FI921900A - Inhibitorer av purinukleosid- fosforylas. - Google Patents

Inhibitorer av purinukleosid- fosforylas. Download PDF

Info

Publication number: FI921900A
Authority: FI; Finland
Prior art keywords: purinucleosid; inhibitorer; phosphoryl
Prior art date: 1989-10-31

Application number

FI921900A

Other languages

English (en)

Other versions

FI103972B1 (fi

FI103972B (fi

FI921900A0 (fi

Inventor

John A Secrist Iii

Mark David Erion

John A Montgomery

Steven E Ealick

Wayne C Guida

Shri Niwas

Original Assignee

Biocryst Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-31

Filing date

1992-04-28

Publication date

1992-04-28

1989-10-31 Priority claimed from US07/429,100 external-priority patent/US4985433A/en

1989-10-31 Priority claimed from US07/429,099 external-priority patent/US5008265A/en

1989-10-31 Priority claimed from US07/429,098 external-priority patent/US4985434A/en

1989-10-31 Priority claimed from US07/429,097 external-priority patent/US5008270A/en

1992-04-28 Application filed by Biocryst Pharm Inc filed Critical Biocryst Pharm Inc

1992-04-28 Publication of FI921900A0 publication Critical patent/FI921900A0/fi

1992-04-28 Publication of FI921900A publication Critical patent/FI921900A/fi

1999-10-29 Application granted granted Critical

1999-10-29 Publication of FI103972B1 publication Critical patent/FI103972B1/fi

1999-10-29 Publication of FI103972B publication Critical patent/FI103972B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/31—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/35—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/40—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by doubly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

FI921900A 1989-10-31 1992-04-28 Menetelmä puriininukleosidifosforylaasi-inhibiittorien valmistamiseksi FI103972B (fi)

Applications Claiming Priority (12)

Application Number	Priority Date	Filing Date	Title
US42909789		1989-10-31
US07/429,100 US4985433A (en)	1989-10-31	1989-10-31	2-amino-7-(pyridinylmethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US07/429,099 US5008265A (en)	1989-10-31	1989-10-31	2-amino-7-(alicyclomethyl)-3H,5H,-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US42909889		1989-10-31
US42910089		1989-10-31
US07/429,098 US4985434A (en)	1989-10-31	1989-10-31	7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimidin-4-ones and pharamceutical uses and compositions containing the same
US42909989		1989-10-31
US07/429,097 US5008270A (en)	1989-10-31	1989-10-31	2-amino-7-(heterocyclomethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same
US44279889A	1989-11-29	1989-11-29
US44279889		1989-11-29
PCT/US1990/005756 WO1991006548A1 (en)	1989-10-31	1990-10-12	Inhibitors of purine nucleoside phosphorylase
US9005756		1990-10-12

Publications (4)

Publication Number	Publication Date
FI921900A0 FI921900A0 (fi)	1992-04-28
FI921900A true FI921900A (fi)	1992-04-28
FI103972B1 FI103972B1 (fi)	1999-10-29
FI103972B FI103972B (fi)	1999-10-29

Family

ID=27541578

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI921900A FI103972B (fi)	1989-10-31	1992-04-28	Menetelmä puriininukleosidifosforylaasi-inhibiittorien valmistamiseksi

Country Status (9)

