt unknown
- 1994-07-11 WO PCT/US1994/007706 patent/WO1995002584A2/en active IP Right Grant
- 1994-07-11 NZ NZ269904A patent/NZ269904A/en not_active IP Right Cessation
- 1994-07-11 RU RU96103642A patent/RU2125561C1/ru not_active IP Right Cessation
- 1994-07-11 SK SK55-96A patent/SK282616B6/sk not_active IP Right Cessation
- 1994-07-11 AU AU73588/94A patent/AU676079B2/en not_active Ceased
- 1994-07-11 ES ES94922511T patent/ES2155091T3/es not_active Expired - Lifetime
- 1994-07-11 PL PL94312613A patent/PL179039B1/pl not_active IP Right Cessation
- 1994-07-11 CZ CZ1996131A patent/CZ293953B6/cs not_active IP Right Cessation
- 1994-07-11 DK DK94922511T patent/DK0708762T3/da active
- 1994-07-17 IL IL11034294A patent/IL110342A/en not_active IP Right Cessation
1995
- 1995-06-02 US US08/458,379 patent/US5491238A/en not_active Expired - Lifetime
- 1995-06-21 US US08/459,069 patent/US5496948A/en not_active Expired - Lifetime
1996
- 1996-01-15 NO NO960168A patent/NO306297B1/no not_active IP Right Cessation
- 1996-01-15 FI FI960184A patent/FI119473B/sv active IP Right Grant
1999
- 1999-08-10 CN CNB991117905A patent/CN1192014C/zh not_active Expired - Fee Related
2001
- 2001-03-29 GR GR20010400119T patent/GR3035645T3/el unknown
2002
- 2002-03-15 LV LVP-02-39A patent/LV12825B/xx unknown

Also Published As

Publication number	Publication date
PT708762E (pt)	2001-07-31
PL179039B1 (pl)	2000-07-31
DE69426979T2 (de)	2001-09-20
SK282616B6 (sk)	2002-10-08
NO960168L (no)	1996-03-15
CN1066723C (zh)	2001-06-06
HUT74583A (en)	1997-01-28
CN1252402A (zh)	2000-05-10
DK0708762T3 (da)	2001-04-30
SK5596A3 (en)	1997-01-08
WO1995002584A2 (en)	1995-01-26
US5491238A (en)	1996-02-13
GR3035645T3 (en)	2001-06-29
WO1995002584A3 (en)	1995-03-09
CN1130380A (zh)	1996-09-04
US5496948A (en)	1996-03-05
JP3547136B2 (ja)	2004-07-28
HU9600077D0 (en)	1996-03-28
AU676079B2 (en)	1997-02-27
JPH08509985A (ja)	1996-10-22
LV12825A (en)	2002-05-20
EP0708762A1 (en)	1996-05-01
IL110342A0 (en)	1994-10-21
NZ269904A (en)	1997-11-24
IL110342A (en)	1998-12-27
AU7358894A (en)	1995-02-13
NO306297B1 (no)	1999-10-18
CZ293953B6 (cs)	2004-08-18
FI960184A0 (sv)	1996-01-15
EP0708762B1 (en)	2001-03-28
RU2125561C1 (ru)	1999-01-27
DE69426979D1 (de)	2001-05-03
FI119473B (sv)	2008-11-28
LV12825B (lv)	2002-09-20
PL312613A1 (en)	1996-04-29
ATE200079T1 (de)	2001-04-15
CN1192014C (zh)	2005-03-09
NO960168D0 (no)	1996-01-15
CZ13196A3 (en)	1996-04-17
ES2155091T3 (es)	2001-05-01

Publication	Publication Date	Title
DK0722439T3 (da)	2002-12-16	HIV-proteaseinhibitorer
FI962069L (sv)	1996-05-15	Förfarande för framställning av karpolaktam
FI956135A0 (sv)	1995-12-20	Separeringsförfarande
AU9122391A (en)	1992-06-25	Hiv protease inhibitors
FI962488L (sv)	1996-06-14	HIV proteas inhibitorer
FI955800L (sv)	1995-12-01	Metod att framställa aminoalkylguanidiner
FI963054L (sv)	1996-08-01	Förfarande för framställning av HIV proteas inhibitorer
FI931850L (sv)	1994-10-24	Foerfarande foer framstaellning av en mellanprodukt
FI960184L (sv)	1996-03-14	Förfarande för tillverkning av HIV-proteasinhibitorer
FI960206L (sv)	1996-03-14	Förfarande för framställning av HIV-proteasinhibitorer
FI942102L (sv)	1994-11-07	Förfarande för framställning av aluminoxaner
ZA945234B (en)	1995-02-28	Process for making HIV protease inhibitors
EP0443560A3 (en)	1992-07-01	Hiv protease inhibitors
EE04750B1 (et)	2006-12-15	HIV-proteaasi inhibiitorite valmistamismeetod
EP0594586A4 (en)	1994-08-17	Hiv protease inhibitors
MX9100121A (es)	1992-02-28	Inhibidores de proteasas asparticas
FI954786L (sv)	1995-10-06	Förfarande för framställning av aminometanfosfonsyra
DK1361216T3 (da)	2006-01-23	Fremgangsmåde til fremstilling af en HIV-proteaseinhibitor
FI934516L (sv)	1995-04-14	Förfarande för lokalisering av tvärskärningar
NO920023D0 (no)	1992-01-02	Hiv-proteaseinhibitorer
SG49247A1 (en)	1998-05-18	Hiv protease inhibitors
ZA919721B (en)	1992-12-30	Hiv protease inhibitors
HU0900220D0 (en)	2009-06-29	Hiv protease inhibitors
FI955027L (sv)	1995-10-20	Förfarande för framställning av en mellanprodukt

Legal Events

Date	Code	Title	Description
2008-11-28	FG	Patent granted	Ref document number: 119473 Country of ref document: FI
2010-03-16	PC	Transfer of assignment of patent	Owner name: MERCK SHARP & DOHME CORP. Free format text: MERCK SHARP & DOHME CORP.

Date

Code

Title

Description

2008-11-28

Patent granted

Ref document number: 119473

Country of ref document: FI

2010-03-16

Transfer of assignment of patent

Owner name: MERCK SHARP & DOHME CORP.

Free format text: MERCK SHARP & DOHME CORP.