FI890282L - Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi Download PDF

Info

Publication number: FI890282L
Authority: FI; Finland
Prior art keywords: hydroxyciferol; didehydro; derivatives; preparation; therapeutically useful
Prior art date: 1988-01-20

Application number

FI890282A

Other languages

English (en)

Swedish (sv)

Other versions

FI890282A0 (fi

FI92193C (fi

FI92193B (fi

Inventor

Enrico Giuseppe Baggiolini

John Joseph Partridge

Shian-Jan Shiuey

Gary Arthur Truitt

Milan Radoje Uskokovic

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-20

Filing date

1989-01-19

Publication date

1989-07-21

1989-01-19 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1989-01-19 Publication of FI890282A0 publication Critical patent/FI890282A0/fi

1989-07-21 Publication of FI890282L publication Critical patent/FI890282L/fi

1994-06-30 Application granted granted Critical

1994-06-30 Publication of FI92193B publication Critical patent/FI92193B/fi

1994-10-10 Publication of FI92193C publication Critical patent/FI92193C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
- C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
- C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
- C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Nutrition Science (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Hydrogenated Pyridines (AREA)

FI890282A 1988-01-20 1989-01-19 Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi FI92193C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/145,867 US4804502A (en)	1988-01-20	1988-01-20	Vitamin D compounds
US14586788		1988-01-20

Publications (4)

Publication Number	Publication Date
FI890282A0 FI890282A0 (fi)	1989-01-19
FI890282L true FI890282L (fi)	1989-07-21
FI92193B FI92193B (fi)	1994-06-30
FI92193C FI92193C (fi)	1994-10-10

Family

ID=22514903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI890282A FI92193C (fi)	1988-01-20	1989-01-19	Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi

Country Status (23)

