FI884497A - Förfarande för framställning av nya aromatasinhiberande 4(5)-imidazoler - Google Patents

Förfarande för framställning av nya aromatasinhiberande 4(5)-imidazoler Download PDF

Info

Publication number: FI884497A
Authority: FI; Finland
Prior art keywords: imidazoles; inhibiting; preparation; aromatase; novel
Prior art date: 1987-10-09

Application number

FI884497A

Other languages

English (en)

Finnish (fi)

Other versions

FI93105B (sv

FI884497A0 (sv

FI93105C (sv

Inventor

Arto Johannes Karjalainen

Lauri Veikko Matti Kangas

Kauko Oiva Antero Kurkela

Original Assignee

Farmos Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-09

Filing date

1988-09-30

Publication date

1989-04-10

1988-09-30 Application filed by Farmos Oy filed Critical Farmos Oy

1988-09-30 Publication of FI884497A0 publication Critical patent/FI884497A0/sv

1989-04-10 Publication of FI884497A publication Critical patent/FI884497A/sv

1994-11-15 Publication of FI93105B publication Critical patent/FI93105B/sv

1995-02-27 Application granted granted Critical

1995-02-27 Publication of FI93105C publication Critical patent/FI93105C/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

FI884497A 1987-10-09 1988-09-30 Förfarande för framställning av nya aromatasinhiberande 4(5)-imidazoler FI93105C (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8723715		1987-10-09
GB8723715A GB2210875B (en)	1987-10-09	1987-10-09	Aromatase inhibiting 4(5)-imidazoles

Publications (4)

Publication Number	Publication Date
FI884497A0 FI884497A0 (sv)	1988-09-30
FI884497A true FI884497A (sv)	1989-04-10
FI93105B FI93105B (sv)	1994-11-15
FI93105C FI93105C (sv)	1995-02-27

Family

ID=10625036

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI884497A FI93105C (sv)	1987-10-09	1988-09-30	Förfarande för framställning av nya aromatasinhiberande 4(5)-imidazoler

Country Status (24)

