[go: up one dir, main page]

FI894335L - A continuous ultrasonic method for producing protein-encapsulated microbubbles - Google Patents

A continuous ultrasonic method for producing protein-encapsulated microbubbles Download PDF

Info

Publication number
FI894335L
FI894335L FI894335A FI894335A FI894335L FI 894335 L FI894335 L FI 894335L FI 894335 A FI894335 A FI 894335A FI 894335 A FI894335 A FI 894335A FI 894335 L FI894335 L FI 894335L
Authority
FI
Finland
Prior art keywords
ultrasonic method
continuous ultrasonic
producing protein
encapsulated microbubbles
microbubbles
Prior art date
Application number
FI894335A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI894335A0 (en
FI95872B (en
FI95872C (en
Inventor
David Cerny
Gary J Mills
Peter J Westkaemper
Original Assignee
Molecular Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Biosystems Inc filed Critical Molecular Biosystems Inc
Publication of FI894335A0 publication Critical patent/FI894335A0/en
Publication of FI894335L publication Critical patent/FI894335L/en
Publication of FI95872B publication Critical patent/FI95872B/en
Application granted granted Critical
Publication of FI95872C publication Critical patent/FI95872C/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/04Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Surgical Instruments (AREA)
  • Apparatuses For Generation Of Mechanical Vibrations (AREA)
  • Medicinal Preparation (AREA)
FI894335A 1988-09-14 1989-09-13 A continuous ultrasound method for producing protein-encapsulated microbubbles FI95872C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/244,844 US4957656A (en) 1988-09-14 1988-09-14 Continuous sonication method for preparing protein encapsulated microbubbles
US24484488 1988-09-14

Publications (4)

Publication Number Publication Date
FI894335A0 FI894335A0 (en) 1989-09-13
FI894335L true FI894335L (en) 1990-03-15
FI95872B FI95872B (en) 1995-12-29
FI95872C FI95872C (en) 1996-04-10

Family

ID=22924352

Family Applications (1)

Application Number Title Priority Date Filing Date
FI894335A FI95872C (en) 1988-09-14 1989-09-13 A continuous ultrasound method for producing protein-encapsulated microbubbles

Country Status (15)

Country Link
US (1) US4957656A (en)
EP (1) EP0359246B1 (en)
JP (1) JPH0720545B2 (en)
KR (1) KR0135754B1 (en)
AT (1) ATE87217T1 (en)
AU (1) AU617215B2 (en)
CA (1) CA1337286C (en)
DE (1) DE68905557T2 (en)
DK (1) DK175484B1 (en)
ES (1) ES2054964T3 (en)
FI (1) FI95872C (en)
GR (1) GR3007483T3 (en)
IE (1) IE62602B1 (en)
IL (1) IL91593A0 (en)
NO (1) NO176871C (en)

