FI90979B - Förfarande för framställning av terapeutiskt användbara substituerade 3,4-dihydro-2H-benzopyraner - Google Patents
Förfarande för framställning av terapeutiskt användbara substituerade 3,4-dihydro-2H-benzopyraner Download PDFInfo
- Publication number
- FI90979B FI90979B FI880467A FI880467A FI90979B FI 90979 B FI90979 B FI 90979B FI 880467 A FI880467 A FI 880467A FI 880467 A FI880467 A FI 880467A FI 90979 B FI90979 B FI 90979B
- Authority
- FI
- Finland
- Prior art keywords
- dimethyl
- dihydro
- benzo
- pyran
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Claims (2)
1. Förfarande för framställning av terapeutiskt användbara 3,4-dihydro-2H-benso[b]pyraner med formeln I O Ar-SO°H ΎΛΤ T f1» 10 1 1 -2\-r2 V väri R1 är H eller C,.2-alkoxi; R2 och R3 är samma eller olika och de är CM-alkyler; Ar är en fenyl sora är osubstituerad 15 eller substituerad med en metylgrupp, metoxigrupp, halogen eller cyanogrupp, eller Ar är tienyl; n är 1 eller 2; och X betecknar en kedja (CH2)r, väri r är 3 eller 4, kännetecknat därav, att a) föreningar med formeln II 20 OH Ar-SOn^^rVBr R1'-\^\0^'\-r3 (II)
25 R2 väri symboler R1 - R3 och Ar-SO„ har ovan angivna betydel-ser, bringas att reagera med laktamer med formeln III 30 r (m) H 35 90979 25 b) föreningar med formeln IV ir-so”Y^ 5 (IV) R2 väri symboler R1 - R3 och Ar-SOn har ovan angivna betydel-ser, bringas att reagera med laktamer med formeln III 10. v. O’ I (III) H 15 c) föreningar med formeln V nh2 ArS\'y^Y^Y 0H
20 A·;3 <v) IT vari symboler R1 - R3 och Ar-SOn har ovan angivna betydel-ser, acyleras till föreningar med formeln VI 25 0 Ϊ HN ^^X-Y "“•'TofS-0* (VI) väri Y är en avlägsnande grupp och symboler R1 - R3 och 35 Ar-SOa har ovan angivna betydelser, och dessa cykliseras 26 till föreningar med formeln I.
2. Förfarande enligt patentkrav 1, känne-t e c k n a t därav, att (+)-3,4-dihydro-2,2-dimetyl-7-metoxi-6-fenylsulfonyl-trans-4-(2-oxo-l-pyrrolidinyl)-2H-5 benso[b]pyran-3-ol framställs.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3703227 | 1987-02-04 | ||
| DE19873703227 DE3703227A1 (de) | 1987-02-04 | 1987-02-04 | Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI880467A0 FI880467A0 (sv) | 1988-02-02 |
| FI880467A FI880467A (sv) | 1988-08-05 |
| FI90979B true FI90979B (sv) | 1994-01-14 |
| FI90979C FI90979C (sv) | 1994-04-25 |
Family
ID=6320136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI880467A FI90979C (sv) | 1987-02-04 | 1988-02-02 | Förfarande för framställning av terapeutiskt användbara substituerade 3,4-dihydro-2H-benzopyraner |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4999371A (sv) |
| EP (1) | EP0277612B1 (sv) |
| JP (1) | JPH0730072B2 (sv) |
| KR (1) | KR960005151B1 (sv) |
| AR (1) | AR243180A1 (sv) |
| AT (1) | ATE92060T1 (sv) |
| AU (1) | AU604525B2 (sv) |
| CA (1) | CA1335504C (sv) |
| CS (1) | CS408591A3 (sv) |
| DE (2) | DE3703227A1 (sv) |
| DK (1) | DK166279C (sv) |
| ES (1) | ES2058149T3 (sv) |
| FI (1) | FI90979C (sv) |
| HU (1) | HU205107B (sv) |
| IE (1) | IE62220B1 (sv) |
| IL (1) | IL85290A (sv) |
| NO (1) | NO169963C (sv) |
| NZ (1) | NZ223383A (sv) |
| PH (1) | PH24326A (sv) |
| PT (1) | PT86690B (sv) |
| ZA (1) | ZA88754B (sv) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5387587A (en) * | 1986-12-23 | 1995-02-07 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Chroman derivatives |
| ES2058148T3 (es) * | 1987-02-04 | 1994-11-01 | Hoechst Ag | N-benzopiranil-lactamas sustituidas con alquilo, procedimiento para su preparacion, su empleo, asi como preparados farmaceuticos a base de estos compuestos. |
| US5284838A (en) * | 1987-06-23 | 1994-02-08 | Elf Sanofi | Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma |
| GB8800199D0 (en) * | 1988-01-06 | 1988-02-10 | Beecham Group Plc | Pharmaceutical preparation |
| DE3823533A1 (de) * | 1988-07-12 | 1990-02-08 | Beiersdorf Ag | Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate |
| US5364878A (en) * | 1988-07-19 | 1994-11-15 | Hoechst Aktiengesellschaft | Use of substituted 3,4-dihydro-2H-benzopyrans as remedies for obstructive functional disorders of the lungs |
