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FI885504A0 - Vaskulaera antikoagulerande proteiner, dessa koderande dna, deras framstaellningsfoerfarande och deras anvaendning. - Google Patents

Vaskulaera antikoagulerande proteiner, dessa koderande dna, deras framstaellningsfoerfarande och deras anvaendning.

Info

Publication number
FI885504A0
FI885504A0 FI885504A FI885504A FI885504A0 FI 885504 A0 FI885504 A0 FI 885504A0 FI 885504 A FI885504 A FI 885504A FI 885504 A FI885504 A FI 885504A FI 885504 A0 FI885504 A0 FI 885504A0
Authority
FI
Finland
Prior art keywords
deras
dna
vaskulaera
koderande
antikoagulerande
Prior art date
Application number
FI885504A
Other languages
English (en)
Other versions
FI885504A (fi
FI103892B (fi
FI103892B1 (fi
Inventor
Rudolf Hauptmann
Ingrid Maurer-Fogy
Gerhard Bodo
Peter Swetly
Christian Stratowa
Egard Falkner
Guenther Adolf
Christian Mar Reutelingsperger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19873710430 external-priority patent/DE3710430A1/de
Priority claimed from DE19873710364 external-priority patent/DE3710364A1/de
Priority claimed from DE19873710309 external-priority patent/DE3710309A1/de
Priority claimed from DE19873737367 external-priority patent/DE3737367A1/de
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of FI885504A publication Critical patent/FI885504A/fi
Publication of FI885504A0 publication Critical patent/FI885504A0/fi
Application granted granted Critical
Publication of FI103892B publication Critical patent/FI103892B/fi
Publication of FI103892B1 publication Critical patent/FI103892B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
FI885504A 1987-03-28 1988-11-28 Rekombinantti-DNA-molekyyli, joka koodaa polypeptidiä/proteiinia, jolla on oleellisesti vaskulaaristen antikoaguloivien proteiinien biologiset ominaisuudet sekä niiden valmistus FI103892B1 (fi)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DE19873710430 DE3710430A1 (de) 1987-03-28 1987-03-28 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
DE3710309 1987-03-28
DE3710364 1987-03-28
DE19873710364 DE3710364A1 (de) 1987-03-28 1987-03-28 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
DE19873710309 DE3710309A1 (de) 1987-03-28 1987-03-28 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
DE3710430 1987-03-28
DE19873737367 DE3737367A1 (de) 1987-11-04 1987-11-04 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
DE3737367 1987-11-04
PCT/EP1988/000266 WO1988007576A2 (fr) 1987-03-28 1988-03-26 Proteines vasculaires anticoagulantes, leurs adn de codage, production et utilisation
EP8800266 1988-03-26

Publications (4)

Publication Number Publication Date
FI885504A FI885504A (fi) 1988-11-28
FI885504A0 true FI885504A0 (fi) 1988-11-28
FI103892B FI103892B (fi) 1999-10-15
FI103892B1 FI103892B1 (fi) 1999-10-15

Family

ID=27433878

Family Applications (1)

Application Number Title Priority Date Filing Date
FI885504A FI103892B1 (fi) 1987-03-28 1988-11-28 Rekombinantti-DNA-molekyyli, joka koodaa polypeptidiä/proteiinia, jolla on oleellisesti vaskulaaristen antikoaguloivien proteiinien biologiset ominaisuudet sekä niiden valmistus

Country Status (17)

