FI955165A - 4-aryl-4-hydroxi-tetrahydropyraner och 3-aryl-3-hydroxi-tetrahydrofuraner som 5-lipoxygenas inhibitorer - Google Patents

4-aryl-4-hydroxi-tetrahydropyraner och 3-aryl-3-hydroxi-tetrahydrofuraner som 5-lipoxygenas inhibitorer Download PDF

Info

Publication number: FI955165A
Authority: FI; Finland
Prior art keywords: aryl; hydroxy; tetrahydropyrans; tetrahydrofurans; lipoxygenase inhibitors
Prior art date: 1993-04-29

Application number

FI955165A

Other languages

English (en)

Finnish (fi)

Other versions

FI109123B (sv

FI955165A0 (sv

Inventor

Thomas Geoffrey Colerick Bird

Graham Charles Crawley

Michael Stewart Large

Patrick Ple

Original Assignee

Zeneca Ltd

Zeneca Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-29

Filing date

1995-10-27

Publication date

1995-10-27

1995-10-27 Application filed by Zeneca Ltd, Zeneca Pharma Sa filed Critical Zeneca Ltd

1995-10-27 Publication of FI955165A0 publication Critical patent/FI955165A0/sv

1995-10-27 Publication of FI955165A publication Critical patent/FI955165A/sv

2002-05-31 Application granted granted Critical

2002-05-31 Publication of FI109123B publication Critical patent/FI109123B/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Thiazole And Isothizaole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

FI955165A 1993-04-29 1995-10-27 Analogiförfarande för framställning av som 5-lipoxigenas-inhibitorer användbara 4-aryl-4-hydroxi-tetrahydropyraner och 3-aryl-3-hydroxi-tetrahydrofuraner FI109123B (sv)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
EP93401120		1993-04-29
EP93401120		1993-04-29
EP93401991		1993-08-02
EP93401991		1993-08-02
EP94400190		1994-01-28
EP94400190		1994-01-28
EP9401277		1994-04-25
PCT/EP1994/001277 WO1994025453A1 (en)	1993-04-29	1994-04-25	4-aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors

Publications (3)

Publication Number	Publication Date
FI955165A0 FI955165A0 (sv)	1995-10-27
FI955165A true FI955165A (sv)	1995-10-27
FI109123B FI109123B (sv)	2002-05-31

Family

ID=27235558

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
FI955165A FI109123B (sv)	1993-04-29	1995-10-27	Analogiförfarande för framställning av som 5-lipoxigenas-inhibitorer användbara 4-aryl-4-hydroxi-tetrahydropyraner och 3-aryl-3-hydroxi-tetrahydrofuraner
FI20020270A FI20020270L (sv)	1993-04-29	2002-02-11	4-aryl-4-hydroxi-tetrahydropyraner och 3-aryl-3-hydroxi-tetrahydrofuraner som 5-lipoxygenas inhibitorer

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
FI20020270A FI20020270L (sv)	1993-04-29	2002-02-11	4-aryl-4-hydroxi-tetrahydropyraner och 3-aryl-3-hydroxi-tetrahydrofuraner som 5-lipoxygenas inhibitorer

Country Status (24)