Families Citing this family (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5086620A (en) * 1991-02-14 1992-02-11 Wayne State University Method of microencapsulation of hyperbaric gas
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US6001335A (en) * 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5228446A (en) * 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5773024A (en) * 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5656211A (en) * 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US6146657A (en) * 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (en) 1990-04-02 1993-05-01 Sint Sa
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
WO1992005806A1 (en) * 1990-10-05 1992-04-16 Sintetica S.A. Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
US5107842A (en) * 1991-02-22 1992-04-28 Molecular Biosystems, Inc. Method of ultrasound imaging of the gastrointestinal tract
US5179955A (en) * 1991-02-22 1993-01-19 Molecular Biosystems, Inc. Method of abdominal ultrasound imaging
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5993805A (en) * 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
GB9111880D0 (en) * 1991-06-03 1991-07-24 Unilever Plc Forming minute gas cells in a liquid medium
NZ244147A (en) 1991-09-03 1994-09-27 Hoechst Ag Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents
US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
EP0605477B2 (en) * 1991-09-17 2007-06-20 GE Healthcare AS Gaseous ultrasound contrast media
MX9205298A (en) 1991-09-17 1993-05-01 Steven Carl Quay GASEOUS ULTRASOUND CONTRASTING MEDIA AND METHOD FOR SELECTING GASES TO BE USED AS ULTRASOUND CONTRASTING MEDIA
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US5196183A (en) * 1991-12-04 1993-03-23 Sterling Winthrop Inc. Contrast agents for ultrasound imaging
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
JPH05262673A (en) * 1992-03-19 1993-10-12 Nippon Paint Co Ltd Contrast medium for ultrasonic diagnosis
US5302372A (en) * 1992-07-27 1994-04-12 National Science Council Method to opacify left ventricle in echocardiography
AU5321694A (en) * 1992-10-06 1994-04-26 Molecular Biosystems, Inc. Method of ultrasonic imaging of body cavities
GB9221329D0 (en) * 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
AU5457394A (en) * 1992-11-02 1994-05-24 Drexel University Surfactant-stabilized microbubble mixtures, process for preparing and methods of using the same
CN1042190C (en) * 1992-12-02 1999-02-24 尤尼利弗公司 Frozen confections
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Phase shift colloids as ultrasound contrast agents
DE69427185T2 (en) * 1993-01-25 2001-12-06 Sonus Pharmaceutical, Inc. Phase-pen colloids for use as ultrasound contrast agents
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US5701899A (en) * 1993-05-12 1997-12-30 The Board Of Regents Of The University Of Nebraska Perfluorobutane ultrasound contrast agent and methods for its manufacture and use
US5695740A (en) * 1993-05-12 1997-12-09 The Board Of Regents Of The University Of Nebraska Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
ES2068151B1 (en) 1993-06-23 1995-11-16 Cabrera Garrido Juan INJECTABLE MICROS FOAM FOR SCLEROSIS.
US5855865A (en) * 1993-07-02 1999-01-05 Molecular Biosystems, Inc. Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
KR100218642B1 (en) * 1993-07-02 1999-09-01 스티븐 로손 Method for preparing encapsulated microspheres from heat denatured protein
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
EP0711179B2 (en) * 1993-07-30 2010-09-01 IMCOR Pharmaceutical Co. Stabilized microbubble compositions for ultrasound
US5385147A (en) * 1993-09-22 1995-01-31 Molecular Biosystems, Inc. Method of ultrasonic imaging of the gastrointestinal tract and upper abdominal organs using an orally administered negative contrast medium
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
DE69432295T2 (en) * 1993-12-15 2003-08-14 Bracco Research Sa GAS MIXTURES CAN BE USED AS ULTRASONIC CONTRAST
JPH10503480A (en) * 1994-05-03 1998-03-31 モレキュラー バイオシステムズ, インコーポレイテッド Composition for ultrasonically quantifying myocardial perfusion
US5736121A (en) * 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US5585064A (en) 1994-07-20 1996-12-17 The Goodyear Tire & Rubber Company Ventless segmented tire mold and method therefore
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
US5965109A (en) * 1994-08-02 1999-10-12 Molecular Biosystems, Inc. Process for making insoluble gas-filled microspheres containing a liquid hydrophobic barrier
US5562893A (en) * 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
GB9423419D0 (en) 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) * 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5560364A (en) * 1995-05-12 1996-10-01 The Board Of Regents Of The University Of Nebraska Suspended ultra-sound induced microbubble cavitation imaging
US5997898A (en) * 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US5820850A (en) * 1995-06-07 1998-10-13 Molecular Biosystems, Inc. Gas-filled amino acid block co-polymer microspheres useful as ultrasound contrast agents
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6033645A (en) * 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US5897851A (en) * 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
US5955143A (en) * 1995-12-21 1999-09-21 Drexel University Hollow polymer microcapsules and method of producing the same
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
JP3178724B2 (en) * 1996-03-05 2001-06-25 エイカスフィアー・インコーポレーテッド Microencapsulated fluorinated gas for use as an imaging agent
US6245747B1 (en) 1996-03-12 2001-06-12 The Board Of Regents Of The University Of Nebraska Targeted site specific antisense oligodeoxynucleotide delivery method
US5875776A (en) * 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
ATE345682T1 (en) 1996-05-01 2006-12-15 Imarx Pharmaceutical Corp IN VITRO METHOD FOR INTRODUCING NUCLEIC ACIDS INTO A CELL
US5976501A (en) * 1996-06-07 1999-11-02 Molecular Biosystems, Inc. Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion
US5849727A (en) * 1996-06-28 1998-12-15 Board Of Regents Of The University Of Nebraska Compositions and methods for altering the biodistribution of biological agents
