FI944823A - Galantamiinijohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö lääkeaineissa - Google Patents

Galantamiinijohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö lääkeaineissa Download PDF

Info

Publication number: FI944823A
Authority: FI; Finland
Prior art keywords: pharmaceuticals; processes; preparation; compounds; galantamine derivatives
Prior art date: 1993-10-15

Application number

FI944823A

Other languages

English (en)

Swedish (sv)

Other versions

FI944823A0 (fi

FI108722B (fi

Inventor

Jr Raymond J Kosley

Larry Davis

Veronica Taberna

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-15

Filing date

1994-10-13

Publication date

1995-04-16

1994-10-13 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1994-10-13 Publication of FI944823A0 publication Critical patent/FI944823A0/fi

1995-04-16 Publication of FI944823A publication Critical patent/FI944823A/fi

2002-03-15 Application granted granted Critical

2002-03-15 Publication of FI108722B publication Critical patent/FI108722B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Psychiatry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

FI944823A 1993-10-15 1994-10-13 Menetelmä terapeuttisesti käyttökelpoisten 4a,5,9,10,11,12-heksahydro-11-metyyli-6H-bentsofuro[3a,3,2-ef][2]bentsatsepiini-3,6-diolin alkyylikarbonyyli- ja alkoksikarbonyylijohdannaisten valmistamiseksi FI108722B (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US13744493		1993-10-15
US08/137,444 US6316439B1 (en)	1993-10-15	1993-10-15	Galanthamine derivatives as acetylcholinesterase inhibitors

Publications (3)

Publication Number	Publication Date
FI944823A0 FI944823A0 (fi)	1994-10-13
FI944823A true FI944823A (fi)	1995-04-16
FI108722B FI108722B (fi)	2002-03-15

Family

ID=22477461

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI944823A FI108722B (fi)	1993-10-15	1994-10-13	Menetelmä terapeuttisesti käyttökelpoisten 4a,5,9,10,11,12-heksahydro-11-metyyli-6H-bentsofuro[3a,3,2-ef][2]bentsatsepiini-3,6-diolin alkyylikarbonyyli- ja alkoksikarbonyylijohdannaisten valmistamiseksi

Country Status (23)

Country	Link
US (1)	US6316439B1 (fi)
EP (1)	EP0649846B1 (fi)
JP (1)	JP2664343B2 (fi)
KR (1)	KR100227957B1 (fi)
CN (1)	CN1039910C (fi)
AT (1)	ATE211474T1 (fi)
AU (1)	AU696170B2 (fi)
CA (1)	CA2118172C (fi)
CZ (1)	CZ283731B6 (fi)
DE (1)	DE69429570T2 (fi)
DK (1)	DK0649846T3 (fi)
EG (1)	EG20726A (fi)
ES (1)	ES2170759T3 (fi)
FI (1)	FI108722B (fi)
IL (1)	IL111275A (fi)
NO (1)	NO307464B1 (fi)
NZ (1)	NZ264682A (fi)
PL (1)	PL177549B1 (fi)
PT (1)	PT649846E (fi)
RO (1)	RO114134B1 (fi)
RU (1)	RU2109743C1 (fi)
TW (1)	TW289754B (fi)
ZA (1)	ZA948061B (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT403803B (de)	1996-04-19	1998-05-25	Sanochemia Ltd	Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
MXPA02005667A (es) *	1999-12-10	2004-09-10	Bonnie Davis	Analogos de galantamina y licoramina como moduladores de los receptores nicotinicos.
WO2002088138A1 (en) *	2001-04-30	2002-11-07	Bayer Corporation	Novel 4-amino-5,6-substituted thiopheno[2,3-d]pyrimidines
US20030162770A1 (en) *	2002-02-22	2003-08-28	Davis Bonnie M.	Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US20040254146A1 (en) *	2002-05-21	2004-12-16	Nastech Pharmaceutical Company Inc.	Carboxylate salts of galantamine and their pharmaceutical use
US20050143350A1 (en) *	2003-11-19	2005-06-30	Seed John C.	Combination drug therapy to treat obesity
US20050142193A1 (en) *	2003-12-31	2005-06-30	Lijuan Tang	Galantamine formulations
CA2551946A1 (en) *	2003-12-31	2005-07-21	Actavis Group Hf	Immediate, controlled and sustained release formulations of galantamine
EP1779867A4 (en) *	2004-07-01	2009-12-02	Eisai R&D Man Co Ltd	MEANS FOR PROMOTING NERVE REVENERATION
EP1827468B1 (en) *	2004-12-23	2012-08-22	Curaxis Pharmaceutical Corporation	Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease
DK1895994T3 (da) *	2005-05-13	2010-12-20	Alza Corp	Multilagsmedikamentleveringssystem med barriere mod reservoirmaterialeflow
US20080188510A1 (en) *	2005-05-23	2008-08-07	Eisai R & D Management Co., Ltd.	Novel methods using zonisamide
US20090253654A1 (en)	2005-09-22	2009-10-08	Galantos Pharma Gmbh	Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
US20070104771A1 (en) *	2005-09-23	2007-05-10	Jay Audett	Transdermal galantamine delivery system
CA2721007C (en)	2008-04-14	2014-04-29	Galantos Pharma Gmbh	Derivatives of galantamine as pro-drugs for the treatment of human brain diseases
BR112012001551A2 (pt) *	2009-07-23	2017-07-11	Shire Llc	profármacos de aminoácido galantamina e peptídeo e usos dos mesmos
EP3142669A2 (en) *	2014-05-16	2017-03-22	Synaptec Development LLC	CLEARANCE OF AMYLOID ß
EP4029867A1 (en)	2021-01-13	2022-07-20	Alpha Cognition Inc.	Solid forms of galantamine benzoate gluconate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL122665B1 (en)	1978-11-21	1982-08-31	Edinen Zentar Chim	Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en)	1986-01-15	1987-05-05	Bonnie Davis	Method of treating Alzheimer's disease
US6150354A (en) *	1987-01-15	2000-11-21	Bonnie Davis	Compounds for the treatment of Alzheimer's disease
ATE411026T1 (de) *	1987-05-04	2008-10-15	Bonnie Davis	Mittel zur behandlung der alzheimer-krankheit
NL8800350A (nl)	1988-02-12	1989-09-01	Stichting Biomedical Research	Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
EP0584185B1 (en)	1991-05-14	1999-08-11	Ernir Snorrason	Treatment of fatigue syndrome with cholinesterase inhibitors
US5153193A (en)	1991-10-01	1992-10-06	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