Country Link
US (1) US5837842A (fi)
EP (1) EP0293567B1 (fi)
JP (1) JPH01503515A (fi)
KR (1) KR890700666A (fi)
AT (1) ATE133707T1 (fi)
AU (1) AU625214B2 (fi)
DD (1) DD273285A5 (fi)
DE (1) DE3854950D1 (fi)
DK (1) DK175468B1 (fi)
FI (1) FI103892B1 (fi)
HU (1) HUT52544A (fi)
IE (2) IE74679B1 (fi)
IL (1) IL85878A (fi)
NO (1) NO885275L (fi)
NZ (1) NZ224057A (fi)
PT (1) PT87083B (fi)
WO (1) WO1988007576A2 (fi)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2660514B2 (ja) * 1987-02-20 1997-10-08 興和株式会社 抗血液凝固作用を有するポリペプチド
ATE124087T1 (de) * 1988-02-26 1995-07-15 Biogen Inc Dna-sequenzen, rekombinante dna-moleküle und verfahren zur herstellung von lipocortin iii, iv, v, und vi.
AU3231189A (en) * 1988-03-31 1989-10-05 Rorer International (Overseas) Inc. Recombinant endonexin ii
DE3910240A1 (de) * 1989-03-30 1990-10-04 Behringwerke Ag Pp4-delta, seine herstellung und verwendung
ATE89169T1 (de) * 1989-07-15 1993-05-15 Boehringer Ingelheim Int Antikoagulanz enthaltendes mittel.
DE3937607A1 (de) * 1989-11-11 1991-05-16 Boehringer Ingelheim Int Verwendung eines antikoagulanz zur behandlung von tumorerkrankungen
ES2113372T3 (es) * 1989-12-27 1998-05-01 Boehringer Ingelheim Int Utilizacion de un anticoagulante como agente de diagnostico.
US5627036A (en) * 1989-12-27 1997-05-06 Boehringer Ingelheim International Gmbh Use of an anticoagulant as a diagnostic agent
WO1992019279A1 (en) * 1991-05-09 1992-11-12 Board Of Regents Of The University Of Washington Phospholipid-targeted thrombolytic agents
US5632986A (en) * 1991-05-09 1997-05-27 The University Of Washington Phospholipid-targeted thrombolytic agents
EP0968648A1 (en) * 1992-07-08 2000-01-05 N.V. Innogenetics S.A. Mammalian nonhuman transgenic animal having a constitutive or inducible expression of the human endonexin II gene or its muteins or its fragments
US20030220233A1 (en) 1994-01-24 2003-11-27 Neorx Corporation Radiolabeled annexins
US5968477A (en) 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator
WO1996015152A1 (fr) * 1994-11-11 1996-05-23 International Reagents Corporation Anticorps monoclonal antiannexine-v, procede pour produire cet anticorps, et utilisation de cet anticorps
US7645739B2 (en) 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
US6962903B2 (en) * 2001-02-21 2005-11-08 Alavita, Inc. Modified annexin proteins and methods for preventing thrombosis
US7635680B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury
US20090291086A1 (en) * 2001-02-21 2009-11-26 Alavita Pharmaceuticals, Inc. Compositions and Methods for Treating Cerebral Thrombosis and Global Cerebral Ischemia
US20050222030A1 (en) * 2001-02-21 2005-10-06 Anthony Allison Modified annexin proteins and methods for preventing thrombosis
US7635676B2 (en) * 2001-02-21 2009-12-22 Alavita Pharmaccuticals, Inc. Modified annexin proteins and methods for their use in organ transplantation
AU784548B2 (en) * 2001-03-16 2006-04-27 Ortho-Clinical Diagnostics, Inc. Reg-like protein
EP1445613B1 (en) * 2001-05-21 2010-07-07 FUJIFILM Corporation Biochemical analysis unit and method for its production
US7622260B2 (en) 2001-09-05 2009-11-24 The Brigham And Women's Hospital, Inc. Diagnostic and prognostic tests
FR2841557B1 (fr) 2002-07-01 2005-12-09 Commissariat Energie Atomique Peptides ayant une affinite pour un phospholipide et utilisations
FR2841558B1 (fr) * 2002-07-01 2004-08-13 Commissariat Energie Atomique Peptides marques ayant une affinite pour un phospholipide et utilisations
EP1533619B1 (en) * 2003-11-20 2009-04-29 F. Hoffmann-Roche AG Specific markers for metabolic syndrome

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
US5066788A (en) * 1984-09-21 1991-11-19 Boehringer Ingelheim International Gmbh Blood coagulation inhibiting proteins, processes for preparing them and their uses
NO164991C (no) * 1984-09-21 1990-12-05 Boehringer Ingelheim Int Fremgangsmaate for fremstilling av blodkoaguleringshemmende proteiner.
CN86100721A (zh) * 1985-01-10 1987-02-11 比奥根公司 为人类脂皮质激素多肽编码的脱氧核糖核酸顺序，含有它的重组脱氧核糖核酸分子及制造该多肽的方法
AU5770786A (en) * 1985-04-15 1986-11-05 Biotechnology Research Partners Limited Human anti-inflammatory phospholipase inhibitor protein
CA1265446A (en) * 1985-09-30 1990-02-06 Masahiro Maki Anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component
JPH01502667A (ja) * 1987-02-06 1989-09-14 ザイモジェネティクス，インコーポレイティド 抗凝固活性及び抗炎症活性を有するヒト蛋白質
US4937324A (en) * 1987-02-06 1990-06-26 Zymogenetics, Inc. Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity
US5179081A (en) * 1988-07-21 1993-01-12 Kowa Co., Ltd. Method of treatment using an anticoagulant polypeptide

Also Published As

Publication number Publication date
WO1988007576A2 (fr) 1988-10-06
FI885504A (fi) 1988-11-28
EP0293567B1 (de) 1996-01-31
KR890700666A (ko) 1989-11-26
WO1988007576A3 (fr) 1989-01-26
IL85878A (en) 1993-07-08
NZ224057A (en) 1991-04-26
EP0293567A1 (de) 1988-12-07
DD273285A5 (de) 1989-11-08
ATE133707T1 (de) 1996-02-15
DK662288A (da) 1989-01-25
IE880928L (en) 1988-09-28
DE3854950D1 (de) 1996-03-14
NO885275D0 (no) 1988-11-25
AU625214B2 (en) 1992-07-02
DK175468B1 (da) 2004-11-01
IE960853L (en) 1988-09-28
AU1402788A (en) 1988-09-29
PT87083B (pt) 1992-07-31
IE74679B1 (en) 1997-07-30
FI103892B (fi) 1999-10-15
HUT52544A (en) 1990-07-28
IL85878A0 (en) 1988-09-30
FI103892B1 (fi) 1999-10-15
NO885275L (no) 1989-01-25
JPH01503515A (ja) 1989-11-30
DK662288D0 (da) 1988-11-25
US5837842A (en) 1998-11-17
PT87083A (pt) 1988-04-01

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Legal Events

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FG Patent granted

Owner name: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

MA Patent expired