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FI883688A - MOLEKYLAER KLONING OCH EXPRESSION AV HUMANT INTERLEUKIN-3. - Google Patents

MOLEKYLAER KLONING OCH EXPRESSION AV HUMANT INTERLEUKIN-3. Download PDF

Info

Publication number
FI883688A
FI883688A FI883688A FI883688A FI883688A FI 883688 A FI883688 A FI 883688A FI 883688 A FI883688 A FI 883688A FI 883688 A FI883688 A FI 883688A FI 883688 A FI883688 A FI 883688A
Authority
FI
Finland
Prior art keywords
interleukin
expression
molekylaer
kloning
humant
Prior art date
Application number
FI883688A
Other languages
Finnish (fi)
Other versions
FI102293B (en
FI883688A0 (en
FI102293B1 (en
Inventor
Lambertus Christiaan Dorssers
Gerard Wagemaker
Yvonne Johanna Vos
Leen Robert Willem Van
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Publication of FI883688A0 publication Critical patent/FI883688A0/en
Publication of FI883688A publication Critical patent/FI883688A/en
Application granted granted Critical
Publication of FI102293B publication Critical patent/FI102293B/en
Publication of FI102293B1 publication Critical patent/FI102293B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A cDNA encoding human interleukin-3, also designated herein hIL-3 or hmulti-CSF, has been disposed in expression systems and caused to produce hIL-3 substantially free of impurities normally accompanying this protein as it is produced $i(inter alia) by peripheral blood lymphocytes in nature. The resulting hIL-3 can be produced in practical amounts and is useful in a variety of therapeutic and diagnostic protocols.
FI883688A 1986-12-16 1988-08-08 Molecular cloning and expression of human interleukin-3 FI102293B1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP86202285 1986-12-16
EP86202285 1986-12-16
NL8700037 1987-01-09
EP87201322 1987-07-13
EP87201322 1987-07-13
PCT/NL1987/000037 WO1988004691A1 (en) 1986-12-16 1987-12-16 Molecular cloning and expression of human il-3

Publications (4)

Publication Number Publication Date
FI883688A0 FI883688A0 (en) 1988-08-08
FI883688A true FI883688A (en) 1988-08-08
FI102293B FI102293B (en) 1998-11-13
FI102293B1 FI102293B1 (en) 1998-11-13

Family

ID=26103432

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883688A FI102293B1 (en) 1986-12-16 1988-08-08 Molecular cloning and expression of human interleukin-3

Country Status (14)

Country Link
JP (2) JPH01502157A (en)
AT (1) ATE161882T1 (en)
AU (1) AU617095B2 (en)
CA (1) CA1341503C (en)
DE (1) DE3752158T2 (en)
ES (1) ES2113338T3 (en)
FI (1) FI102293B1 (en)
GR (1) GR3025857T3 (en)
IE (1) IE81129B1 (en)
IL (1) IL84852A (en)
NO (1) NO180544C (en)
NZ (1) NZ222939A (en)
PT (1) PT86381B (en)
WO (1) WO1988004691A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR871029B (en) * 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors
US6238889B1 (en) 1986-12-16 2001-05-29 Dsm N.V. Molecular cloning and expression of the Pro8 isoform of human IL-3
OA09736A (en) * 1987-02-18 1993-11-30 Schering Biotech Corp "Human interleukin-3 and muteins thereof".
US5304637A (en) * 1987-07-13 1994-04-19 Gist-Brocades N.V. Expression and purification of human interleukin-3 and muteins thereof
GB2210883B (en) * 1987-10-08 1992-01-02 British Bio Technology Synthetic interleukin-3 gene
US6384194B1 (en) 1987-12-16 2002-05-07 Dsm N.V. Expression and purification of human interleukin-3 and muteins thereof
AU3864089A (en) * 1988-07-20 1990-02-19 Immunex Corporation Nonglycosylated human interleukin-3 compositions
NZ232913A (en) * 1989-03-15 1992-08-26 Gist Brocades Nv Il-3 produced recombinantly and purified to homogeneity; vectors and pharmaceutical preparations
US5128450A (en) * 1989-06-30 1992-07-07 Urdal David L Nonglycosylated human interleukin-3 analog proteins
DK0413383T3 (en) 1989-08-14 1997-07-07 Gist Brocades Nv Mutants of human interleukin-3.
US5516512A (en) 1989-08-14 1996-05-14 Gist-Brocades, N.V. N- and C-terminal truncation and deletion mutants of human interleukin-3
DK0596881T3 (en) * 1991-08-01 1997-10-13 Fond Nat Transfusion Sanguine Expression in non-tumoral human lymphoblastoids with an integrative vector
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
ATE251669T1 (en) * 1992-11-24 2003-10-15 Searle & Co MUTATED POLYPEPTIDES OF INTERLEUKIN-3(IL-3)
US5501962A (en) * 1993-06-21 1996-03-26 G. D. Searle & Co. Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same
US6017523A (en) * 1995-06-06 2000-01-25 G.D. Searle & Co. Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides
WO1999041382A2 (en) * 1998-02-17 1999-08-19 Hyseq, Inc. A novel interleukin-3 and uses thereof
WO2006079169A1 (en) * 2005-01-25 2006-08-03 Apollo Life Sciences Limited Parameter selected gm-csf, il-3, il-4, il-5 and chimeras thereof for therapeutic and diagnostic purposes
JP2009532061A (en) * 2006-04-03 2009-09-10 ニユー・イングランド・バイオレイブス・インコーポレイテツド Expression, secretion and purification of recombinant bovine serum albumin (rBSA) and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695542A (en) * 1983-10-04 1987-09-22 Dnax Research Institute Of Molecular And Cellular Biology, Inc. cDNA clones coding for polypeptides exhibiting multi-lineage cellular growth factor activity
AU570762B2 (en) * 1983-12-23 1988-03-24 Australian National University, The Cloning of cdna for il-3
GR871029B (en) * 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors

Also Published As

Publication number Publication date
ATE161882T1 (en) 1998-01-15
IL84852A0 (en) 1988-06-30
GR3025857T3 (en) 1998-04-30
NO180544C (en) 1997-05-07
AU617095B2 (en) 1991-11-21
DE3752158T2 (en) 1998-05-20
FI102293B (en) 1998-11-13
ES2113338T3 (en) 1998-05-01
FI883688A0 (en) 1988-08-08
CA1341503C (en) 2006-04-04
NO180544B (en) 1997-01-27
FI102293B1 (en) 1998-11-13
NO883614D0 (en) 1988-08-12
PT86381B (en) 1990-11-20
NO883614L (en) 1988-08-12
WO1988004691A1 (en) 1988-06-30
NZ222939A (en) 1991-03-26
AU1057788A (en) 1988-07-15
JPH1080286A (en) 1998-03-31
IE81129B1 (en) 2000-03-22
PT86381A (en) 1988-01-01
DE3752158D1 (en) 1998-02-12
JPH01502157A (en) 1989-08-03
IE873409L (en) 1988-06-12
IL84852A (en) 1994-06-24

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Legal Events

Date Code Title Description
PC Transfer of assignment of patent

Owner name: DSM N.V.

MM Patent lapsed

Owner name: DSM N.V.