FI90064B - En analogimetod foer framstaellning av bicykliska sulfonamidderivat - Google Patents
En analogimetod foer framstaellning av bicykliska sulfonamidderivat Download PDFInfo
- Publication number
- FI90064B FI90064B FI864675A FI864675A FI90064B FI 90064 B FI90064 B FI 90064B FI 864675 A FI864675 A FI 864675A FI 864675 A FI864675 A FI 864675A FI 90064 B FI90064 B FI 90064B
- Authority
- FI
- Finland
- Prior art keywords
- acid
- compound
- mixture
- reaction
- chloride
- Prior art date
Links
- 0 C*(C)[C@]1[C@](CC2)C[C@@]2[C@@]1* Chemical compound C*(C)[C@]1[C@](CC2)C[C@@]2[C@@]1* 0.000 description 11
- QGMMKSUHQMVLRO-VGRMVHKJSA-N N[C@@H]1[C@@H](CC2)C[C@@H]2[C@@H]1CO Chemical compound N[C@@H]1[C@@H](CC2)C[C@@H]2[C@@H]1CO QGMMKSUHQMVLRO-VGRMVHKJSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
- C07D213/34—Sulfur atoms to which a second hetero atom is attached
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (3)
1. En analogimetod för framställning av sulfonamidderivat eller deras salters enligt formeIn, 239 n () 6 4 5 (C«. V I (chT)T^hhso>-R! io i vilken forroel R1 är väte, en nedre alkyl eller en sait bil-dande grupp, R2 är en alkyl, substituerad eller osubstituerad aryl, aralkyl eller en heterocykel, säsom pyridyl, R3 är väte eller metyl, X en alkylen eller alkenylen, som kan vara 15 substituerad med en fluoratom eller -atomer och som i kedjan kan innehälla syre, svavel och/eller fenylen, Y är en rakked-jad eller förgrenad alkylen eller alkenylen, syre eller svavel, när talet 0 eller 1 och n är 0, 1 eller 2, kännetecknad av, att antingen 20 a) en förening enligt formeln, (CHa Jn-^^^^^X-COORi R> (CH,)· M*. 25 där Rj' är en nedre alkyl och symbolerna R3, Y, m och n har ovan beskrivna betydelse, fäs att reagera med en förening enligt formeln, 30 , Hai—S02—R2 där R2 har ovan beskrivna betydelse och Hai är en halogen, eller i 240 - ,-. r. . , y 0 0 6 4 b) en förening enligt formeln, ?'
5 XX 1 i där symbolerna R2, R3, m och n har ovan beskrivna betydelse 10 och R8 är väte eller fluor, fäs att reagera med en förening enligt formeln, i » Hal®(Ar) 3-F^-CH2-A-COOR1 15 dSr Rj' är en nedre alkyl, Ar är en aromatisk kolvätegrupp, A är en alkylen eller fenylen och Hal Sr en halogen, och vid behov reduceras produkten, frAn den avlSgsnas skyddsgrupperna och/eller den görs till ett salt.