Country	Link
US (2)	US5478842A (sv)
EP (1)	EP0623614B1 (sv)
JP (1)	JP3553127B2 (sv)
KR (1)	KR100358464B1 (sv)
CN (1)	CN1052002C (sv)
AP (1)	AP9400632A0 (sv)
AT (1)	ATE163417T1 (sv)
AU (1)	AU681886B2 (sv)
CA (1)	CA2121199C (sv)
CZ (1)	CZ280695A3 (sv)
DE (1)	DE69408593T2 (sv)
DK (1)	DK0623614T3 (sv)
ES (1)	ES2112483T3 (sv)
FI (2)	FI109123B (sv)
GB (1)	GB9408001D0 (sv)
HK (1)	HK1004777A1 (sv)
HU (1)	HU9502968D0 (sv)
IL (1)	IL109254A (sv)
NO (1)	NO309191B1 (sv)
NZ (1)	NZ266139A (sv)
PL (1)	PL311300A1 (sv)
SK (1)	SK134995A3 (sv)
TW (1)	TW252978B (sv)
WO (1)	WO1994025453A1 (sv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3990972B2 (ja) *	2001-11-20	2007-10-17	有限会社キック	血管再狭窄防止薬及び該防止薬がコーティングされた血管内埋め込み器具
SE0104274D0 (sv) *	2001-12-17	2001-12-17	Astrazeneca Ab	Novel process
DE102004002557A1 (de) *	2004-01-17	2005-08-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen
US8158362B2 (en)	2005-03-30	2012-04-17	Decode Genetics Ehf.	Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
WO2007087250A2 (en)	2006-01-23	2007-08-02	Amira Pharmaceuticals, Inc.	Tricyclic inhibitors of 5-lipoxygenase
EP2086531A4 (en)	2006-11-30	2009-09-30	Amira Pharmaceuticals Inc	COMPOSITIONS AND TREATMENTS COMPRISING 5-LIPOXYGENASE-ACTIVATING PROTEIN INHIBITORS AND NITRIC OXIDE MODULATORS
US10793515B2 (en) *	2008-03-19	2020-10-06	Aurimmed Pharma, Inc.	Compounds advantageous in the treatment of central nervous system diseases and disorders
SG175390A1 (en)	2009-04-29	2011-12-29	Amarin Corp Plc	Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
AU2015214317B2 (en)	2014-02-04	2020-01-16	Bioscience Pharma Partners, Llc	Use of FLAP inhibitors to reduce neuroinflammation mediated injury in the central nervous system
LT3670499T (lt)	2015-05-04	2021-12-27	Astrazeneca Ab	Pirazolo dariniai tinkami naudoti kaip 5-lipooksigenazę aktyvinančio baltymo (flap) inhibitoriai
AU2017348598B2 (en)	2016-10-28	2020-02-20	Astrazeneca Ab	Crystalline form of (1R,2R)-2-[4-(3-methyl-1H-pyrazol-5-yl)benzoyl]-N- (4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3- yl)cyclohexanecarboxamide

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4794188A (en) *	1982-12-01	1988-12-27	Usv Pharmaceutical Corporation	Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
US4567184A (en) *	1982-12-01	1986-01-28	Usv Pharmaceutical Corporation	Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
US4625034A (en) *	1985-02-04	1986-11-25	Usv Pharmaceutical Corp.	1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives
US4725619A (en) *	1985-04-16	1988-02-16	Usv Pharmaceutical Corporation	Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4839369A (en) *	1985-04-16	1989-06-13	Rorer Pharmaceutical Corporation	Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4728668A (en) *	1985-04-16	1988-03-01	Usv Pharmaceutical Corporation	Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4631287A (en) *	1985-04-16	1986-12-23	Usv Pharmaceutical Corp.	Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4868193A (en) *	1986-09-24	1989-09-19	Rorer Pharmaceutical Corporation	Styryl tetrazoles and anti-allergic use thereof
GB8926981D0 (en) *	1988-12-23	1990-01-17	Ici Plc	Heterocyclic derivatives
US5234950A (en) *	1988-12-23	1993-08-10	Imperial Chemical Industries Plc	Tetrahydrofuran derivatives
US5236919A (en) *	1989-02-28	1993-08-17	Imperial Chemical Industries Plc	Quinoxalinyl derivatives suitable for use in leukotriene mediated disease
IE70521B1 (en) *	1989-02-28	1996-12-11	Zeneca Pharma Sa	Heterocycles with inhibitory activity of 5-lipoxygenase
US5202326A (en) *	1989-02-28	1993-04-13	Imperial Chemical Industries Plc	Heterocyclic ethers
US5134148A (en) *	1989-02-28	1992-07-28	Imperial Chemical Industries Plc	Heterocycles for use as inhibitors of leukotrienes
IE64358B1 (en) *	1989-07-18	1995-07-26	Ici Plc	Diaryl ether heterocycles
GB9018134D0 (en) *	1989-09-29	1990-10-03	Ici Plc	Heterocyclic derivatives
US5088927A (en) *	1990-06-18	1992-02-18	Lee Howard G	Radio opaque plastics and process of making
IE911853A1 (en) *	1990-06-21	1992-01-01	Ici Plc	Heterocyclene derivatives
IE911919A1 (en) *	1990-06-21	1992-01-01	Zeneca Ltd	Bicyclic heterocyclic compounds
GB9113137D0 (en) *	1990-07-13	1991-08-07	Ici Plc	Thioxo heterocycles
IE913866A1 (en) *	1990-11-28	1992-06-03	Ici Plc	Aryl derivatives
US5272173A (en) *	1990-11-28	1993-12-21	Imperial Chemical Industries Plc	5-lipoxygenase inhibitors
EP0501578A1 (en) *	1991-02-28	1992-09-02	Merck Frosst Canada Inc.	Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis
EP0501579A1 (en) *	1991-02-28	1992-09-02	Merck Frosst Canada Inc.	Naphthalene lactones as inhibitors of leukotriene biosynthesis
US5308852A (en) *	1992-06-29	1994-05-03	Merck Frosst Canada, Inc.	Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis

1994
- 1994-04-07 IL IL10925494A patent/IL109254A/en not_active IP Right Cessation
- 1994-04-07 AP APAP/P/1994/000632A patent/AP9400632A0/en unknown
- 1994-04-13 CA CA002121199A patent/CA2121199C/en not_active Expired - Fee Related
- 1994-04-22 GB GB9408001A patent/GB9408001D0/en active Pending
- 1994-04-25 SK SK1349-95A patent/SK134995A3/sk unknown
- 1994-04-25 WO PCT/EP1994/001277 patent/WO1994025453A1/en active IP Right Grant
- 1994-04-25 AU AU67212/94A patent/AU681886B2/en not_active Ceased
- 1994-04-25 CZ CZ952806A patent/CZ280695A3/cs unknown
- 1994-04-25 KR KR1019950704723A patent/KR100358464B1/ko not_active Expired - Fee Related
- 1994-04-25 HU HU9502968A patent/HU9502968D0/hu unknown
- 1994-04-25 NZ NZ266139A patent/NZ266139A/xx not_active IP Right Cessation
- 1994-04-25 CN CN94191925A patent/CN1052002C/zh not_active Expired - Fee Related
- 1994-04-25 PL PL94311300A patent/PL311300A1/xx unknown
- 1994-04-26 DK DK94303012T patent/DK0623614T3/da active
- 1994-04-26 EP EP94303012A patent/EP0623614B1/en not_active Expired - Lifetime
- 1994-04-26 ES ES94303012T patent/ES2112483T3/es not_active Expired - Lifetime
- 1994-04-26 JP JP08882694A patent/JP3553127B2/ja not_active Expired - Fee Related
- 1994-04-26 DE DE69408593T patent/DE69408593T2/de not_active Expired - Fee Related
- 1994-04-26 AT AT94303012T patent/ATE163417T1/de not_active IP Right Cessation
- 1994-04-28 US US08/234,148 patent/US5478842A/en not_active Expired - Lifetime
- 1994-04-30 TW TW083103922A patent/TW252978B/zh active
1995
- 1995-05-12 US US08/440,132 patent/US5512594A/en not_active Expired - Lifetime
- 1995-10-27 FI FI955165A patent/FI109123B/sv active
- 1995-10-27 NO NO954321A patent/NO309191B1/no not_active IP Right Cessation
1998
- 1998-05-05 HK HK98103836A patent/HK1004777A1/xx not_active IP Right Cessation
2002
- 2002-02-11 FI FI20020270A patent/FI20020270L/sv unknown

