FI880469A - Nya polyaminderivat. - Google Patents

Nya polyaminderivat. Download PDF

Info

Publication number: FI880469A
Authority: FI; Finland
Prior art keywords: polyaminderivat; nya; nya polyaminderivat
Prior art date: 1987-02-03

Application number

FI880469A

Other languages

English (en)

Other versions

FI880469A0 (fi

FI108030B (fi

Inventor

David M Stemerick

Alan J Bitonti

Michael L Edwards

Peter P Mccann

Albert Sjoerdsma

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-02-03

Filing date

1988-02-02

Publication date

1988-08-04

1988-02-02 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1988-02-02 Publication of FI880469A0 publication Critical patent/FI880469A0/fi

1988-08-04 Publication of FI880469A publication Critical patent/FI880469A/fi

2001-11-15 Application granted granted Critical

2001-11-15 Publication of FI108030B publication Critical patent/FI108030B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/13—Amines containing three or more amino groups bound to the carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
- C07C211/23—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton the carbon skeleton containing carbon-to-carbon triple bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/57—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton
- C07C211/58—Naphthylamines; N-substituted derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/50—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

FI880469A 1987-02-03 1988-02-02 Menetelmä terapeuttisesti käyttökelpoisten polyamiinijohdannaisten valmistamiseksi FI108030B (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1038087A	1987-02-03	1987-02-03
US1038087		1987-02-03

Publications (3)

Publication Number	Publication Date
FI880469A0 FI880469A0 (fi)	1988-02-02
FI880469A true FI880469A (fi)	1988-08-04
FI108030B FI108030B (fi)	2001-11-15

Family

ID=21745504

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI880469A FI108030B (fi)	1987-02-03	1988-02-02	Menetelmä terapeuttisesti käyttökelpoisten polyamiinijohdannaisten valmistamiseksi

Country Status (20)

