FI920486A0 - Bensimidazoler, dess foereningar innehaollande laekemedel och foerfarande foer deras framstaellning. - Google Patents

Bensimidazoler, dess foereningar innehaollande laekemedel och foerfarande foer deras framstaellning.

Info

Publication number: FI920486A0
Authority: FI; Finland
Prior art keywords: benzimidazolyl; alkyl; substd; opt; cooh
Prior art date: 1991-02-06

Application number

FI920486A

Other languages

English (en)

Other versions

FI105547B (fi

FI920486A (fi

Inventor

Norbert Hauel

Berthold Narr

Uwe Ries

Meel Jacques Van

Wolfgang Wienen

Michael Entzeroth

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-06

Filing date

1992-02-05

Publication date

1992-02-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27202166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI920486(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1991-02-06 Priority claimed from DE4103492A external-priority patent/DE4103492A1/de

1992-02-05 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1992-02-05 Publication of FI920486A0 publication Critical patent/FI920486A0/fi

1992-08-07 Publication of FI920486A publication Critical patent/FI920486A/fi

2000-09-15 Application granted granted Critical

2000-09-15 Publication of FI105547B publication Critical patent/FI105547B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Professional, Industrial, Or Sporting Protective Garments (AREA)
Electroluminescent Light Sources (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Battery Electrode And Active Subsutance (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

FI920486A 1991-02-06 1992-02-05 Menetelmä valmistaa farmaseuttisesti käyttökelpoisia bentsimidatsoleja FI105547B (fi)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
DE4103492A DE4103492A1 (de)	1991-02-06	1991-02-06	Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4103492		1991-02-06
DE4117121		1991-05-25
DE4117121A DE4117121A1 (de)	1991-02-06	1991-05-25	Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4137812		1991-11-16
DE4137812A DE4137812A1 (de)	1991-02-06	1991-11-16	Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (3)

Publication Number	Publication Date
FI920486A0 true FI920486A0 (fi)	1992-02-05
FI920486A FI920486A (fi)	1992-08-07
FI105547B FI105547B (fi)	2000-09-15

Family

ID=27202166

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI920486A FI105547B (fi)	1991-02-06	1992-02-05	Menetelmä valmistaa farmaseuttisesti käyttökelpoisia bentsimidatsoleja

Country Status (26)