Also Published As

Publication number	Publication date
DE69408593T2 (de)	1998-07-16
CA2121199C (en)	2001-08-07
NO954321D0 (no)	1995-10-27
DE69408593D1 (de)	1998-04-02
IL109254A0 (en)	1994-07-31
ATE163417T1 (de)	1998-03-15
NO954321L (no)	1995-10-27
CZ280695A3 (en)	1996-01-17
PL311300A1 (en)	1996-02-05
HU9502968D0 (en)	1995-12-28
WO1994025453A1 (en)	1994-11-10
NZ266139A (en)	1997-08-22
FI109123B (sv)	2002-05-31
CN1052002C (zh)	2000-05-03
TW252978B (en)	1995-08-01
FI955165A0 (sv)	1995-10-27
HK1004777A1 (en)	1998-12-04
JPH0770114A (ja)	1995-03-14
EP0623614A1 (en)	1994-11-09
US5512594A (en)	1996-04-30
CA2121199A1 (en)	1994-10-30
AU681886B2 (en)	1997-09-11
JP3553127B2 (ja)	2004-08-11
CN1121715A (zh)	1996-05-01
GB9408001D0 (en)	1994-06-15
AP9400632A0 (en)	1995-10-07
AU6721294A (en)	1994-11-21
US5478842A (en)	1995-12-26
SK134995A3 (en)	1996-07-03
ES2112483T3 (es)	1998-04-01
IL109254A (en)	1999-03-12
DK0623614T3 (da)	1998-09-28
EP0623614B1 (en)	1998-02-25
FI20020270L (sv)	2002-02-11
KR100358464B1 (ko)	2003-02-05
NO309191B1 (no)	2000-12-27

Publication	Publication Date	Title
NO942064D0 (no)	1994-06-03	yminhibitorer
NO962269D0 (no)	1996-05-31	Enzyminhibitorer
FI932135A0 (fi)	1993-05-11	Foerfarande och anlaeggning foer brandbekaempning
FI930424A0 (fi)	1993-02-01	Fiberarmerad och vaermeisolerande konstruktionsdel
FI955165A (sv)	1995-10-27	4-aryl-4-hydroxi-tetrahydropyraner och 3-aryl-3-hydroxi-tetrahydrofuraner som 5-lipoxygenas inhibitorer
FI935559A0 (fi)	1993-12-10	Foerfarande foer faestning av haordmetallstift i en borrkrona och en borrkrona
FI935613A0 (fi)	1993-12-14	Pappersmaskin och flerlagrig pappersbildningsanordning
DE69431454D1 (de)	2002-11-07	Amylase Inhibitoren
BR7301860U (pt)	1994-02-22	Cotonete
FI936U1 (fi)	1993-10-14	Blaendskydd foer fordon och motsvarande
FI920U1 (fi)	1993-09-29	Bollgunga foer lekplatser och innerutrymmen
FI933097A0 (fi)	1993-07-06	Foerfarande och anordning foer immunologiska bestaemningar
FI932597A0 (fi)	1993-06-07	Befaestningssystem och vaeggelement foer befaestning
FI932644A0 (fi)	1993-06-10	Foerfarande och anordning foer flishuggning
FI932646A0 (fi)	1993-06-10	Laminerad skiva och foerfarande foer framstaellning daerav
FI932779A0 (fi)	1993-06-17	Bevattningsanordning foer buskar och blomstersaengar
FI931727A0 (fi)	1993-04-16	Styrventil foer smoerjmedel och liknande
FI933428A0 (fi)	1993-08-02	Borrspetsdragnit och borrnitdrivare
FI933867A0 (fi)	1993-09-03	Reglerbar nyckel foer muttrar och motsvarande
FI934216A0 (fi)	1993-09-24	Linearmotor och linearmotorhiss
FI934265A0 (fi)	1993-09-29	Polyesterbaserad plastplandning och foerfarande
FI934729A0 (fi)	1993-10-26	Slirskyddsmedel foer fordon och en doseringsanordning foer detsamma
FI931209A0 (fi)	1993-03-18	Skiktstruktur foer smartkort och foerfarande foer framstaellning daerav
FI934870A0 (fi)	1993-11-03	Oeverfraesbaenk och fraesfoerfarande
FI935047A0 (fi)	1993-11-15	Foerfarande foer datakommunikation och anordning