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
EP1683517A1 (en) 1996-08-19 2006-07-26 American Bioscience, Inc. Methods for the production of protein particles useful for delivery of pharmacological agents
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US6017310A (en) * 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
DK0977597T3 (en) * 1996-09-11 2003-05-05 Imarx Pharmaceutical Corp Improved methods of diagnostic imaging using a contrast agent and a vasodilator.
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6083484A (en) 1996-10-17 2000-07-04 Molecular Biosystems, Inc. Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents
US6068600A (en) * 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6143276A (en) * 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
GB9708246D0 (en) 1997-04-24 1997-06-18 Nycomed Imaging As Improvements in or relating to ultrasound imaging
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
AU7702798A (en) * 1997-05-30 1998-12-30 Alliance Pharmaceutical Corporation Methods and apparatus for monitoring and quantifying the movement of fluid
DK1023050T3 (en) * 1997-06-27 2013-10-14 Abraxis Bioscience Llc NEW FORMULATIONS OF PHARMACOLOGICAL AGENTS, PROCEDURES FOR THE PRODUCTION THEREOF AND PROCEDURES FOR USE THEREOF
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6123923A (en) * 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) * 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
GB9813568D0 (en) 1998-06-23 1998-08-19 Nycomed Imaging As Improvements in or relating to cardiac imaging
DK1139799T3 (en) * 1998-12-23 2003-10-20 Unilever Nv Pourable water and oil containing emulsions containing gas bubbles
US6444192B1 (en) 1999-02-05 2002-09-03 The Regents Of The University Of California Diagnostic imaging of lymph structures
GB9912356D0 (en) 1999-05-26 1999-07-28 Btg Int Ltd Generation of microfoam
US6258419B1 (en) 1999-09-02 2001-07-10 Micron Technology, Inc. Sonication of monolayer films
US6210611B1 (en) 1999-11-30 2001-04-03 Duke University Methods for producing gas microbubbles having lipid-containing shells formed thereon
US8512680B2 (en) 2001-08-08 2013-08-20 Btg International Ltd. Injectables in foam, new pharmaceutical applications
WO2003090717A1 (en) * 2002-04-23 2003-11-06 Nanotherapeutics, Inc Process of forming and modifying particles and compositions produced thereby
US20040126400A1 (en) * 2002-05-03 2004-07-01 Iversen Patrick L. Delivery of therapeutic compounds via microparticles or microbubbles
US8048439B2 (en) 2003-11-17 2011-11-01 Btg International Ltd. Therapeutic foam
CZ2006315A3 (en) 2003-11-17 2006-10-11 Btg International Limited Therapeutic foam
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
WO2006137933A2 (en) * 2004-11-03 2006-12-28 Leucadia Technologies, Inc. Microbubbles for affinity separation
US8338579B2 (en) 2004-11-03 2012-12-25 Iris Molecular Diagnostics, Inc. Homogeneous analyte detection
GB0509824D0 (en) 2005-05-13 2005-06-22 Btg Int Ltd Therapeutic foam
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9486274B2 (en) * 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US7967763B2 (en) 2005-09-07 2011-06-28 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues
US9358033B2 (en) 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US8518069B2 (en) 2005-09-07 2013-08-27 Cabochon Aesthetics, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US7799023B2 (en) * 2005-09-26 2010-09-21 Coherex Medical, Inc. Compliant electrode for patent foramen ovale closure device
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
US7885793B2 (en) 2007-05-22 2011-02-08 International Business Machines Corporation Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution
US8221405B2 (en) * 2006-02-06 2012-07-17 Coherex Medical, Inc. Patent foramen ovale closure device and methods for determining RF dose for patent foramen ovale closure
US7938826B2 (en) * 2006-05-30 2011-05-10 Coherex Medical, Inc. Methods, systems, and devices for closing a patent foramen ovale using mechanical structures
US8402974B2 (en) * 2006-05-30 2013-03-26 Coherex Medical, Inc. Methods, systems, and devices for sensing, measuring, and controlling closure of a patent foramen ovale
US8439940B2 (en) 2010-12-22 2013-05-14 Cabochon Aesthetics, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
KR100965479B1 (en) * 2007-10-29 2010-06-24 한국식품연구원 Ultrasound-Accepted Muscle Proteins
US8647696B2 (en) 2008-12-12 2014-02-11 The University Of Birmingham Low fat food containing gas bubbles
US8167280B2 (en) * 2009-03-23 2012-05-01 Cabochon Aesthetics, Inc. Bubble generator having disposable bubble cartridges
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
EP2470287A4 (en) 2009-08-28 2015-01-21 Univ Columbia SYSTEMS, METHODS, AND DEVICES FOR PRODUCING GAS FILLED MICROBULLES
US9532769B2 (en) 2009-09-04 2017-01-03 The University Of North Carolina At Chapel Hill Systems, methods, and computer readable media for high frequency contrast imaging and image-guided therapeutics
JP5427080B2 (en) * 2010-03-23 2014-02-26 富士フイルム株式会社 Fine particle production method and fine particle production apparatus
US9427410B2 (en) 2010-10-08 2016-08-30 The University Of North Carolina At Chapel Hill Formulation of acoustically activatable particles having low vaporization energy and methods for using same
US10279053B2 (en) 2011-07-19 2019-05-07 Nuvox Pharma Llc Microbubble compositions, method of making same, and method using same
JP6420761B2 (en) * 2012-06-26 2018-11-07 ジーイー・ヘルスケア・アクスイェ・セルスカプ Preparation of compositions containing gaseous microbubbles
WO2014055832A1 (en) 2012-10-04 2014-04-10 The University Of North Carolina At Chapel Hill Methods and systems for using encapsulated microbubbles to process biological samples
TWI616210B (en) * 2016-01-07 2018-03-01 國立臺灣科技大學 Modified microbubble and method of making the same
KR102296972B1 (en) * 2021-02-18 2021-09-02 내외코리아 주식회사 Fire extinguisher micro capsule manufacturing device
US20240173931A1 (en) 2022-11-30 2024-05-30 The Goodyear Tire & Rubber Company Mold for producing annular rubber component
US20240227335A1 (en) 2023-01-11 2024-07-11 The Goodyear Tire & Rubber Company Molding method for tire production

