FI883745A - NYA KONDENSERADE DIAZEPINONER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA FOERENINGAR INNEHAOLLANDE CEEEMEDEL. - Google Patents
NYA KONDENSERADE DIAZEPINONER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA FOERENINGAR INNEHAOLLANDE CEEEMEDEL. Download PDFInfo
- Publication number
- FI883745A FI883745A FI883745A FI883745A FI883745A FI 883745 A FI883745 A FI 883745A FI 883745 A FI883745 A FI 883745A FI 883745 A FI883745 A FI 883745A FI 883745 A FI883745 A FI 883745A
- Authority
- FI
- Finland
- Prior art keywords
- atom
- group
- hydrogen
- image
- lower alkyl
- Prior art date
Links
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 229910052801 chlorine Inorganic materials 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- -1 methylimino Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 208000006218 bradycardia Diseases 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- DHZYXWMZLAKTQV-UHFFFAOYSA-N diazepin-3-one Chemical class O=C1C=CC=CN=N1 DHZYXWMZLAKTQV-UHFFFAOYSA-N 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 206010039424 Salivary hypersecretion Diseases 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 230000036471 bradycardia Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 230000002911 mydriatic effect Effects 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 208000026451 salivation Diseases 0.000 abstract 1
- 230000001515 vagal effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Condensed diazepinones of the general formula I <IMAGE> in which <IMAGE> represents one of the divalent radicals <IMAGE> and X<1>, X<2>, A, R<1> to R<1><0> and Z have the following meanings: X<1> and X<2> represent a = CH-group or, if <IMAGE> assumes the meanings of the abovementioned divalent radicals (S), (U) or (W), both or only X<1> or only X<2> can also represent a nitrogen atom; A is an alkylene radical having two to seven carbon atoms; which can also be interrupted by an oxygen or sulphur atom or by the methylimino or ethylimino group; Z is a single bond, an oxygen or sulphur atom, the methylene or 1,2-ethylene group; R<1> is a lower alkyl radical or the benzyl group; R<2> is an alkyl radical having 1 to 7 carbon atoms, which can optionally be further substituted by a hydroxyl group on its 2nd to 7th carbon atom, a cycloalkyl or a cycloalkylmethyl radical, where the cycloalkyl ring can optionally be further substituted by a hydroxyl group; R<1> and R<2>, however, together with the nitrogen atom lying in between, can also form a 4- to 7-membered saturated, monocyclic heterocyclic ring which can optionally be interrupted by an oxygen atom or by the N-CH3 group; R<2> can, however, also be linked to A via an alkylene bridge such that, together with the group NR<1>, a saturated, 5 to 7-membered heterocyclic ring system is formed; R<3> is a lower alkyl group, a chlorine atom or a hydrogen atom; R<4> is a hydrogen atom or a methyl group; R<5> and R<6> each denote a hydrogen atom, a fluorine, chlorine or bromine atom or a lower alkyl group; R<7> is a hydrogen or chlorine atom or a methyl group; R<8> is a hydrogen atom or a lower alkyl radical; R<9> is a hydrogen or halogen atom or a lower alkyl group and R<1><0> is a hydrogen atom or a methyl group, where in the case in which <IMAGE> represents the divalent radical (T) and R<7> is hydrogen, R<3> cannot be chlorine and Z cannot be sulphur. Processes for their preparation and medicaments which contain these compounds are also described. In view of the lack of gastric acid secretion-inhibiting, salivation-inhibiting and mydriatic influences, the novel diazepinones are suitable as vagal pacemakers for the treatment of bradycardias and bradyarrhythmias in human and veterinary medicine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873726908 DE3726908A1 (en) | 1987-08-13 | 1987-08-13 | NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI883745A0 FI883745A0 (en) | 1988-08-12 |
| FI883745A true FI883745A (en) | 1989-02-14 |
Family