Country	Link
EP (1)	EP0502314B1 (fi)
JP (1)	JP2709225B2 (fi)
AT (1)	ATE166346T1 (fi)
BG (1)	BG62309B2 (fi)
CA (1)	CA2060624C (fi)
CH (1)	CH0502314H1 (fi)
CZ (1)	CZ287607B6 (fi)
DE (2)	DE59209330C5 (fi)
DK (1)	DK0502314T3 (fi)
ES (1)	ES2118095T4 (fi)
FI (1)	FI105547B (fi)
HK (1)	HK1011145A1 (fi)
HR (1)	HRP940752B1 (fi)
HU (2)	HU217084B (fi)
IE (1)	IE81111B1 (fi)
IL (1)	IL100864A (fi)
LU (3)	LU90372I2 (fi)
MX (1)	MX9200509A (fi)
NL (2)	NL990007I2 (fi)
NO (3)	NO301585B1 (fi)
NZ (1)	NZ241515A (fi)
PL (1)	PL169675B1 (fi)
RU (1)	RU2053229C1 (fi)
SG (1)	SG50481A1 (fi)
SI (1)	SI9210098B (fi)
SK (1)	SK279261B6 (fi)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4224752A1 (de) *	1992-04-11	1994-02-03	Thomae Gmbh Dr K	Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4224133A1 (de) *	1992-07-22	1994-01-27	Thomae Gmbh Dr K	Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4225756A1 (de)	1992-01-22	1994-03-10	Thomae Gmbh Dr K	Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
TW274551B (fi) *	1991-04-16	1996-04-21	Takeda Pharm Industry Co Ltd
DE4207904A1 (de) *	1992-03-12	1993-09-16	Thomae Gmbh Dr K	Substituierte benzimidazolylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5972990A (en) †	1992-04-10	1999-10-26	Brigham And Women's Hospital, Inc.	Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
GB9218449D0 (en)	1992-08-29	1992-10-14	Boots Co Plc	Therapeutic agents
DE4315349A1 (de) *	1992-10-06	1994-11-10	Thomae Gmbh Dr K	Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
JP3057471B2 (ja)	1993-06-07	2000-06-26	武田薬品工業株式会社	アンジオテンシンｉｉ介在性諸疾患の予防または治療剤
DE4408497A1 (de) *	1994-03-14	1995-09-21	Thomae Gmbh Dr K	Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
MY119312A (en) *	1995-10-06	2005-05-31	Novartis Ag	At 1-receptor antagonists for preventing and treating postischemic renal failure and for protecting ischemic kidneys
TW453999B (en) *	1997-06-27	2001-09-11	Fujisawa Pharmaceutical Co	Benzimidazole derivatives
AU742506B2 (en) *	1997-10-17	2002-01-03	Eurogene Limited	The use of inhibitors of the renin-angiotensin system
AU1042199A (en) *	1998-11-06	2000-05-29	Boehringer Ingelheim International Gmbh	Antihypertensive medicaments containing lacidipine and telmisartan
CN1636561A (zh) *	1998-12-23	2005-07-13	诺瓦提斯公司	At－1受体拮抗剂在治疗与at－1受体增加有关的疾病中的应用
EP1013273A1 (en) *	1998-12-23	2000-06-28	Novartis AG	Use of AT-1 receptor antagonist or AT-2 receptor modulator for treating diseases associated with an increase of AT-1 or AT-2 receptors
US6358986B1 (en)	1999-01-19	2002-03-19	Boehringer Ingelheim Pharma Kg	Polymorphs of telmisartan
DE19901921C2 (de) *	1999-01-19	2001-01-04	Boehringer Ingelheim Pharma	Polymorphe von Telmisartan, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung eines Arzneimittels
SE9903028D0 (sv)	1999-08-27	1999-08-27	Astra Ab	New use
PE20020617A1 (es)	2000-08-22	2002-08-05	Novartis Ag	Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina
DE10153737A1 (de) *	2001-10-31	2003-05-28	Boehringer Ingelheim Pharma	Kristallines Natriumsalz des Telmisartans, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US6737432B2 (en)	2001-10-31	2004-05-18	Boehringer Ingelheim Pharma Kg	Crystalline form of telmisartan sodium
KR100876302B1 (ko) †	2002-01-16	2008-12-31	베링거 잉겔하임 파르마 게엠베하 운트 코 카게	사실상 비결정질 형태인 텔미사르탄의 제조방법
EG24716A (en)	2002-05-17	2010-06-07	Novartis Ag	Combination of organic compounds
DE10335027A1 (de)	2003-07-31	2005-02-17	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verwendung von Angiotensin II Rezeptor Antagonisten
DE10306179A1 (de)	2003-02-13	2004-08-26	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verwendung von Dipyridamol in Kombination mit Acetylsalicylsäure und einem Angiotensin II-Antagonisten zur Schlaganfall-Prophylaxe
DE10314702A1 (de) *	2003-03-31	2004-10-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung von Telmisartan