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
AU545866B2 (en) * 1980-11-17 1985-08-01 Schering Aktiengesellschaft Microbubble precursors and methods for their production and use
DE3141641A1 (en) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen ULTRASONIC CONTRAST AGENTS AND THEIR PRODUCTION
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
DE3529195A1 (en) * 1985-08-14 1987-02-26 Max Planck Gesellschaft CONTRAST AGENTS FOR ULTRASONIC EXAMINATIONS AND METHOD FOR THE PRODUCTION THEREOF
IE61591B1 (en) * 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent

Also Published As

Publication number Publication date
NO893671L (en) 1990-03-15
DE68905557D1 (en) 1993-04-29
KR0135754B1 (en) 1998-04-22
EP0359246A2 (en) 1990-03-21
AU617215B2 (en) 1991-11-21
FI894335A0 (en) 1989-09-13
DK451189A (en) 1990-03-15
IL91593A0 (en) 1990-04-29
DK175484B1 (en) 2004-11-08
NO176871C (en) 1995-06-14
IE62602B1 (en) 1995-02-22
JPH0720545B2 (en) 1995-03-08
US4957656A (en) 1990-09-18
ATE87217T1 (en) 1993-04-15
FI95872B (en) 1995-12-29
NO176871B (en) 1995-03-06
GR3007483T3 (en) 1993-07-30
NO893671D0 (en) 1989-09-13
EP0359246A3 (en) 1991-08-28
KR900004395A (en) 1990-04-12
FI95872C (en) 1996-04-10
AU4131289A (en) 1990-03-22
JPH02115037A (en) 1990-04-27
IE892837L (en) 1990-03-14
DE68905557T2 (en) 1993-07-01
ES2054964T3 (en) 1994-08-16
EP0359246B1 (en) 1993-03-24
CA1337286C (en) 1995-10-10
DK451189D0 (en) 1989-09-13

Similar Documents

Publication Publication Date Title
FI894335L (en) A continuous ultrasonic method for producing protein-encapsulated microbubbles
FI892649L (en) Method for producing a tissue adhesive
GB2219088B (en) Vibrating transducers
DE68918165D1 (en) Ultrasonic transducer and method for its production.
FI873261L (en) Method for producing fiber-reinforced thermoplastic structure
FI891389L (en) Process for producing sweeteners
FI892055L (en) Method for producing a nicotine-emitting device
GB8723980D0 (en) Ultrasonic apparatus
FI881743L (en) Method for producing bifunctional proteins
PT87014A (en) METHOD FOR PRODUCING IBUPROFEN
EP0335577A3 (en) Ultrasonic transducer system
KR900009515A (en) Propylene production method
FI875295L (en) Method for producing a hirudin variant
GB2190818B (en) A method for providing a desired sound field as well as an ultrasonic transducer for carrying out the method
GB2203978B (en) Ultrasonic vibrational cutting apparatus
GB2222862B (en) A vibrator
EP0257825A3 (en) Ultrasonic vibrator horn
GB2244764B (en) Bonding apparatus
FI881060L (en) Method for producing a cheese-flavored flavoring mixture
EP0224116A3 (en) A method for producing cycloalkanols
KR900007855A (en) Method for producing N-phosphonomethylglycine
KR900700238A (en) Ultrasonic polishing method
RO102743B1 (en) Sodium-bichromate producing method
IT8647699A0 (en) METHOD AND DISTRIBUTOR FOR PRODUCING A FOAM
FI892527L (en) Method for producing a tube feeding

Legal Events

Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: MOLECULAR BIOSYSTEMS, INC.