Country	Link
US (1)	US5098923A (sv)
EP (1)	EP0311447B1 (sv)
JP (1)	JPH01132568A (sv)
KR (1)	KR890006593A (sv)
CN (1)	CN1036993C (sv)
AU (1)	AU615482B2 (sv)
CA (1)	CA1329616C (sv)
DD (1)	DD282912A5 (sv)
DE (1)	DE3874073T2 (sv)
DK (1)	DK550988A (sv)
ES (1)	ES2043839T3 (sv)
FI (1)	FI93105C (sv)
GB (1)	GB2210875B (sv)
GR (1)	GR3006343T3 (sv)
HU (1)	HU201024B (sv)
IE (1)	IE61180B1 (sv)
IL (1)	IL87969A (sv)
LT (1)	LT3658B (sv)
NO (1)	NO172048C (sv)
NZ (1)	NZ226483A (sv)
PT (1)	PT88717B (sv)
RU (2)	RU1819263C (sv)
UA (1)	UA13218A (sv)
ZA (1)	ZA887545B (sv)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2210875B (en)	1987-10-09	1991-05-29	Farmos Oy	Aromatase inhibiting 4(5)-imidazoles
GB8818561D0 (en) *	1988-08-04	1988-09-07	Ici Plc	Diphenylethane derivatives
GB2229719B (en) *	1989-03-30	1992-04-29	Farmos Oy	Novel aromatase inhibiting 4(5)-imidazoles
US5439928A (en) *	1989-03-30	1995-08-08	Orion-Yhtyma Oy	Aromatase inhibiting 4(5)-imidazoles
GB2248058B (en)	1990-09-21	1994-09-14	Orion Yhtymae Oy	Aromatase inhibiting 4(5)-imidazoles
JPH032168A (ja) *	1989-03-30	1991-01-08	Farmos Yhtymae Oy	アロマターゼ阻害活性を有する新規な４（５）―イミダゾール
GB9125924D0 (en)	1991-06-18	1992-02-05	Orion Yhtymae Oy	Stereoisomers of an imidazole derivative
US6479526B1 (en)	1995-04-12	2002-11-12	The Procter & Gamble Company	Pharmaceutical composition for inhibiting the growth of viruses and cancers
US6262093B1 (en)	1995-04-12	2001-07-17	The Proctor & Gamble Company	Methods of treating cancer with benzimidazoles
ZA962879B (en) *	1995-04-12	1997-03-17	Procter & Gamble	A pharmaceutical composition for inhibiting the growth of viruses and cancers
US6265427B1 (en)	1995-06-07	2001-07-24	The Proctor & Gamble Company	Pharmaceutical composition for the method of treating leukemia
WO1997026246A1 (en) *	1996-01-16	1997-07-24	Warner-Lambert Company	Substituted histidine inhibitors of protein farnesyltransferase
US5900429A (en) *	1997-01-28	1999-05-04	The Procter & Gamble Company	Method for inhibiting the growth of cancers
US6506783B1 (en)	1997-05-16	2003-01-14	The Procter & Gamble Company	Cancer treatments and pharmaceutical compositions therefor
US6245789B1 (en)	1998-05-19	2001-06-12	The Procter & Gamble Company	HIV and viral treatment
US6423734B1 (en)	1999-08-13	2002-07-23	The Procter & Gamble Company	Method of preventing cancer
US6380232B1 (en)	2000-09-26	2002-04-30	The Procter & Gamble Company	Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof
US6462062B1 (en)	2000-09-26	2002-10-08	The Procter & Gamble Company	Compounds and methods for use thereof in the treatment of cancer or viral infections
US6608096B1 (en) *	2000-09-26	2003-08-19	University Of Arizona Foundation	Compounds and methods for use thereof in the treatment of cancer or viral infections
US6407105B1 (en)	2000-09-26	2002-06-18	The Procter & Gamble Company	Compounds and methods for use thereof in the treatment of cancer or viral infections
US6515074B2 (en) *	2001-01-22	2003-02-04	Delphi Technologies, Inc.	Thermoplastic polymer alloy compositions and process for manufacture thereof
DE60318188T2 (de)	2002-03-26	2008-12-11	Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield	Glucocorticoid-mimetika, deren herstellung, pharmazeutische zusammensetzungen und verwendung
JP2005521717A (ja) *	2002-03-26	2005-07-21	ベーリンガーインゲルハイムファーマシューティカルズインコーポレイテッド	グルココルチコイドミメチックス、その製造方法、その医薬組成物、及び使用
US7074806B2 (en)	2002-06-06	2006-07-11	Boehringer Ingelheim Pharmaceuticals, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
AU2003297471A1 (en)	2003-01-03	2004-08-10	Boehringer Ingelheim Pharmaceuticals, Inc.	1-propanol and 1-propylamine derivatives and their use as glucocorticoid ligands
UY28526A1 (es)	2003-09-24	2005-04-29	Boehringer Ingelheim Pharma	Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7795272B2 (en)	2004-03-13	2010-09-14	Boehringer Ingelheim Pharmaceutical, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
JP2008525525A (ja)	2004-12-27	2008-07-17	ベーリンガーインゲルハイムファーマシューティカルズインコーポレイテッド	グルココルチコイドミメティクス、その製法、医薬組成物及び使用
CA2671990A1 (en)	2006-12-06	2008-06-12	Boehringer Ingelheim International Gmbh	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
EP2095819A1 (en) *	2008-02-28	2009-09-02	Maastricht University	N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors
AU2009256289A1 (en)	2008-06-06	2009-12-10	Boehringer Ingelheim International Gmbh	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2069481B (en) *	1980-02-13	1983-07-27	Farmos Oy	Substituted imidazole derivatives
GB2092569B (en) *	1981-02-05	1984-09-19	Farmos Oy	Substituted imidazole derivatives and their preparation and use
GB2096987B (en) *	1981-04-22	1984-04-04	Farmos Oy	Substituted imidazole and imidazole derivatives and their preparation and use
GB2101114B (en) *	1981-07-10	1985-05-22	Farmos Group Ltd	Substituted imidazole derivatives and their preparation and use
US4605661A (en) *	1984-06-18	1986-08-12	Eli Lilly And Company	Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
LU85747A1 (fr) *	1985-01-28	1986-08-04	Continental Pharma	Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives
GB2210875B (en)	1987-10-09	1991-05-29	Farmos Oy	Aromatase inhibiting 4(5)-imidazoles
JPH032168A (ja)	1989-03-30	1991-01-08	Farmos Yhtymae Oy	アロマターゼ阻害活性を有する新規な４（５）―イミダゾール