1993
- 1993-10-15 US US08/137,444 patent/US6316439B1/en not_active Expired - Lifetime
1994
- 1994-10-10 DE DE69429570T patent/DE69429570T2/de not_active Expired - Lifetime
- 1994-10-10 AT AT94115961T patent/ATE211474T1/de active
- 1994-10-10 EP EP94115961A patent/EP0649846B1/en not_active Expired - Lifetime
- 1994-10-10 ES ES94115961T patent/ES2170759T3/es not_active Expired - Lifetime
- 1994-10-10 PT PT94115961T patent/PT649846E/pt unknown
- 1994-10-10 DK DK94115961T patent/DK0649846T3/da active
- 1994-10-13 NZ NZ264682A patent/NZ264682A/en not_active IP Right Cessation
- 1994-10-13 RU RU94036745A patent/RU2109743C1/ru active
- 1994-10-13 FI FI944823A patent/FI108722B/fi not_active IP Right Cessation
- 1994-10-13 IL IL11127594A patent/IL111275A/xx not_active IP Right Cessation
- 1994-10-14 TW TW083109527A patent/TW289754B/zh not_active IP Right Cessation
- 1994-10-14 KR KR1019940026305A patent/KR100227957B1/ko active IP Right Grant
- 1994-10-14 RO RO94-01670A patent/RO114134B1/ro unknown
- 1994-10-14 CZ CZ942545A patent/CZ283731B6/cs not_active IP Right Cessation
- 1994-10-14 ZA ZA948061A patent/ZA948061B/xx unknown
- 1994-10-14 CA CA002118172A patent/CA2118172C/en not_active Expired - Lifetime
- 1994-10-14 AU AU75813/94A patent/AU696170B2/en not_active Expired
- 1994-10-14 NO NO943895A patent/NO307464B1/no not_active IP Right Cessation
- 1994-10-14 CN CN94117062A patent/CN1039910C/zh not_active Expired - Lifetime
- 1994-10-14 PL PL94305457A patent/PL177549B1/pl unknown
- 1994-10-15 EG EG64694A patent/EG20726A/xx active
- 1994-10-17 JP JP6250777A patent/JP2664343B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NZ264682A (en)	1995-07-26
EG20726A (en)	1999-12-29
AU7581394A (en)	1995-05-04
CZ254594A3 (en)	1995-07-12
DE69429570D1 (de)	2002-02-07
AU696170B2 (en)	1998-09-03
KR100227957B1 (ko)	1999-11-01
FI944823A0 (fi)	1994-10-13
IL111275A (en)	2003-01-12
NO307464B1 (no)	2000-04-10
EP0649846A1 (en)	1995-04-26
PL177549B1 (pl)	1999-12-31
TW289754B (fi)	1996-11-01
KR950011445A (ko)	1995-05-15
NO943895L (no)	1995-04-18
DK0649846T3 (da)	2002-04-15
US6316439B1 (en)	2001-11-13
DE69429570T2 (de)	2002-08-29
CZ283731B6 (cs)	1998-06-17
EP0649846B1 (en)	2002-01-02
ES2170759T3 (es)	2002-08-16
JP2664343B2 (ja)	1997-10-15
PT649846E (pt)	2002-06-28
CN1108657A (zh)	1995-09-20
NO943895D0 (no)	1994-10-14
RU94036745A (ru)	1996-12-10
PL305457A1 (en)	1995-04-18
CA2118172C (en)	2000-01-04
RU2109743C1 (ru)	1998-04-27
JPH07188239A (ja)	1995-07-25
CN1039910C (zh)	1998-09-23
IL111275A0 (en)	1994-12-29
ATE211474T1 (de)	2002-01-15
ZA948061B (en)	1995-06-06
FI108722B (fi)	2002-03-15
RO114134B1 (ro)	1999-01-29
CA2118172A1 (en)	1995-04-16