Country	Link
US (1)	US4804502A (fi)
EP (1)	EP0326875B1 (fi)
JP (1)	JPH0764805B2 (fi)
KR (1)	KR960009118B1 (fi)
AR (1)	AR246253A1 (fi)
AT (1)	ATE74125T1 (fi)
AU (1)	AU621851B2 (fi)
CA (1)	CA1314906C (fi)
DE (1)	DE58901003D1 (fi)
DK (1)	DK171966B1 (fi)
ES (1)	ES2032613T3 (fi)
FI (1)	FI92193C (fi)
GR (1)	GR3004785T3 (fi)
HU (1)	HU201736B (fi)
IE (1)	IE60920B1 (fi)
IL (1)	IL88988A (fi)
MC (1)	MC1997A1 (fi)
NO (1)	NO174547C (fi)
NZ (1)	NZ227642A (fi)
PH (1)	PH24442A (fi)
PT (1)	PT89485B (fi)
YU (1)	YU47204B (fi)
ZA (1)	ZA8922B (fi)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4898855A (en) *	1987-09-14	1990-02-06	Hoffman-La Roche Inc.	Deuterated analogs of 1,25-dihydroxycholecalciferol
US5145846A (en) *	1988-01-20	1992-09-08	Hoffmann-La Roche Inc.	Vitamin D3 analogs
ZA8923B (en) *	1988-01-20	1989-09-27	Hoffmann La Roche	16-dehydro-vitamin d3-derivatives
US5087619A (en) *	1988-01-20	1992-02-11	Hoffman-La Roche Inc.	Vitamin D3 analogs
US4927815A (en) *	1988-04-29	1990-05-22	Wisconsin Alumni Research Foundation	Compounds effective in inducing cell differentiation and process for preparing same
EP0398217B1 (de) *	1989-05-18	1994-01-12	F. Hoffmann-La Roche Ag	Dehydrocholecalciferolderivate
GB9017890D0 (en)	1990-08-15	1990-09-26	Leo Pharm Prod Ltd	Chemical compounds i
US5258559A (en) *	1990-11-27	1993-11-02	Hoffmann-La Roche Inc.	Process for the preparation of [1R-(1β(R*), 3aα, 4β, 7aβ)] octahydro-1-(5-hydroxy-1,5-dimethylhexyl)-7a-methyl-4H-inden-4-one
ES2200238T3 (es) *	1991-01-08	2004-03-01	Bone Care International, Inc.	Procedimiento para la preparacion de la 1-alpha-24-dihidroxi vitamina d2.
US20040009958A1 (en) *	1991-01-08	2004-01-15	Bone Care International, Inc.	Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
AU650751B2 (en) *	1991-05-28	1994-06-30	Wisconsin Alumni Research Foundation	Novel synthesis of 19-nor vitamin D compounds
EP0521550B1 (en) *	1991-07-05	1996-09-18	Duphar International Research B.V	Vitamin D compound, method of preparing this compound and intermediate therefor
IL99368A (en) *	1991-09-02	1996-01-19	Teva Pharma	Preparations for the treatment of psoriasis and atopic dermatitis, which contain the result of xanthine
US5200536A (en) *	1992-02-10	1993-04-06	Daikin Industries Ltd.	Fluorine-containing vitamin D3 analogues
DE69304279T2 (de) *	1992-05-20	1997-02-20	Hoffmann La Roche	Fluorierte Analoge Vitamins D3
DE4220757A1 (de) *	1992-06-24	1994-01-05	Schering Ag	Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DE4221961A1 (de) *	1992-06-30	1994-01-05	Schering Ag	22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
CA2096105A1 (en) *	1992-10-07	1994-04-08	Enrico Giuseppe Baggiolini (Deceased)	Vitamin d3 fluorinated analogs
US5753638A (en) *	1992-10-07	1998-05-19	Hoffmann-La Roche Inc.	Method of treating hyperproliferative skin disease with Vitamin D3 fluorinated analogs
GB9223061D0 (en) *	1992-11-04	1992-12-16	Leo Pharm Prod Ltd	Chemical compounds
TW267161B (fi) *	1992-11-20	1996-01-01	Hoffmann La Roche
US5547947A (en) *	1993-03-11	1996-08-20	Hoffmann-La Roche Inc.	Methods of treatment
GB9314400D0 (en) *	1993-07-12	1993-08-25	Leo Pharm Prod Ltd	Produktionsaktieselskab) chemical compounds
US5401733A (en) *	1993-10-01	1995-03-28	Hoffmann-La Roche Inc.	Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) *	1993-11-24	1995-06-27	Hoffmann-La Roche Inc.	Vitamin D3 fluorinated analogs
US6121469A (en)	1993-12-23	2000-09-19	The Regents Of The University Of California	Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs
US6103709A (en) *	1993-12-23	2000-08-15	The Regents Of The University Of California	Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
WO1997016193A1 (en) *	1995-10-27	1997-05-09	F. Hoffmann-La Roche Ag	Pharmaceutical composition for treating osteoporosis
US5696103A (en) *	1995-11-17	1997-12-09	Syntex (U.S.A.) Inc.	Method for treating osteoporosis
US5939408A (en)	1996-05-23	1999-08-17	Hoffman-La Roche Inc.	Vitamin D3 analogs
NO971934L (no) *	1996-05-23	1997-11-24	Hoffmann La Roche	Flourinerte vitamin D3 -analoger
WO1998051678A1 (en) *	1997-05-16	1998-11-19	Women & Infants Hospital	CYCLIC ETHER VITAMIN D3 COMPOUNDS, 1α (OH) 3-EPI-VITAMIN D3 COMPOUNDS AND USES THEREOF
US6017908A (en) *	1997-05-16	2000-01-25	Women And Infants Hospital	3-EPI vitamin D2 compounds and uses thereof
AU7497798A (en) *	1997-05-16	1998-12-08	F. Hoffmann-La Roche Ag	3-epi compounds of vitamin d3 and uses thereof
US6087350A (en)	1997-08-29	2000-07-11	University Of Pittsburgh Of The Commonwealth System Of Higher Education	Use of pretreatment chemicals to enhance efficacy of cytotoxic agents
DE69814109T2 (de) *	1997-09-08	2004-02-26	F. Hoffmann-La Roche Ag	1,3-dihydroxy-20,20-dialkyl-vitamin d3 analoga
US5919986A (en) *	1997-10-17	1999-07-06	Hoffmann-La Roche Inc.	D-homo vitamin D3 derivatives
EP1064000B1 (en) *	1998-03-27	2011-07-06	Oregon Health & Science University	Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders
WO2006120681A2 (en) *	2005-05-10	2006-11-16	Dermipsor Ltd.	Compositions and methods for skin care
EP1314427A4 (en) *	2000-08-17	2006-05-03	Chugai Pharmaceutical Co Ltd	THERAPEUTIC AGENT FOR THE TREATMENT OF OSTEOPOROSIS
GB0305332D0 (en) *	2003-03-10	2003-04-09	Leuven K U Res & Dev	Biological evaluation of novel vitamin D analogues
GB0422929D0 (en) *	2004-10-15	2004-11-17	Leuven K U Res & Dev	Bioactive vitamin D analogues
US7094775B2 (en) *	2004-06-30	2006-08-22	Bone Care International, Llc	Method of treating breast cancer using a combination of vitamin D analogues and other agents
US20060003950A1 (en) *	2004-06-30	2006-01-05	Bone Care International, Inc.	Method of treating prostatic diseases using a combination of vitamin D analogues and other agents
AU2005303773A1 (en)	2004-11-12	2006-05-18	Bioxell Spa	Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer
US9173835B2 (en) *	2005-05-10	2015-11-03	Dermipsor Ltd.	Compositions and methods for treating hyperproliferative epidermal diseases
KR101366457B1 (ko) *	2006-03-15	2014-03-12	니혼 마이크로바이오팜 가부시키가이샤	인덴 유도체의 제조 방법 및 그 제조 중간체
US20110319644A1 (en)	2006-11-02	2011-12-29	Asako Toyoda	Process for production of 1-hydroxy-19-norcyclovitamin d derivative and intermediate for the production
CR20170434A (es)	2009-01-27	2017-11-21	Berg Llc	VITAMINA D3 Y ANALOGOS DE LA MISMA PARA ALIVIAR EFECTOS SECUNDARIOS ASOCIADOS CON LA QUIMIOTERAPIA. (Divisional 2011-0445)
KR101791828B1 (ko)	2009-08-14	2017-10-31	베르그 엘엘씨	탈모증 치료용 비타민 ｄ3 및 이의 유사체들
EP2634171B8 (en)	2010-10-25	2016-01-13	Teijin Pharma Limited	23-yne-vitamin d3 derivative
AU2014274099A1 (en)	2013-05-29	2015-12-24	Berg Llc	Preventing or mitigating chemotherapy induced alopecia using vitamin D
WO2017209934A1 (en)	2016-05-13	2017-12-07	Case Western Reserve University	Autophagy activators for treating or preventing skin injury

