FI90663B - Förfarande för framställning av terapeutiskt användbara makrolidföreningar - Google Patents
Förfarande för framställning av terapeutiskt användbara makrolidföreningar Download PDFInfo
- Publication number
- FI90663B FI90663B FI872517A FI872517A FI90663B FI 90663 B FI90663 B FI 90663B FI 872517 A FI872517 A FI 872517A FI 872517 A FI872517 A FI 872517A FI 90663 B FI90663 B FI 90663B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- compound
- group
- compounds
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Insects & Arthropods (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (2)
1 CH CH, 3 4 1
30. CH3 CH3""K, H Xr1 Y %c-·0 UI) °—!j cH3 OR3 37 90663 väri R1 och OR3 är som ovan definierats, omsätts med ett reagens H2NOR2 eller ett sait därav, väri R3 är som ovan definierats, eller (B) för framställning av en förening med formeln I, * 5 väri OR3 är en hydroxylgrupp, reduceras en förening med formeln (III) NOR2 Jk. ,, CH-. CH S 3 I 3 H f L J h [i ch3"']\ >C,h \ r1 H L o J> (I111
15 Uj/ 0 Ργ^" ch3 H o 20 väri R1 och R2 är som ovan definierats, och om sä önskas, utförs en eller flera av följande reak-tioner: (i) en förening med formeln I, väri OR3 är en grupp 2 5 -OR4, -OCOR4, -0C02R4 eller -OCONR8R9, hydrolyseras för fram ställning av motsvarande förening med formeln I, väri OR3 är en hydroxylgrupp, (ii) en förening med formeln I, väri R2 är lägre alkyl eller allyl och R3 är väte, företras eller acyleras för 30 framställning av motsvarande förening med formeln I, väri OR3 är en grupp -OR4, -OCOR4, -OC02R4 eller -OCONRV, och (iii) en förening med formeln I, väri R2 är väte och OR3 är en grupp -OR4, -OCOR4, -0C02R4 eller -OCONR8R9, omsätts med en företrande förening R2Y, väri R2 är lägre alkyl el- 38 90663 ler allyl och Y är en avgäende grupp, för framställning av motsvarande förening med formeln I, väri R2 är lägre alkyl eller allyl.
1. Förfarande för framställning av terapeutiskt användbara makrolidföreningar med formeln (I)
5 NOR2 JL XCH „ ch3 H tf ΜΓo ; 3 i rv IL rt s. H | 10 ν''* X ^ 1 CH' kT-. ^ R 31 'H (1) H ' °v° J)l 9h]>^h is iti °-fsjX^CH3 väri OR3 R1 är metyl, etyl eller isopropyl;
20 R2 är väte, lägre alkyl eller allyl och grupp =NOR2 före-ligger i E-konfiguration; och OR3 är en hydroxylgrupp eller en grupp -OR4, -OCOR4 eller -OCOjR4, väri R4 är lägre alkyl, eller en grupp -OCONR8R9, väri R8 och R9 vardera självständigt är väte eller lägre 25 alkyl, kännetecknat därav, att (A) en förening med formeln (II) 0
2. Förfarande enligt patentkrav l, kanne-5 tecknat därav, att Rl är isopropyl, R2 är metyl och R} är väte.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI923445A FI90549C (sv) | 1986-06-06 | 1992-07-30 | Makrolidföreningar och användning av dem vid bekämpning av skadekryp |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8613790 | 1986-06-06 | ||
| GB868613790A GB8613790D0 (en) | 1986-06-06 | 1986-06-06 | Chemical compounds |
| GB868625854A GB8625854D0 (en) | 1986-10-29 | 1986-10-29 | Chemical process |
| GB8625854 | 1986-10-29 | ||
| GB8708423 | 1987-04-08 | ||
| GB878708423A GB8708423D0 (en) | 1987-04-08 | 1987-04-08 | Chemical compounds |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI872517A0 FI872517A0 (sv) | 1987-06-04 |
| FI872517A FI872517A (sv) | 1987-12-07 |
| FI90663B true FI90663B (sv) | 1993-11-30 |
| FI90663C FI90663C (sv) | 1994-03-10 |
Family
ID=27263057
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI872517A FI90663C (sv) | 1986-06-06 | 1987-06-04 | Förfarande för framställning av terapeutiskt användbara makrolidföreningar |
| FI923445A FI90549C (sv) | 1986-06-06 | 1992-07-30 | Makrolidföreningar och användning av dem vid bekämpning av skadekryp |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI923445A FI90549C (sv) | 1986-06-06 | 1992-07-30 | Makrolidföreningar och användning av dem vid bekämpning av skadekryp |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US4900753A (sv) |