Publication	Publication Date	Title
FI944823A (fi)	1995-04-16	Galantamiinijohdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö lääkeaineissa
TR200003478T2 (tr)	2001-03-21	Antikanser maddeleri olarak faydalı izotiyazol türevleri
DE3775882D1 (de)	1992-02-20	Substituierte 6-fluor-4-oxo-1,4-dihydrochinolin-3-carbonsaeuren ; deren derivate; diese verbindung enthaltende pharmazeutische zubereitungen und verfahren zur herstellung dieser verbindungen.
CA2258548A1 (en)	1997-12-31	Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
IL109526A0 (en)	1994-08-26	Benzofuranyl- and thiophenyl-alkanecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
DE69716810D1 (de)	2002-12-12	2,3-Disubstituierte-(5,6)-heteroarylkondensierte-pyrimidin-4-one
FI920023A0 (fi)	1992-01-03	Heteroarylpiperazinfoereningar som antipsykotiska aemnen.
PT992509E (pt)	2004-12-31	Novos derivados macrolidos
DE69008142D1 (de)	1994-05-19	4-Substituierten Imidazolen zur Senkung des intraokularen Druckes.
MA23639A1 (fr)	1996-04-01	Derives pyrrocarbazole, leur preparation, les compositions pharmaceutiques les contenant, leur utilisation dans le traitement des tumeurs malignes.
FI935800A0 (fi)	1993-12-22	Antidepressiva och mot Parkisons sjukdom verksamma foereningar
FI960658A0 (fi)	1996-02-14	Uudet bis-naftalimidit syövän hoitamiseksi
DE69330601D1 (de)	2001-09-20	Serotoninergische ergolin derivate
FR2681864B1 (fr)	1995-03-31	Nouveaux derives bicycliques azotes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
HUT70761A (en)	1995-10-30	Alkyl derivatives of trazodone having action for central nervous system, pharmaceutical compositions for preparing thereof
ES2062214T3 (es)	1994-12-16	Derivados de aminooligohidroxi inhibidores de renina.
ITMI920082A1 (it)	1993-07-17	Derivati solforati di acidi biliari
WO2000008006A3 (en)	2000-08-03	Piperidine and piperazine derivatives, process for their preparation and pharmaceutical compounds containing them
PT889044E (pt)	2005-01-31	Derivados do 5-(heteroaril)alquil-3-oxo-pirido-(1,2-a)benzimidazole-4-carboxamida (pbi) uteis no tratamento de perturbacoes do sistema nervoso central
DE69908855D1 (de)	2003-07-24	9a, 11b-dehydro Derivative von 9-oxime-3-keto-6-0-methylerythromycin

Legal Events

Date	Code	Title	Description
1997-06-12	GB	Transfer or assigment of application	Owner name: HOECHST MARION ROUSSEL, INC.
2010-06-09	PC	Transfer of assignment of patent	Owner name: AVENTISUB II INC. Free format text: AVENTISUB II INC.
2014-11-19	MA	Patent expired

Date

Code

Title

Description

1997-06-12

Transfer or assigment of application

Owner name: HOECHST MARION ROUSSEL, INC.

2010-06-09

Transfer of assignment of patent

Owner name: AVENTISUB II INC.

Free format text: AVENTISUB II INC.

2014-11-19

Patent expired