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FI951731A - Heterosykliset yhdisteet, joilla on sokeritautia vastustava vaikutus, niiden valmistus ja käyttö - Google Patents

Heterosykliset yhdisteet, joilla on sokeritautia vastustava vaikutus, niiden valmistus ja käyttö Download PDF

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Publication number
FI951731A
FI951731A FI951731A FI951731A FI951731A FI 951731 A FI951731 A FI 951731A FI 951731 A FI951731 A FI 951731A FI 951731 A FI951731 A FI 951731A FI 951731 A FI951731 A FI 951731A
Authority
FI
Finland
Prior art keywords
group
formula
heterocyclic compounds
carboxylic acyl
atom
Prior art date
Application number
FI951731A
Other languages
English (en)
Swedish (sv)
Other versions
FI951731A0 (fi
Inventor
Takashi Fujita
Koichi Fujimoto
Takao Yoshioka
Hiroaki Yanagisawa
Toshihiko Fujiwara
Hiroyoshi Horikoshi
Minoru Oguchi
Kunio Wada
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of FI951731A0 publication Critical patent/FI951731A0/fi
Publication of FI951731A publication Critical patent/FI951731A/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
FI951731A 1994-04-11 1995-04-11 Heterosykliset yhdisteet, joilla on sokeritautia vastustava vaikutus, niiden valmistus ja käyttö FI951731A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7208394 1994-04-11

Publications (2)

Publication Number Publication Date
FI951731A0 FI951731A0 (fi) 1995-04-11
FI951731A true FI951731A (fi) 1995-10-12

Family

ID=13479165

Family Applications (1)

Application Number Title Priority Date Filing Date
FI951731A FI951731A (fi) 1994-04-11 1995-04-11 Heterosykliset yhdisteet, joilla on sokeritautia vastustava vaikutus, niiden valmistus ja käyttö

Country Status (22)

Country Link
US (6) US5624935A (fi)
EP (2) EP0676398B1 (fi)
KR (1) KR950032188A (fi)
CN (1) CN1060173C (fi)
AT (2) ATE207488T1 (fi)
AU (1) AU683348B2 (fi)
CA (1) CA2146701A1 (fi)
CZ (1) CZ289317B6 (fi)
DE (2) DE69523358T2 (fi)
DK (2) DK0676398T3 (fi)
ES (2) ES2180477T3 (fi)
FI (1) FI951731A (fi)
HK (2) HK1029338A1 (fi)
HU (1) HU219887B (fi)
ID (1) ID20564A (fi)
IL (1) IL113313A (fi)
NO (2) NO305987B1 (fi)
NZ (1) NZ270917A (fi)
PT (2) PT1022274E (fi)
RU (2) RU2151145C1 (fi)
TW (2) TW407156B (fi)
ZA (1) ZA952990B (fi)

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US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
IL118474A (en) * 1995-06-01 2001-08-08 Sankyo Co Benzimideol derivatives and pharmaceutical preparations containing them
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ZA973850B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them.
ZA973848B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
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US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
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RS60229B1 (sr) 2007-12-07 2020-06-30 Vertex Pharma Čvrsti oblici 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiridin-2-il) benzojeve kiseline
CN101463031B (zh) * 2007-12-20 2014-02-12 中国医学科学院药物研究所 吲唑及四氢吲唑类化合物及其制法和其药物组合物与用途
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Also Published As

Publication number Publication date
CN1060173C (zh) 2001-01-03
CZ91095A3 (en) 1997-12-17
CA2146701A1 (en) 1995-10-12
ATE207488T1 (de) 2001-11-15
DE69523358D1 (de) 2001-11-29
DE69523358T2 (de) 2002-07-11
AU1638395A (en) 1995-10-19
EP0676398A2 (en) 1995-10-11
US5624935A (en) 1997-04-29
AU683348B2 (en) 1997-11-06
NO951398D0 (no) 1995-04-10
TW503237B (en) 2002-09-21
EP1022274B1 (en) 2002-08-28
HU219887B (hu) 2001-08-28
DK0676398T3 (da) 2001-12-10
HU9501040D0 (en) 1995-06-28
NO983900D0 (no) 1998-08-25
PT1022274E (pt) 2002-11-29
RU2151145C1 (ru) 2000-06-20
NO951398L (no) 1995-10-12
DE69528000T2 (de) 2003-05-28
DK1022274T3 (da) 2002-10-28
US5739345A (en) 1998-04-14
CN1118781A (zh) 1996-03-20
US5977365A (en) 1999-11-02
HUT73765A (en) 1996-09-30
ZA952990B (en) 1995-12-21
TW407156B (en) 2000-10-01
US6117893A (en) 2000-09-12
US5834501A (en) 1998-11-10
EP0676398A3 (en) 1998-07-01
PT676398E (pt) 2002-03-28
US5962470A (en) 1999-10-05
IL113313A0 (en) 1995-07-31
EP0676398B1 (en) 2001-10-24
FI951731A0 (fi) 1995-04-11
HK1011365A1 (en) 1999-07-09
EP1022274A1 (en) 2000-07-26
DE69528000D1 (de) 2002-10-02
NO305987B1 (no) 1999-08-30
ID20564A (id) 1999-01-14
ES2180477T3 (es) 2003-02-16
HK1029338A1 (en) 2001-03-30
IL113313A (en) 1999-09-22
NO307299B1 (no) 2000-03-13
NO983900L (no) 1995-10-12
ES2165895T3 (es) 2002-04-01
RU2114844C1 (ru) 1998-07-10
ATE222895T1 (de) 2002-09-15
RU95105423A (ru) 1997-03-20
CZ289317B6 (cs) 2002-01-16
NZ270917A (en) 1996-12-20
KR950032188A (ko) 1995-12-20

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