Country	Link
EP (1)	EP0277635B1 (fi)
JP (1)	JP2556720B2 (fi)
KR (1)	KR960006551B1 (fi)
CN (1)	CN1021817C (fi)
AR (1)	AR246093A1 (fi)
AT (1)	ATE99668T1 (fi)
AU (1)	AU602186B2 (fi)
CA (1)	CA1338764C (fi)
DE (1)	DE3886784T2 (fi)
DK (1)	DK174418B1 (fi)
ES (1)	ES2061528T3 (fi)
FI (1)	FI108030B (fi)
HU (2)	HU202188B (fi)
IE (1)	IE61496B1 (fi)
IL (1)	IL85247A (fi)
NO (1)	NO166362C (fi)
NZ (1)	NZ223340A (fi)
PH (1)	PH30970A (fi)
PT (1)	PT86687B (fi)
ZA (1)	ZA88600B (fi)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5753714A (en) *	1987-02-03	1998-05-19	Merrell Pharmaceuticals Inc.	Polyamine derivatives
US5109024A (en) *	1987-02-03	1992-04-28	Merrell Dow Pharmaceuticals Inc.	Polyamine derivatives as antineoplastic agents
ZA887410B (en) *	1987-10-08	1989-06-28	Merrell Dow Pharma	Polyamine derivatives as antineoplastic agents
US4935449A (en) *	1988-08-04	1990-06-19	Merrell Dow Pharmaceuticals Inc.	N-2,3-butadienyl tri- and tetraaminoalkane derivatives
DE69018099T2 (de) *	1989-01-10	1995-08-03	Merrell Dow Pharma	Polyamin-Derivate als antineoplastische Mittel.
AU628174B2 (en) *	1989-05-23	1992-09-10	Merrell Dow Pharmaceuticals Inc.	A method of potentiating cell-mediated immunity utilizing polyamine derivatives
US5079262A (en) *	1989-07-28	1992-01-07	Queen's University At Kingston	Method of detection and treatment of malignant and non-malignant lesions utilizing 5-aminolevulinic acid
US5561136A (en) *	1990-12-13	1996-10-01	Merrell Pharmaceuticals Inc.	Method of treating cancer by conjunctive therapy with N,N'-bis[ethylamino)propyl]-1,7-heptanediamine and a cytotoxic agent
AU648846B2 (en) *	1990-12-13	1994-05-05	Merrell Dow Pharmaceuticals Inc.	Method of treating cancer by conjunctive therapy with N,N-bis(3-(ethylamino)propyl)-1,7-heptanediamine and a cytotoxic agent
US5354782A (en) *	1991-01-17	1994-10-11	Merrell Dow Pharmaceuticals Inc.	Polyamine phenols as radioprotective agents
US5217964A (en) *	1991-01-23	1993-06-08	Merrell Dow Pharmaceuticals Inc.	Polyamine thiols as radioprotective agents
JPH08509699A (ja) *	1993-02-23	1996-10-15	メレルダウファーマスーティカルズインコーポレイテッド	放射線防護剤としてのポリアミン誘導体類
CN1121707A (zh) *	1993-12-27	1996-05-01	西巴-盖尔基股份公司	用作抗癌剂和抗原生动物剂的不饱和氨基化合物
US5516807A (en) *	1994-10-25	1996-05-14	Warner-Lambert Company	Method for treating vascular proliferative disorders following balloon angioplasty
DE69635460T2 (de) *	1995-06-26	2006-08-10	Chelator Llc, Concord	Methode zur Hemmung des Wachstums von Bakterien oder Pilzen mit einem Komplexbildner
FR2749845B1 (fr) *	1996-06-18	1998-08-21	Oreal	Nouveaux derives benzyl substitue(s) de polyalkylene-polyamines et leur utilisation dans des compositions cosmetiques et pharmaceutiques
US7087648B1 (en)	1997-10-27	2006-08-08	The Regents Of The University Of California	Methods for modulating macrophage proliferation using polyamine analogs
US8198334B2 (en)	1997-10-27	2012-06-12	Pathologica Llc	Methods for modulating macrophage proliferation in ocular disease using polyamine analogs
US7045550B2 (en)	2001-08-07	2006-05-16	Wisconsin Alumni Research Foundation	Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
KR20080088570A (ko) *	2005-08-10	2008-10-02	더 존스 홉킨스 유니버시티	항기생충 및 항암 치료제 및 라이신-특이적인 디메틸라제억제제로 유용한 폴리아민
WO2009038463A1 (en) *	2007-09-18	2009-03-26	Fujifilm Manufacturing Europe B.V.	Uv absorbing compounds
US8853457B2 (en)	2010-01-04	2014-10-07	Rhodia Operations	Polyamine and method for producing thereof
CN103242256A (zh) *	2013-05-21	2013-08-14	苏州科捷生物医药有限公司	一种3-胺甲基-异噁唑盐酸盐的合成方法
EP4257581A1 (en) *	2018-01-30	2023-10-11	Panbela Therapeutics, Inc.	Methods for producing (6s,15s)-3,8,13,18-tetraazaicosane-6,15-diol
EP3774716B1 (de) *	2018-04-06	2022-03-16	Basf Se	Verfahren zur herstellung von aminen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3013020A (en) *	1958-01-24	1961-12-12	Miles Lab	N,n'-bis-phenyl-alkylene-diamines
DE2458222A1 (de) *	1973-12-19	1975-07-03	Sandoz Ag	Verfahren zur herstellung neuer phenylaethylaminderivate
DE2557657A1 (de) *	1975-12-20	1977-06-30	Knoll Ag	Neue spermin-derivate
DE2938710A1 (de) *	1979-09-25	1981-04-09	Hoechst Ag, 6000 Frankfurt	N,n'-dialkylaminoalkylethylendiamine und verfahren zu deren herstellung
NZ212053A (en) *	1984-05-17	1988-02-29	Merrell Dow Pharma	Polyamine containing pharmaceutical compositions for treating neoplasms
GB8419103D0 (en) *	1984-07-26	1984-08-30	Beecham Wuelfing Gmbh & Co Kg	Compounds
ZA887410B (en) *	1987-10-08	1989-06-28	Merrell Dow Pharma	Polyamine derivatives as antineoplastic agents

1988
- 1988-01-28 AU AU10902/88A patent/AU602186B2/en not_active Ceased
- 1988-01-28 NZ NZ223340A patent/NZ223340A/en unknown
- 1988-01-28 CA CA000557585A patent/CA1338764C/en not_active Expired - Fee Related
- 1988-01-28 ZA ZA880600A patent/ZA88600B/xx unknown
- 1988-01-29 IL IL85247A patent/IL85247A/xx not_active IP Right Cessation
- 1988-02-01 AR AR88309985A patent/AR246093A1/es active
- 1988-02-02 JP JP63021440A patent/JP2556720B2/ja not_active Expired - Fee Related
- 1988-02-02 HU HU88453A patent/HU202188B/hu not_active IP Right Cessation
- 1988-02-02 IE IE28588A patent/IE61496B1/en not_active IP Right Cessation
- 1988-02-02 PH PH36445A patent/PH30970A/en unknown
- 1988-02-02 ES ES88101472T patent/ES2061528T3/es not_active Expired - Lifetime
- 1988-02-02 FI FI880469A patent/FI108030B/fi not_active IP Right Cessation
- 1988-02-02 EP EP88101472A patent/EP0277635B1/en not_active Expired - Lifetime
- 1988-02-02 PT PT86687A patent/PT86687B/pt not_active IP Right Cessation
- 1988-02-02 NO NO880452A patent/NO166362C/no not_active IP Right Cessation
- 1988-02-02 DE DE88101472T patent/DE3886784T2/de not_active Expired - Fee Related
- 1988-02-02 DK DK198800523A patent/DK174418B1/da not_active IP Right Cessation
- 1988-02-02 AT AT88101472T patent/ATE99668T1/de not_active IP Right Cessation
- 1988-02-03 CN CN88100500A patent/CN1021817C/zh not_active Expired - Fee Related
- 1988-02-03 KR KR1019880000970A patent/KR960006551B1/ko not_active IP Right Cessation
1994
- 1994-11-09 HU HU94P/P00043P patent/HU210205A9/hu unknown