US9029363B2 (en)	2003-04-30	2015-05-12	Boehringer Ingelheim International Gmbh	Telmisartan sodium salt pharmaceutical formulation
DE10319450A1 (de) *	2003-04-30	2004-11-18	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pharmazeutische Formulierung des Telmisartan Natriumsalzes
DE10319592A1 (de) *	2003-05-02	2004-11-18	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Behandlung von diabetischer Retinopathie mit Angiotensin II-Rezeptorblockern
US7732162B2 (en)	2003-05-05	2010-06-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0316546D0 (en)	2003-07-15	2003-08-20	Novartis Ag	Process for the manufacture of organic compounds
US7829552B2 (en)	2003-11-19	2010-11-09	Metabasis Therapeutics, Inc.	Phosphorus-containing thyromimetics
GB2414019A (en)	2004-05-11	2005-11-16	Cipla Ltd	One-step preparation of telmisartan by condensation and hydrolysis
MX2007004426A (es) *	2004-10-15	2007-06-14	Teva Pharma	Procesos para preparar telmisartan.
WO2006046593A1 (ja)	2004-10-27	2006-05-04	Daiichi Sankyo Company, Limited	２以上の置換基を有するベンゼン化合物
ITMI20050801A1 (it)	2005-05-03	2006-11-04	Dipharma Spa	Procedimento per la preparazione di telmisartan
WO2006136916A2 (en) *	2005-06-20	2006-12-28	Glenmark Pharmaceuticals Limited	Substantially pure micronized particles of telmisartan and pharmaceutical compositions containing same
US7884214B2 (en) *	2005-07-19	2011-02-08	Matrix Laboratories Limited	Process for the preparation of Telmisartan
ES2246742B1 (es) *	2005-09-06	2007-02-01	Prous Institute For Biomedical Research S.A.	Uso de un derivado de imidazol.
EP1908469A1 (en)	2006-10-06	2008-04-09	Boehringer Ingelheim Vetmedica Gmbh	Angiotensin II receptor antagonist for the treatment of systemic diseases in cats
US8242151B2 (en)	2007-02-07	2012-08-14	Kyowa Hakko Kirin Co., Ltd.	Tricyclic compounds
FR2916757B1 (fr) *	2007-05-30	2009-07-17	Servier Lab	Nouveaux derives diazeniumdiolates,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US20100120694A1 (en)	2008-06-04	2010-05-13	Synergy Pharmaceuticals, Inc.	Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7879802B2 (en)	2007-06-04	2011-02-01	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
TWI406850B (zh) *	2007-06-05	2013-09-01	Theravance Inc	雙效苯并咪唑抗高血壓劑
CN101743228B (zh) *	2007-07-03	2014-01-29	新梅斯托克尔卡托瓦纳兹德拉韦尔公司	替米沙坦的制备方法
CA2705921A1 (en) *	2007-12-11	2009-06-18	Theravance, Inc.	Dual-acting benzoimidazole derivatives and their use as antihypertensive agents
US8445693B2 (en)	2008-03-20	2013-05-21	Lek Pharmaceuticals D.D.	Catalyzed carbonylation in the synthesis of angiotensin II antagonists
EP2103588A1 (en)	2008-03-20	2009-09-23	Lek Pharmaceuticals D.D.	2'-Halobiphenyl-4-yl intermediates in the synthesis of angiotensin II antagonists
EP2103609A1 (en)	2008-03-20	2009-09-23	Lek Pharmaceuticals D.D.	Catalyzed carbonylation in the synthesis of angiotensin ii antagonists
WO2009123483A1 (en)	2008-03-31	2009-10-08	Zaklady Farmaceutyczne Polpharma Sa	Process for preparation of telmisartan
WO2009135646A2 (en)	2008-05-05	2009-11-12	Farmaprojects, Sa	Stable pharmaceutical compositions and their processes for preparation suitable for industrial scale
EP2123648A1 (en)	2008-05-20	2009-11-25	Chemo Ibérica, S.A.	A process for the preparation of Telmisartan.
WO2010004385A1 (en) *	2008-06-17	2010-01-14	Aurobindo Pharma Limited	Process for the preparation of pure 4'-[4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid
EP2149566A1 (en)	2008-07-15	2010-02-03	Chemo Ibérica, S.A.	A process for the preparation of telmisartan
ES2624828T3 (es)	2008-07-16	2017-07-17	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
WO2010016549A1 (ja)	2008-08-06	2010-02-11	協和発酵キリン株式会社	３環系化合物
US20120046364A1 (en)	2009-02-10	2012-02-23	Metabasis Therapeutics, Inc.	Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
