FI91407B - Förfarande för framställning av terapeutiskt användbara 5-substituerade /4,5-c/imidazopyridinderivat - Google Patents
Förfarande för framställning av terapeutiskt användbara 5-substituerade /4,5-c/imidazopyridinderivat Download PDFInfo
- Publication number
- FI91407B FI91407B FI891200A FI891200A FI91407B FI 91407 B FI91407 B FI 91407B FI 891200 A FI891200 A FI 891200A FI 891200 A FI891200 A FI 891200A FI 91407 B FI91407 B FI 91407B
- Authority
- FI
- Finland
- Prior art keywords
- carbon atoms
- alkyl
- substituted
- pyridine
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (9)
1. Förfarande för framställning av terapeutiskt an-vändbara i 5-ställning substituerade [4,5-c]imidatsopyri-5 dinderivat med formeln I och farmaceutiskt godtagbara sy-raadditionssalter av dessa väri
15 Rt och R2 bäda sj älvständigt betecknar väte; rakke- dad eller förgrenad alkyl innehällande 1-12 kolatomer; cykloalkyl innehällande 3-6 kolatomer; substituerad cyk-loalkyl, väri som substituenter kan finnas en eller flera alkylgrupper innehdllande 1-6 kolatomer, bicykloalkyl, 20 väri bäda ringarna innehäller 3-8 kolatomer; fenyl; py-ridyl; substituerad pyridyl, väri som substituenter kan finnas en eller flera alkylgrupper, innehällande 1-3 kolatomer; och Rx och Rz kan ej bäda beteckna väte; X betecknar en eller flera substituenter i en eller 25 flera av fenylgruppens positioner 2, 3, 5 eller 6, själv-ständigt valda ur en grupp bestäende väte, metoxi, fluor och brom; n är ett heltal 1-3; R3 är en grupp som utgör en substituent i 4-ställ-. . 30 ning hos imidazopyridinringsystemets pyridinring, och som är väte, hydroxi, metoxi, metyl, fluor, klor eller brom; R4 är väte, metyl eller metoxi; kännetecknat därav, att en imidazopyridin med formeln 35 « « · · 49 91407 K’Xr bringas att reagera med en halogenalkylbensamid med for-mein 10 (CH ) L Λ O" 15 (III) R, Xr2 vari
20 L är klor, brom eller metansulfonyloxi; varefter, om sä önskas, av de sälunda erhällna för-enlngarna med formeln I framställes syraadditionssalt en-ligt vedertagna metoder.
2. Förfarande enligt patentkrav 1, k ä n n e - 25 tecknat därav, att man framställer 5-[4-{(N-cyk-lopentyl,N-cyklohexy1)karboxiamido}-2-metoxibensyl]imida-zo[4,5-c]pyridin.
3. Förfarande enligt patentkrav 1, känne-tecknat därav, att man framställer 5-[4-{(N-iso- 30 propyl, N-cyklohexyl) karboxiamido }bensyl] imidatso[4,5-c]py- ridin.
4. Förfarande enligt patentkrav 1, känne-tecknat därav, att man framställer 5-[4-(N-isop-ropyl-N-cyklohexsylkarboxiamido)bensyl] imidatso- [4, 5-c]py- 35 ridin. 50
5. Förfarande enligt patentkrav 1, känne-t e c k n a t därav, att man framställer 5-[4-(N-cyklobu-tyl-N-cyklohexylkarboxiamido)bensyl]imidatso-[4,5-c]pyri-din. 5
6. Förfarande enligt patentkrav 1, k ä n n e - t e c k n a t därav, att man framställer 5-[4-(N-cyklo-pentyl-N-cyklohexylkarboxiamido)bensyl]imidatso[4,5-c]py-ridin.
7. Förfarande enligt patentkrav 1, känne- 10 tecknat därav, att man framställer 5-[4-(N,N-dicyk-lopentylkarboxiamido)bensyl]-4-metylimidatso-[4,5-c]pyri-din.
