[go: up one dir, main page]

FI881889A - Process for the preparation of pharmaceutically useful benzo-3,4-dihydropyridine derivatives - Google Patents

Process for the preparation of pharmaceutically useful benzo-3,4-dihydropyridine derivatives Download PDF

Info

Publication number
FI881889A
FI881889A FI881889A FI881889A FI881889A FI 881889 A FI881889 A FI 881889A FI 881889 A FI881889 A FI 881889A FI 881889 A FI881889 A FI 881889A FI 881889 A FI881889 A FI 881889A
Authority
FI
Finland
Prior art keywords
benzo
image
group
denote
alkyl
Prior art date
Application number
FI881889A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI881889A0 (en
FI91750B (en
FI91750C (en
Inventor
Walter Loesel
Otto Roos
Gerd Schnorrenberg
Dietrich Arndts
Georg Speck
Ilse Streller
Franz Josef Kuhn
Guenther Schingnitz
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19873713743 external-priority patent/DE3713743A1/en
Priority claimed from DE19873718570 external-priority patent/DE3718570A1/en
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of FI881889A0 publication Critical patent/FI881889A0/en
Publication of FI881889A publication Critical patent/FI881889A/en
Priority to FI921018A priority Critical patent/FI921018A0/en
Priority to FI935966A priority patent/FI935966A/en
Publication of FI91750B publication Critical patent/FI91750B/en
Application granted granted Critical
Publication of FI91750C publication Critical patent/FI91750C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Benzo- and thieno-3,4-dihydropyridine derivatives of the formula I <IMAGE> in which D denotes a group of the formula Ia or Ib <IMAGE> and A and B denote a benzo or thieno radical; and R4 denotes (C1-C4)alkoxy or an -NR9R10 group in which R9 and R10 independently of one another denote (a) hydrogen, (b) branched or unbranched alkyl, alkenyl or alkynyl (where the alkyl can be substituted, for example by the group <IMAGE> (c) cycloalkyl having 3-7 ring members, (d) dimethylamino, (e) amino(C2-C4)alkyl, (f) phenyl, (g) morpholinyl or (h) pyridinyl, or R9 and R10, together with the nitrogen atom to which they are bonded, denote a pyrrolidinyl, piperidinyl, morpholinyl or piperazinyl radical; and their pharmaceutically acceptable salts. The compounds have cardioprotective and/or cerebral protective action.
FI881889A 1987-04-24 1988-04-22 Process for the preparation of pharmaceutically useful benzo-3,4-dihydropyridine derivatives FI91750C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FI921018A FI921018A0 (en) 1987-06-03 1992-03-09 BENZO- OCH TIENO-3,4-DIHYDRO-PYRIDINDERIVAT, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA FOERENINGAR INNEHAOLLANDE CEILING MODEL.
FI935966A FI935966A (en) 1987-04-24 1993-12-31 BENZO- OCH THIENO-3,4-DIHYDRO-PYRIDIN DERIVATIVES, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESSA FOERENINGAR INNEHAOLLANDE CEE

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19873713743 DE3713743A1 (en) 1987-04-24 1987-04-24 CONDENSED BIS- (3,4-DIHYDRO-L-PYRIDINYL) METHANES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3713743 1987-04-24
DE3718570 1987-06-03
DE19873718570 DE3718570A1 (en) 1987-06-03 1987-06-03 Benzo- and thieno-3,4-dihydro-1-pyridinylacetic acid derivatives, process for their preparation, and medicaments containing these compounds

Publications (4)

Publication Number Publication Date
FI881889A0 FI881889A0 (en) 1988-04-22
FI881889A true FI881889A (en) 1988-10-25
FI91750B FI91750B (en) 1994-04-29
FI91750C FI91750C (en) 1994-08-10

Family

ID=25854932

Family Applications (1)

Application Number Title Priority Date Filing Date
FI881889A FI91750C (en) 1987-04-24 1988-04-22 Process for the preparation of pharmaceutically useful benzo-3,4-dihydropyridine derivatives

Country Status (16)