SI2443094T1 (sl)	2009-06-19	2013-08-30	Krka, Tovarna Zdravil, D.D., Novo Mesto	Postopek za pripravo telmisartana
EP2277866A1 (en)	2009-06-22	2011-01-26	Inke, S.A.	Process for preparing telmisartan
WO2011002425A2 (en)	2009-07-02	2011-01-06	Bilgig Mahmut	Pharmaceutical composition increasing solubility and stability
WO2011002423A2 (en)	2009-07-02	2011-01-06	Mahmut Bilgic	Solubility enhancing pharmaceutical composition
TR200906506A2 (tr)	2009-08-24	2011-03-21	Bi̇lgi̇ç Mahmut	Telmisartan içeren katı dozaj formları.
EP2305650A1 (en)	2009-09-21	2011-04-06	Chemo Ibérica, S.A.	Novel process for the preparation of telmisartan
CN101798300B (zh) *	2010-02-23	2013-09-25	陈志龙	N-苯基吲哚甲基取代的双苯并咪唑衍生物及其降压等应用
WO2011149438A1 (en)	2010-05-28	2011-12-01	Mahmut Bilgic	Combination of antihypertensive agents
WO2011161123A2 (en)	2010-06-21	2011-12-29	Krka, Tovarna Zdravil, D.D., Novo Mesto	Multilayer pharmaceutical tablet comprising telmisartan and a diuretic
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
EA025946B1 (ru)	2010-10-27	2017-02-28	Крка, Товарна Здравил, Д. Д., Ново Место	Многослойная фармацевтическая композиция, содержащая телмисартан и амлодипин
AU2012303683B2 (en)	2011-08-26	2016-09-08	Wockhardt Limited	Methods for treating cardiovascular disorders
EP2612658A1 (en)	2012-01-05	2013-07-10	Laboratorios Lesvi, S.L.	Pharmaceutical compositions of 4'-[(1,4'dimethyl-2'-propyl[2,6'-bi-1h-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid and is 6-chloro-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
CA2905438A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
EP3004138B1 (en)	2013-06-05	2024-03-13	Bausch Health Ireland Limited	Ultra-pure agonists of guanylate cyclase c, method of making and using same
ES2806135T3 (es)	2013-06-21	2021-02-16	Zenith Epigenetics Ltd	Nuevos inhibidores de bromodominios bicíclicos
ES2661437T3 (es)	2013-06-21	2018-04-02	Zenith Epigenetics Corp.	Nuevos compuestos bicíclicos sustituidos como inhibidores de bromodominio
EP3027604B1 (en)	2013-07-31	2019-02-20	Zenith Epigenetics Ltd.	Novel quinazolinones as bromodomain inhibitors
EP2979691A1 (en)	2014-07-30	2016-02-03	Boehringer Ingelheim International GmbH	Oral disintegrating tablet
EP3227281A4 (en)	2014-12-01	2018-05-30	Zenith Epigenetics Ltd.	Substituted pyridinones as bromodomain inhibitors
CA2966449A1 (en)	2014-12-11	2016-06-16	Zenith Epigenetics Ltd.	Substituted heterocycles as bromodomain inhibitors
CN107406438B (zh)	2014-12-17	2021-05-14	恒翼生物医药科技(上海)有限公司	溴结构域的抑制剂
JP5871294B1 (ja)	2015-02-27	2016-03-01	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	即時放出経口錠剤
KR20170001921A (ko)	2015-06-26	2017-01-05	대원제약주식회사	안정성이 개선된 텔미사르탄을 함유하는 약제학적 조성물 및 이의 제조방법
KR20170012703A (ko)	2015-07-22	2017-02-03	대원제약주식회사	텔미사르탄을 함유하는 약제학적 조성물 및 이의 제조방법
JP6411662B2 (ja)	2016-05-30	2018-10-24	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	固定容量配合剤
KR101872726B1 (ko)	2016-07-28	2018-06-29	주식회사 씨트리	텔미사르탄 메탄술폰산염 및 이를 포함하는 약제학적 조성물
KR20250007040A (ko)	2017-07-07	2025-01-13	베링거잉겔하임베트메디카게엠베하	고양이에서 전신 질환의 예방 또는 치료를 위한 안지오텐신 ii 수용체 길항제
CN111918866B (zh) *	2018-03-30	2023-07-04	千纸鹤治疗公司	杂环化合物
EP4373474A1 (en)	2021-07-22	2024-05-29	KRKA, D.D., Novo Mesto	Bilayer tablet comprising telmisartan and indapamide
JP2024536342A (ja) *	2021-10-04	2024-10-04	ボルトバイオセラピューティクス、インコーポレーテッド	非対称ビス－ベンゾイミダゾールｓｔｉｎｇアゴニスト免疫複合体及びその使用
US20240390317A1 (en)	2023-05-24	2024-11-28	Boehringer Ingelheim Vetmedica Gmbh	Combination treatment and/or prevention of cardiac diseases in non-human mammals comprising one or more sglt-2 inhibitors and pimobendan and/or telmisartan
US20240390332A1 (en)	2023-05-24	2024-11-28	Boehringer Ingelheim Vetmedica Gmbh	Combination treatment and/or prevention of renal diseases and/or hypertension in non-human mammals comprising one or more SGLT-2 inhibitors and telmisartan