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25915485 | 1985-11-18 | ||
| JP25915485 | 1985-11-18 | ||
| JP3013086 | 1986-02-13 | ||
| JP3013086 | 1986-02-13 | ||
| JP11559986 | 1986-05-19 | ||
| JP11559986 | 1986-05-19 | ||
| JP12901186 | 1986-06-03 | ||
| JP12901186 | 1986-06-03 | ||
| JP16925786 | 1986-07-17 | ||
| JP16925786 | 1986-07-17 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI864675A0 FI864675A0 (fi) | 1986-11-17 |
| FI864675A FI864675A (fi) | 1987-05-19 |
| FI90064B true FI90064B (fi) | 1993-09-15 |
| FI90064C FI90064C (sv) | 1993-12-27 |
Family
ID=27521199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI864675A FI90064C (sv) | 1985-11-18 | 1986-11-17 | En analogimetod för framställning av bicykliska sulfonamidderivat |
Country Status (20)
| Country | Link |
|---|---|
| US (6) | US4861913A (sv) |
| EP (1) | EP0226346B1 (sv) |
| JP (1) | JPS63139161A (sv) |
| CN (1) | CN1019194B (sv) |
| AR (1) | AR245102A1 (sv) |
| AT (1) | ATE66207T1 (sv) |
| AU (1) | AU595554B2 (sv) |
| CA (1) | CA1278577C (sv) |
| DE (1) | DE3680884D1 (sv) |
| DK (1) | DK169918B1 (sv) |
| ES (1) | ES2051693T3 (sv) |
| FI (1) | FI90064C (sv) |
| GB (1) | GB2184118B (sv) |
| GR (1) | GR3002489T3 (sv) |
| HU (1) | HU203078B (sv) |
| IE (1) | IE58988B1 (sv) |
| IL (1) | IL80670A (sv) |
| NO (1) | NO165442C (sv) |
| NZ (1) | NZ218115A (sv) |
| PT (1) | PT83744B (sv) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1278577C (en) * | 1985-11-18 | 1991-01-02 | Tatsuo Tsuri | Bicyclic sulfonamide derivatives |
| GB8708233D0 (en) * | 1987-04-07 | 1987-05-13 | Smith Kline French Lab | Pharmaceutically active compounds |
| CA1294974C (en) * | 1987-05-08 | 1992-01-28 | Sanji Hagishita | Bicyclic sulfonamide derivatives and process therefor |
| GB8717374D0 (en) * | 1987-07-22 | 1987-08-26 | Smith Kline French Lab | Pharmaceutically active compounds |
| EP0312906A3 (en) * | 1987-10-23 | 1990-09-05 | Ono Pharmaceutical Co., Ltd. | Novel sulfonamide derivatives |
| JP2565746B2 (ja) * | 1987-10-23 | 1996-12-18 | 小野薬品工業株式会社 | 新規な炭素環系スルホンアミド誘導体 |
| EP0516181A1 (en) * | 1987-10-23 | 1992-12-02 | Ono Pharmaceutical Co., Ltd. | Novel sulfonamide derivatives |
| EP0516180A1 (en) * | 1988-04-19 | 1992-12-02 | Ono Pharmaceutical Co., Ltd. | Novel sulfonamide derivatives |
| CA1332607C (en) * | 1988-07-19 | 1994-10-18 | Masayuki Narisada | Alkenyltetrazole derivatives |
| US5008409A (en) * | 1988-12-14 | 1991-04-16 | Shionogi & Co., Ltd. | Process for preparing 1,4-bridged cyclohexane carboxylic acid derivatives |
| US5241104A (en) * | 1988-12-14 | 1993-08-31 | Shionogi & Co., Ltd. | Mono ester of dicarboxylic acid and process thereof |
| KR0138528B1 (en) * | 1988-12-14 | 1998-05-01 | Shionogi Seiyaku Kk | Preparation of 2,3-trans-1,4-bridged cyclohexane sulfonamide derivatives |
| US5047574A (en) * | 1988-12-14 | 1991-09-10 | Shionogi & Co., Ltd. | Certain optically active mono esters of dicarboxylic acids |
| US5117039A (en) * | 1988-12-14 | 1992-05-26 | Shionogi & Co., Ltd. | Monoesters of arylacetic acid and the process thereof |
| JP2756689B2 (ja) * | 1989-02-20 | 1998-05-25 | 塩野義製薬株式会社 | 置換ヘキセン酸誘導体 |
| DK0557519T3 (da) * | 1989-10-18 | 1997-06-23 | Shionogi & Co | Fremgangsmåde til fremstilling af sulfonamidderivater af norbornan |