1987
- 1987-10-09 GB GB8723715A patent/GB2210875B/en not_active Revoked
1988
- 1988-09-22 CA CA000578192A patent/CA1329616C/en not_active Expired - Fee Related
- 1988-09-30 FI FI884497A patent/FI93105C/sv not_active IP Right Cessation
- 1988-10-03 DK DK550988A patent/DK550988A/da not_active Application Discontinuation
- 1988-10-06 AU AU23490/88A patent/AU615482B2/en not_active Ceased
- 1988-10-06 DD DD88320542A patent/DD282912A5/de not_active IP Right Cessation
- 1988-10-06 NZ NZ226483A patent/NZ226483A/xx unknown
- 1988-10-07 UA UA4356681A patent/UA13218A/uk unknown
- 1988-10-07 RU SU884356681A patent/RU1819263C/ru active
- 1988-10-07 IL IL87969A patent/IL87969A/xx not_active IP Right Cessation
- 1988-10-07 ZA ZA887545A patent/ZA887545B/xx unknown
- 1988-10-07 EP EP88309413A patent/EP0311447B1/en not_active Expired - Lifetime
- 1988-10-07 PT PT88717A patent/PT88717B/pt not_active IP Right Cessation
- 1988-10-07 NO NO884473A patent/NO172048C/no unknown
- 1988-10-07 IE IE305588A patent/IE61180B1/en not_active IP Right Cessation
- 1988-10-07 ES ES88309413T patent/ES2043839T3/es not_active Expired - Lifetime
- 1988-10-07 DE DE8888309413T patent/DE3874073T2/de not_active Expired - Fee Related
- 1988-10-07 HU HU885213A patent/HU201024B/hu not_active IP Right Cessation
- 1988-10-08 JP JP63254665A patent/JPH01132568A/ja active Pending
- 1988-10-08 CN CN88108425A patent/CN1036993C/zh not_active Expired - Fee Related
- 1988-10-08 KR KR1019880013196A patent/KR890006593A/ko not_active Application Discontinuation
1990
- 1990-09-27 US US07/588,873 patent/US5098923A/en not_active Expired - Fee Related
1992
- 1992-01-23 RU SU925010700A patent/RU2045519C1/ru active
- 1992-11-26 GR GR920402701T patent/GR3006343T3/el unknown
1993
- 1993-08-31 LT LTIP916A patent/LT3658B/lt not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO884473L (no)	1989-04-10
HUT49582A (en)	1989-10-30
ZA887545B (en)	1989-06-28
EP0311447B1 (en)	1992-08-26
FI93105B (sv)	1994-11-15
KR890006593A (ko)	1989-06-14
HU201024B (en)	1990-09-28
NO884473D0 (no)	1988-10-07
CA1329616C (en)	1994-05-17
AU615482B2 (en)	1991-10-03
GB2210875B (en)	1991-05-29
UA13218A (uk)	1997-02-28
RU2045519C1 (ru)	1995-10-10
IE61180B1 (en)	1994-10-05
GB8723715D0 (en)	1987-11-11
IL87969A (en)	1993-04-04
US5098923A (en)	1992-03-24
FI884497A0 (sv)	1988-09-30
GR3006343T3 (sv)	1993-06-21
EP0311447A1 (en)	1989-04-12
DE3874073D1 (de)	1992-10-01
DK550988A (da)	1989-04-10
NZ226483A (en)	1991-02-26
CN1036993C (zh)	1998-01-14
NO172048C (no)	1993-06-02
LTIP916A (en)	1995-03-27
DD282912A5 (de)	1990-09-26
FI93105C (sv)	1995-02-27
GB2210875A (en)	1989-06-21
DE3874073T2 (de)	1993-01-21
JPH01132568A (ja)	1989-05-25
RU1819263C (ru)	1993-05-30
IE883055L (en)	1989-04-09
ES2043839T3 (es)	1994-01-01
PT88717B (pt)	1992-12-31
IL87969A0 (en)	1989-03-31
DK550988D0 (da)	1988-10-03
LT3658B (en)	1996-01-25
CN1033995A (zh)	1989-07-19
NO172048B (no)	1993-02-22
AU2349088A (en)	1989-04-13