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4880804A (en) *	1988-01-07	1989-11-14	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking benzimidazoles
DE3928177A1 (de) *	1989-04-08	1991-02-28	Thomae Gmbh Dr K	Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA2016710A1 (en) *	1989-05-15	1990-11-15	Prasun K. Chakravarty	Substituted benzimidazoles as angiotensin ii antagonists
IE64514B1 (en) *	1989-05-23	1995-08-09	Zeneca Ltd	Azaindenes
GB8911854D0 (en) *	1989-05-23	1989-07-12	Ici Plc	Heterocyclic compounds
IL94390A (en) *	1989-05-30	1996-03-31	Merck & Co Inc	The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
IE70593B1 (en) *	1989-09-29	1996-12-11	Eisai Co Ltd	Biphenylmethane derivative the use of it and pharmacological compositions containing same
US5196444A (en) *	1990-04-27	1993-03-23	Takeda Chemical Industries, Ltd.	1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
RU1836357C (ru) *	1990-07-23	1993-08-23	Др.Карл Томэ ГмбХ	Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами

1992
- 1992-01-30 SI SI9210098A patent/SI9210098B/sl unknown
- 1992-01-31 AT AT92101579T patent/ATE166346T1/de active
- 1992-01-31 DK DK92101579T patent/DK0502314T3/da active
- 1992-01-31 CH CH92101579.8T patent/CH0502314H1/de unknown
- 1992-01-31 DE DE59209330T patent/DE59209330C5/de not_active Expired - Lifetime
- 1992-01-31 ES ES92101579T patent/ES2118095T4/es not_active Expired - Lifetime
- 1992-01-31 SG SG1996002482A patent/SG50481A1/en unknown
- 1992-01-31 DE DE2002199029 patent/DE10299029I2/de active Active
- 1992-01-31 EP EP92101579A patent/EP0502314B1/de not_active Expired - Lifetime
- 1992-02-04 SK SK306-92A patent/SK279261B6/sk active Protection Beyond IP Right Term
- 1992-02-04 NZ NZ241515A patent/NZ241515A/en not_active IP Right Cessation
- 1992-02-04 CZ CS1992306A patent/CZ287607B6/cs not_active IP Right Cessation
- 1992-02-04 IL IL10086492A patent/IL100864A/en not_active IP Right Cessation
- 1992-02-04 CA CA002060624A patent/CA2060624C/en not_active Expired - Lifetime
- 1992-02-05 NO NO920476A patent/NO301585B1/no not_active IP Right Cessation
- 1992-02-05 IE IE920373A patent/IE81111B1/en active IP Right Review Request
- 1992-02-05 FI FI920486A patent/FI105547B/fi not_active IP Right Cessation
- 1992-02-05 JP JP4019852A patent/JP2709225B2/ja not_active Expired - Lifetime
- 1992-02-05 RU SU5010824/04A patent/RU2053229C1/ru active Protection Beyond IP Right Term
- 1992-02-05 HU HU9200355A patent/HU217084B/hu unknown
- 1992-02-05 PL PL92293387A patent/PL169675B1/pl unknown
- 1992-02-06 MX MX9200509A patent/MX9200509A/es unknown
1994
- 1994-01-24 BG BG098408A patent/BG62309B2/bg unknown
- 1994-10-25 HR HRP-98/92 patent/HRP940752B1/xx not_active IP Right Cessation
1995
- 1995-06-02 HU HU95P/P00157P patent/HU211524A9/hu active Protection Beyond IP Right Term
1998
- 1998-11-09 HK HK98111854A patent/HK1011145A1/xx not_active IP Right Cessation
1999
- 1999-03-12 LU LU90372C patent/LU90372I2/xx unknown
- 1999-03-16 NL NL990007C patent/NL990007I2/nl unknown
2002
- 2002-07-18 NL NL300095C patent/NL300095I2/nl unknown
- 2002-08-30 LU LU90950C patent/LU90950I2/fr unknown
- 2002-10-21 NO NO2002011C patent/NO2002011I2/no unknown
2011
- 2011-03-29 LU LU91802C patent/LU91802I2/fr unknown
- 2011-05-03 NO NO2011005C patent/NO2011005I1/no unknown