ID=6333620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI883745A FI883745A (en) | 1987-08-13 | 1988-08-12 | NYA KONDENSERADE DIAZEPINONER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA FOERENINGAR INNEHAOLLANDE CEEEMEDEL. |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0306698B1 (en) |
| JP (1) | JPS6466186A (en) |
| KR (1) | KR890003763A (en) |
| AT (1) | ATE74133T1 (en) |
| AU (1) | AU608641B2 (en) |
| DD (1) | DD282226A5 (en) |
| DE (2) | DE3726908A1 (en) |
| DK (1) | DK451688A (en) |
| FI (1) | FI883745A (en) |
| HU (1) | HU201924B (en) |
| IL (1) | IL87433A (en) |
| NO (1) | NO167145C (en) |
| NZ (1) | NZ225790A (en) |
| PH (1) | PH25578A (en) |
| PT (1) | PT88262A (en) |
| ZA (1) | ZA885955B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3819444A1 (en) * | 1988-06-08 | 1989-12-14 | Thomae Gmbh Dr K | NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
| DE3820345A1 (en) * | 1988-06-15 | 1989-12-21 | Thomae Gmbh Dr K | CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING THESE COMPOUNDS |
| DD295849A5 (en) * | 1989-06-28 | 1991-11-14 | �������������@��������@��������@����Kk�� | NOVEL 5,11-DIHYDO-6H-DIPYRIDO [3,2-B: 2 ', 3'-E] DIAZEPINE-6-ONE AND THIONE AND THEIR USE IN THE PRESENTATION OF THE INVENTION TREATMENT OF AIDS |
| DE3930262A1 (en) * | 1989-09-11 | 1991-03-21 | Thomae Gmbh Dr K | CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING THESE COMPOUNDS |
| DE3930266A1 (en) * | 1989-09-11 | 1991-03-14 | Thomae Gmbh Dr K | CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING THESE COMPOUNDS |
| CA2030056C (en) * | 1989-11-17 | 1995-10-17 | Karl D. Hargrave | 5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection |
| IE912239A1 (en) * | 1990-07-24 | 1992-01-29 | Akzo Nv | Tetrahydropyridinyldibenzazepine derivatives |
| US8278313B2 (en) | 2008-03-11 | 2012-10-02 | Abbott Laboratories | Macrocyclic spiro pyrimidine derivatives |
| US8436005B2 (en) | 2008-04-03 | 2013-05-07 | Abbott Laboratories | Macrocyclic pyrimidine derivatives |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1795183B1 (en) * | 1968-08-20 | 1972-07-20 | Thomae Gmbh Dr K | 5,11-dihydro-6H-pyrido [2,3-b] [1,4] benzodiazepin-6-one derivatives and drugs |
| DE2724434A1 (en) * | 1977-05-31 | 1979-02-22 | Thomae Gmbh Dr K | NEW, 11-POSITION SUBSTITUTED 5,11-DIHYDRO-6H-PYRIDO SQUARE CLAMP ON 2.3-B SQUARE CLAMP ON SQUARE CLAMP ON 1.4 SQUARED CLAMP ON BENZODIAZEPIN-6-ONE, METHOD FOR THEIR PRODUCTION AND THESE CONNECTIONS DRUG |
| DE2724478C2 (en) * | 1977-05-31 | 1986-05-22 | Dr. Karl Thomae Gmbh, 7950 Biberach | 5,11-Dihydro-6H-pyrido [2,3-b] [1,4] benzodiazepin-6-one derivatives, processes for their preparation and pharmaceuticals containing these compounds |
| EP0064775A1 (en) * | 1979-08-03 | 1982-11-17 | Byk Gulden Lomberg Chemische Fabrik GmbH | Substituted tetraazatricyclic compounds, process for their preparation and their use |
| IL62792A (en) * | 1980-05-07 | 1985-02-28 | Byk Gulden Lomberg Chem Fab | Acylated dihydrothienodiazepinone compounds,process for their preparation,and medicaments containing them |
| DE3204157A1 (en) * | 1982-02-06 | 1983-08-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | SUBSTITUTED DIBENZODIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING IT |
| DE3204153A1 (en) * | 1982-02-06 | 1983-08-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | SUBSTITUTED THIENOBENZODIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING IT |
| DE3204403A1 (en) * | 1982-02-09 | 1983-08-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | NEW PYRIDOBENZODIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| IT1212742B (en) * | 1983-05-17 | 1989-11-30 | Dompe Farmaceutici Spa | DIBENZO DERIVATIVES [1,4] PYRID DIAZEPINONIC [1,4] BENZODIAZEPINONIC, PYRID [1,5] BENZODIAZEPINONIC AND THEIR PHARMACOLOGICAL ACTIVITY |
| DD236731B3 (en) * | 1983-10-19 | 1992-12-10 | Dresden Arzneimittel | PROCESS FOR PREPARING NEW 5-POSITION SUBSTITUTED 5,10-DIHYDRO-11H-DIBENZO | B, E¨ | 1,4¨DIAZEPINE-11-ONEN |