| US5763647A (en) * | 1990-03-30 | 1998-06-09 | Shionogi & Co., Ltd. | Preparation of optically active 1,4-bridged-cyclohexane carboxylic acid derivatives |
| JP2891740B2 (ja) * | 1990-03-30 | 1999-05-17 | 塩野義製薬株式会社 | 光学活性ノルボルナン系アミン誘導体の製造方法 |
| JP2984077B2 (ja) * | 1990-04-19 | 1999-11-29 | 塩野義製薬株式会社 | スルホニルアミノ置換ビシクロ環系ヒドロキサム酸誘導体 |
| FR2665440B1 (fr) * | 1990-07-31 | 1994-02-04 | Lipha | Nouveaux cycloalkylsulfonamides substitues, procedes de preparation et medicaments les contenant. |
| US5550248A (en) * | 1990-11-29 | 1996-08-27 | E.R. Squibb & Sons, Inc. | Substituted stryl heterocyclic amido prostaglandin analogs |
| US5334369A (en) * | 1991-06-11 | 1994-08-02 | Medical University Of South Carolina | Platelet receptor antagonists useful in detecting intravascular platelet aggregation |
| US5827868A (en) * | 1991-10-07 | 1998-10-27 | E. R. Squibb & Sons, Inc. | Prostaglandin analogs |
| CA2113787A1 (en) * | 1993-01-29 | 1994-07-30 | Nobuyuki Hamanaka | Carbocyclic sulfonamides |
| EP0837052B1 (en) | 1995-06-21 | 2006-08-23 | Shionogi & Co., Ltd. | Bicyclic amino derivatives and pgd 2 antagonist containing the same |
| IL118727A (en) * | 1995-06-29 | 2003-01-12 | Lilly Co Eli | (-)-2-spiro-5-hydantoinbicyclo [3.1.0] hexane-6-carboxylic acid, salts thereof and use thereof for the preparation of (+)-(2) aminobicyclo [3.1.0] hexane-2,6-dicarboxylic acid |
| ZA969485B (en) * | 1995-11-16 | 1998-05-12 | Lilly Co Eli | Excitatory amino acid receptor antagonists. |
| KR19990067597A (ko) * | 1995-11-16 | 1999-08-25 | 피터 지. 스트링거 | 흥분성 아미노산 수용체 길항제 |
| DE69717810T2 (de) * | 1996-04-26 | 2003-09-18 | Shionogi & Co., Ltd. | S1452-tabletten mit schneller freisetzung |
| WO1998025915A1 (fr) * | 1996-12-12 | 1998-06-18 | Shionogi & Co., Ltd. | Derives d'amide d'acide benzenecarboxylique condenses heterocycliques et antagonistes pgd2 renfermant ces derives |
| PT944614E (pt) * | 1996-12-13 | 2003-01-31 | Shionogi & Co | Derivados da benzotiofenocarboxamida e antagonistas de pgd2 que os contem |
| ZA984040B (en) | 1997-05-15 | 1998-11-20 | Ono Pharmaceutical Co | Benzenesulfonamide compounds |
| DE69819350T2 (de) | 1997-09-19 | 2004-07-22 | Shionogi & Co., Ltd. | Verbindungen mit [2.2.1]bicyclischer molekülstruktur |
| WO1999050260A1 (fr) * | 1998-03-31 | 1999-10-07 | Shionogi & Co., Ltd. | PROCEDE DE PRODUCTION DE DERIVES D'ACIDE 5-HYDROXYBENZO[b]THIOPHENE-3-CARBOXYLIQUE |
| PA8469401A1 (es) * | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
| AU1179000A (en) * | 1998-11-19 | 2000-06-13 | Shionogi & Co., Ltd. | Preventives and/or remedies for central nervous system diseases containing compounds having TXA2 receptor antagonism and/or TXA2 synthase inhibitory effect |
| JP2000351729A (ja) * | 1999-06-08 | 2000-12-19 | Shionogi & Co Ltd | トロンボキサンａ２受容体拮抗剤の経皮吸収製剤 |
| CA2389681C (en) | 1999-11-26 | 2010-11-02 | Shionogi & Co., Ltd. | Npy y5 antagonist |
| US7365196B2 (en) * | 2000-03-20 | 2008-04-29 | Merck Sharp & Dohme Ltd. | Sulphonamido-substituted bridged bicycloalkyl derivatives |
| US6727277B1 (en) | 2002-11-12 | 2004-04-27 | Kansas State University Research Foundation | Compounds affecting cholesterol absorption |