| JP (1) | JP2648147B2 (sv) |
| KR (1) | KR950010077B1 (sv) |
| CN (1) | CN1023858C (sv) |
| AR (1) | AR244691A1 (sv) |
| AT (1) | AT398571B (sv) |
| AU (1) | AU609399B2 (sv) |
| BE (1) | BE1000201A4 (sv) |
| BR (1) | BR8702866A (sv) |
| CA (1) | CA1296329C (sv) |
| CH (1) | CH677670A5 (sv) |
| DE (3) | DE3718926C2 (sv) |
| DK (1) | DK166498B1 (sv) |
| EG (1) | EG18752A (sv) |
| ES (1) | ES2006479A6 (sv) |
| FI (2) | FI90663C (sv) |
| FR (1) | FR2599742B1 (sv) |
| GB (1) | GB2192630B (sv) |
| GE (1) | GEP19981388B (sv) |
| GR (1) | GR870891B (sv) |
| HU (1) | HU199847B (sv) |
| IE (1) | IE60411B1 (sv) |
| IL (1) | IL82776A (sv) |
| IT (1) | IT1206015B (sv) |
| LU (2) | LU86908A1 (sv) |
| LV (2) | LV10280A (sv) |
| NL (2) | NL193376C (sv) |
| NZ (1) | NZ220587A (sv) |
| OA (1) | OA08606A (sv) |
| PH (1) | PH23948A (sv) |
| PL (3) | PL155723B1 (sv) |
| PT (1) | PT85018B (sv) |
| SE (1) | SE503399C2 (sv) |
| TR (1) | TR28970A (sv) |
| UA (1) | UA45300C2 (sv) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4886828A (en) * | 1986-09-12 | 1989-12-12 | American Cyanamid Company | Δ22 -derivatives of LL-F28249 compounds |
| EP0260537A1 (en) * | 1986-09-12 | 1988-03-23 | American Cyanamid Company | 13-Deoxy-23-oxo(keto) and 23-imino derivatives of 13-deoxy C-076-aglycone compounds |
| ES2058082T3 (es) * | 1986-09-12 | 1994-11-01 | American Cyanamid Co | Derivados 23-oxo (ceto) y 23-imino de compuestos ll-f28249. |
| GB8721377D0 (en) * | 1987-09-11 | 1987-10-21 | Glaxo Group Ltd | Chemical compounds |
| GB8811036D0 (en) * | 1988-05-10 | 1988-06-15 | Glaxo Group Ltd | Chemical compounds |
| GB8813150D0 (en) * | 1988-06-03 | 1988-07-06 | American Cyanamid Co | Chemical compounds |
| GB8905605D0 (en) * | 1989-03-11 | 1989-04-26 | Beecham Group Plc | Novel compounds |
| NZ233680A (en) * | 1989-05-17 | 1995-02-24 | Beecham Group Plc | Avermectins and milbemycins and compositions thereof |
| US4988824A (en) * | 1989-09-11 | 1991-01-29 | Maulding Donald R | Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds |
| JPH06505711A (ja) * | 1990-12-07 | 1994-06-30 | テンプル ユニバーシティ−オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | 安定化された昆虫寄生性線虫組成物 |
| JP2855181B2 (ja) | 1993-12-10 | 1999-02-10 | 敏雄 鈴木 | 松類の枯損防止用組成物及び防止方法 |
| PT1197215E (pt) | 2000-10-10 | 2006-07-31 | Wyeth Corp | Composicoes antelminticas |
| US7348417B2 (en) | 2003-08-07 | 2008-03-25 | Wyeth | Method of purifying moxidectin through crystallization |
| US20090214676A1 (en) | 2005-04-30 | 2009-08-27 | Tissuetech, Inc. | Method for treating ocular demodex |
| JP4939025B2 (ja) * | 2005-09-30 | 2012-05-23 | 三菱電線工業株式会社 | 電熱ヒータ付きハンドル用グリップ部材 |
| EP1849363A1 (en) * | 2006-03-09 | 2007-10-31 | Cheminova A/S | Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin |
| US8128968B2 (en) | 2007-08-29 | 2012-03-06 | Tissuetech, Inc. | Compositions and methods for treating Demodex infestations |
| AU2012345813B2 (en) | 2011-12-02 | 2017-02-02 | Boehringer lngelheim Vetmedica GMBH | Long-acting injectable moxidectin formulations and novel moxidectin crystal forms |
| FR2995605B1 (fr) * | 2012-09-18 | 2014-09-19 | Sanofi Sa | Derives de macrolides, leur preparation et leur application therapeutique. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH15982A (en) * | 1977-10-03 | 1983-05-18 | Merck & Co Inc | Selective hydrogenation producta of c-076 compounds and derivatives thereof |
| US4289760A (en) * | 1980-05-02 | 1981-09-15 | Merck & Co., Inc. | 23-Keto derivatives of C-076 compounds |
| US4423209A (en) * | 1982-02-26 | 1983-12-27 | Merck & Co., Inc. | Processes for the interconversion of avermectin compounds |
| JPS59108785A (ja) * | 1982-11-25 | 1984-06-23 | Sankyo Co Ltd | ミルベマイシン類の５−オキシム誘導体 |
| JPS60126289A (ja) * | 1983-11-14 | 1985-07-05 | Sankyo Co Ltd | ミルベマイシン類の５−カ−ボネ−ト誘導体 |