| DE3824446A1 (de) * | 1988-07-19 | 1990-01-25 | Hoechst Ag, 6230 Frankfurt | Verwendung substituierter 3,4-dihydro-2h-benzopyrane als heilmittel gegen obstruktive funktionsstoerungen der lunge und/oder stoerungen der ableitenden harnwege |
| DE3827532A1 (de) * | 1988-08-13 | 1990-03-01 | Hoechst Ag | 6-aroyl-substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen |
| DE3837809A1 (de) * | 1988-11-08 | 1990-05-10 | Merck Patent Gmbh | Tetralinderivate |
| GB8924373D0 (en) * | 1989-10-30 | 1989-12-20 | Beecham Group Plc | Novel compounds |
| JP2575226B2 (ja) * | 1990-05-11 | 1997-01-22 | 吉富製薬株式会社 | 光学活性な３，４−ジヒドロ−３，４−エポキシ−２ｈ−１ベンゾピラン化合物の製造法およびその合成中間体 |
| TW244350B (sv) * | 1991-12-14 | 1995-04-01 | Hoechst Ag | |
| JP3502403B2 (ja) * | 1991-12-16 | 2004-03-02 | アベンティス ファーマ株式会社 | 骨吸収抑制剤 |
| HUT72741A (en) * | 1992-12-19 | 1996-05-28 | Alkaloida Vegyeszeti Gyar | Method for producing benzopyrane derivatives and pharmaceutical compositions containing them |
| GB9316111D0 (en) * | 1993-08-04 | 1993-09-22 | Pfizer Ltd | Benzopyrans |
| KR100691836B1 (ko) * | 2005-03-30 | 2007-03-12 | 한국화학연구원 | 2,2' 위치에 이중치환된 6-아미노술포닐 벤조피란 유도체 및 그를 유효성분으로 함유하는 항우울제 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ183551A (en) * | 1976-04-02 | 1978-09-20 | Beecham Group Ltd | Aminochromanols and pharmaceutical compositions containingthem |
| DE3064286D1 (en) * | 1979-09-28 | 1983-08-25 | Beecham Group Plc | Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them |
| ATE23718T1 (de) * | 1981-09-25 | 1986-12-15 | Beecham Group Plc | Benzopyran-verbindungen mit pharmazeutischer wirkung. |
| DE3364145D1 (de) * | 1982-04-08 | 1986-07-24 | Beecham Group Plc | Antihypertensive benzopyranols |
| DE3364734D1 (en) * | 1982-10-19 | 1986-08-28 | Beecham Group Plc | Novel chromans and chromenes |
| GB8308062D0 (en) * | 1983-03-24 | 1983-05-05 | Beecham Group Plc | Active compounds |
| GB8419516D0 (en) * | 1984-07-31 | 1984-09-05 | Beecham Group Plc | Treatment |
| GB8521857D0 (en) * | 1985-09-03 | 1985-10-09 | Beecham Group Plc | Active compounds |
| ES2058148T3 (es) * | 1987-02-04 | 1994-11-01 | Hoechst Ag | N-benzopiranil-lactamas sustituidas con alquilo, procedimiento para su preparacion, su empleo, asi como preparados farmaceuticos a base de estos compuestos. |
-
1987
- 1987-02-04 DE DE19873703227 patent/DE3703227A1/de not_active Withdrawn
-
1988
- 1988-01-30 DE DE8888101345T patent/DE3882544D1/de not_active Expired - Fee Related
- 1988-01-30 ES ES88101345T patent/ES2058149T3/es not_active Expired - Lifetime
- 1988-01-30 AT AT88101345T patent/ATE92060T1/de not_active IP Right Cessation
- 1988-01-30 EP EP88101345A patent/EP0277612B1/de not_active Expired - Lifetime
- 1988-02-02 IL IL8529088A patent/IL85290A/en not_active IP Right Cessation
- 1988-02-02 HU HU88451A patent/HU205107B/hu not_active IP Right Cessation
- 1988-02-02 FI FI880467A patent/FI90979C/sv not_active IP Right Cessation
- 1988-02-02 PH PH36448A patent/PH24326A/en unknown
- 1988-02-02 NZ NZ223383A patent/NZ223383A/en unknown
- 1988-02-02 US US07/151,584 patent/US4999371A/en not_active Expired - Lifetime
- 1988-02-02 AR AR88309999A patent/AR243180A1/es active
- 1988-02-03 DK DK055088A patent/DK166279C/da not_active IP Right Cessation
- 1988-02-03 NO NO880473A patent/NO169963C/no not_active IP Right Cessation
- 1988-02-03 IE IE29488A patent/IE62220B1/en not_active IP Right Cessation
- 1988-02-03 CA CA000558044A patent/CA1335504C/en not_active Expired - Fee Related
- 1988-02-03 JP JP63022151A patent/JPH0730072B2/ja not_active Expired - Fee Related
- 1988-02-03 ZA ZA880754A patent/ZA88754B/xx unknown
- 1988-02-03 AU AU11226/88A patent/AU604525B2/en not_active Ceased
- 1988-02-03 PT PT86690A patent/PT86690B/pt not_active IP Right Cessation
- 1988-02-04 KR KR1019880001003A patent/KR960005151B1/ko not_active IP Right Cessation
-
1991
- 1991-12-27 CS CS914085A patent/CS408591A3/cs unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed |
Owner name: HOECHST AKTIENGESELLSCHAFT |