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7803154A (nl) *	1977-03-24	1978-09-26	Wisconsin Alumni Res Found	Vitamine d-antagonisten, werkwijze voor de be- reiding daarvan, en preparaten die ze bevatten.
DE2920092A1 (de) *	1978-05-19	1979-11-29	Wisconsin Alumni Res Found	Antivitamin d-verbindungen und diese enthaltende pharmazeutische zusammensetzungen
US4358406A (en) *	1981-07-27	1982-11-09	Wisconsin Alumni Research Foundation	26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
US4360471A (en) *	1981-12-11	1982-11-23	Wisconsin Alumni Research Foundation	23-Dehydro-25-hydroxyvitamin D3
US4508651A (en) *	1983-03-21	1985-04-02	Hoffmann-La Roche Inc.	Synthesis of 1α,25-dihydroxyergocalciferol
US4689180A (en) *	1984-01-30	1987-08-25	Wisconsin Alumni Research Foundation	1α,25-dihydroxy-22Z-dehydroxyvitamin D compound
US4505906A (en) *	1984-01-30	1985-03-19	Wisconsin Alumni Research Foundation	Hydroxyvitamin D2 isomers
US4521410A (en) *	1984-05-03	1985-06-04	The General Hospital Corporation	Vitamin D glycosyl orthoesters
US4612308A (en) *	1984-11-29	1986-09-16	Hoffmann-La Roche Inc.	25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
US4898855A (en) *	1987-09-14	1990-02-06	Hoffman-La Roche Inc.	Deuterated analogs of 1,25-dihydroxycholecalciferol
ZA8923B (en) *	1988-01-20	1989-09-27	Hoffmann La Roche	16-dehydro-vitamin d3-derivatives