8. Förfarande enligt patentkrav 1, känne-tecknat därav, att man framställer 5-[4-(N-isopro- 15 py1-N-cyklohexylkarboxiamido)-2-metoxibensyl]-im- idatso[4,5-c]pyridin.
9. Förfarande enligt patentkrav 1, känne-tecknat därav, att man framställer 5-[4-(N-isopro-pyl-N-cyklohexylkarboxiamido)-2-metoxibensyl]imidatso- 20 [4,5-c]pyridinhydroklorid.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/167,671 US4914108A (en) | 1988-03-14 | 1988-03-14 | 5-substituted(4,5-c)imidazopyridine compounds which have useful platelet activating factor antagonistic activity |
| US16767188 | 1988-03-14 | ||
| US31787189 | 1989-03-06 | ||
| US07/317,871 US5019581A (en) | 1988-03-14 | 1989-03-06 | 5-substituted (4,5-c) imidazopyridine compounds which have useful platelet activating factor antagonistic activity |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI891200A0 FI891200A0 (sv) | 1989-03-14 |
| FI891200A FI891200A (sv) | 1989-09-15 |
| FI91407B true FI91407B (sv) | 1994-03-15 |
| FI91407C FI91407C (sv) | 1994-06-27 |
Family
ID=26863369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI891200A FI91407C (sv) | 1988-03-14 | 1989-03-14 | Förfarande för framställning av terapeutiskt användbara 5-substituerade /4,5-c/imidazopyridinderivat |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5019581A (sv) |
| EP (1) | EP0344414B1 (sv) |
| JP (1) | JP2714426B2 (sv) |
| KR (1) | KR890014537A (sv) |
| AT (1) | ATE112774T1 (sv) |
| AU (1) | AU625058B2 (sv) |
| CA (1) | CA1337072C (sv) |
| DE (1) | DE68918755T2 (sv) |
| DK (1) | DK169872B1 (sv) |
| ES (1) | ES2061753T3 (sv) |
| FI (1) | FI91407C (sv) |
| IL (1) | IL89588A0 (sv) |
| NO (1) | NO169965C (sv) |
| NZ (1) | NZ228336A (sv) |
| PH (1) | PH26967A (sv) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5227384A (en) * | 1988-03-14 | 1993-07-13 | G. D. Searle & Co. | 5-substituted [4,5-c] imidazopyridines and pharmaceutical use thereof |
| US5302601A (en) * | 1988-03-14 | 1994-04-12 | G. D. Searle & Co. | 5-substituted imidazo[4,5-c]pyridines |
| US4990518A (en) * | 1989-09-13 | 1991-02-05 | G. D. Searle & Co. | Pharmacologically active heteroaryl substituted imidazo (4,5-c) pyridines |
| GB9116056D0 (en) * | 1991-07-24 | 1991-09-11 | British Bio Technology | Compounds |
| US5223539A (en) * | 1991-11-22 | 1993-06-29 | G. D. Searle & Co. | N,n-di-alkyl(phenoxy)benzamide derivatives |
| US5208242A (en) * | 1992-08-26 | 1993-05-04 | G. D. Searle & Co. | 5-substituted-4-phenyl-5H-imidazo[4,5-c]pyridine derivatives |
| US5262426A (en) * | 1993-01-22 | 1993-11-16 | G. D. Searle & Co. | N,N'-cycloalkyl/alkyl carboxamide 4H-imidazo-[4,5-b]pyridine compounds as PAF antagonists |
| US5360907A (en) * | 1993-06-14 | 1994-11-01 | G.D. Searle & Co. | Pyrrolo[3,2-B]pyridinylalkyl benzamide derivatives |
| US5496855A (en) * | 1995-01-27 | 1996-03-05 | Smithkline Beecham Corp. | Anti-inflammatory compounds |
| GB0215293D0 (en) * | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
| US20050222198A1 (en) * | 2003-12-22 | 2005-10-06 | K.U. Leuven Research & Development, Gerhard Puerstinger And Gilead Sciences, Inc. | Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment |
| DE602005013580D1 (de) * | 2004-12-21 | 2009-05-07 | Leuven K U Res & Dev | Imidazoä4,5-cüpyridinverbindung und verfahren zur antiviralen behandlung |
| TW200808695A (en) * | 2006-06-08 | 2008-02-16 | Amgen Inc | Benzamide derivatives and uses related thereto |
| AU2007269614B2 (en) * | 2006-07-07 | 2011-09-08 | Gilead Sciences, Inc. | Novel pyridazine compound and use thereof |
| UA99466C2 (en) | 2007-07-06 | 2012-08-27 | Гилиад Сайенсиз, Инк. | Crystalline pyridazine compound |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4281005A (en) * | 1979-03-05 | 1981-07-28 | Merck & Co., Inc. | Novel 2-pyridylimidazole compounds |
| DE2927987A1 (de) * | 1979-07-11 | 1981-02-05 | Thomae Gmbh Dr K | Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel |
| RO86850B (ro) * | 1982-05-03 | 1985-05-31 | Eli Lilly And Company | Procedeu pentru prepararea unor 2-fenilimidazo [4,5 c] piridine |
| US4804658A (en) * | 1986-09-15 | 1989-02-14 | G. D. Searle & Co. | Imidazopyridine derivatives and pharmaceutical compositions |
-
1989
- 1989-03-06 US US07/317,871 patent/US5019581A/en not_active Expired - Lifetime
- 1989-03-13 NO NO891058A patent/NO169965C/no unknown
- 1989-03-13 CA CA000593520A patent/CA1337072C/en not_active Expired - Fee Related
- 1989-03-13 DK DK121189A patent/DK169872B1/da not_active IP Right Cessation
- 1989-03-13 IL IL89588A patent/IL89588A0/xx not_active IP Right Cessation
- 1989-03-14 AU AU31270/89A patent/AU625058B2/en not_active Ceased
- 1989-03-14 FI FI891200A patent/FI91407C/sv not_active IP Right Cessation
- 1989-03-14 ES ES89104464T patent/ES2061753T3/es not_active Expired - Lifetime
- 1989-03-14 DE DE68918755T patent/DE68918755T2/de not_active Expired - Fee Related
- 1989-03-14 KR KR1019890003132A patent/KR890014537A/ko not_active Application Discontinuation
- 1989-03-14 EP EP89104464A patent/EP0344414B1/en not_active Expired - Lifetime
- 1989-03-14 NZ NZ228336A patent/NZ228336A/en unknown
- 1989-03-14 AT AT89104464T patent/ATE112774T1/de active
- 1989-03-14 PH PH38328A patent/PH26967A/en unknown
- 1989-03-14 JP JP1061979A patent/JP2714426B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA1337072C (en) | 1995-09-19 |
| DK121189A (da) | 1989-09-15 |
| NO891058D0 (no) | 1989-03-13 |
| JPH01316378A (ja) | 1989-12-21 |
| ES2061753T3 (es) | 1994-12-16 |
| FI891200A0 (sv) | 1989-03-14 |
| EP0344414A1 (en) | 1989-12-06 |
| AU625058B2 (en) | 1992-07-02 |
| JP2714426B2 (ja) | 1998-02-16 |
| DE68918755T2 (de) | 1995-03-09 |
| FI91407C (sv) | 1994-06-27 |
| NO891058L (no) | 1989-09-15 |
| NZ228336A (en) | 1992-01-29 |
| KR890014537A (ko) | 1989-10-24 |
| NO169965B (no) | 1992-05-18 |
| IL89588A0 (en) | 1989-09-10 |
| PH26967A (en) | 1992-12-28 |
| FI891200A (sv) | 1989-09-15 |
| ATE112774T1 (de) | 1994-10-15 |
| DE68918755D1 (de) | 1994-11-17 |
| DK121189D0 (da) | 1989-03-13 |
| AU3127089A (en) | 1989-09-14 |
| DK169872B1 (da) | 1995-03-20 |
| US5019581A (en) | 1991-05-28 |
| NO169965C (no) | 1992-08-26 |
| EP0344414B1 (en) | 1994-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: G D SEARLE & CO. |