Country	Link
EP (1)	EP0500653A4 (fi)
JP (1)	JP2866478B2 (fi)
AU (1)	AU654264B2 (fi)
CA (1)	CA2072123C (fi)
FI (1)	FI103972B (fi)
HU (1)	HUT61765A (fi)
LV (1)	LV10100B (fi)
NO (1)	NO301423B1 (fi)
WO (1)	WO1991006548A1 (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5726311A (en) *	1989-11-29	1998-03-10	Biocryst Pharmaceuticals, Inc.	7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo 3,2-d!pyrimidine and pharmaceutical uses and compositions containing the same
US5236926A (en) *	1992-02-03	1993-08-17	Warner-Lambert Company	9-substituted-8-halo or -8-hydroxy-9-deazaguanines as inhibitors or PNP for pharmaceutical compositions
KR950701335A (ko) *	1992-04-21	1995-03-23	존 에어. 몽고메리	7-이치환된 메틸-4-옥소-3H,5H-피롤로[3,2-d]-피리미딘 및 이를 함유하는 약제 조성물
HUT77436A (hu) *	1994-10-05	1998-04-28	Darwin Discovery Limited	Purin- és guaninszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk gyógyszerkészítmények előállítására
GB9520364D0 (en) *	1995-10-05	1995-12-06	Chiroscience Ltd	Compouundds
GB9520363D0 (en) *	1995-10-05	1995-12-06	Chiroscience Ltd	Compounds
BR9809178A (pt) *	1997-05-29	2000-08-01	Novartis Ag	2-amino-7-(1-substituìdo-2-hidroxietil)-3,5-dihidro-pir rolo[3,2-d]pirimidin-4-onas
US6174888B1 (en)	1998-05-28	2001-01-16	Novartis Ag	2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydropyrrolo[3,2-D]pyrimidin-4-ones
JP4496586B2 (ja) *	2000-01-24	2010-07-07	日産化学工業株式会社	キノリルアクリロニトリルの製造法及びその中間体
US7553839B2 (en) *	2002-08-21	2009-06-30	Industrial Research Limited	5h-pyrrolo[3,2-D] pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
NZ523970A (en) *	2003-02-04	2005-02-25	Ind Res Ltd	Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
US8466151B2 (en)	2007-12-26	2013-06-18	Critical Outcome Technologies, Inc.	Compounds and method for treatment of cancer
CA2999321A1 (en)	2008-07-17	2010-01-21	Critical Outcome Technologies Inc.	Thiosemicarbazone inhibitor compounds and cancer treatment methods
CA2999435A1 (en)	2010-04-01	2011-10-06	Critical Outcome Technologies Inc.	Compounds and method for treatment of hiv

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5988484A (ja) *	1982-11-09	1984-05-22	Takeda Chem Ind Ltd	新規７−デアザプリン誘導体
IE60433B1 (en) *	1986-08-26	1994-07-13	Warner Lambert Co	Novel 9-deazaguanines
CA1294960C (en) *	1986-10-24	1992-01-28	Thomas C. Malone	7-deazaguanines as immunomodulators
US4921858A (en) *	1986-10-24	1990-05-01	Warner-Lambert Company	7-deazaguanines as immunomodulators
DE3726044A1 (de) *	1987-02-11	1988-08-25	Bayer Ag	Akarizide mittel auf basis von azomethinderivaten und azomethine des 2,3-diaminomaleinsaeurenitrils
US4927830A (en) *	1988-04-08	1990-05-22	The Regents Of The University Of Michigan	Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents
CA2047216C (en) *	1989-02-27	1999-03-30	John A. Secrist, Iii	9-substituted-8-unsubstituted-9-deazaguanines
US4985434A (en) *	1989-10-31	1991-01-15	Biocryst, Inc.	7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimidin-4-ones and pharamceutical uses and compositions containing the same
US4985433A (en) *	1989-10-31	1991-01-15	Biocryst, Inc.	2-amino-7-(pyridinylmethyl)-3H,5H-pyrrolo[3,2-d]pyrimidin-4-ones and pharmaceutical uses and compositions containing the same

1990
- 1990-10-12 JP JP2515550A patent/JP2866478B2/ja not_active Expired - Lifetime
- 1990-10-12 AU AU67125/90A patent/AU654264B2/en not_active Ceased
- 1990-10-12 WO PCT/US1990/005756 patent/WO1991006548A1/en not_active Application Discontinuation
- 1990-10-12 EP EP90916628A patent/EP0500653A4/en not_active Withdrawn
- 1990-10-12 HU HU9201450A patent/HUT61765A/hu unknown
- 1990-10-12 CA CA002072123A patent/CA2072123C/en not_active Expired - Fee Related
1992
- 1992-04-28 FI FI921900A patent/FI103972B/fi active
- 1992-04-29 NO NO921679A patent/NO301423B1/no not_active IP Right Cessation
1993
- 1993-05-14 LV LVP-93-342A patent/LV10100B/en unknown