Publication	Publication Date	Title
FI884497A (sv)	1989-04-10	Förfarande för framställning av nya aromatasinhiberande 4(5)-imidazoler
EP0302020A3 (en)	1990-08-01	Process for the preparation of 2,2,6,6-tetramethyl-4-piperidyl-amines
PT86875A (pt)	1988-04-01	Process for the preparation of phenylcarbamate
FI891338A (sv)	1989-09-25	Förbättring i förfarandet för framställning av en 2',3'-dideoxi-2',3'-didehydronukleosid
PT87191A (pt)	1988-05-01	Process for the preparation of nucleosides
KR950010075B1 (en)	1995-09-06	Process for the preparation of 1,2,3,6-tetrahydro-5-nitro-pyrimidine derivatives
GR3001619T3 (en)	1992-11-23	Process for the preparation of (2,2)-paracyclophane
FI880467A0 (sv)	1988-02-02	Förfarande för framställning av terapeutiskt användbara substituerade 3,4-dihydro-2H-benzopyraner
FI91961C (sv)	1994-09-12	Förfarande för tillverkning av (S)- -etyl-2-oxo-1-pyrrolidinacetamid
PT87503A (pt)	1989-05-31	Process for the preparation of new cathecolamine by products
IL82858A0 (en)	1987-12-20	Process for the preparation of 1,2,5,6,9,10-hexabromo-cyclododecane
IS3589A7 (is)	1990-12-23	Aðferð við framleiðslu á efnasambandinu Indenoindoles I
PT84959A (en)	1987-06-01	Process for the preparation of novel 1,4-dihydropyridines
FI895662A0 (sv)	1989-11-27	Förfarande för framställning av en 3,4-difluorsubstituerad bensen
PT87857A (pt)	1988-07-01	Process for the preparation of novel immunossupressant peptides
RO89363A (ro)	1986-05-30	Procedeu pentru prepararea unor cefalosporine
IL86646A (en)	1992-02-16	Process for the preparation of 5,11-di-and 5,6,11,12-tetraphenylnaphthacenes
RO87709A (ro)	1985-10-31	Procedeu pentru prepararea unor 1,1-alcandioli-carboxilati
EP0297496A3 (en)	1990-06-20	Novel process for the preparation of 6,7-diacyl-7-deacetylforskolin derivatives
PT86623A (pt)	1988-02-01	Process for the preparation of derivatives of 3-aryl-5-alkylthio-4h-1,2,4-triazoles
RO92377A (ro)	1987-11-30	Procedeu pentru prepararea 8-halo-5,6-dialcoxichinazoli-2,4-dionelor
FR2549039B1 (fr)	1986-12-26	Procede de preparation de 3,3,3-trifluoro-2-trifluoro-mehylpropene
PT83799A (en)	1986-12-01	Process for the preparation of novel 2,2:-bi-1h-imidazoles
IT8719363A0 (it)	1987-02-13	Procedimento per la produzione di calcourea.
PT87732A (pt)	1988-07-01	Process for the preparation of (e)-(p-fluorophenethyl)-3-fluoroallylamine

Legal Events

Date	Code	Title	Description
1993-03-29	GB	Transfer or assigment of application	Owner name: ORION-YHTYMAE OY
1994-10-17	BB	Publication of examined application
1997-09-30	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: ORION-YHTYMAE OY