1988
- 1988-01-20 US US07/145,867 patent/US4804502A/en not_active Expired - Fee Related
1989
- 1989-01-03 ZA ZA8922A patent/ZA8922B/xx unknown
- 1989-01-17 CA CA000588385A patent/CA1314906C/en not_active Expired - Fee Related
- 1989-01-17 DK DK019689A patent/DK171966B1/da not_active IP Right Cessation
- 1989-01-17 PH PH38058A patent/PH24442A/en unknown
- 1989-01-17 NZ NZ227642A patent/NZ227642A/en unknown
- 1989-01-18 AR AR89313012A patent/AR246253A1/es active
- 1989-01-18 HU HU89174A patent/HU201736B/hu not_active IP Right Cessation
- 1989-01-18 IL IL88988A patent/IL88988A/xx not_active IP Right Cessation
- 1989-01-19 PT PT89485A patent/PT89485B/pt not_active IP Right Cessation
- 1989-01-19 IE IE15689A patent/IE60920B1/en not_active IP Right Cessation
- 1989-01-19 FI FI890282A patent/FI92193C/fi not_active IP Right Cessation
- 1989-01-19 JP JP1008781A patent/JPH0764805B2/ja not_active Expired - Lifetime
- 1989-01-19 AU AU28643/89A patent/AU621851B2/en not_active Ceased
- 1989-01-19 KR KR89000513A patent/KR960009118B1/ko not_active Expired - Lifetime
- 1989-01-19 MC MC892028A patent/MC1997A1/xx unknown
- 1989-01-19 NO NO890240A patent/NO174547C/no unknown
- 1989-01-19 YU YU11889A patent/YU47204B/sh unknown
- 1989-01-20 EP EP89100973A patent/EP0326875B1/de not_active Expired - Lifetime
- 1989-01-20 ES ES198989100973T patent/ES2032613T3/es not_active Expired - Lifetime
- 1989-01-20 AT AT89100973T patent/ATE74125T1/de not_active IP Right Cessation
- 1989-01-20 DE DE8989100973T patent/DE58901003D1/de not_active Expired - Lifetime
1992
- 1992-06-03 GR GR920401137T patent/GR3004785T3/el unknown

Also Published As

Publication number	Publication date
ATE74125T1 (de)	1992-04-15
FI890282A0 (fi)	1989-01-19
EP0326875A1 (de)	1989-08-09
NO174547C (no)	1994-05-25
JPH0764805B2 (ja)	1995-07-12
IE60920B1 (en)	1994-08-24
AU621851B2 (en)	1992-03-26
NZ227642A (en)	1991-06-25
CA1314906C (en)	1993-03-23
DE58901003D1 (de)	1992-04-30
EP0326875B1 (de)	1992-03-25
NO174547B (no)	1994-02-14
FI92193C (fi)	1994-10-10
HU201736B (en)	1990-12-28
GR3004785T3 (fi)	1993-04-28
NO890240L (no)	1989-07-21
PT89485A (pt)	1989-10-04
DK171966B1 (da)	1997-09-01
DK19689A (da)	1989-07-21
PH24442A (en)	1990-06-25
AR246253A1 (es)	1994-07-29
HUT49316A (en)	1989-09-28
NO890240D0 (no)	1989-01-19
JPH029860A (ja)	1990-01-12
MC1997A1 (fr)	1990-01-26
KR960009118B1 (en)	1996-07-13
FI92193B (fi)	1994-06-30
KR890011837A (ko)	1989-08-22
PT89485B (pt)	1993-12-31
IL88988A (en)	1993-08-18
YU11889A (en)	1991-04-30
ES2032613T3 (es)	1993-02-16
ZA8922B (en)	1989-09-27
US4804502A (en)	1989-02-14
IL88988A0 (en)	1989-08-15
IE890156L (en)	1989-07-20
YU47204B (sh)	1995-01-31
DK19689D0 (da)	1989-01-17
AU2864389A (en)	1989-07-20