| DE3409237A1 (en) * | 1984-03-14 | 1985-09-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| DE3529372A1 (en) * | 1985-08-16 | 1987-02-19 | Dompe Farmaceutici Spa | AMINOACYL DERIVATIVE OF 4,9-DIHYDRO-10H-PYRIDO (3,2-B) -THIENO (3,2-E) (1,4) -DIAZEPINONE AND OF 4,9-DIHYDRO-10H-PYRIDO (3, 2-B) THIENO (3,4-E) (1,4) DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
| DE3626095A1 (en) * | 1986-07-31 | 1988-02-11 | Thomae Gmbh Dr K | NEW SUBSTITUTED PYRIDO (2,3-B) (1,4) BENZODIAZEPIN-6-ONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| IT8721978A0 (en) * | 1987-09-21 | 1987-09-21 | Angeli Inst Spa | NEW TRICYCLIC AMIDE DERIVATIVES. |
| DE3802334A1 (en) * | 1988-01-27 | 1989-08-10 | Thomae Gmbh Dr K | NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
| DE3818299A1 (en) * | 1988-05-30 | 1989-12-07 | Thomae Gmbh Dr K | NEW CONDENSED DIAZEPINONE, PROCESS FOR THEIR MANUFACTURE AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
-
1987
- 1987-08-13 DE DE19873726908 patent/DE3726908A1/en not_active Withdrawn
-
1988
- 1988-08-01 DE DE8888112443T patent/DE3869523D1/en not_active Expired - Lifetime
- 1988-08-01 EP EP88112443A patent/EP0306698B1/en not_active Expired - Lifetime
- 1988-08-01 AT AT88112443T patent/ATE74133T1/en not_active IP Right Cessation
- 1988-08-09 PH PH37376A patent/PH25578A/en unknown
- 1988-08-11 DD DD88318853A patent/DD282226A5/en not_active IP Right Cessation
- 1988-08-11 NZ NZ225790A patent/NZ225790A/en unknown
- 1988-08-12 ZA ZA885955A patent/ZA885955B/en unknown
- 1988-08-12 NO NO883585A patent/NO167145C/en unknown
- 1988-08-12 KR KR1019880010276A patent/KR890003763A/en not_active Application Discontinuation
- 1988-08-12 JP JP63201788A patent/JPS6466186A/en active Pending
- 1988-08-12 HU HU884348A patent/HU201924B/en unknown
- 1988-08-12 DK DK451688A patent/DK451688A/en not_active Application Discontinuation
- 1988-08-12 PT PT88262A patent/PT88262A/en unknown
- 1988-08-12 IL IL87433A patent/IL87433A/en unknown
- 1988-08-12 AU AU20912/88A patent/AU608641B2/en not_active Ceased
- 1988-08-12 FI FI883745A patent/FI883745A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3726908A1 (en) | 1989-02-23 |
| IL87433A0 (en) | 1989-01-31 |
| EP0306698B1 (en) | 1992-03-25 |
| ZA885955B (en) | 1990-04-25 |
| DE3869523D1 (en) | 1992-04-30 |
| PT88262A (en) | 1989-06-30 |
| PH25578A (en) | 1991-08-08 |
| NO167145C (en) | 1991-10-09 |
| KR890003763A (en) | 1989-04-17 |
| JPS6466186A (en) | 1989-03-13 |
| EP0306698A1 (en) | 1989-03-15 |
| NZ225790A (en) | 1991-01-29 |
| HUT50793A (en) | 1990-03-28 |
| DK451688A (en) | 1989-02-14 |
| IL87433A (en) | 1991-12-12 |
| AU2091288A (en) | 1989-02-16 |
| DD282226A5 (en) | 1990-09-05 |
| NO883585D0 (en) | 1988-08-12 |
| NO883585L (en) | 1989-02-14 |
| FI883745A0 (en) | 1988-08-12 |
| DK451688D0 (en) | 1988-08-12 |
| AU608641B2 (en) | 1991-04-11 |
| ATE74133T1 (en) | 1992-04-15 |
| NO167145B (en) | 1991-07-01 |
| HU201924B (en) | 1991-01-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO901571D0 (en) | ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE BENZIMIDAZOLES. | |
| ES8504143A1 (en) | Dihydropyrimidines, process for their preparation and their use in medicaments. | |
| FI883745A (en) | NYA KONDENSERADE DIAZEPINONER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA FOERENINGAR INNEHAOLLANDE CEEEMEDEL. | |
| DK397687A (en) | SUBSTITUTED PYRIDO OE2,3-BAAOE1,4AABENZODIAZEPIN-6-ONER AND MEDICINES CONTAINING SUCH COMPOUNDS | |
| PT86032A (en) | IFOSFAMID LYOPHILISATE AND METHOD FOR THE PRODUCTION THEREOF | |
| ATE123779T1 (en) | USE OF THIAZOLO-(2,3-A>ISOINDOLE DERIVATIVES AS ANTIVIRAL DRUGS AND NEW THIAZOLO-(2,3-A>ISOINDOLE DERIVATIVES. | |
| ATE115145T1 (en) | PENEM DERIVATIVES, THEIR PREPARATION AND USE. | |
| ATE86993T1 (en) | HETEROTETRACYCLIC LACTAM DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM. | |
| LT2199B (en) | THE 2-TRIZOLIDINONE'S BODY RECEIVING | |
| ATE107637T1 (en) | 3-ARYLCARBAMOYL-5-AMINOMETHYL-OXAZOLIDINE AND THEIR SALTS WITH PHARMACOLOGICALLY TOLERABLE ACIDS. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application lapsed |
Owner name: DR. KARL THOMAE GESELLSCHAFT MIT BESCHRAE |