[go: up one dir, main page]

FI913754L - Förfarande för framställning av terapeutiskt användbara 3,4-bis(3-indolyl)-1H-pyrrol-2,5-dionderivat och föreningar som är användbara mellanprodukter i förfarandet - Google Patents

Förfarande för framställning av terapeutiskt användbara 3,4-bis(3-indolyl)-1H-pyrrol-2,5-dionderivat och föreningar som är användbara mellanprodukter i förfarandet Download PDF

Info

Publication number
FI913754L
FI913754L FI913754A FI913754A FI913754L FI 913754 L FI913754 L FI 913754L FI 913754 A FI913754 A FI 913754A FI 913754 A FI913754 A FI 913754A FI 913754 L FI913754 L FI 913754L
Authority
FI
Finland
Prior art keywords
useful
indolyl
pyrrole
bis
dione derivatives
Prior art date
Application number
FI913754A
Other languages
English (en)
Finnish (fi)
Other versions
FI95909B (sv
FI913754A0 (sv
FI95909C (sv
Inventor
Peter David Davis
Christopher Huw Hill
Geoffrey Lawton
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909017269A external-priority patent/GB9017269D0/en
Priority claimed from GB919109959A external-priority patent/GB9109959D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI913754A0 publication Critical patent/FI913754A0/sv
Publication of FI913754L publication Critical patent/FI913754L/sv
Publication of FI95909B publication Critical patent/FI95909B/sv
Application granted granted Critical
Publication of FI95909C publication Critical patent/FI95909C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI913754A 1990-08-07 1991-08-07 Förfarande för framställning av terapeutiskt användbara 3,4-bis(3-indolyl)-1H-pyrrol-2,5-dionderivat och föreningar som är användbara mellanprodukter i förfarandet FI95909C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB909017269A GB9017269D0 (en) 1990-08-07 1990-08-07 Substituted pyrroles
GB9017269 1990-08-07
GB919109959A GB9109959D0 (en) 1991-05-08 1991-05-08 Substituted pyrroles
GB9109959 1991-05-08

Publications (4)

Publication Number Publication Date
FI913754A0 FI913754A0 (sv) 1991-08-07
FI913754L true FI913754L (sv) 1992-02-08
FI95909B FI95909B (sv) 1995-12-29
FI95909C FI95909C (sv) 1996-04-10

Family

ID=26297468

Family Applications (1)

Application Number Title Priority Date Filing Date
FI913754A FI95909C (sv) 1990-08-07 1991-08-07 Förfarande för framställning av terapeutiskt användbara 3,4-bis(3-indolyl)-1H-pyrrol-2,5-dionderivat och föreningar som är användbara mellanprodukter i förfarandet

Country Status (26)

Country Link
EP (1) EP0470490B1 (sv)
JP (1) JPH0780880B2 (sv)
KR (1) KR100233964B1 (sv)
AT (1) ATE179710T1 (sv)
AU (1) AU649699B2 (sv)
CA (1) CA2046801C (sv)
CZ (1) CZ280359B6 (sv)
DE (1) DE69131190T2 (sv)
DK (1) DK0470490T3 (sv)
DZ (1) DZ1521A1 (sv)
ES (1) ES2132076T3 (sv)
FI (1) FI95909C (sv)
GR (1) GR3030677T3 (sv)
HU (1) HU210547B (sv)
IE (1) IE912787A1 (sv)
IL (1) IL99064A (sv)
IS (1) IS1682B (sv)
MC (1) MC2279A1 (sv)
MY (1) MY106400A (sv)
NO (1) NO179143C (sv)
NZ (1) NZ239216A (sv)
PT (1) PT98583B (sv)
RO (1) RO112724B1 (sv)
RU (1) RU2075474C1 (sv)
SK (1) SK279566B6 (sv)
UA (1) UA27100A1 (sv)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
EP0630241A1 (en) * 1992-03-20 1994-12-28 The Wellcome Foundation Limited Indole derivatives with antiviral activity
AU678435B2 (en) * 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
US5721230A (en) * 1993-05-10 1998-02-24 Hoffmann-La Roche Inc. Substituted pyrroles
US5405864A (en) * 1993-10-15 1995-04-11 Syntex (U.S.A.) Inc. Chemotherapeutic maleimides
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
HUT69164A (en) * 1993-12-07 1995-08-28 Lilly Co Eli Improved process for producing bis-indolyl-maleimide derivatives
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
ES2162843T3 (es) * 1993-12-07 2002-01-16 Lilly Co Eli Inhibidores de la proteina quinasa c.
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US6025897A (en) 1993-12-21 2000-02-15 3M Innovative Properties Co. Display with reflective polarizer and randomizing cavity
US6804058B1 (en) 1993-12-21 2004-10-12 3M Innovative Properties Company Electroluminescent light source and display incorporating same
DK0817627T3 (da) * 1993-12-23 2005-06-06 Lilly Co Eli Inhibitorer af proteinkinase C
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
US5554608A (en) * 1994-09-28 1996-09-10 Ahluwalia; Gurpreet S. Inhibition of hair growth
CA2268399C (en) * 1996-10-31 2008-08-19 Harbor Branch Oceanographic Institution, Inc. Anti-neurogenic inflammatory compounds and compositions and methods of use thereof
ATE277010T1 (de) 1998-07-08 2004-10-15 Harbor Branch Oceanographic Bis-indolederivate und ihre verwendung als entzündungshemmende mittel
GB9828640D0 (en) * 1998-12-23 1999-02-17 Smithkline Beecham Plc Novel method and compounds
FR2796274B1 (fr) * 1999-07-16 2001-09-21 Oreal Utilisation de l'acide 4,6-dimethoxy-indole 2-carboxylique ou de ses derives pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
CA2393720C (en) 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
TWI324604B (en) * 2003-06-18 2010-05-11 Novartis Ag New use of staurosporine derivatives
CA2533861A1 (en) 2003-08-08 2005-02-17 Novartis Ag Combinations comprising staurosporines
EP1734952A1 (en) * 2004-04-08 2006-12-27 Novartis AG Protein kinase c inhibitors for the treatment of autoimmune diseases and of transplant rejection
FR2870538B1 (fr) * 2004-05-19 2006-07-14 Servier Lab Nouveaux derives de pyrrolidines et de thiazolidines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20170209488A1 (en) 2014-07-17 2017-07-27 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for treating neuromuscular junction-related diseases
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
MC2096A1 (fr) * 1989-02-23 1991-02-15 Hoffmann La Roche Pyrroles substitues
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
NZ239216A (en) 1994-05-26
HU912589D0 (en) 1992-01-28
JPH0780880B2 (ja) 1995-08-30
CA2046801A1 (en) 1992-02-08
ATE179710T1 (de) 1999-05-15
NO913051D0 (no) 1991-08-06
DE69131190D1 (de) 1999-06-10
PT98583A (pt) 1992-06-30
MC2279A1 (fr) 1993-06-23
AU649699B2 (en) 1994-06-02
IS3741A7 (is) 1992-02-08
JPH04230686A (ja) 1992-08-19
SK279566B6 (sk) 1999-01-11
PT98583B (pt) 1999-03-31
FI95909B (sv) 1995-12-29
CA2046801C (en) 2002-02-26
RO112724B1 (ro) 1997-12-30
EP0470490B1 (en) 1999-05-06
EP0470490A1 (en) 1992-02-12
FI913754A0 (sv) 1991-08-07
NO179143B (no) 1996-05-06
DK0470490T3 (da) 1999-11-01
UA27100A1 (uk) 2000-02-28
KR100233964B1 (ko) 1999-12-15
AU8167291A (en) 1992-02-13
KR920004380A (ko) 1992-03-27
DE69131190T2 (de) 1999-11-04
IS1682B (is) 1998-02-24
IL99064A (en) 1995-08-31
ES2132076T3 (es) 1999-08-16
NO179143C (no) 1996-08-14
CS243591A3 (en) 1992-02-19
FI95909C (sv) 1996-04-10
RU2075474C1 (ru) 1997-03-20
HU210547B (en) 1995-05-29
IL99064A0 (en) 1992-07-15
MY106400A (en) 1995-05-30
GR3030677T3 (en) 1999-11-30
DZ1521A1 (fr) 2004-09-13
HUT61542A (en) 1993-01-28
IE912787A1 (en) 1992-02-12
NO913051L (no) 1992-02-10
CZ280359B6 (cs) 1995-12-13