| JP5861884B2 (ja) * | 2012-03-29 | 2016-02-16 | 荒川化学工業株式会社 | エキソ型ノルボルネン化合物の製造方法 |
| CN110563006A (zh) * | 2019-09-25 | 2019-12-13 | 新乡市锦源化工有限公司 | 一种对位酯生产中亚硫酸氢钠处理方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL33813A (en) * | 1969-02-14 | 1973-10-25 | Sparamedica Ag | Bornanocarboxamides and their salts,and their preparation |
| US3988362A (en) * | 1972-08-10 | 1976-10-26 | Hoffmann-La Roche Inc. | Intermediates for preparation of 2,2,3-endotrimethyl-7-anti-amino-norbornanes |
| EP0013607B1 (en) * | 1979-01-05 | 1983-03-23 | National Research Development Corporation | Substituted bicyclo (2,2,1)heptanes and bicyclo (2,2,1) hept-2-enes and their pharmaceutical compositions |
| DE3162659D1 (en) * | 1980-07-22 | 1984-04-19 | Ono Pharmaceutical Co | 9,11-methano-13-aza-11a-carbathrombanoic acid analogues and pharmaceutical use thereof |
| JPS5813551A (ja) | 1981-07-16 | 1983-01-26 | Ono Pharmaceut Co Ltd | １３−アザトロンボキサン類似化合物、その製造方法及びその化合物を有効成分として含有するトロンボキサン起因疾患治療剤 |
| JPS58502148A (ja) * | 1981-12-23 | 1983-12-15 | ナシヨナル リサ−チ デイベロツプメント コ−ポレイシヨン | プロスタグランジン |
| US4456615A (en) * | 1982-10-25 | 1984-06-26 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
| US4456616A (en) * | 1982-12-27 | 1984-06-26 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
| US4647585A (en) * | 1984-11-08 | 1987-03-03 | E. R. Squibb & Sons, Inc. | Bicycloheptane substituted ethers |
| US4663336A (en) * | 1985-07-01 | 1987-05-05 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted diamide and its congener prostaglandin analogs useful in the treatment of thrombotic disease |
| US4654357A (en) * | 1985-08-09 | 1987-03-31 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted sulfonamide prostaglandin analogs |
| CA1278577C (en) * | 1985-11-18 | 1991-01-02 | Tatsuo Tsuri | Bicyclic sulfonamide derivatives |
| US4734424A (en) * | 1986-09-24 | 1988-03-29 | E. R. Squibb & Sons, Inc. | Bicycloheptane substituted diamide and its congener prostaglandin analogs |
| CA1294974C (en) * | 1987-05-08 | 1992-01-28 | Sanji Hagishita | Bicyclic sulfonamide derivatives and process therefor |
-
1986
- 1986-10-30 CA CA000521812A patent/CA1278577C/en not_active Expired - Fee Related
- 1986-10-30 NZ NZ218115A patent/NZ218115A/xx unknown
- 1986-11-05 US US06/927,823 patent/US4861913A/en not_active Expired - Lifetime
- 1986-11-13 IE IE300286A patent/IE58988B1/en not_active IP Right Cessation
- 1986-11-14 PT PT83744A patent/PT83744B/pt not_active IP Right Cessation
- 1986-11-14 NO NO864542A patent/NO165442C/no not_active IP Right Cessation
- 1986-11-16 AR AR86305933A patent/AR245102A1/es active
- 1986-11-17 JP JP61273372A patent/JPS63139161A/ja active Granted
- 1986-11-17 HU HU864742A patent/HU203078B/hu not_active IP Right Cessation
- 1986-11-17 IL IL80670A patent/IL80670A/xx unknown
- 1986-11-17 FI FI864675A patent/FI90064C/sv not_active IP Right Cessation
- 1986-11-17 DK DK549086A patent/DK169918B1/da not_active IP Right Cessation
- 1986-11-18 EP EP86309016A patent/EP0226346B1/en not_active Expired - Lifetime
- 1986-11-18 GB GB8627561A patent/GB2184118B/en not_active Expired - Fee Related
- 1986-11-18 ES ES86309016T patent/ES2051693T3/es not_active Expired - Lifetime
- 1986-11-18 AT AT86309016T patent/ATE66207T1/de not_active IP Right Cessation