Also Published As

Publication number	Publication date
ES2118095T4 (es)	2011-04-07
DK0502314T3 (da)	1999-03-29
HU9200355D0 (en)	1992-04-28
NZ241515A (en)	1994-10-26
SI9210098A (en)	1994-12-31
HK1011145A1 (en)	1999-07-02
FI105547B (fi)	2000-09-15
CA2060624A1 (en)	1992-08-07
DE59209330D1 (de)	1998-06-25
DE10299029I2 (de)	2006-06-29
CZ287607B6 (cs)	2001-01-17
IL100864A (en)	1996-01-19
MX9200509A (es)	1992-08-01
SI9210098B (sl)	2000-06-30
HRP940752A2 (en)	1997-04-30
PL293387A1 (en)	1993-01-25
SK279261B6 (sk)	1998-08-05
NO920476D0 (no)	1992-02-05
HUT60493A (en)	1992-09-28
CH0502314H1 (fi)	2012-03-15
AU655794B2 (en)	1995-01-12
FI920486A (fi)	1992-08-07
CS30692A3 (en)	1992-08-12
IL100864A0 (en)	1992-11-15
IE920373A1 (en)	1992-08-12
NL990007I2 (nl)	1999-07-01
ATE166346T1 (de)	1998-06-15
EP0502314A1 (de)	1992-09-09
NO2002011I2 (no)	2008-03-03
NO301585B1 (no)	1997-11-17
HRP940752B1 (en)	2001-02-28
NL300095I2 (nl)	2002-11-01
NO2011005I1 (no)	2011-05-16
NO920476L (no)	1992-08-07
ES2118095T3 (es)	1998-09-16
IE81111B1 (en)	2000-03-08
BG62309B2 (bg)	1999-07-30
LU91802I2 (fr)	2011-05-30
NL990007I1 (nl)	1999-06-01
EP0502314B1 (de)	1998-05-20
LU90372I2 (fr)	1999-05-12
JP2709225B2 (ja)	1998-02-04
NL300095I1 (nl)	2002-09-02
AU1070792A (en)	1992-08-13
SG50481A1 (en)	1998-07-20
DE10299029I1 (de)	2003-01-23
HU211524A9 (en)	1995-11-28
DE59209330C5 (de)	2013-10-31
JPH04346978A (ja)	1992-12-02
LU90950I2 (fr)	2002-10-30
PL169675B1 (pl)	1996-08-30
RU2053229C1 (ru)	1996-01-27
HU217084B (hu)	1999-11-29
CA2060624C (en)	1999-12-21

Publication	Publication Date	Title
FI920486A0 (fi)	1992-02-05	Bensimidazoler, dess foereningar innehaollande laekemedel och foerfarande foer deras framstaellning.
FI103508B (fi)	1999-07-15	Menetelmä anti-inflammatorisen aktiivisuuden omaavien 2-substituoituje n tiatsolidinonien, oksatsolidinonien ja imidatsolidinonien 3,5-di-ter t.butyyli-4-hydroksifenyylimetyleenijohdannaisten valmistamiseksi
AU7186494A (en)	1995-01-24	Substituted spiroheterocyclic 1h-3-arylpyrrolidine-2,4-dione derivatives, methods of preparing them and their use as pest-control agents
NO894425L (no)	1989-11-07	Hypoglykemiske tiazolidinon-derivater.
CA2413000A1 (en)	2002-01-10	Five-membered ring compounds
EP0237289A3 (en)	1988-07-27	Pyrazolo [3,4-d] pyrimidine derivatives, their production and use
AU7193094A (en)	1995-02-28	Process for the preparation of fluoroathenylthio heterocyclic derivatives
CS743389A3 (en)	1992-03-18	Amino(methyl)phenyl derivatives, process for their preparation and use
ES8601987A1 (es)	1985-11-16	Un procedimiento para preparar derivados de acido 4,7-dihidropirazolo (3,4-b)piridin-5-carboxilico
ES334756A1 (es)	1968-03-01	Procedimiento para la produccion de derivados de la benzo- tiacepin - 4 - ona.
EP0072508A3 (de)	1983-03-16	Pyrazolonderivate, ihre Herstellung und ihre Verwendung als Kupplungskomponenten
IT1230754B (it)	1991-10-29	Camposti con attivita' analgesica centrale.
IT1217657B (it)	1990-03-30	Composti con attivita' analgesica centrale
FI921298A (fi)	1992-03-25	Menetelmä lääkeaineena käyttökelpoisen 5-(6-imidatso/1,2-a/pyridyyli)pyridiini-johdannaisen valmistamiseksi

Legal Events

Date	Code	Title	Description
2002-07-25	SPCF	Supplementary protection certificate application filed	Spc suppl protection certif: L20020005
2008-05-30	SPCG	Supplementary protection certificate granted	Spc suppl protection certif: 218 Extension date: 20170205
2011-04-06	SPCF	Supplementary protection certificate application filed	Free format text: C20110007
2011-05-04	SPCG	Supplementary protection certificate granted	Spc suppl protection certif: 301 Extension date: 20170205
2012-03-29	MA	Patent expired
2014-04-28	SPCR	Lapse or expiry of a supplementary protection certificate	Spc suppl protection certif: 301 Effective date: 20140428
2015-04-08	SPCR	Lapse or expiry of a supplementary protection certificate	Spc suppl protection certif: 218 Effective date: 20150408