Similar Documents

Publication Publication Date Title
FI913754L (sv) Förfarande för framställning av terapeutiskt användbara 3,4-bis(3-indolyl)-1H-pyrrol-2,5-dionderivat och föreningar som är användbara mellanprodukter i förfarandet
GB2251746B (en) Parallel amplifier arrangements
GB2251614B (en) Indole derivatives
FI915146L (fi) 3-amidoindolyl derivat.
FI894205L (fi) Foerfarande foer framstaellning av etanol och alkoholdrycker med anvaendning av immobiliserade jaest.
NO913745L (no) Fremgangsmaate for fremstilling av 1,3-benzoksazinderivater
FI910895A0 (sv) Förfarande för framställning av ett terapeutiskt användbart 4-(di-n-propyl)amino-6-aminokarbonyl-1,3,4,5-tetrahydrobenso/c,d/indolhippurat
FI913099A0 (fi) Foerfarande och anordning foer behandling av analogisignal.
NO913686L (no) Fremgangsmaate for fremstilling av 9-substituerte guaninderivater og mellomprodukter for anvendelse i fremgangsmaaten.
FI910303L (fi) Derivat av tiazolidin med blodtrycksnedsaenkande effekt och terapeutisk anvaendning av dessa.
FI925260L (sv) Förfarande för framställning av terapeutiskt användbara 6-amino-substituerade oktahydro-1,7,8-indolizintriolderivat
EP0474129A3 (en) 1,4-dihydropyridine derivatives and process for preparing the same
FI943778L (sv) Förfarande för framställning av 1,1-diklor-1-fluoretan
FI982081L (sv) Bensendimetanol som lämpar sig till mikronisering
FI953361L (sv) Förfarande för framställning av substituerade indolonderivat
NO931897D0 (no) Fremgangsmaate for fremstilling av dibeskyttet 2,3-hydroksymetyl-cyklobutanol
FI923812A0 (fi) Anordning foer aostadkommande av en rymdladdning i atmosfaeren.
DE69103046D1 (de) Heissklebeverfahren.
ITMI910789A0 (it) Procedimento per produrre lastre di legno massicce
FI910448A (sv) Förfarande för framställning av terapeutiskt användbara 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimetyl-pyrrolo/2,3-b/indolderivat
EP0445827A3 (en) 4-hydroxytetrahydropyran-2-one derivatives and intermediates for synthesizing the same
GB9115199D0 (en) Amplifying arrangements
FI942888L (sv) Förfarande för framställning av mellanprodukter, vilka är änvändbara vid framställning av pyranylcyanguanidinderivat
FI911282L (sv) Förfarande för framställning av nya terapeutiskt användbara 3,4-dihydroxi-2,5-dihydrofuranoner
FI900301A0 (fi) Foerfarande foer framstaellning av eten-propen-kopolymerer i partikelform.

Legal Events

Date Code Title Description
MA Patent expired