- 1986-11-18 AU AU65360/86A patent/AU595554B2/en not_active Ceased
- 1986-11-18 CN CN86108584A patent/CN1019194B/zh not_active Expired
- 1986-11-18 DE DE8686309016T patent/DE3680884D1/de not_active Expired - Fee Related
-
1989
- 1989-03-23 US US07/327,772 patent/US4960909A/en not_active Expired - Lifetime
- 1989-03-23 US US07/327,778 patent/US4976891A/en not_active Expired - Lifetime
-
1990
- 1990-04-27 US US07/516,141 patent/US5043456A/en not_active Expired - Lifetime
- 1990-04-27 US US07/516,140 patent/US5043451A/en not_active Expired - Lifetime
- 1990-06-20 US US07/541,491 patent/US5041635A/en not_active Expired - Lifetime
-
1991
- 1991-08-16 GR GR91401163T patent/GR3002489T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI90064B (fi) | En analogimetod foer framstaellning av bicykliska sulfonamidderivat | |
| JPH025739B2 (sv) | ||
| Newkome et al. | Chemistry of heterocyclic compounds. 23. Synthesis of multiheteromacrocycles possessing 2, 6-pyridino subunits connected by carbon-oxygen linkages | |
| DE3882795T2 (de) | Bicyclische Sulfonamidderivate, ihre Herstellung, ihre Anwendung und Zubereitungen die sie enthalten. | |
| Murphy et al. | Tetrathiafulvalene-mediated stereoselective synthesis of the tetracyclic core of Aspidosperma alkaloids | |
| EP1431285B1 (en) | Reverse hydroxamic acid derivatives | |
| HU190530B (en) | Process for producing 7-oxabicyclo-heptane-substituted analogues of prostaglandines | |
| Maezaki et al. | Studies on Intramolecular Alkylation of an α-Sulfinyl Vinylic Carbanion: a Novel Route to Chiral 1-Cycloalkenyl Sulfoxides | |
| Nakamura et al. | Synthesis of macrocyclic dilactones by cyclization of sulfonium salts | |
| Ruano et al. | Synthesis and conformational analysis of some oxisuran metabolites and their O-methylderivatives | |
| CA1273919A (en) | Prostaglandin derivatives, their preparation and use | |
| De Graaf et al. | Functionalized enamines—XV: Reactivity patterns of carbene addition to morpholine enamine of 1-β-acetoxy-6-oxo-8a-methyl-Δ4a (5)-octalin | |
| JP2561466B2 (ja) | フェニルスルホニルアミノアルキルビシクロヘプチルヘプテン酸誘導体 | |
| HU188559B (en) | Process for preparing new inter-m-phenylene-prostacyclin derivatives | |
| SE427556B (sv) | Forfarande for framstellning av 16r- och 16s-alkylsubstituerade prost-5-en-13-ynsyraderivat | |
| KR950001024B1 (ko) | 비시클로환계 술폰아미드 유도체의 제조방법 | |
| KR940011909B1 (ko) | 비시클로환계 술폰아미드 유도체 | |
| US4138409A (en) | Epoxysultone | |
| TWI520956B (zh) | 伊莎匹隆及其中間體之製備方法 | |
| JPS6344143B2 (sv) | ||
| US20040138485A1 (en) | Chemical synthons and intermediates | |
| Dunlap | A SYNTHETIC APPROACH TO THE QUASSINOIDS: A TETRACYCLIC ABCD RING INTERMEDIATE (BRUCEANTIN, MANGANIC ACETATE, IODOTRIMETHYLSILANE) | |
| 田中圭 et al. | Synthetic studies on a picrotoxane sesquiterpene, coriamyrtin. III. Completion of the stereococtrolled total synthesis of (.+-.)-coriamyrtin. | |
| WO1991014675A1 (de) | Bicyclo[3.3.0]octan-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung | |
| JPS6243A (ja) | ７−（２−アルキリデン−３−シクロペンテニル）−５−ヘプテン酸誘導体 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Owner name: SHIONOGI & CO., LTD. |
|
| BB | Publication of examined application | ||
| MM | Patent lapsed |
Owner name: SHIONOGI & CO, LTD |