| PT80577B (pt) * | 1984-06-05 | 1987-09-18 | American Cyanamid Co | Processo para a producao de novos agentes macrolidos ll-f28249 uteis no tratamento de infeccoes helminticas por ectoparasitas artropodes e por acarideos |
| US4579864A (en) * | 1984-06-11 | 1986-04-01 | Merck & Co., Inc. | Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives |
| BR8504457A (pt) * | 1984-09-14 | 1986-07-15 | Glaxo Group Ltd | Processos para a preparacao de um composto e de uma composicao para combater infeccoes ou infestacoes |
| AU596586B2 (en) * | 1985-04-30 | 1990-05-10 | American Cyanamid Company | Chemical derivatives of antibiotics S541 |
| ES2058082T3 (es) * | 1986-09-12 | 1994-11-01 | American Cyanamid Co | Derivados 23-oxo (ceto) y 23-imino de compuestos ll-f28249. |
-
1987
- 1987-05-26 CA CA000537979A patent/CA1296329C/en not_active Expired - Lifetime
- 1987-06-02 OA OA59131A patent/OA08606A/xx unknown
- 1987-06-04 FI FI872517A patent/FI90663C/sv not_active IP Right Cessation
- 1987-06-04 EG EG32487A patent/EG18752A/xx active
- 1987-06-04 DK DK290287A patent/DK166498B1/da not_active IP Right Cessation
- 1987-06-04 ES ES8701645A patent/ES2006479A6/es not_active Expired
- 1987-06-05 PL PL1987282198A patent/PL155723B1/pl unknown
- 1987-06-05 KR KR1019870005694A patent/KR950010077B1/ko not_active IP Right Cessation
- 1987-06-05 GB GB8713239A patent/GB2192630B/en not_active Expired - Lifetime
- 1987-06-05 JP JP62140139A patent/JP2648147B2/ja not_active Expired - Lifetime
- 1987-06-05 BE BE8700626A patent/BE1000201A4/fr not_active IP Right Cessation
- 1987-06-05 BR BR8702866A patent/BR8702866A/pt not_active IP Right Cessation
- 1987-06-05 SE SE8702361A patent/SE503399C2/sv not_active IP Right Cessation
- 1987-06-05 DE DE3718926A patent/DE3718926C2/de not_active Expired - Lifetime
- 1987-06-05 NZ NZ220587A patent/NZ220587A/xx unknown
- 1987-06-05 PL PL1987283187A patent/PL153036B1/pl unknown
- 1987-06-05 PL PL1987266100A patent/PL153226B1/pl unknown
- 1987-06-05 TR TR00392/87A patent/TR28970A/xx unknown
- 1987-06-05 GR GR870891A patent/GR870891B/el unknown
- 1987-06-05 AU AU73873/87A patent/AU609399B2/en not_active Expired
- 1987-06-05 LU LU86908A patent/LU86908A1/fr active Protection Beyond IP Right Term
- 1987-06-05 NL NL8701322A patent/NL193376C/nl not_active IP Right Cessation
- 1987-06-05 AT AT0143887A patent/AT398571B/de not_active IP Right Cessation
- 1987-06-05 DE DE3745133A patent/DE3745133C2/de not_active Expired - Lifetime
- 1987-06-05 IE IE149687A patent/IE60411B1/en not_active IP Right Cessation
- 1987-06-05 FR FR878707915A patent/FR2599742B1/fr not_active Expired
- 1987-06-05 AR AR87307796A patent/AR244691A1/es active
- 1987-06-05 PT PT85018A patent/PT85018B/pt unknown
- 1987-06-05 DE DE1998175029 patent/DE19875029I2/de active Active
- 1987-06-05 IT IT8748023A patent/IT1206015B/it active
- 1987-06-05 CH CH2150/87A patent/CH677670A5/de not_active IP Right Cessation
- 1987-06-05 PH PH35347A patent/PH23948A/en unknown
- 1987-06-05 CN CN87104431A patent/CN1023858C/zh not_active Expired - Lifetime
- 1987-06-05 US US07/058,856 patent/US4900753A/en not_active Expired - Lifetime
- 1987-06-05 HU HU872583A patent/HU199847B/hu unknown
- 1987-06-05 IL IL82776A patent/IL82776A/xx not_active IP Right Cessation
-
1992
- 1992-07-30 FI FI923445A patent/FI90549C/sv not_active IP Right Cessation
- 1992-12-30 LV LV920561A patent/LV10280A/xx unknown
-
1993
- 1993-08-25 GE GEAP19931498A patent/GEP19981388B/en unknown
- 1993-09-15 UA UA93003885A patent/UA45300C2/uk unknown
- 1993-11-15 LV LVP-93-1233A patent/LV10781B/lv unknown
-
1996
- 1996-07-17 LU LU88790C patent/LU88790I2/fr unknown
-
1999
- 1999-08-18 NL NL990026C patent/NL990026I2/nl unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| SPCG | Supplementary protection certificate granted |
Spc suppl protection certif: L124 Extension date: 20091229 |
|
| FG | Patent granted |
Owner name: WYETH HOLDINGS CORPORATION |
|
| MA | Patent expired |