Also Published As

Publication number	Publication date
NO921679L (no)	1992-06-17
LV10100A (lv)	1994-05-10
HUT61765A (en)	1993-03-01
CA2072123C (en)	2001-06-12
JP2866478B2 (ja)	1999-03-08
AU654264B2 (en)	1994-11-03
WO1991006548A1 (en)	1991-05-16
EP0500653A1 (en)	1992-09-02
CA2072123A1 (en)	1991-05-01
NO301423B1 (no)	1997-10-27
FI103972B1 (fi)	1999-10-29
HU9201450D0 (en)	1992-09-28
EP0500653A4 (en)	1995-08-23
LV10100B (en)	1995-08-20
NO921679D0 (no)	1992-04-29
AU6712590A (en)	1991-05-31
FI103972B (fi)	1999-10-29
FI921900A0 (fi)	1992-04-28
JPH05504551A (ja)	1993-07-15

Publication	Publication Date	Title
FI890552A0 (fi)	1989-02-06	Maetning av blodets sammansaettning.
FI890429A (fi)	1990-07-28	Foerfarande foer framstaellning av vaeteperoxid.
FI921900A0 (fi)	1992-04-28	Inhibitorer av purinukleosid- fosforylas.
FI83359B (fi)	1991-03-15	Foerfarande foer framstaellning av en takskiva.
FI890463A (fi)	1990-08-01	Foerfarande foer detektering av metallstycken.
FI890765A (fi)	1990-08-17	Nytt foerfarande foer framstaellning av en polymeriseringskatalysatorkomponent foer olefiner.
FI890428A0 (fi)	1989-01-27	Foerfarande foer framstaellning av vaeteperoxid.
FI890963A0 (fi)	1989-03-01	Foerfarande foer behandling av braenngas producerad av avlutar fraon alkaliska cellulosaprocesser.
FI86245B (fi)	1992-04-30	Foerfarande foer tillverkning av en konserv.
FI890360A0 (fi)	1989-01-25	Anlaeggning foer roekning av livsmedel.
FI890397A (fi)	1990-07-28	Industriell framstaellning av torrkoett.
FI890061A (fi)	1990-07-06	Foerfarande foer styrning av en mekanisk resonanshand.
FI890212A (fi)	1990-07-17	Anordning foer odling av mikroorganismer.
FI890222A (fi)	1990-07-17	Foerfarande foer framstaellning av granulerade peroxidfoereningar.
FI890330A0 (fi)	1989-01-23	Foerfarande foer framstaellning av laminatmaterial.
FI890057A (fi)	1990-07-06	Anordning foer vaendning av buntar.
FI890371A (fi)	1990-07-26	Gripanordning foer en gaffeltruck foer lyftning av en rullpall.
FI890025A0 (fi)	1989-01-04	Anordning foer lottning av lottonummer.
FI890378A (fi)	1990-07-27	Knivarrangemang foer framstaellning av granultorv.
FI890680A0 (fi)	1989-02-13	Aong- och kondensatkoppling foer torkningscylindern av en pappersmaskin.
FI890546A0 (fi)	1989-02-06	Anordning foer tillverkning av en katsa.
FI890023A0 (fi)	1989-01-04	Stroemkrets foer aostadkommande av stroembegraensad spaenningstillfoersel.
FI890596A (fi)	1990-08-09	Foerfarande foer framstaellning av terapeutiskt anvaendbara oxadiazolyl-azabicykloheptaner.
FI890597A (fi)	1990-08-09	Foerfarande foer framstaellning av terapeutiskt anvaendbara lipofiliska oxadiazoler.
FI890610A (fi)	1990-08-10	Anordning foer lyftande av fiskar.