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FI953981A - 2-Bensyl-polycykliska guaninderivat och förfarande för deras framställning - Google Patents

2-Bensyl-polycykliska guaninderivat och förfarande för deras framställning Download PDF

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Publication number
FI953981A
FI953981A FI953981A FI953981A FI953981A FI 953981 A FI953981 A FI 953981A FI 953981 A FI953981 A FI 953981A FI 953981 A FI953981 A FI 953981A FI 953981 A FI953981 A FI 953981A
Authority
FI
Finland
Prior art keywords
benzyl
preparation
guanine derivatives
polycyclic guanine
polycyclic
Prior art date
Application number
FI953981A
Other languages
English (en)
Finnish (fi)
Other versions
FI953981A0 (sv
Inventor
Deen Tulshian
Brian A Mckittrick
Yan Xia
Samuel Chackalamannil
Dinesh Gala
Donald J Dibenedetto
Max Kugelman
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of FI953981A publication Critical patent/FI953981A/sv
Publication of FI953981A0 publication Critical patent/FI953981A0/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FI953981A 1993-02-26 1995-08-24 2-Bensyl-polycykliska guaninderivat och förfarande för deras framställning FI953981A0 (sv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2354993A 1993-02-26 1993-02-26
US2459993A 1993-02-26 1993-02-26
PCT/US1994/001728 WO1994019351A1 (en) 1993-02-26 1994-02-24 2-benzyl-polycyclic guanine derivatives and process for preparing them

Publications (2)

Publication Number Publication Date
FI953981A true FI953981A (sv) 1995-08-24
FI953981A0 FI953981A0 (sv) 1995-08-24

Family

ID=26697306

Family Applications (1)

Application Number Title Priority Date Filing Date
FI953981A FI953981A0 (sv) 1993-02-26 1995-08-24 2-Bensyl-polycykliska guaninderivat och förfarande för deras framställning

Country Status (14)

Country Link
US (1) US5939419A (sv)
EP (1) EP0686157A1 (sv)
JP (1) JPH08507068A (sv)
KR (1) KR960701058A (sv)
CN (1) CN1118600A (sv)
AU (1) AU681875B2 (sv)
CA (1) CA2156918A1 (sv)
FI (1) FI953981A0 (sv)
HU (1) HUT72640A (sv)
IL (1) IL108754A0 (sv)
NZ (1) NZ262797A (sv)
SG (1) SG43809A1 (sv)
TW (1) TW270118B (sv)
WO (1) WO1994019351A1 (sv)

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US6187779B1 (en) 1998-11-20 2001-02-13 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives
US6369092B1 (en) 1998-11-23 2002-04-09 Cell Pathways, Inc. Method for treating neoplasia by exposure to substituted benzimidazole derivatives
US6034099A (en) * 1998-11-24 2000-03-07 Cell Pathways, Inc. Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones
US6077842A (en) * 1998-11-24 2000-06-20 Cell Pathways, Inc. Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives
US6486155B1 (en) 1998-11-24 2002-11-26 Cell Pathways Inc Method of inhibiting neoplastic cells with isoquinoline derivatives
US6025394A (en) 1999-01-29 2000-02-15 Cell Pathways, Inc. Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
US6020379A (en) * 1999-02-19 2000-02-01 Cell Pathways, Inc. Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia
US6403799B1 (en) * 1999-10-21 2002-06-11 Agouron Pharmaceuticals, Inc. Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
AR036674A1 (es) * 2001-08-28 2004-09-29 Schering Corp Inhibidores de fosfodiesterasa v de guanina de policiclicos, composicion farmaceutica, y el uso de dichos compuestos para la preparacion de medicamentos para tratar desordenes fisiologicos
EP1790652A1 (en) * 2001-08-28 2007-05-30 Schering Corporation Polycyclic guanine phosphodiesterase V inhibitors
EP1575916B1 (en) 2001-08-31 2013-05-22 The Rockefeller University Phosphodiesterase activity and regulation of phosphodiesterase 1-b-mediated signaling in brain
EP1442042A1 (en) * 2001-11-09 2004-08-04 Schering Corporation Polycyclic guanine derivative phosphodiesterase v inhibitors
EP1719772A1 (en) 2002-05-31 2006-11-08 Schering Corporation Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof
WO2005012303A1 (en) * 2003-07-31 2005-02-10 Schering Corporation Metabolite of xanthine phosphodiesterase 5 inhibitor and derivatives thereof useful for treatment of erectile dysfunction
CA2546248A1 (en) * 2003-11-21 2005-06-09 Schering Corporation Phosphodiesterase v inhibitor formulations
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US20070004745A1 (en) * 2005-03-25 2007-01-04 Schering-Plough Corporation Methods of treating benign prostatic hyperplasia or lower urinary tract symptoms by using PDE 5 inhibitors
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PE20110944A1 (es) 2008-12-06 2012-01-25 Intra Cellular Therapies Inc DERIVADOS DE PIRAZOLO[3,4-d]PIRIMIDINA COMO INHIBIDORES PDE1
MA32941B1 (fr) 2008-12-06 2012-01-02 Intra Cellular Therapies Inc Composes organiques
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CN102232077A (zh) 2008-12-06 2011-11-02 细胞内治疗公司 有机化合物
WO2010098839A1 (en) 2009-02-25 2010-09-02 Intra-Cellular Therapies, Inc. Pde 1 inhibitors for ophthalmic disorders
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US8785639B2 (en) 2009-12-01 2014-07-22 Abbvie Inc. Substituted dihydropyrazolo[3,4-D]pyrrolo[2,3-B]pyridines and methods of use thereof
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US9434730B2 (en) 2010-05-31 2016-09-06 Intra-Cellular Therapies, Inc. PDE1 inhibitor compounds
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JP6549040B2 (ja) 2013-02-17 2019-07-24 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規使用
ES2717688T3 (es) 2013-03-15 2019-06-24 Intra Cellular Therapies Inc Inhibidores de la PDE1 para uso en el tratamiento y/o prevención de lesiones de SNC, y enfermedades, trastornos o lesiones de SNP
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Also Published As

Publication number Publication date
JPH08507068A (ja) 1996-07-30
AU6268794A (en) 1994-09-14
AU681875B2 (en) 1997-09-11
US5939419A (en) 1999-08-17
HUT72640A (en) 1996-05-28
KR960701058A (ko) 1996-02-24
WO1994019351A1 (en) 1994-09-01
HU9502464D0 (en) 1995-10-30
EP0686157A1 (en) 1995-12-13
CA2156918A1 (en) 1994-09-01
FI953981A0 (sv) 1995-08-24
IL108754A0 (en) 1994-06-24
NZ262797A (en) 1997-08-22
SG43809A1 (en) 1997-11-14
TW270118B (sv) 1996-02-11
CN1118600A (zh) 1996-03-13

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