Also Published As

Publication number	Publication date
JPS63222149A (ja)	1988-09-16
NO880452L (no)	1988-08-04
IE880285L (en)	1988-08-03
EP0277635A2 (en)	1988-08-10
HU210205A9 (en)	1995-02-28
CA1338764C (en)	1996-12-03
FI880469A0 (fi)	1988-02-02
ATE99668T1 (de)	1994-01-15
NO166362C (no)	1991-07-10
KR960006551B1 (ko)	1996-05-17
IL85247A (en)	1992-03-29
DK174418B1 (da)	2003-02-17
ES2061528T3 (es)	1994-12-16
NZ223340A (en)	1991-03-26
DK52388A (da)	1988-08-04
ZA88600B (en)	1988-07-28
NO166362B (no)	1991-04-02
AU602186B2 (en)	1990-10-04
DE3886784D1 (de)	1994-02-17
IL85247A0 (en)	1988-07-31
PH30970A (en)	1997-12-23
EP0277635B1 (en)	1994-01-05
PT86687B (pt)	1992-04-30
CN88100500A (zh)	1988-09-07
JP2556720B2 (ja)	1996-11-20
KR880009903A (ko)	1988-10-05
PT86687A (pt)	1988-03-01
EP0277635A3 (en)	1989-07-19
CN1021817C (zh)	1993-08-18
NO880452D0 (no)	1988-02-02
IE61496B1 (en)	1994-11-02
AR246093A1 (es)	1994-03-30
DE3886784T2 (de)	1994-05-05
HUT50315A (en)	1990-01-29
HU202188B (en)	1991-02-28
FI108030B (fi)	2001-11-15
AU1090288A (en)	1988-08-11
DK52388D0 (da)	1988-02-02

Publication	Publication Date	Title
FI884914A0 (fi)	1988-10-24	Nya insulinderivat.
FI880173A (fi)	1988-07-17	Nya peptidasinhibitorer.
FI881825A0 (fi)	1988-04-19	Framstaellning av nya heterobicykliska kinolonderivat.
FI881650A0 (fi)	1988-04-08	Foerfarande foer framstaellning av nya acylderivat.
FI880469A (fi)	1988-08-04	Nya polyaminderivat.
FI884305A0 (fi)	1988-09-20	Nya amidinotricyklderivat.
FI884363A0 (fi)	1988-09-22	Nya aluminium-magnesium -hydroxifoereningar.
FI884627A (fi)	1989-04-10	Foerfarande foer framstaellning av nya terapeutiskt anvaendbara dideoxicytidinderivat.
FI881571A (fi)	1988-10-07	Nya ribofuransyraderivator.
FI893937A0 (fi)	1989-08-22	Nya antiarytmiska aemnen ii.
FI881639A0 (fi)	1988-04-08	Foerfarande foer framstaellning av nya substituerade anilidderivat.
FI884304A0 (fi)	1988-09-20	Nya amidinoderivat.
FI882640A0 (fi)	1988-06-03	Nya heterocykliska pesticida foereningar.
FI881641A0 (fi)	1988-04-08	Foerfarande foer framstaellning av nya acylderivat.
FI883146A0 (fi)	1988-06-30	Nya foereningar.
FI884106A0 (fi)	1988-09-06	Foerfarande foer framstaellning av nya antibakteriella 4-oxo-3-kinolinkarboxylsyror.
FI871320A (fi)	1988-09-26	Nya langmuir-blodgettmembranstrukturer.
FI884901A0 (fi)	1988-10-24	Nya rifamycinderivat.
FI885063A0 (fi)	1988-11-03	Nya 4-demetoxi-antracyklinderivat.
FI884535A (fi)	1989-04-03	Foerfarande foer framstaellning av nya kinolinium- och isokinoliniumderivat.
FI881921A0 (fi)	1988-04-22	Foerfarande foer framstaellning av nya terapeutiskt anvaendbara kinolintioetrar.
FI871462A0 (fi)	1987-04-03	Nya mineralprodukter.
FI873336A0 (fi)	1987-07-31	Nya makromolekyler.
FI880144A (fi)	1989-02-01	Nya makromolekyler.
FI870573A0 (fi)	1987-02-11	Nya etyleniskt omaettade foereningar innehaollande fosfinyl.

Legal Events

Date	Code	Title	Description
2004-08-31	FG	Patent granted	Owner name: MERRELL DOW PHARMACEUTICALS INC.
2005-08-31	MA	Patent expired