Publication	Publication Date	Title
FI890282A0 (fi)	1989-01-19	Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi
FI92934B (fi)	1994-10-14	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-deoksinojirimysiinijohdannaisten valmistamiseksi
FI875660L (fi)	1987-12-22	Menetelmä terapeuttisesti käyttökelpoisten 5-fenyyli-2-pyrimidinonijohdannaisten valmistamiseksi
FI881180L (fi)	1988-09-14	Menetelmä terapeuttisesti käytettävien tetrahydronaftaleenijohdannaisten valmistamiseksi
FI892182A0 (fi)	1989-05-05	Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
FI874459A0 (fi)	1987-10-09	Menetelmä uusien terapeuttisesti käyttökelpoisten piperidiinijohdannaisten valmistamiseksi
FI891700L (fi)	1989-10-14	Menetelmä beta-laktaamijohdannaisten valmistamiseksi
FI94752C (fi)	1995-10-25	Menetelmä terapeuttisesti käyttökelpoisten propenonioksiimieettereiden valmistamiseksi
FI906408L (fi)	1991-06-29	Menetelmä terapeuttisesti käyttökelpoisten 2-aminopyrimidiini-4-karboksamidijohdannaisten valmistamiseksi
FI880467A (fi)	1988-08-05	Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 3,4-dihydro-2H-bentsopyraanien valmistamiseksi
FI873350A (fi)	1988-02-05	Menetelmä terapeuttisesti käyttökelpoisten 1,4-dihydropyridiinijohdannaisten valmistamiseksi
NO173334C (no)	1993-12-01	Analogifremgangsm}te for fremstilling av terapeutisk aktive alkylaminoalkylenderivater 2H-1-benzopyraner
FI93215C (fi)	1995-03-10	Menetelmä terapeuttisesti käyttökelpoisten aminoalkoksifenyylijohdannaisten valmistamiseksi
FI892948A (fi)	1989-12-17	Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
FI902727A0 (fi)	1990-06-01	Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
FI903863A0 (fi)	1990-08-03	Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
FI893003L (fi)	1989-12-21	Menetelmä uusien terapeuttisesti käyttökelpoisten neplanosiinijohdannaisten valmistamiseksi
FI891677L (fi)	1989-10-12	Menetelmä 4-demetoksidaunomysinonin valmistamiseksi
FI884660A0 (fi)	1988-10-11	Menetelmä terapeuttisesti aktiivisten 2,2-dimetyylikromeenijohdannaisten valmistamiseksi
FI903077A0 (fi)	1990-06-19	Menetelmä valmistaa terapeuttisesti aktiivisia R(-)-3-kinuklidinolijohdannaisia
FI94351B (fi)	1995-05-15	Menetelmä terapeuttisesti käyttökelpoisten peptidijohdannaisten valmistamiseksi
FI893682L (fi)	1990-02-14	Menetelmä terapeuttisesti käyttökelpoisten 1,2,5-ditiatsosiinijohdannaisten valmistamiseksi
FI900145A0 (fi)	1990-01-11	Menetelmä farmaseuttisesti käyttökelpoisten 1,1-diokso-kefem-4-karbotiolihappojohdannaisten valmistamiseksi
FI891473L (fi)	1989-09-29	Menetelmä terapeuttisesti käyttökelpoisten 4-aryyli-4-piperidiinikarbinolien valmistamiseksi
FI92188C (fi)	1994-10-10	Menetelmä terapeuttisesti käyttökelpoisten fenoksialkyylipyrokatekolijohdannaisten valmistamiseksi

Legal Events

Date	Code	Title	Description
1994-06-01	BB	Publication of examined application
2004-08-31	MM	Patent lapsed	Owner name: F. HOFFMANN-LA ROCHE AG