Country Link
EP (1) EP0288048B1 (en)
JP (1) JP2669468B2 (en)
KR (1) KR880012594A (en)
AT (1) ATE107921T1 (en)
AU (1) AU609121B2 (en)
CA (1) CA1330798C (en)
DE (1) DE3850437D1 (en)
DK (1) DK219488A (en)
ES (1) ES2055717T3 (en)
FI (1) FI91750C (en)
HU (1) HU208673B (en)
IL (1) IL86131A0 (en)
NO (1) NO174548C (en)
PL (1) PL160019B1 (en)
PT (1) PT87300B (en)
YU (1) YU80488A (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3827727A1 (en) * 1988-08-16 1990-02-22 Boehringer Ingelheim Kg ANALYZED TETRAHYDROPYRIDINE IGNESE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE OF SUCH CONNECTIONS FOR CARDIRO PROTECTION
GB8921304D0 (en) * 1989-09-20 1989-11-08 Wyeth John & Brother Ltd New method of treatment and heterocyclic compounds used therein
DE9017900U1 (en) * 1990-12-22 1993-01-28 Boehringer Ingelheim Kg, 55218 Ingelheim 3,4-Dihydro-1-benzyl-6,7-dimethoxy-α-[di-2-(2,3,4-trimethoxyphenyl)ethyl] aminocarbonyl-isoquinoline
DE4104257A1 (en) * 1991-02-13 1992-08-20 Boehringer Ingelheim Kg USE OF ANALYZED TETRAHYDROPYRIDINE IGNESE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL ILLNESSES
CN1056832C (en) * 1992-06-22 2000-09-27 贝林格尔·英格海姆公司 Carbocyclic and heterocyclic annelleted dihydropyridine and application of same in preparation of pharmaceutical
KR100291706B1 (en) * 1992-06-22 2001-10-24 베링거 인겔하임 카게 Closed dihydropyridine, preparation method thereof and pharmaceutical composition comprising the same
US5643919A (en) * 1992-06-22 1997-07-01 Boehringer Ingelheim Kg Anellated dihydropyridines and the use thereof for the production of pharmaceutical preparation
DE59305890D1 (en) * 1992-06-22 1997-04-24 Boehringer Ingelheim Kg USE OF CONDENSED BIS- (3,4-DIHYDRO-PYRIDINYL) METHANE FOR THE TREATMENT OF MORBUS CROHN, COLITIS ULCEROSA, CHRONICALLY INFLAMMATORY PROCESSES AND AS AN ANTIPROLIFERATIVE AGENTS
PT736012E (en) * 1993-12-21 2001-03-30 Boehringer Ingelheim Pharma CYCLED DI-HYDROPYRIDINES AND THEIR USE FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS
DE4343683A1 (en) * 1993-12-21 1995-06-22 Boehringer Ingelheim Kg Anellated dihydropyridines and their use for the preparation of pharmaceutical preparations
RU2665688C2 (en) * 2013-04-12 2018-09-04 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Dicarboxylic acid bisamide derivatives, their application, the pharmaceutical composition on their basis, methods for their production

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3007710C2 (en) * 1980-02-29 1982-04-15 Gödecke AG, 1000 Berlin 5,6; 8,9-Tetrahydro-7H-dibenz (d, f) azonine derivatives, processes for their preparation and pharmaceuticals
DE3013906A1 (en) * 1980-04-11 1981-10-15 C.H. Boehringer Sohn, 6507 Ingelheim SUBSTITUTED (ALPHA) -AMINOCARBONYL-L-BENZYL-3,4-DIHYDRO-ISOCHINOLINE, METHOD FOR THE PRODUCTION AND USE THEREOF
EP0198227A3 (en) * 1985-03-20 1988-01-13 Boehringer Ingelheim Kg Imidazo-isoquinoline and imidazo-thienopyridine compounds, medicaments containing them and process for their preparation
DE3621413A1 (en) * 1986-06-26 1988-01-07 Boehringer Ingelheim Kg USE OF CARBOCYCLIC AND HETEROCYCLICALLY FURNISHED DIHYDROPYRIDINE AS A CARDIOPROTECTIVE AGENT AND NEW HETEROCYCLIC AND CARBOCYCLICALLY FURNISHED DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND ITS ADDITIONAL PRODUCTS

Also Published As

Publication number Publication date
DK219488A (en) 1988-10-25
IL86131A0 (en) 1988-11-15
ATE107921T1 (en) 1994-07-15
AU1509088A (en) 1988-10-27
EP0288048B1 (en) 1994-06-29
CA1330798C (en) 1994-07-19
PT87300B (en) 1992-08-31
DE3850437D1 (en) 1994-08-04
FI881889A0 (en) 1988-04-22
HUT47915A (en) 1989-04-28
PL271963A1 (en) 1989-06-12
JP2669468B2 (en) 1997-10-27
HU208673B (en) 1993-12-28
JPS63280069A (en) 1988-11-17
KR880012594A (en) 1988-11-28
NO174548B (en) 1994-02-14
FI91750B (en) 1994-04-29
YU80488A (en) 1990-04-30
NO881759L (en) 1988-10-25
NO881759D0 (en) 1988-04-22
PL160019B1 (en) 1993-01-29
FI91750C (en) 1994-08-10
EP0288048A3 (en) 1990-06-13
PT87300A (en) 1988-05-01
ES2055717T3 (en) 1994-09-01
DK219488D0 (en) 1988-04-22
NO174548C (en) 1994-05-25
AU609121B2 (en) 1991-04-26
EP0288048A2 (en) 1988-10-26

Similar Documents

Publication Publication Date Title
MY107756A (en) Piperazine derivatives.
NO905067L (en) NEW ISOINDOLOND DERIVATIVES AND THEIR PREPARATION.
AU589427B2 (en) Pyridonecarboxylic acid derivatives and process for their preparation
FI881889A0 (en) Process for the preparation of pharmaceutically useful benzo-3,4-dihydropyridine derivatives
NZ214156A (en) Quindone derivatives and pharmaceutical compositions
PT81004A (en) Process for preparing tricyclic oxindole useful as antiinflammatory agents
NO934227L (en) Pyrrole derivatives, processes for their preparation and therapeutic use
HUT64940A (en) Tetrahydro-naphtaline derivatives and methods for producing these compounds and for preparing pharmaceutical preparatives containing them
NZ291855A (en) Bridged azabicyclo-piperazin-1-yl-2-phenyl-butan-1-one derivatives as 5-ht1a antagonists
AU3626189A (en) New derivatives of phenothiazine, their preparation and the compositions which contain them
ES2006336A6 (en) 2,3-Dihydro-3-phenyl-benzofuran-2-one acetamide derivatives, processes for their preparation and pharmaceutical compositions containing them.
ES444384A1 (en) Biguanides and therapeutic compositions and uses of the same

Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: BOEHRINGER INGELHEIM KG